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by Palles, Claire and Cazier, Jean-Baptiste and Howarth, Kimberley M and Domingo, Enric and Jones, Angela M and Broderick, Peter and Kemp, Zoe and Spain, Sarah L and Almeida, Estrella Guarino and Salguero, Israel and Sherborne, Amy and Chubb, Daniel and Carvajal-Carmona, Luis G and Ma, Yusanne and Kaur, Kulvinder and Dobbins, Sara and Barclay, Ella and Gorman, Maggie and Martin, Lynn and Kovac, Michal B and Humphray, Sean and Lucassen, Anneke and Holmes, Christopher H and Bentley, David and Donnelly, Peter and Taylor, Jenny and Petridis, Christos and Roylance, Rebecca and Sawyer, Elinor J and Kerr, David J and Clark, Susan and Grimes, Jonathan and Kearsey, Stephen E and Thomas, Huw J.W and McVean, Gilean and Houlston, Richard S and Tomlinson, Ian and Thomas, Huw J.W and Maher, Eamonn and Evans, Gareth and Cummings, Carole and Stevens, Margaret and Walker, Lisa and Halliday, Dorothy and Armstrong, Ruth and Paterson, Joan and Hodgson, Shirley and Homfray, Tessa and Side, Lucy and Izatt, Louise and Donaldson, Alan and Tomkins, Susan and Morrison, Patrick and Goodman, Selina and Brewer, Carole and Henderson, Alex and Davidson, Rosemarie and Murday, Victoria and Cook, Jaqueline and Haites, Nneva and Bishop, Timothy and Sheridan, Eamonn and Green, Andrew and Marks, Christopher and Carpenter, Sue and Broughton, Mary and Greenhalge, Lynn and Suri, Mohnish and Bell, John and Ratcliffe, Peter and Wilkie, Andrew and Broxholme, John and Buck, David and Cornall, Richard and Gregory, Lorna and Knight, Julian and Lunter, Gerton and Kingsbury, Zoya and Grocock, Russell and Hatton, Edouard and Holmes, Christopher C and Hughes, Linda and Humburg, Peter and Kanapin, Alexander and Murray, Lisa and Rimmer, Andy and WGS500 Consortium and CORGI Consortium and The WGS500 Consortium and The CORGI Consortium
Nature Genetics, ISSN 1061-4036, 02/2013, Volume 45, Issue 2, pp. 136 - 143
Journal Article
by Morrissy, A. Sorana and Garzia, Livia and Shih, David J. H and Zuyderduyn, Scott and Huang, Xi and Skowron, Patryk and Remke, Marc and Cavalli, Florence M. G and Ramaswamy, Vijay and Lindsay, Patricia E and Jelveh, Salomeh and Donovan, Laura K and Wang, Xin and Luu, Betty and Zayne, Kory and Li, Yisu and Mayoh, Chelsea and Thiessen, Nina and Mercier, Eloi and Mungall, Karen L and Ma, Yusanne and Tse, Kane and Zeng, Thomas and Shumansky, Karey and Roth, Andrew J. L and Shah, Sohrab and Farooq, Hamza and Kijima, Noriyuki and Holgado, Borja L and Lee, John J. Y and Matan-Lithwick, Stuart and Liu, Jessica and Mack, Stephen C and Manno, Alex and Michealraj, K.A and Nor, Carolina and Peacock, John and Qin, Lei and Reimand, Juri and Rolider, Adi and Thompson, Yuan Y and Wu, Xiaochong and Pugh, Trevor and Ally, Adrian and Bilenky, Mikhail and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Young and Chuah, Eric and Corbett, Richard D and Dhalla, Noreen and He, An and Lee, Darlene and Li, Haiyan I and Long, William and Mayo, Michael and Plettner, Patrick and Qian, Jenny Q and Schein, Jacqueline E and Tam, Angela and Wong, Tina and Birol, Inanc and Zhao, Yongjun and Faria, Claudia C and Pimentel, José and Nunes, Sofia and Shalaby, Tarek and Grotzer, Michael and Pollack, Ian F and Hamilton, Ronald L and Li, Xiao-Nan and Bendel, Anne E and Fults, Daniel W and Walter, Andrew W and Kumabe, Toshihiro and Tominaga, Teiji and Collins, V. Peter and Cho, Yoon-Jae and Hoffman, Caitlin and Lyden, David and Wisoff, Jeffrey H and Garvin, James H and Stearns, Duncan S and Massimi, Luca and Schüller, Ulrich and Sterba, Jaroslav and Zitterbart, Karel and Puget, Stephanie and Ayrault, Olivier and Dunn, Sandra E and Tirapelli, Daniela P. C and Carlotti, Carlos G and Wheeler, Helen and Hallahan, Andrew R and Ingram, Wendy and MacDonald, Tobey J and Olson, Jeffrey J and Van Meir, Erwin G and Lee, Ji-Yeoun and Wang, Kyu-Chang and ...
