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1. Full Text Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally
by Huang, Huilin and Weng, Hengyou and Zhou, Keren and Wu, Tong and Zhao, Boxuan Simen and Sun, Mingli and Chen, Zhenhua and Deng, Xiaolan and Xiao, Gang and Auer, Franziska and Klemm, Lars and Wu, Huizhe and Zuo, Zhixiang and Qin, Xi and Dong, Yunzhu and Zhou, Yile and Qin, Hanjun and Tao, Shu and Du, Juan and Liu, Jun and Lu, Zhike and Yin, Hang and Mesquita, Ana and Yuan, Celvie L and Hu, Yueh-Chiang and Sun, Wenju and Su, Rui and Dong, Lei and Shen, Chao and Li, Chenying and Qing, Ying and Jiang, Xi and Wu, Xiwei and Sun, Miao and Guan, Jun-Lin and Qu, Lianghu and Wei, Minjie and Müschen, Markus and Huang, Gang and He, Chuan and Yang, Jianhua and Chen, Jianjun
Nature (London), ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, pp. 414 - 419
Cell Line | Embryonic Stem Cells - metabolism | Histones - chemistry | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Transcriptome - genetics | RNA Polymerase II - metabolism | RNA, Messenger - metabolism | Methyltransferases - deficiency | Transcription Elongation, Genetic | Animals | Adenosine - analogs & derivatives | Adenosine - metabolism | RNA, Messenger - chemistry | Transcription, Genetic | Cell Differentiation | Lysine - metabolism | Mice | Histones - metabolism | Lysine - chemistry | Methylation
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2. Full Text Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia
by Gang, E.J and Hsieh, Y.-T and Pham, J and Zhao, Y and Nguyen, C and Huantes, S and Park, E and Naing, K and Klemm, L and Swaminathan, S and Conway, E.M and Pelus, L.M and Crispino, J and Mullighan, C.G and McMillan, M and Müschen, M and Kahn, M and Kim, Y.-M
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 17, pp. 2169 - 2178
CBP | p300 | ICG-001 | small-molecule inhibitor | drug resistance | acute lymphoblastic leukemia | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sialoglycoproteins - genetics | Vincristine - pharmacology | Inhibitor of Apoptosis Proteins - genetics | Humans | Sialoglycoproteins - metabolism | Drug Resistance, Neoplasm | Asparaginase - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Peptide Fragments - genetics | Wnt Signaling Pathway | Cell Survival - drug effects | Peptide Fragments - metabolism | Sialoglycoproteins - antagonists & inhibitors | Down-Regulation - drug effects | Mice, SCID | beta Catenin - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mutation | Care and treatment | Oncology, Experimental | Genetic aspects | Acute lymphocytic leukemia | Research | Drug resistance | Cancer | Cloning | Leukemia | Index Medicus | Acute lymphoblastic leukemia | small molecule inhibitor
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3. Full Text Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation
by McCracken, A.N and McMonigle, R.J and Tessier, J and Fransson, R and Perryman, M.S and Chen, B and Keebaugh, A and Selwan, E and Barr, S.A and Kim, S.M and Roy, S.G and Liu, G and Fallegger, D and Sernissi, L and Brandt, C and Moitessier, N and Snider, A.J and Clare, S and Müschen, M and Huwiler, A and Kleinman, M.T and Hanessian, S and Edinger, A.L
Leukemia, ISSN 0887-6924, 03/2017, Volume 31, Issue 3, pp. 669 - 677
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Fingolimod Hydrochloride - pharmacology | Phosphorylation | Leukemia - pathology | Apoptosis - drug effects | Humans | Leukemia - drug therapy | Phosphotransferases (Alcohol Group Acceptor) - genetics | Leukemia - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Cell Line, Tumor | Receptors, Lysosphingolipid - agonists | Female | Antineoplastic Agents - pharmacology | Mice | Receptors, Lysosphingolipid - metabolism | Leukemia - genetics | Disease Models, Animal | Usage | Leukemia | Sphingosine | Development and progression | Genetic aspects | Research | Drug approval | Health aspects | Index Medicus
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4. Full Text Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition
by Köhrer, S and Havranek, O and Seyfried, F and Hurtz, C and Coffey, G.P and Kim, E and Ten Hacken, E and Jäger, U and Vanura, K and O'Brien, S and Thomas, D.A and Kantarjian, H and Ghosh, D and Wang, Z and Zhang, M and Ma, W and Jumaa, H and Debatin, K.-M and Müschen, M and Meyer, L.H and Davis, R.E and Burger, J.A
Leukemia, ISSN 0887-6924, 06/2016, Volume 30, Issue 6, pp. 1246 - 1254
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Line | Forkhead Box Protein O1 - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Signal Transduction | Humans | Phosphatidylinositol 3-Kinases - metabolism | Receptors, Antigen, B-Cell - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Syk Kinase - metabolism | Animals | Heterografts | Precursor Cells, B-Lymphoid - chemistry | Mice | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Lymphomas | Properties | Health aspects | Index Medicus | pre-BCR | SYK | B-ALL
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5. Full Text BCOR regulates myeloid cell proliferation and differentiation
by Cao, Q and Gearhart, M.D and Gery, S and Shojaee, S and Yang, H and Sun, H and Lin, D.-C and Bai, J.-W and Mead, M and Zhao, Z and Chen, Q and Chien, W.-W and Alkan, S and Alpermann, T and Haferlach, T and Müschen, M and Bardwell, V.J and Koeffler, H.P
