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Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 608 - 612
Deregulated expression of the MYC oncoprotein contributes to the genesis of many human tumours, yet strategies to exploit this for a rational tumour therapy... 
CANCER-CELLS | METABOLISM | GLUTAMINE | MITOCHONDRIAL BIOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | SYNTHETIC LETHAL INTERACTION | C-MYC | B KINASE | SUPPRESSION | ADDICTION | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Electron Transport | Protein Biosynthesis | Protein Kinases - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Homeostasis | Repressor Proteins - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 1 | Oncogene Protein p55(v-myc) - genetics | Carcinoma, Hepatocellular - drug therapy | Cell Respiration | RNA Interference | Repressor Proteins - deficiency | Cell Transformation, Neoplastic - genetics | Adenosine Triphosphate - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Protein Kinases - deficiency | Repressor Proteins - metabolism | Disease Models, Animal | Oncogene Protein p55(v-myc) - metabolism | Liver Neoplasms - genetics | Signal Transduction | Cell Survival | Liver Neoplasms - drug therapy | Repressor Proteins - genetics | Mitochondria - metabolism | Animals | Proteins - metabolism | Genes, myc - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Doxycycline - pharmacology | Mice | Proteins - antagonists & inhibitors | Apoptosis | Carcinoma, Hepatocellular - metabolism | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Drug therapy | Protein kinases | Tumors | Proteins | Liver cancer | Cell growth | Phosphorylation | Automation | Protein synthesis | Dependence | Glucose | Kinases | Autophagy
Journal Article
by Cole, John W and Xu, Huichun and Ryan, Kathleen and Jaworek, Thomas and Dueker, Nicole and McArdle, Patrick and Gaynor, Brady and Cheng, Yu-Ching and O'Connell, Jeffrey and Bevan, Steve and Malik, Rainer and Ahmed, Naveed Uddin and Amouyel, Philippe and Anjum, Sheraz and Bis, Joshua C and Crosslin, David and Danesh, John and Engelter, Stefan T and Fornage, Myriam and Frossard, Philippe and Gieger, Christian and Giese, Anne-Katrin and Grond-Ginsbach, Caspar and Ho, Weang Kee and Holliday, Elizabeth and Hopewell, Jemma and Hussain, M and Iqbal, W and Jabeen, S and Jannes, Jim and Kamal, Ayeesha and Kamatani, Yoichiro and Kanse, Sandip and Kloss, Manja and Lathrop, Mark and Leys, Didier and Lindgren, Arne and LongstrethJr, W.T and Mahmood, Khalid and Meisinger, Christa and Metso, Tiina M and Mosley, Thomas and Müller-Nurasyid, Martina and Norrving, Bo and Parati, Eugenio and Peters, Annette and Pezzini, Alessandro and Quereshi, I and Rasheed, Asif and Rauf, A and Salam, T and Shen, Jess and Slowik, Agnieszka and Stanne, Tara and Strauch, Konstantin and Tatlisumak, Turgut and Thijs, Vincent N and Tiedt, Steffen and Traylor, Matthew and Waldenberger, Melanie and Walters, Matthew and Zhao, Wei and Boncoraglio, Giorgio and Debette, Stephanie and Jern, Christina and Levi, Christopher and Markus, Hugh and Meschia, James and Rolfs, Arndt and Rothwell, Peter and Saleheen, Danish and Seshadri, Sudha and Sharma, Pankaj and Sudlow, Cathie and Worrall, Bradford and Stine, O. Colin and Kittner, Steven J and Mitchell, Braxton D and WTCCC-2 Consortium and METASTROKE Consortium ISGC and METASTROKE Consortium of the ISGC and Institutionen för biomedicin and Sahlgrenska akademin and Institute of Biomedicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
PLoS ONE, ISSN 1932-6203, 11/2018, Volume 13, Issue 11, p. e0206554
Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that... 
YOUNG-ADULTS | MORTALITY | POPULATION | FACTOR-V-LEIDEN | POLYMORPHISMS | METAANALYSIS | MYOCARDIAL-INFARCTION | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | MECHANISMS | GENOME-WIDE ASSOCIATION | Brain Ischemia - epidemiology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Middle Aged | Brain Ischemia - genetics | African Americans - genetics | Male | Endothelial Protein C Receptor - genetics | Case-Control Studies | Stroke - genetics | Young Adult | Adolescent | Age of Onset | Adult | Female | Stroke - epidemiology | Polymorphism, Single Nucleotide | Thrombomodulin - genetics | Stroke (Disease) | Genetic variation | African Americans | Genetic aspects | Research | Health aspects | Endothelium | Membrane proteins | Heart attacks | Population studies | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Risk factors | Proteins | Receptors | Ischemia | Pruning | Genetics | Thrombomodulin | Age | Stroke | Health risks | Protein C | Genetic diversity | Risk analysis | Minority & ethnic groups | Endothelial cells | Medicine | Hospitals | Replication | Health risk assessment | Age composition | Neurologi | Endothelial Protein C Receptor | Brain Ischemia | European Continental Ancestry Group | Single Nucleotide | Neurology | epidemiology | genetics | Polymorphism
Journal Article
FEMS Microbiology Ecology, ISSN 0168-6496, 10/2018, Volume 94, Issue 10
Journal Article