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7586, pp. 351 - 357
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related... 
HETEROGENEITY | CANCER EVOLUTION | CELLS | IMPACT | MULTIDISCIPLINARY SCIENCES | SUBGROUP MEDULLOBLASTOMA | DYNAMICS | MUTATIONS | SEQUENCING DATA | LYMPHOBLASTIC-LEUKEMIA | GENOME | Clone Cells - drug effects | Humans | Male | Medulloblastoma - therapy | Radiotherapy, Image-Guided | Selection, Genetic - drug effects | Drosophila melanogaster - genetics | Neoplasm Recurrence, Local - pathology | Medulloblastoma - radiotherapy | DNA Mutational Analysis | Medulloblastoma - pathology | Female | Medulloblastoma - surgery | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Molecular Targeted Therapy - methods | Disease Models, Animal | Signal Transduction | Neoplasm Recurrence, Local - therapy | Drosophila melanogaster - cytology | Cerebellar Neoplasms - genetics | Clone Cells - metabolism | Genome, Human - genetics | Xenograft Model Antitumor Assays | Animals | Clone Cells - pathology | Craniospinal Irradiation | Neoplasm Recurrence, Local - genetics | Mice | Cerebellar Neoplasms - therapy | Cerebellar Neoplasms - surgery | Cerebellar Neoplasms - radiotherapy | Clonal selection theory | Care and treatment | Medulloblastoma | Oncology, Experimental | Genetic aspects | Research | Cancer | Genes | Cloning | Clinical trials | Cytotoxicity | Genomes | Radiation therapy | Metastasis | Cancer therapies | Rodents | Medical prognosis | Mutation | Tumors | Index Medicus
Journal Article
by Dunlop, Malcolm G and Dobbins, Sara E and Farrington, Susan Mary and Jones, Angela M and Palles, Claire and Whiffin, Nicola and Tenesa, Albert and Spain, Sarah and Broderick, Peter and Ooi, Li-Yin and Domingo, Enric and Smillie, Claire and Henrion, Marc and Frampton, Matthew and Martin, Lynn and Grimes, Graeme and Gorman, Maggie and Semple, Colin and Ma, Yusanne P and Barclay, Ella and Prendergast, James and Cazier, Jean-Baptiste and Olver, Bianca and Penegar, Steven and Lubbe, Steven and Chander, Ian and Carvajal-Carmona, Luis G and Ballereau, Stephane and Lloyd, Amy and Vijayakrishnan, Jayaram and Zgaga, Lina and Rudan, Igor and Theodoratou, Evropi and Thomas, Huw and Maher, Eamonn and Evans, Gareth and Walker, Lisa and Halliday, Dorothy and Lucassen, Anneke and Paterson, Joan and Hodgson, Shirley and Homfray, Tessa and Side, Lucy and Izatt, Louise and Donaldson, Alan and Tomkins, Susan and Morrison, Patrick and Brewer, Carole and Henderson, Alex and Davidson, Rosemarie and Murday, Victoria and Cook, Jaqueline and Haites, Neva and Bishop, Timothy and Sheridan, Eamonn and Green, Andrew and Marks, Christopher and Carpenter, Sue and Broughton, Mary and Greenhalge, Lynn and Suri, Mohnish and Starr, John M and Deary, Ian and Kirac, Iva and Kovacevia, Dujo and Aaltonen, Lauri A and Renkonen-Sinisalo, Laura and Mecklin, Jukka-Pekka and Matsuda, Koichi and Nakamura, Yusuke and Okada, Yukinori and Gallinger, Steven and Duggan, David J and Conti, David and Newcomb, Polly and Hopper, John and Jenkins, Mark A and Schumacher, Fredrick and Casey, Graham and Easton, Douglas and Shah, Mitul and Pharoah, Paul and Lindblom, Annika and Liu, Tao and Edler, David and Lenander, Claes and Dalén, Johan and Hjern, Fredrik and Lundqvist, Nils and Lindforss, Ulrik and Påhlman, Lars and Smedh, Kennet and Törnqvist, Anders and Holm, Jörn and Janson, Martin and Andersson, Magnus and Ekelund, Susanne and Olsson, Louise and Smith, Christopher G and West, Hannah and ... and Colorectal Tumour Gene Identificat and Coin Collaborative Grp and Swedish Low-Risk Colorectal Canc and COIN Collaborative Group and Swedish Low-Risk Colorectal Cancer Study Group and Colorectal Tumour Gene Identification (CORGI) Consortium and The Swedish Low-Risk Colorectal Cancer Study Group and The COIN Collaborative Group and The Colorectal Tumour Gene Identification (CORGI) Consortium and Inst för molekylär medicin och kirurgi and Karolinska Institutet and Dept of Molecular Medicine and Surgery
