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1.
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Histone H3 trimethylation at lysine 36 guides m 6 A RNA modification co-transcriptionally
Nature (London), ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, pp. 414 - 419
Cell Line | Embryonic Stem Cells - metabolism | Histones - chemistry | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Transcriptome - genetics | RNA Polymerase II - metabolism | RNA, Messenger - metabolism | Methyltransferases - deficiency | Transcription Elongation, Genetic | Animals | Adenosine - analogs & derivatives | Adenosine - metabolism | RNA, Messenger - chemistry | Transcription, Genetic | Cell Differentiation | Lysine - metabolism | Mice | Histones - metabolism | Lysine - chemistry | Methylation
Journal Article
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 17, pp. 2169 - 2178
CBP | p300 | ICG-001 | small-molecule inhibitor | drug resistance | acute lymphoblastic leukemia | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sialoglycoproteins - genetics | Vincristine - pharmacology | Inhibitor of Apoptosis Proteins - genetics | Humans | Sialoglycoproteins - metabolism | Drug Resistance, Neoplasm | Asparaginase - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Peptide Fragments - genetics | Wnt Signaling Pathway | Cell Survival - drug effects | Peptide Fragments - metabolism | Sialoglycoproteins - antagonists & inhibitors | Down-Regulation - drug effects | Mice, SCID | beta Catenin - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mutation | Care and treatment | Oncology, Experimental | Genetic aspects | Acute lymphocytic leukemia | Research | Drug resistance | Cancer | Cloning | Leukemia | Index Medicus | Acute lymphoblastic leukemia | small molecule inhibitor
Journal Article
Leukemia, ISSN 0887-6924, 03/2017, Volume 31, Issue 3, pp. 669 - 677
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Fingolimod Hydrochloride - pharmacology | Phosphorylation | Leukemia - pathology | Apoptosis - drug effects | Humans | Leukemia - drug therapy | Phosphotransferases (Alcohol Group Acceptor) - genetics | Leukemia - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Cell Line, Tumor | Receptors, Lysosphingolipid - agonists | Female | Antineoplastic Agents - pharmacology | Mice | Receptors, Lysosphingolipid - metabolism | Leukemia - genetics | Disease Models, Animal | Usage | Leukemia | Sphingosine | Development and progression | Genetic aspects | Research | Drug approval | Health aspects | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 06/2016, Volume 30, Issue 6, pp. 1246 - 1254
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Line | Forkhead Box Protein O1 - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Signal Transduction | Humans | Phosphatidylinositol 3-Kinases - metabolism | Receptors, Antigen, B-Cell - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Syk Kinase - metabolism | Animals | Heterografts | Precursor Cells, B-Lymphoid - chemistry | Mice | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Lymphomas | Properties | Health aspects | Index Medicus | pre-BCR | SYK | B-ALL
Journal Article
Leukemia, ISSN 0887-6924, 05/2016, Volume 30, Issue 5, pp. 1155 - 1165
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Proliferation | Mutagenesis, Site-Directed | Leukemia, Myeloid, Acute - pathology | Humans | Gene Expression Regulation | Repressor Proteins - genetics | Genes, Homeobox - genetics | Repressor Proteins - physiology | Animals | Polycomb Repressive Complex 1 - physiology | Hematopoiesis | Myeloid Progenitor Cells - cytology | Cell Differentiation | Mice | Cell proliferation | Cellular proteins | Genetic aspects | Properties | Cell differentiation | Index Medicus
Journal Article
6.
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Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally
Nature (London), ISSN 0028-0836, 03/2019, Volume 567, Issue 7748, p. 414
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 12/2015, Volume 13, Issue 12, pp. 2715 - 2727
MLL/AF4 | apoptosis pathways | bcl-2 family members | leukemias | H3K79 methylation | DOT1L | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Histone-Lysine N-Methyltransferase - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Genes, bcl-2 | Mice, SCID | Sulfonamides - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Cell Line, Tumor | Mice, Inbred NOD | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Methylation | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
Journal Article
8.
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Development of resistance to dasatinib in Bcr Abl-positive acute lymphoblastic leukemia
Leukemia, ISSN 0887-6924, 04/2010, Volume 24, Issue 4, pp. 813 - 820
CXCR4 | SFK | Suboptimal dose | Stromal support | AMD3100 | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Chromosome aberrations | Medical genetics | Embryo, Mammalian - drug effects | Phosphorylation | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Embryo, Mammalian - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Stromal Cells - drug effects | src-Family Kinases - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Fibroblasts - metabolism | Leukemia, Experimental - pathology | Dasatinib | Leukemia, Experimental - drug therapy | Stromal Cells - metabolism | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | Pyrimidines - pharmacology | Mice, SCID | Blotting, Western | Mice, Knockout | Receptors, CXCR4 - metabolism | Animals | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Fusion Proteins, bcr-abl - metabolism | Leukemia, Experimental - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Stromal Cells - radiation effects | Complications and side effects | Genetic aspects | Dosage and administration | Acute lymphocytic leukemia | Research | Drug therapy | Drug resistance | Risk factors | Index Medicus | drug stability and suboptimal dose | CCL12 | stromal support | tyrosine kinase inhibition | Ph-positive ALL
Journal Article
9.
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Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Nature immunology, ISSN 1529-2908, 2017, Volume 18, Issue 6, pp. 694 - 704
Life Sciences & Biomedicine | Immunology | Science & Technology | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Protein Kinase C beta - genetics | B-Lymphocytes | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | NF-kappa B p50 Subunit - genetics | Ikaros Transcription Factor - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Chromatin Immunoprecipitation | Trans-Activators - genetics | Pre-B Cell Receptors - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | PAX5 Transcription Factor - genetics | Interferon Regulatory Factors - genetics | Proto-Oncogene Proteins - genetics | Survival Rate | Multiplex Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Agammaglobulinaemia Tyrosine Kinase | Adaptor Proteins, Signal Transducing - genetics | Mice | Care and treatment | Immune response | Development and progression | STAT5 | Genetic aspects | Acute lymphocytic leukemia | Health aspects | Protein kinase C | Transcription factors | Ikaros protein | Acute lymphatic leukemia | Cell survival | Leukemia | Gene regulation | T cell receptors | Stat5 protein | Lymphatic leukemia | B-cell receptor | Gene expression | Pax5 protein | Defects | Enhancers | PU.1 protein | BLNK protein | Lymphocytes B | Interferon regulatory factor 4 | Index Medicus
Journal Article