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Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 17, pp. 2169 - 2178
Drug resistance in acute lymphoblastic leukemia (ALL) remains a major problem warranting new treatment strategies. Wnt/catenin signaling is critical for the... 
CBP | p300 | ICG-001 | small-molecule inhibitor | drug resistance | acute lymphoblastic leukemia | RUBINSTEIN-TAYBI-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL COACTIVATOR CBP | SELF-RENEWAL | BETA-CATENIN | HISTONE ACETYLATION | CELL BIOLOGY | CREB-BINDING PROTEIN | ONCOLOGY | PRE-B | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | WNT/BETA-CATENIN PATHWAY | DIFFERENTIAL ROLES | Sialoglycoproteins - genetics | Vincristine - pharmacology | Inhibitor of Apoptosis Proteins - genetics | Humans | Sialoglycoproteins - metabolism | Drug Resistance, Neoplasm | Asparaginase - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Peptide Fragments - genetics | Wnt Signaling Pathway | Cell Survival - drug effects | Peptide Fragments - metabolism | Sialoglycoproteins - antagonists & inhibitors | Down-Regulation - drug effects | Mice, SCID | beta Catenin - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mutation | Care and treatment | Oncology, Experimental | Genetic aspects | Acute lymphocytic leukemia | Research | Drug resistance | Cancer | Cloning | Leukemia | Index Medicus | Acute lymphoblastic leukemia | small molecule inhibitor
Journal Article
Nature, ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, pp. 414 - 419
DNA and histone modifications have notable effects on gene expression . Being the most prevalent internal modification in mRNA, the N -methyladenosine (m A)... 
Journal Article
Leukemia, ISSN 0887-6924, 03/2017, Volume 31, Issue 3, pp. 669 - 677
Journal Article
by Huang, HL and Weng, HY and Zhou, KR and Wu, T and Zhao, BS and Sun, ML and Chen, ZH and Deng, XL and Xiao, G and Auer, F and Klemm, L and Wu, HZ and Zuo, ZX and Qin, X and Dong, YZ and Zhou, YL and Qin, HJ and Tao, S and Du, J and Liu, J and Lu, ZK and Yin, H and Mesquita, A and Yuan, CL and Hu, YC and Sun, WJ and Su, R and Dong, L and Shen, C and Li, CY and Qing, Y and Jiang, X and Wu, XW and Sun, M and Guan, JL and Qu, LH and Wei, MJ and Muschen, M and Huang, G and He, C and Yang, J and Chen, J
NATURE, ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, pp. 414 - 414
DNA and histone modifications have notable effects on gene expression(1). Being the most prevalent internal modification in mRNA, the N-6-methyladenosine... 
METHYLATION | DOMAIN | DEACETYLATION | STABILITY | MULTIDISCIPLINARY SCIENCES | ENRICHMENT | REVEALS
Journal Article
Journal Article
by Townsend, Elizabeth C and Murakami, Mark A and Murakami, Masato and Christodoulou, Alexandra and Christie, Amanda L and Köster, Johannes and DeSouza, Tiffany A and Morgan, Elizabeth A and Kallgren, Scott P and Liu, Huiyun and Wu, Shuo-Chieh and Plana, Olivia and Montero, Joan and Stevenson, Kristen E and Rao, Prakash and Vadhi, Raga and Andreeff, Michael and Armand, Philippe and Ballen, Karen K and Barzaghi-Rinaudo, Patrizia and Cahill, Sarah and Clark, Rachael A and Cooke, Vesselina G and Davids, Matthew S and DeAngelo, Daniel J and Dorfman, David M and Eaton, Hilary and Ebert, Benjamin L and Etchin, Julia and Firestone, Brant and Fisher, David C and Freedman, Arnold S and Galinsky, Ilene A and Gao, Hui and Garcia, Jacqueline S and Garnache-Ottou, Francine and Graubert, Timothy A and Gutierrez, Alejandro and Halilovic, Ensar and Harris, Marian H and Herbert, Zachary T and Horwitz, Steven M and Inghirami, Giorgio and Intlekofer, Andrew M and Ito, Moriko and Izraeli, Shai and Jacobsen, Eric D and Jacobson, Caron A and Jeay, Sébastien and Jeremias, Irmela and Kelliher, Michelle A and Koch, Raphael and Konopleva, Marina and Kopp, Nadja and Kornblau, Steven M and Kung, Andrew L and Kupper, Thomas S and LeBoeuf, Nicole R and LaCasce, Ann S and Lees, Emma and Li, Loretta S and Look, A. Thomas and Muschen, Markus and Neuberg, Donna and Ng, Samuel Y and Odejide, Oreofe O and Orkin, Stuart H and Paquette, Rachel R and Place, Andrew E and Roderick, Justine E and Ryan, Jeremy A and Sallan, Stephen E and Shoji, Brent and Silverman, Lewis B and Soiffer, Robert J and Steensma, David P and Stegmaier, Kimberly and Stone, Richard M and Tamburini, Jerome and Thorner, Aaron R and van Hummelen, Paul and Wadleigh, Martha and Wiesmann, Marion and Weng, Andrew P and Wuerthner, Jens U and Williams, David A and Wollison, Bruce M and Lane, Andrew A and Letai, Anthony and Bertagnolli, Monica M and Ritz, Jerome and Brown, Myles and Long, Henry and Aster, Jon C and Shipp, Margaret A and Griffin, James D and Weinstock, David M