Nature Genetics, ISSN 1061-4036, 07/2012, Volume 44, Issue 7, pp. 770 - 776
Journal Article
by Morrissy, A. Sorana and Cavalli, Florence M. G and Remke, Marc and Ramaswamy, Vijay and Shih, David J. H and Holgado, Borja L and Farooq, Hamza and Donovan, Laura K and Garzia, Livia and Agnihotri, Sameer and Kiehna, Erin N and Mercier, Eloi and Mayoh, Chelsea and Papillon-Cavanagh, Simon and Nikbakht, Hamid and Gayden, Tenzin and Torchia, Jonathon and Picard, Daniel and Merino, Diana M and Vladoiu, Maria and Luu, Betty and Wu, Xiaochong and Daniels, Craig and Horswell, Stuart and Thompson, Yuan Yao and Hovestadt, Volker and Northcott, Paul A and Jones, David T. W and Peacock, John and Wang, Xin and Mack, Stephen C and Reimand, Jüri and Albrecht, Steffen and Fontebasso, Adam M and Thiessen, Nina and Li, Yisu and Schein, Jacqueline E and Lee, Darlene and Carlsen, Rebecca and Mayo, Michael and Tse, Kane and Tam, Angela and Dhalla, Noreen and Ally, Adrian and Chuah, Eric and Cheng, Young and Plettner, Patrick and Li, Haiyan I and Corbett, Richard D and Wong, Tina and Long, William and Loukides, James and Buczkowicz, Pawel and Hawkins, Cynthia E and Tabori, Uri and Rood, Brian R and Myseros, John S and Packer, Roger J and Korshunov, Andrey and Lichter, Peter and Kool, Marcel and Pfister, Stefan M and Schüller, Ulrich and Dirks, Peter and Huang, Annie and Bouffet, Eric and Rutka, James T and Bader, Gary D and Swanton, Charles and Ma, Yusanne and Moore, Richard A and Mungall, Andrew J and Majewski, Jacek and Jones, Steven J. M and Das, Sunit and Malkin, David and Jabado, Nada and Marra, Marco A and Taylor, Michael D
Nature Genetics, ISSN 1061-4036, 05/2017, Volume 49, Issue 5, pp. 780 - 788
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification... 
IN-VITRO | EVOLUTION | SOLID TUMORS | SUBTYPES | INTRATUMOR HETEROGENEITY | GROWTH | GENETICS & HEREDITY | EXPRESSION | RENAL-CELL CARCINOMA | T-CELLS | LYMPHOCYTES | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Child, Preschool | Male | INDEL Mutation | DNA Copy Number Variations | Medulloblastoma - pathology | Aged, 80 and over | Adult | Female | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Child | Principal Component Analysis | Genome-Wide Association Study | Gene Expression Profiling - methods | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genetic Heterogeneity | Aged | Polymorphism, Single Nucleotide | Mutation | Cluster Analysis | Brain | Gene mutations | Biopsy | Medulloblastoma | Genetic aspects | Diagnosis | Health aspects | Methods | Pediatrics | Laboratories | Neuropathology | Brain cancer | Colleges & universities | Oncology | Genomes | Biology | Neurosurgery | Consortia | Heterogeneity | Immunology | Renal cell carcinoma | Genetics | Bioindicators | Research centers | Medical research | Hematology | Gene expression | Children & youth | Genetic markers | Hospitals | Glioma | Biomarkers | Tumors | Index Medicus | Spatial heterogeneity | glioblastoma multiforme | renal cell carcinoma | gene expression profiling | medulloblastoma | whole exome sequencing
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 1122 - 1122
Journal Article
Nature genetics, ISSN 1061-4036, 2/2013, Volume 45, Issue 2, pp. 136 - 144
Many individuals with multiple or large colorectal adenomas, or early-onset colorectal cancer (CRC), have no detectable germline mutations in the known cancer... 
Journal Article
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