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Annals of Neurology, ISSN 0364-5134, 03/2006, Volume 59, Issue 3, pp. 512 - 519
Journal Article
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, ISSN 0161-5505, 07/2019, Volume 60, Issue 7, pp. 11N - 12N
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2002, Volume 5, Issue 2, pp. 169 - 174
Disruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron... 
DRUG-ABUSE | INDIVIDUAL VULNERABILITY | HOUSING CONDITIONS | POSITRON-EMISSION-TOMOGRAPHY | RHESUS-MONKEYS | BEHAVIOR | RATS | BINDING CHARACTERISTICS | D-AMPHETAMINE | NEUROSCIENCES | ADDICTION
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 11/2009, Volume 1, Issue 8‐9, pp. 371 - 380
Alzheimer's disease (AD) pathology is estimated to develop many years before detectable cognitive decline. Fluid and imaging biomarkers may identify people in... 
amyloid | biomarker | preclinical Alzheimer's disease | Pittsburgh compound B | cerebrospinal fluid | Biomarker | Amyloid | Cerebrospinal fluid | Preclinical Alzheimer's disease | Report
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 2, pp. 397 - 401
Reactive oxygen species (ROS) are believed to play an important role in the proinflammatory form of neuroinflammation. Therefore, the availability of a... 
Neuroinflammation | Reactive oxygen species | Superoxide | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Medical colleges | Usage | PET imaging | Neurons | Mitogens | Medical imaging equipment
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 07/2019, Volume 18, Issue 7, pp. 1195 - 1204
Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting... 
CELLS | THERAPY | ONCOLOGY | NUCLEUS | INHIBITORS | HIGH-RISK NEUROBLASTOMA | EXPRESSION | BMN 673
Journal Article
Organic letters, ISSN 1523-7060, 10/2016, Volume 18, Issue 20, pp. 5272 - 5275
A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiparazines under aerobic conditions is reported.... 
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 18, pp. 2690 - 2694
As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a... 
Drug addiction | CHEMISTRY, MEDICINAL | Dopamine receptor | D-2 | CHEMISTRY, ORGANIC | COCAINE | D-3 | G-protein coupled receptor (GPCR) | D3 RECEPTOR | BRAIN
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 08/2018, Volume 171, pp. 46 - 53
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2017, Volume 60, Issue 23, pp. 9905 - 9910
A series of potent and selective D3 receptor (D3R) analogues with diazaspiro alkane cores were synthesized. Radioligand binding of compounds 11, 14, 15a, and... 
Index Medicus | If you are submitting your paper to a journal that requires keywords | provide significant keywords to aid the reader in literature retrieval
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 12/2018, Volume 175, pp. 123 - 129
The dopamine D3 receptor (D3R) is a pharmacotherapeutic target for drug dependence. We have successfully imaged human D3Rs using radiolabeled LS-3-134, an... 
Reinforcement (psychology) | Substance use disorders | Cocaine-seeking behavior | Extinction | Progressive ratio | Reinstatement | Phenylpiperazine | ANTAGONIST | INDUCED REINSTATEMENT | ADDICTIONS | RATS | MECHANISMS | D-3 | REWARD | NEUROSCIENCES | ANIMAL-MODELS | DRUG-SEEKING BEHAVIOR | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | EXPRESSION | Phenols | Medical colleges | Drug abuse | Cocaine | Dopamine
Journal Article
Pharmacology Biochemistry and Behavior, ISSN 0091-3057, 08/2018, Volume 171, pp. 46 - 53
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2017, Volume 58, Issue 5, pp. 466 - 469
Application of Buchwald-Hartwig catalysis for development of biologically relevant arylspirodiamine compounds is reported. This synthetic methodology requires... 
Arylation | Pd cross-coupling | RuPhos | C-N cross-coupling | Spirodiamine | GHRELIN RECEPTOR | DESIGN | BUILDING-BLOCKS | IIB-IIIA ANTAGONISTS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | MEDICINAL CHEMISTRY | INVERSE AGONISTS | CROSS-COUPLING REACTIONS | POTENT | ARYL HALIDES | Palladium | Medical colleges | Catalysis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 5132 - 5147
Previously, we reported a 3-(2-methoxyphenyl)-9-(3-((4-methyl-5-phenyl-4 H-1,2,4-triazol-3-yl)thio)propyl)-3,9-diazaspiro[5.5]undecane (1) compound with... 
Journal Article
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