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1. Full Text John Ole Askedal, Ian Roberts, Tomonori Matsushita, and Hiroshi Hasegawa (eds.), Germanic Languages and Linguistic Universals, Amsterdam: John Benjamins, 2009, v+213pp
by MAEDA Mitsuru
Studies in English literature, ISSN 0387-3439, 03/2012, pp. 145 - 151
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2. Full Text The quiescent intracluster medium in the core of the Perseus cluster
by Aharonian, Felix and Akamatsu, Hiroki and Akimoto, Fumie and Allen, Steven W and Anabuki, Naohisa and Angelini, Lorella and Arnaud, Keith and Audard, Marc and Awaki, Hisamitsu and Axelsson, Magnus and Bamba, Aya and Bautz, Marshall and Blandford, Roger and Brenneman, Laura and Brown, Gregory V and Bulbul, Esra and Cackett, Edward and Chernyakova, Maria and Chiao, Meng and Coppi, Paolo and Costantini, Elisa and De Plaa, Jelle and Den Herder, Jan-Willem and Done, Chris and Dotani, Tadayasu and Ebisawa, Ken and Eckart, Megan and Enoto, Teruaki and Ezoe, Yuichiro and Fabian, Andrew C and Ferrigno, Carlo and Foster, Adam and Fujimoto, Ryuichi and Fukazawa, Yasushi and Furuzawa, Akihiro and Galeazzi, Massimiliano and Gallo, Luigi and Gandhi, Poshak and Giustini, Margherita and Goldwurm, Andrea and Gu, Liyi and Guainazzi, Matteo and Haba, Yoshito and Hagino, Kouichi and Hamaguchi, Kenji and Harrus, Ilana and Hatsukade, Isamu and Hayashi, Katsuhiro and Hayashi, Takayuki and Hayashida, Kiyoshi and Hiraga, Junko and Hornschemeier, Ann and Hoshino, Akio and Hughes, John and Iizuka, Ryo and Inoue, Hajime and Inoue, Yoshiyuki and Ishibashi, Kazunori and Ishida, Manabu and Ishikawa, Kumi and Ishisaki, Yoshitaka and Itoh, Masayuki and Iyomoto, Naoko and Kaastra, Jelle and Kallman, Timothy and Kamae, Tuneyoshi and Kara, Erin and Kataoka, Jun and Katsuda, Satoru and Katsuta, Junichiro and Kawaharada, Madoka and Kawai, Nobuyuki and Kelley, Richard and Khangulyan, Dmitry and Kilbourne, Caroline and King, Ashley and Kitaguchi, Takao and Kitamoto, Shunji and Kitayama, Tetsu and Kohmura, Takayoshi and Kokubun, Motohide and Koyama, Shu and Koyama, Katsuji and Kretschmar, Peter and Krimm, Hans and Kubota, Aya and Kunieda, Hideyo and Laurent, Philippe and Lebrun, François and Lee, Shiu-Hang and Leutenegger, Maurice and Limousin, Olivier and Loewenstein, Michael and Long, Knox S and Lumb, David and Madejski, Grzegorz and Maeda, Yoshitomo and Maier, Daniel and Makishima, Kazuo and Markevitch, Maxim and ... and Hitomi Collaboration and SLAC National Accelerator Lab., Menlo Park, CA (United States)
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 117 - 121
Clusters of galaxies are the most massive gravitationally bound objects in the Universe and are still forming. They are thus important probes(1) of... 
NGC 1275 | GALAXY CLUSTERS | TURBULENT VELOCITY | MULTIDISCIPLINARY SCIENCES | LINE | GAS | NGC-1275 | CONSTRAINTS | X-RAY SPECTROSCOPY | XMM-NEWTON | FEEDBACK | Clusters | Observations | Stars | Cosmology | Astrophysics | Velocity | Stars & galaxies | ASTRONOMY AND ASTROPHYSICS | GRQC | ASTRO
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3. Full Text Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
by Maeda, Hiroshi
Advanced Drug Delivery Reviews, ISSN 0169-409X, 08/2015, Volume 91, pp. 3 - 6
The enhanced permeability and retention (EPR) effect of solid tumors as seen with nanomedicines and macromolecular drugs is well known. However, many... 