Leukemia, ISSN 0887-6924, 05/2016, Volume 30, Issue 5, pp. 1155 - 1165
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Proliferation | Mutagenesis, Site-Directed | Leukemia, Myeloid, Acute - pathology | Humans | Gene Expression Regulation | Repressor Proteins - genetics | Genes, Homeobox - genetics | Repressor Proteins - physiology | Animals | Polycomb Repressive Complex 1 - physiology | Hematopoiesis | Myeloid Progenitor Cells - cytology | Cell Differentiation | Mice | Cell proliferation | Cellular proteins | Genetic aspects | Properties | Cell differentiation | Index Medicus
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6. Full Text Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally
by Huang, Huilin and Weng, Hengyou and Zhou, Keren and Wu, Tong and Zhao, Boxuan Simen and Sun, Mingli and Chen, Zhenhua and Deng, Xiaolan and Xiao, Gang and Auer, Franziska and Klemm, Lars and Wu, Huizhe and Zuo, Zhixiang and Qin, Xi and Dong, Yunzhu and Zhou, Yile and Qin, Hanjun and Tao, Shu and Du, Juan and Liu, Jun and Lu, Zhike and Yin, Hang and Mesquita, Ana and Yuan, Celvie L and Hu, Yueh-Chiang and Sun, Wenju and Su, Rui and Dong, Lei and Shen, Chao and Li, Chenying and Qing, Ying and Jiang, Xi and Wu, Xiwei and Sun, Miao and Guan, Jun-Lin and Qu, Lianghu and Wei, Minjie and Muschen, Markus and Huang, Gang and He, Chuan and Yang, Jianhua and Chen, Jianjun
Nature (London), ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, p. 414
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology
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7. Full Text MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
by Benito, Juliana M and Godfrey, Laura and Kojima, Kensuke and Hogdal, Leah and Wunderlich, Mark and Geng, Huimin and Marzo, Isabel and Harutyunyan, Karine G and Golfman, Leonard and North, Phillip and Kerry, Jon and Ballabio, Erica and Chonghaile, Triona Ní and Gonzalo, Oscar and Qiu, Yihua and Jeremias, Irmela and Debose, LaKiesha and O’Brien, Eric and Ma, Helen and Zhou, Ping and Jacamo, Rodrigo and Park, Eugene and Coombes, Kevin R and Zhang, Nianxiang and Thomas, Deborah A and O’Brien, Susan and Kantarjian, Hagop M and Leverson, Joel D and Kornblau, Steven M and Andreeff, Michael and Müschen, Markus and Zweidler-McKay, Patrick A and Mulloy, James C and Letai, Anthony and Milne, Thomas A and Konopleva, Marina
Cell reports (Cambridge), ISSN 2211-1247, 12/2015, Volume 13, Issue 12, pp. 2715 - 2727
MLL/AF4 | apoptosis pathways | bcl-2 family members | leukemias | H3K79 methylation | DOT1L | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Histone-Lysine N-Methyltransferase - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Genes, bcl-2 | Mice, SCID | Sulfonamides - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Cell Line, Tumor | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Methylation | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
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8. Full Text Development of resistance to dasatinib in Bcr Abl-positive acute lymphoblastic leukemia
by Fei, F and Stoddart, S and Müschen, M and Kim, Y.-M and Groffen, J and Heisterkamp, N
Leukemia, ISSN 0887-6924, 04/2010, Volume 24, Issue 4, pp. 813 - 820
CXCR4 | SFK | Suboptimal dose | Stromal support | AMD3100 | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Chromosome aberrations | Medical genetics | Embryo, Mammalian - drug effects | Phosphorylation | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Embryo, Mammalian - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Stromal Cells - drug effects | src-Family Kinases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Fibroblasts - metabolism | Leukemia, Experimental - pathology | Dasatinib | Leukemia, Experimental - drug therapy | Stromal Cells - metabolism | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | Pyrimidines - pharmacology | Mice, SCID | Blotting, Western | Mice, Knockout | Receptors, CXCR4 - metabolism | Animals | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Fusion Proteins, bcr-abl - metabolism | Leukemia, Experimental - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Stromal Cells - radiation effects | Complications and side effects | Genetic aspects | Dosage and administration | Acute lymphocytic leukemia | Research | Drug therapy | Drug resistance | Risk factors | Index Medicus | drug stability and suboptimal dose | CCL12 | stromal support | tyrosine kinase inhibition | Ph-positive ALL
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9. Full Text Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
by Katerndahl, C.D.S and Heltemes-Harris, L.M and Willette, M.J.L and Henzler, C.M and Frietze, S and Yang, R and Schjerven, H and Silverstein, K.A.T and Ramsey, L.B and Hubbard, G and Wells, A.D and Kuiper, R.P and Scheijen, B and Leeuwen, F.N. van and Muschen, M and Kornblau, S.M and Farrar, M.A
Nature immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
Life Sciences & Biomedicine | Immunology | Science & Technology | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Agammaglobulinaemia Tyrosine Kinase | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4 | Index Medicus
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