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Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article
by Sieh, Weiva, PhD and Köbel, Martin, Dr and Longacre, Teri A, Prof and Bowtell, David D, Prof and deFazio, Anna, PhD and Goodman, Marc T, PhD and Høgdall, Estrid, PhD and Deen, Suha, Prof and Wentzensen, Nicolas, MD and Moysich, Kirsten B, Prof and Brenton, James D, MD and Clarke, Blaise A, MD and Menon, Usha, Prof and Gilks, C Blake, Prof and Kim, Andre, MPH and Madore, Jason, MS and Fereday, Sian, BSc and George, Joshy, MEng and Galletta, Laura, BSc and Lurie, Galina, MD and Wilkens, Lynne R, DrPH and Carney, Michael E, MD and Thompson, Pamela J, MPH and Matsuno, Rayna K, PhD and Kjær, Susanne Krüger, Prof and Jensen, Allan, PhD and Høgdall, Claus, Prof and Kalli, Kimberly R, PhD and Fridley, Brooke L, PhD and Keeney, Gary L, MD and Vierkant, Robert A, MS and Cunningham, Julie M, PhD and Brinton, Louise A, PhD and Yang, Hannah P, PhD and Sherman, Mark E, MD and García-Closas, Montserrat, Prof and Lissowska, Jolanta, PhD and Odunsi, Kunle, Prof and Morrison, Carl, MD and Lele, Shashikant, Prof and Bshara, Wiam, MD and Sucheston, Lara, PhD and Jimenez-Linan, Mercedes, MD and Driver, Kristy, BSc and Alsop, Jennifer, BA and Mack, Marie and McGuire, Valerie, PhD and Rothstein, Joseph H, MS and Rosen, Barry P, Prof and Bernardini, Marcus Q, MD and Mackay, Helen, MD and Oza, Amit, Prof and Wozniak, Eva L, BSc and Benjamin, Elizabeth, MD and Gentry-Maharaj, Aleksandra, PhD and Gayther, Simon A, Prof and Tinker, Anna V, MD and Prentice, Leah M, PhD and Chow, Christine, BMLSc and Anglesio, Michael S, PhD and Johnatty, Sharon E, PhD and Chenevix-Trench, Georgia, Prof and Whittemore, Alice S, Prof and Pharoah, Paul DP, Prof and Goode, Ellen L, PhD and Huntsman, David G, Prof and Ramus, Susan J, PhD
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 9, pp. 853 - 862
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 16, pp. 1532 - 1543
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5024 - 5033
Purpose: Disruption of PD-L1/cytotoxic T-cell PD-1 signaling by immune checkpoint inhibitors improves survival in cancer patients. This study sought to... 
BIOMARKERS | ACTIVATION | THERAPY | ONCOLOGY | EXPANSION | NIVOLUMAB | TIM-3 | CD8-Positive T-Lymphocytes - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Gene Expression Regulation, Neoplastic | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Monoclonal, Humanized - administration & dosage | Melanoma - genetics | Immunotherapy | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Kaplan-Meier Estimate | Drug Resistance, Neoplasm - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Drug Resistance, Neoplasm - genetics | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Biopsy | Melanoma - immunology | Melanoma - drug therapy | Aged | Biomarkers, Tumor - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Biomarkers, Tumor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell survival | PD-1 protein | CD8 antigen | Medical treatment | Melanoma | Cytotoxicity | Lymphocytes T | Macrophages | Patients | Metastases | Signaling | Immune checkpoint | Lymphocytes | Experimental design | PD-L1 protein | Infiltration | Immune system | Cancer
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2009, Volume 360, Issue 26, pp. 2719 - 2729
Journal Article
Histopathology, ISSN 0309-0167, 07/2016, Volume 69, Issue 1, pp. 25 - 34
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4697 - 4709
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 17, pp. 4684 - 4696
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2018, Volume 142, Issue 9, pp. 1926 - 1937
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1408 - 1410
Journal Article