Anticancer drugs | EPR effect dynamics | EPR effect artifacts | EPR effect dependence on time and molecular size | Macromolecular drugs | Nanomedicines | MACROMOLECULAR DRUG-DELIVERY | MALEIC ACID COPOLYMER | ELEVATING BLOOD-PRESSURE | SOLID TUMORS | CANCER-CHEMOTHERAPY | VASCULAR-PERMEABILITY | POLYMER CONJUGATION | OILY CONTRAST-MEDIUM | IMAGE-ENHANCEMENT | IN-VIVO | PHARMACOLOGY & PHARMACY | Humans | Macromolecular Substances - administration & dosage | Antineoplastic Agents - administration & dosage | Permeability | Drug Delivery Systems | Neoplasms - drug therapy | Animals | Micelles | Macromolecular Substances - pharmacokinetics | Drug Liberation | Antineoplastic Agents - pharmacokinetics | Liposomes | Neoplasms - pathology | Nanomedicine | Drugs | Drug delivery systems | Metastasis | Vehicles
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4. Full Text Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
by Maeda, Hiroshi
Journal of Controlled Release, ISSN 0168-3659, 12/2012, Volume 164, Issue 2, pp. 138 - 144
In this review, I have discussed various issues of the cancer drug targeting primarily related to the EPR (enhanced permeability and retention) effect, which... 
SMANCS | Heterogeneity of EPR effect | EPR-effect | Tumor targeting | Vascular permeability | Augmentation of EPR effect | DRUG | HUMAN BREAST | MECHANISM | ANTICANCER AGENTS | POLYMER CONJUGATION | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | NEOCARZINOSTATIN | CETUXIMAB | TUMOR-TARGETED DELIVERY | IMAGE-ENHANCEMENT | PHARMACOLOGY & PHARMACY | Ethiodized Oil - administration & dosage | Neoplasms - metabolism | Polymers - administration & dosage | Animals | Humans | Antineoplastic Agents - administration & dosage | Permeability | Drug and Narcotic Control | Drug Delivery Systems | Marketing | Neoplasms - drug therapy | Care and treatment | Cancer | Antitumor agents | Macromolecules | nanotechnology | Drug delivery | Hepatoma | hepatic artery | Drug development | Controlled release | Feeding | Tumors
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5. Full Text The shikimate pathway and aromatic amino acid biosynthesis in plants
by Maeda, Hiroshi and Dudareva, Natalia
Annual Review of Plant Biology, ISSN 1543-5008, 06/2012, Volume 63, Issue 1, pp. 73 - 105
L-tryptophan, L-phenylalanine, and L-tyrosine are aromatic amino acids (AAAs) that are used for the synthesis of proteins and that in plants also serve as... 
metabolite transport | metabolic engineering | subcellular localization | plant metabolism | metabolic regulation | Phenylalanine - biosynthesis | Tyrosine - biosynthesis | Amino Acids, Aromatic - biosynthesis | Humans | Alkyl and Aryl Transferases - metabolism | 3-Deoxy-7-Phosphoheptulonate Synthase - genetics | Shikimic Acid - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Tryptophan - biosynthesis | Biological Transport | Plants - genetics | Alkyl and Aryl Transferases - genetics | Transcription, Genetic | Hydro-Lyases - metabolism | Anthranilate Synthase - metabolism | Phosphorus-Oxygen Lyases - metabolism | Physiological aspects | Amino acids | Biosynthesis | Research | Phytochemistry | Plant metabolites
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6. Full Text Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
by Maeda, Hiroshi
Bioconjugate Chemistry, ISSN 1043-1802, 05/2010, Volume 21, Issue 5, pp. 797 - 802
This paper briefly documents the history of the discovery of the EPR (enhanced permeability and retention) effect and elucidates an analogy between bacterial... 