by Cheng, Yu-Ching and Stanne, Tara M and Giese, Anne-Katrin and Ho, Weang K and Traylor, Matthew and Amouyel, Philippe and Holliday, Elizabeth and Malik, Rainer and Xu, Huichun and Kittner, Thomas and Cole, John W and O´Connell, J.R and Danesh, John and Rasheed, Asif and Zhao, Wei and Engelter, Stefan and Grond-Ginsbach, Caspar and Kamatani, Yoichiro and Lathrop, Mark and Leys, Didier and Thijs, Vincent and Metso, Tiina M and Tatlisumak, Turgut and Pezzini, Alessano and Parati, Eugenio A and Norrving, Bo and Bevan, Steve and Rothwell, Peter and Sudlow, Cathie and Slowik, Agnieszka and Lindgren, Arne G and Walters, Matthew and Jannes, Jim and Shen, Jess and Crosslin, David and Doheny, Kimberly and Laurie, Cathy and Kanse, Sandip and Bis, Joshua and Fornage, Myriam and Mosley, Thomas H and Hopewell, J and Strauch, Konstantin and Müller-Nurasyid, Martina and Gieger, Christian and Waldenberger, Melanie and Peters, Annette and Meisinger, Christine and Ikram, Arfan and Longstreth, W.T and Meschia, James F and Seshai, Sudha and Sharma, Pankaj and Worrall, Bradford B and Jern, Christina and Levi, Christopher and Kubisch, Christian and Boncoraglio, Giorgio Battista and Markus, Hugh and Debette, Stéphanie and Rolfs, Arndt and Saleheen, D and Mitchell, Braxton and WTCCC-2 Consortium and Institutionen för biomedicin, avdelningen för patologi and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Biomedicine, Department of Pathology and Sahlgrenska Academy
Stroke (1970), ISSN 0039-2499, 02/2016, Volume 47, Issue 2, pp. 307 - 316
Journal Article
Sustainable Production, Life Cycle Engineering and Management, ISSN 2194-0541, 2018, pp. 155 - 176
Journal Article
PloS one, ISSN 1932-6203, 11/2018, Volume 13, Issue 11
Background and purpose Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that... 
Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
Stroke (1970), ISSN 1524-4628, 2016, Volume 47, Issue 2, p. 307
Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association... 
Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Henneman, Peter and Hovingh, G. Kees and Kastelein, John J. P and Chen, Wei and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nature (London), ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
ABDOMINAL ADIPOSITY | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | GLYCEMIC TRAITS | RISK | FALSE DISCOVERY | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Endokrinologi och diabetes | Public Health, Global Health, Social Medicine and Epidemiology | Endocrinology and Diabetes
Journal Article
by Locke, A.E and Kahali, B and Berndt, S.I and Justice, A.E and Pers, T.H and Day, F.R and Powell, C and Vedantam, S and Buchkovich, M.L and Yang, J and Croteau-Chonka, D.C and Esko, T and Fall, T and Ferreira, T and Gustafsson, S and Kutalik, Z and Luan, J and Magi, R and Randall, J.C and Winkler, T.W and Wood, A.R and Workalemahu, T and Faul, J.D and Smith, J.A and Zhao, J and Zhao, W and Chen, J and Fehrmann, R and Hedman, A.K and Karjalainen, J and Schmidt, E.M and Absher, D and Amin, N and Anderson, D and Beekman, M and Bolton, J.L and Bragg-Gresham, J.L and Buyske, S and Demirkan, A and Deng, G and Ehret, G.B and Feenstra, B and Feitosa, M.F and Fischer, K and Goel, A and Gong, J and Jackson, A.U and Kanoni, S and Kleber, M.E and Kristiansson, K and Lim, U and Lotay, V and Mangino, M and Leach, I. Mateo and Medina-Gomez, C and Medland, S.E and Nalls, M.A and Palmer, C.D and Pasko, D and Pechlivanis, S and Peters, M.J.W and Prokopenko, I and Shungin, D and Stancakova, A and Strawbridge, R.J and Sung, Y. Ju and Tanaka, T and Teumer, A and Trompet, S and Laan, S.W. van der and Setten, J. van and Vliet-Ostaptchouk, J.V. Van and Wang, Z and Yengo, L and Zhang, W and Isaacs, A and Albrecht, E and Arnlov, J and Arscott, G.M and Attwood, A.P and Bandinelli, S and Barrett, A and Bas, I.N and Bellis, C and Bennett, A.J and Berne, C and Blagieva, R and Bluher, M and Bohringer, S and Bonnycastle, L.L and Bottcher, Y and Boyd, H.A and Bruinenberg, M and Caspersen, I.H and Chen, Y.D and Clarke, R and Daw, E.W and Craen, A.J. de and Delgado, G and Dimitriou, M and ... and ADIPOGen Consortium and PAGE Consortium and LifeLines Cohort Study and MIGen Consortium and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and CKDGen Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and AGEN-BMI Working Grp and GLGC and International Endogene Consortium and AGEN-BMI Working Group and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GLGC and The GENIE Consortium and The AGEN-BMI Working Group and The MIGen Consortium and The MuTHER Consortium and The LifeLines Cohort Study
Nature (London), ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - 206
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and... 
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Medical and Health Sciences | Insulin: metabolism | Medicin och hälsovetenskap | Obesity: genetics | Europe: ethnology | Glutamic Acid: metabolism | Genetic Predisposition to Disease: genetics | Single Nucleotide: genetics | Klinisk medicin | Synapses: metabolism | Adiposity: genetics | Obesity: metabolism | Clinical Medicine | Energy Metabolism: genetics | Endokrinologi och diabetes | Quantitative Trait Loci: genetics | Insulin: secretion | Adipogenesis: genetics | Polymorphism | Continental Population Groups: genetics | Endocrinology and Diabetes
Journal Article