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by Sieh, Weiva, PhD and Köbel, Martin, Dr and Longacre, Teri A, Prof and Bowtell, David D, Prof and deFazio, Anna, PhD and Goodman, Marc T, PhD and Høgdall, Estrid, PhD and Deen, Suha, Prof and Wentzensen, Nicolas, MD and Moysich, Kirsten B, Prof and Brenton, James D, MD and Clarke, Blaise A, MD and Menon, Usha, Prof and Gilks, C Blake, Prof and Kim, Andre, MPH and Madore, Jason, MS and Fereday, Sian, BSc and George, Joshy, MEng and Galletta, Laura, BSc and Lurie, Galina, MD and Wilkens, Lynne R, DrPH and Carney, Michael E, MD and Thompson, Pamela J, MPH and Matsuno, Rayna K, PhD and Kjær, Susanne Krüger, Prof and Jensen, Allan, PhD and Høgdall, Claus, Prof and Kalli, Kimberly R, PhD and Fridley, Brooke L, PhD and Keeney, Gary L, MD and Vierkant, Robert A, MS and Cunningham, Julie M, PhD and Brinton, Louise A, PhD and Yang, Hannah P, PhD and Sherman, Mark E, MD and García-Closas, Montserrat, Prof and Lissowska, Jolanta, PhD and Odunsi, Kunle, Prof and Morrison, Carl, MD and Lele, Shashikant, Prof and Bshara, Wiam, MD and Sucheston, Lara, PhD and Jimenez-Linan, Mercedes, MD and Driver, Kristy, BSc and Alsop, Jennifer, BA and Mack, Marie and McGuire, Valerie, PhD and Rothstein, Joseph H, MS and Rosen, Barry P, Prof and Bernardini, Marcus Q, MD and Mackay, Helen, MD and Oza, Amit, Prof and Wozniak, Eva L, BSc and Benjamin, Elizabeth, MD and Gentry-Maharaj, Aleksandra, PhD and Gayther, Simon A, Prof and Tinker, Anna V, MD and Prentice, Leah M, PhD and Chow, Christine, BMLSc and Anglesio, Michael S, PhD and Johnatty, Sharon E, PhD and Chenevix-Trench, Georgia, Prof and Whittemore, Alice S, Prof and Pharoah, Paul DP, Prof and Goode, Ellen L, PhD and Huntsman, David G, Prof and Ramus, Susan J, PhD
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 9, pp. 853 - 862
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 16, pp. 1532 - 1543
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5024 - 5033
Purpose: Disruption of PD-L1/cytotoxic T-cell PD-1 signaling by immune checkpoint inhibitors improves survival in cancer patients. This study sought to... 
BIOMARKERS | ACTIVATION | THERAPY | ONCOLOGY | EXPANSION | NIVOLUMAB | TIM-3 | CD8-Positive T-Lymphocytes - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Gene Expression Regulation, Neoplastic | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Monoclonal, Humanized - administration & dosage | Melanoma - genetics | Immunotherapy | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Kaplan-Meier Estimate | Drug Resistance, Neoplasm - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Drug Resistance, Neoplasm - genetics | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Biopsy | Melanoma - immunology | Melanoma - drug therapy | Aged | Biomarkers, Tumor - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Biomarkers, Tumor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell survival | PD-1 protein | CD8 antigen | Medical treatment | Melanoma | Cytotoxicity | Lymphocytes T | Macrophages | Patients | Metastases | Signaling | Immune checkpoint | Lymphocytes | Experimental design | PD-L1 protein | Infiltration | Immune system | Cancer
Journal Article
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2019, Volume 35, Issue 2, pp. 238 - 255.e6
Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and... 
EOMES | predictive biomarkers | RNA-seq | immunotherapy | melanoma | combination therapy | immune checkpoint inhibitors | anti-CTLA-4 | anti-PD-1 | resistance mechanisms | CTLA-4 BLOCKADE | MASS-CYTOMETRY | DENDRITIC CELLS | ONCOLOGY | CARBONIC-ANHYDRASE IX | COMBINATION THERAPY | PD-L1 EXPRESSION | INDOLEAMINE 2,3-DIOXYGENASE | INHIBITORY RECEPTORS | CLINICAL-RESPONSE | CD8 T-CELLS | CELL BIOLOGY | Antigens, CD - immunology | Antineoplastic Agents, Immunological - administration & dosage | Skin Neoplasms - drug therapy | Humans | Middle Aged | Lectins, C-Type - immunology | Drug Resistance, Neoplasm | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunologic Memory - drug effects | Leukocyte Common Antigens - immunology | Antibodies, Monoclonal, Humanized - administration & dosage | Melanoma - genetics | T-Lymphocytes - drug effects | Female | Retrospective Studies | Ipilimumab - administration & dosage | Skin Neoplasms - pathology | Antigens, Differentiation, T-Lymphocyte - immunology | Skin Neoplasms - immunology | Treatment Outcome | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Phenotype | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Skin Neoplasms - genetics | T-Lymphocytes - immunology | Aged | Programmed Cell Death 1 Receptor - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Nivolumab - administration & dosage | RNA | T cells | Gene expression | Analysis | Immunotherapy | Melanoma
Journal Article
OncoImmunology, ISSN 2162-4011, 02/2019, Volume 8, Issue 2, p. e1537581
Purpose: Anti-PD-1 therapy has revolutionized the treatment and improved the survival of stage IV melanoma patients. However, almost half of the patients fail... 
MHC class I | NK cells | anti-PD-1 therapy | Melanoma | GRANZYME-H | SURVIVAL | ONCOLOGY | COMBINED NIVOLUMAB | ACQUIRED-RESISTANCE | IMMUNOLOGY | EXPRESSION | IPILIMUMAB
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1408 - 1410
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2018, Volume 142, Issue 9, pp. 1926 - 1937
Journal Article
BMC Cancer, ISSN 1471-2407, 06/2013, Volume 13, Issue 1, pp. 303 - 303
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45484
Journal Article