ELEVATING BLOOD-PRESSURE | CANCER-CHEMOTHERAPY | KININ-GENERATING CASCADE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | OILY CONTRAST-MEDIUM | ENHANCED VASCULAR-PERMEABILITY | IMAGE-ENHANCEMENT | NITRIC-OXIDE SCAVENGER | HAGEMAN-FACTOR | SOLID TUMOR | TARGETED DELIVERY | Animals | Capillary Permeability | Humans | Macromolecular Substances - administration & dosage | Macromolecular Substances - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - administration & dosage | Drug Delivery Systems - trends | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Drug Delivery Systems - methods | Neoplasms - drug therapy
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7. Full Text Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
by MAEDA, Hiroshi
Proceedings of the Japan Academy, Series B, ISSN 0386-2208, 2012, Volume 88, Issue 3, pp. 53 - 71
Tumor and inflammation have many common features. One hallmark of both is enhanced vascular permeability, which is mediated by various factors including... 
infection and cancer | nanomedicine | nitric oxide/super oxide | vascular permeability | enhanced permeability and retention (EPR) effect | tumor targeted drug delivery | Nitric oxide/super oxide | Enhanced permeability and retention (EPR) effect | Tumor targeted drug delivery | Infection and cancer | Nanomedicine | Vascular permeability | MOLECULAR-WEIGHT | KININ-GENERATING CASCADE | MULTIDISCIPLINARY SCIENCES | BLOOD-FLOW | MICROVASCULAR HYPERPERMEABILITY | HEME OXYGENASE | NITRIC-OXIDE | PEGYLATED ZINC PROTOPORPHYRIN | HAGEMAN-FACTOR | SOLID TUMOR | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - metabolism | Infection - metabolism | Animals | Capillary Permeability | Infection - drug therapy | Humans | Macromolecular Substances - pharmacokinetics | Neoplasms - blood supply | Drug Delivery Systems - methods | Molecular Targeted Therapy - methods | Macromolecular Substances - therapeutic use | Neoplasms - drug therapy | Nanoscience | Drug delivery systems | Cancer therapies | Tumors | nitric oxide | super oxide | Review
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8. Full Text Nationwide Post Event Survey and Analysis of the 2011 Tohoku Earthquake Tsunami
by Mori, Nobuhito and Takahashi, Tomoyuki and 2011 Tohoku Earthquake Tsunami Joint Survey Group and THE 2011 TOHOKU EARTHQUAKE TSUNAMI JOINT SURVEY GROUP
Coastal Engineering Journal, ISSN 2166-4250, 03/2012, Volume 54, Issue 1, pp. 1250001-1 - 1250001-27
At 14:46 local time on March 11, 2011, a magnitude 9.0 earthquake occurred off the coast of northeast Japan. This earthquake generated a tsunami that struck... 
inundation height | Tsunami | run-up height | post event survey | ENGINEERING, CIVIL | SRI-LANKA | ENGINEERING, OCEAN | INDIAN-OCEAN TSUNAMI | Surveys | Tsunamis | Earthquakes | Japan | Databases | Earthquake engineering | Satellite navigation systems | Coastal environments | Seismic phenomena | Inundation | Global Positioning System
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9. Full Text The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect
by Maeda, Hiroshi
Cancer Science, ISSN 1347-9032, 07/2013, Volume 104, Issue 7, pp. 779 - 789
This review focuses primarily on my own research, including pathogenic mechanisms of microbial infection, vascular permeability in infection and tumors, and... 