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 574 - 586
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 3, pp. 362 - 675
Journal Article
Leukemia, ISSN 0887-6924, 05/2016, Volume 30, Issue 5, pp. 1155 - 1165
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2016, Volume 22, Issue 4, pp. 379 - 387
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 479 - 483
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development(1,2), yet lesions of the genes encoding these transcription... 
ENERGY STRESS | ACTIVATION | GENE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | REGULATORY NETWORK | DIFFERENTIATION | MINIMAL RESIDUAL DISEASE | EXPRESSION | Glucocorticoids - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Gene Expression Regulation, Neoplastic | Receptors, Glucocorticoid - metabolism | PAX5 Transcription Factor - deficiency | Carrier Proteins - agonists | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Chromatin Immunoprecipitation | Adenosine Triphosphate - metabolism | Cell Death | Pyruvic Acid - metabolism | Female | Ikaros Transcription Factor - metabolism | Energy Metabolism - genetics | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | AMP-Activated Protein Kinases - antagonists & inhibitors | Carcinogenesis - genetics | PAX5 Transcription Factor - genetics | Mice, Transgenic | Citric Acid Cycle | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carrier Proteins - metabolism | Sequence Analysis, RNA | Glucocorticoids - pharmacology | Glucose - metabolism | Mice | Physiological aspects | Transcription factors | B cells | Proteins | Metabolites | Rodents | Cloning | Leukemia | Glucose | Kinases | Metabolism | Gene expression | Apoptosis
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 766 - 774
Childhood acute lymphoblastic leukemia (ALL) can often be traced to a pre-leukemic clone carrying a prenatal genetic lesion. Postnatally acquired mutations... 
B-CELL DEVELOPMENT | RECOMBINATION | CYTIDINE DEAMINASE AID | ACTIVATION | GENE | CHROMOSOME TRANSLOCATIONS | IMMUNOLOGY | CLASS SWITCH | EXPRESSION | MONOZYGOTIC TWINS | DAY-CARE | Cytidine Deaminase - immunology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Homeodomain Proteins - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Child, Preschool | Immunoblotting | Infant | Male | Precursor Cells, B-Lymphoid - immunology | Homeodomain Proteins - immunology | Clonal Evolution - genetics | DNA-Binding Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Antibody Diversity - genetics | Flow Cytometry | Antibody Diversity - immunology | Female | Tumor Cells, Cultured | Child | B-Lymphocytes - metabolism | DNA-Binding Proteins - immunology | Cytidine Deaminase - genetics | Mice, Transgenic | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Mice, Knockout | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | B-Lymphocytes - immunology | Cytidine Deaminase - metabolism | Adolescent | Mice, Inbred NOD | Clonal Evolution - immunology | Microscopy, Fluorescence | Gene mutations | Genetic susceptibility | Oncology, Experimental | Genetic research | Development and progression | Genetic aspects | Acute lymphocytic leukemia | Research | Identification and classification | Health aspects | Cancer
Journal Article
Nature Immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found... 
MAINTENANCE | ACTIVATION | PROTEIN | DISRUPTION | SUPER-ENHANCERS | IKAROS | ACUTE LYMPHOBLASTIC-LEUKEMIA | RECEPTOR | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Bruton's tyrosine kinase | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4
Journal Article