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Pathogens and Disease, ISSN 2049-632X, 2017, Volume 75, Issue 6
Despite the availability of several anti-retrovirals, there is still an urgent need for developing novel therapeutic strategies and finding new drugs against... 
Hemidesmus indicus | Anti-HIV-1 | α-glucosidase | RNase H | Lupeol | Multitarget inhibitors | INFECTIOUS DISEASES | INTEGRASE | RIBONUCLEASE H | MICROBIOLOGY | DNA-POLYMERASE | IMMUNOLOGY | IDENTIFICATION | alpha-glucosidase | ANTIOXIDANT | multitarget inhibitors | anti-HIV-1 | DUAL INHIBITORS | DERIVATIVES | Anti-HIV Agents - pharmacology | Plant Extracts - chemistry | Hemidesmus - chemistry | Plant Extracts - pharmacology | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | HIV Reverse Transcriptase - genetics | Ribonuclease H - antagonists & inhibitors | HIV-1 - growth & development | Enzyme Inhibitors - chemistry | Protein Interaction Domains and Motifs | HIV Reverse Transcriptase - chemistry | Ribonuclease H - genetics | Protein Structure, Secondary | HIV-1 - drug effects | Jurkat Cells | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Pentacyclic Triterpenes - pharmacology | Pentacyclic Triterpenes - chemistry | Enzyme Inhibitors - isolation & purification | Host-Pathogen Interactions | HIV Reverse Transcriptase - metabolism | alpha-Glucosidases - genetics | Anti-HIV Agents - chemistry | Allosteric Site | Ribonuclease H - chemistry | HIV-1 - enzymology | Molecular Docking Simulation | Anti-HIV Agents - isolation & purification | alpha-Glucosidases - metabolism | Ribonuclease H - metabolism | Medicinal plants | Drugs | Triterpenes | RNA-directed DNA polymerase | DNA polymerase | Ribonuclease H | Glucosidase | Glycoproteins | Ribonucleic acid--RNA | DNA-directed RNA polymerase | Mode of action | Polymerase | Allosteric properties | Phytochemicals | Metabolites | Human immunodeficiency virus--HIV | Antiviral activity | Docking | Endoplasmic reticulum | a-Glucosidase | DNA-directed DNA polymerase | Deoxyribonucleic acid--DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0147225 - e0147225
The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome... 
RNASE-H ACTIVITIES | SITE | HIGH-RESOLUTION STRUCTURES | PRIMER GRIP | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | FORCE-FIELD | DNA-SYNTHESIS | MUTATIONS | Anti-HIV Agents - pharmacology | Protein Structure, Tertiary | Virus Replication - drug effects | Ribonuclease H, Human Immunodeficiency Virus - antagonists & inhibitors | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Isatin - pharmacology | Reverse Transcriptase Inhibitors - pharmacology | Hydrazones - pharmacology | Microbial Sensitivity Tests | Isatin - analogs & derivatives | Benzoxazines - pharmacology | HIV-1 - enzymology | Benzoxazines - antagonists & inhibitors | Molecular Docking Simulation | Binding Sites | Polymerization | DNA polymerases | Ribonuclease | Research | Drug approval | Drugs | RNA-directed DNA polymerase | Addition polymerization | DNA polymerase | Viruses | Ribonuclease H | Genomes | Drug resistance | Efavirenz | Allosteric properties | Human immunodeficiency virus--HIV | Docking | Inhibition | Deoxyribonucleic acid--DNA | Binding | Mode of action | Studies | Polymerase | Environmental science | Inhibitors | Mutagenesis | Mutation | Endonuclease | Binding sites | DNA-directed DNA polymerase | Index Medicus | Deoxyribonucleic acid | HIV | DNA | Human immunodeficiency virus
Journal Article
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 55 - 74
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1526 - 1533
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a-m) was designed and synthesised to evaluate the... 
sulphonamide | dihydrotiazoles | Antitumour agents | carbonic anhydrase inhibitors | ISATIN | CHEMISTRY, MEDICINAL | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | DISCOVERY | ISOFORMS IX | POTENT | TRANSPORT | BENZENESULFONAMIDES | SELECTIVE INHIBITORS | DUAL INHIBITORS
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2016, Volume 11, Issue 16, pp. 1875 - 1875
The back cover picture shows a high‐throughput in silico screening of commercial libraries from several different vendors by means of a combined... 
FRET | circular dichroism | G-quadruplexes | virtual screening | molecular modeling
Journal Article
Journal of Natural Products, ISSN 0163-3864, 05/2019, Volume 82, Issue 5, pp. 1250 - 1257
Journal Article
Antiviral Research, ISSN 0166-3542, 02/2019, Volume 162, pp. 110 - 117
The 4th Summer School on Innovative Approaches for the Identification of Antiviral Agents (IAAASS) was held at the Sardegna Ricerche Research Park in Santa... 
High throughput screening | Summer school | Drug discovery | Computational modeling | RNA-Directed therapeutics | Antiviral strategies | VIROLOGY | PHARMACOLOGY & PHARMACY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 3, pp. 843 - 855
Nowadays, it has been demonstrated that DNA G-quadruplex arrangements are involved in cellular aging and cancer, thus boosting the discovery of selective... 
DRUG | TELOMERIC G-QUADRUPLEX | SHAPE | CHEMISTRY, MEDICINAL | CONFORMER GENERATION | RECOGNITION | DOCKING | MYC | SINGLET OXYGEN | ANTITUMOR-ACTIVITY | DERIVATIVES | Mass Spectrometry | Fluorescence | G-Quadruplexes | Ligands | Biophysics | Nucleic Acid Conformation | Circular Dichroism | Furocoumarins - chemistry
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111617
A number of compounds targeting different processes of the Human Immunodeficiency Virus type 1 (HIV-1) life cycle have been developed in the continuing fight... 
HIV-1 | Integrase | Coumarin derivatives | RNase H | LEDGF/p75 cellular cofactor | Dual inhibitors
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2014, Volume 9, Issue 8, pp. 1869 - 1879
Journal Article