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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 38, p. 10107
An effect of thyroid hormone (TH) on erythropoiesis has been known for more than a century but the molecular mechanism(s) by which TH affects red cell... 
Erythropoiesis | Cell culture | Chromatin | Pol II | Anemia | Blood cells | Erythrocytes | Differentiation (biology) | Reticulocytes | Genomes | Cell differentiation | Gene expression | Ribonucleic acid--RNA | Impact analysis | Recruitment | Studies | Enucleation | Thyroid
Journal Article
Current Biology, ISSN 0960-9822, 06/2015, Volume 25, Issue 12, pp. 1654 - 1660
Replication origins are under tight regulation to ensure activation occurs only once per cell cycle [ ]. Origin re-firing in a single S phase leads to the... 
REREPLICATION | CELLS | GEMININ | ACTIVATION | AMPLICONS | DROSOPHILA-MELANOGASTER | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE AMPLIFICATION | ATR | P53 | CELL BIOLOGY | DNA Replication | Animals | DNA Breaks, Double-Stranded | Drosophila melanogaster - genetics | DNA Repair | DNA damage | Analysis | DNA
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2013, Volume 110, Issue 4, p. 1428
  A monoclonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of... 
Antigens | Peptides | Herpes viruses | Monoclonal antibodies | Amino acids | T cell receptors | Cytoplasm
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1428 - 1433
A monodonal antibody against the C-type lectin DEC205 (αDEC205) is an effective vehicle for delivery of antigens to dendritic cells through creation of... 
T lymphocytes | Proteins | Antigens | Immunization | Dendritic cells | Antibodies | T lymphocyte epitopes | Epitopes | Cytoplasm | Adducts | TCR | vaccine development | DENDRITIC CELLS | vaccines | RECEPTOR DEC-205 | MULTIDISCIPLINARY SCIENCES | MOUSE | MODEL | TRANSNUCLEAR | antibody conjugates | protein engineering | IN-VIVO | MURINE GAMMAHERPESVIRUS 68 | MICE | T-CELLS | Vaccines, Subunit - genetics | Epitopes, T-Lymphocyte - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Lectins, C-Type - metabolism | Protein Engineering | Tumor Virus Infections - immunology | Amino Acid Sequence | Immunoconjugates - metabolism | Mice, Transgenic | Receptors, Cell Surface - immunology | Mice, Knockout | Epitopes, T-Lymphocyte - chemistry | Antigens, Viral - immunology | Immunoconjugates - genetics | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | CD8-Positive T-Lymphocytes - immunology | Herpesviridae Infections - immunology | Receptors, Cell Surface - genetics | Antigens, CD - immunology | Minor Histocompatibility Antigens | Viral Vaccines - genetics | Lectins, C-Type - immunology | Molecular Sequence Data | Antigens, Viral - genetics | Rhadinovirus - immunology | Lectins, C-Type - genetics | Lectins, C-Type - chemistry | Herpesviridae Infections - prevention & control | Immunoconjugates - immunology | Cysteine Endopeptidases - metabolism | Antigen Presentation | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Epitopes, T-Lymphocyte - immunology | Rhadinovirus - genetics | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Antigens, Viral - chemistry | Vaccines, Subunit - immunology | Tumor Virus Infections - prevention & control | Animals | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Viral Vaccines - immunology | Biological Sciences
Journal Article
Developmental Cell, ISSN 1534-5807, 04/2019, Volume 49, Issue 1, pp. 118 - 129.e7
The nature of cell-state transitions during the transit-amplifying phases of many developmental processes—hematopoiesis in particular—is unclear. Here, we use... 
hematopoiesis | single-cell transcriptomics | erythropoiesis | transit-amplification | progenitor cell | self-renewal | HETEROGENEITY | GLUCOCORTICOID-RECEPTOR | ERYTHROPOIESIS | DIAMOND-BLACKFAN ANEMIA | SELF-RENEWAL | STEM-CELL | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | ERYTHROID PROGENITORS | HEMATOPOIETIC STEM | REVEALS | CELL BIOLOGY | RNA sequencing | Corticosteroids | RNA | Cell differentiation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 44, p. 18061
Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation upon detection of pathogens and host tissue injury. TLR-mediated... 
Proteins | Genotype & phenotype | Rodents | Binding sites | Inflammatory diseases
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2011, Volume 7, Issue 5
  DRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we... 
Proteins | Genomics | Nematodes | Genetics | Gene expression
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2019, Volume 116, Issue 34, pp. 16971 - 16980
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2013, Volume 110, Issue 4, pp. 1428 - 1433
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7601, p. 95
Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases, but mechanistic insights are impeded by a... 
Genetic aspects | Parkinson's disease | Gene expression | Health aspects | Risk factors | Membrane proteins | Studies | Transcription factors | Pathogenesis | Cloning | Parkinsons disease | Stem cells | Epigenetics | Genomes
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, p. 474
Many acute and chronic anaemias, including haemolysis, sepsis and genetic bone marrow failure diseases such as Diamond- Blackfan anaemia, are not treatable... 
Physiological aspects | Physiological research | Corticosteroids | Regeneration (Biology) | Research | Anemia | Drugs | Transcription factors | Rodents | Blood
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2013, Volume 24, Issue 3, pp. 310 - 323
Journal Article
Nature, ISSN 0028-0836, 5/2016, Volume 533, Issue 7601, pp. 95 - 99
Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases but mechanistic insights are impeded by the... 
Journal Article