MALEIC ACID COPOLYMER | POLYMER-CONJUGATED PROTEIN | ELEVATING BLOOD-PRESSURE | ONCOLOGY | KININ-GENERATING CASCADE | HIGH-MOLECULAR-WEIGHT | NADPH CYTOCHROME-P-450 REDUCTASE | LIPID CONTRAST-MEDIUM | NITRIC-OXIDE SCAVENGER | OXYGEN FREE-RADICALS | RENAL-CELL CARCINOMA | Guanosine - analogs & derivatives | Neoplasms - metabolism | Nitric Oxide - pharmacology | Humans | Neoplasms - microbiology | Capillary Permeability - drug effects | Neoplasms - blood supply | Infection - microbiology | Neoplasms - drug therapy | Infection - metabolism | Animals | Nanomedicine - methods | Free Radicals - metabolism | Guanosine - pharmacology | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Oxidases | Drugs | Drug delivery systems | Care and treatment | Endothelial growth factors | RNA | Kallikrein | Development and progression | Superoxide | Permeability | Vehicles | Molybdenum compounds | Nitric oxide | Drug therapy | Health aspects | Cancer
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10. Full Text 29th World Congress of Endourology & SWL WCE 2011 Scientific Program & Abstracts
by Chris J, Allender and Jenna L, Bowen and Widatella, Awadalla and Iason, Kyriazis and Nikolaos, Tsopanoglou and Panagiotis, Kallidonis and Odysseas, Andrikopoulos and Despoina, Liourdi and Helen, Papadaki and Konstantina, Geronatsiou and Nicolas, Haseke and Sebastian, Walther and Christan, Gratzke and Christain G, Stief and Ronald, Sroka and Ephrem O, Olweny and Stephen, Faddegon and Stacey, McLeroy and Raul, Fernandez and Bruce E, Gnade and Heather E, Beardsley and Margaret S, Pearle and Jeffrey A, Cadeddu and Jeffrey A, Cadeddu and Tatsuo, Igarashi and Takuro, Ishii and Satoki, Zenbutsu and Yukio, Naya and Nuzhath, Khan and Deirdre, Anderson and Jonathan, Watkiss and Ben, Challacombe and Mohammed Shamim, Khan and Prokar, Dasgupta and Declan, Cahill and Nuzhath, Khan and Deirdre, Anderson and Faria, Khan and Jonathan, Watkiss and Ben, Challacombe and Mohammed Shamim, Khan and Prokar, Dasgupta and Declan, Cahill and Nieroshan, Rajarubendra and Ping Han, Chia and Aasheen, Munshey and Shomik, Sengupta and Damien, Bolton and Oneel, Patel and Lin, Xiao and Joseph, Ischia and Graham, Baldwin and Arthur, Schulkes and Payal, Kapur and Yung K, Tan and Samuel K, Park and Mehrad, Adibi and Sara L, Best and Jeffrey A, Cadeddu and Daniel M, de Bruin and Dirk J, Faber and Ton G, van Leeuwen and Jean J, de la Rosette and Pilar, Laguna and Shubha, De and Leah, Grossman and Niels, Johnsen and Greg, Mitchell and Ted, Klein and Benjamin, Lee and Panagiotis, Kitrou and Dimitrios, Karnabatidis and Christina, Kalogeropoulou and Athanasios, Tsamandas and Theofanis, Vrettos and Ioannis, Georgiopoulos and Aarond D, Benson and Bradley F, Schwartz and Kristina L, Penniston and Lauren, Iwicki and Ibrahim, Saeed and Thomas D, Crenshaw and Stephen Y, Nakada and Vivek, Joshi and Sushil, Karia and Sudhir, Sheth and Jitendra, Amlani and Sunil, Moteria and Mohammad Reza, Darabi mahboub and Eugene, Fuchs and Michael, Conlin and Hassan, Razvi and John D, Denstedt and Linda, Nott and Ad, Hendrikx and Michael, Luke and S.K, Pal and Jean, de la Rosette and Sunil, M and Maria Chiara, Sighinolfi and ...
Journal of Endourology, ISSN 0892-7790, 11/2011, Volume 25, Issue S1, pp. P1 - A373
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11. Full Text EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy
by Maeda, Hiroshi and Matsumura, Yasuhiro
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2011, Volume 63, Issue 3, pp. 129 - 130
Nanomedicine - trends | Animals | Capillary Permeability |