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1. Full Text Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
by Maeda, Hiroshi
Advanced drug delivery reviews, ISSN 0169-409X, 08/2015, Volume 91, pp. 3 - 6
Anticancer drugs | EPR effect dynamics | EPR effect artifacts | EPR effect dependence on time and molecular size | Macromolecular drugs | Nanomedicines | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Macromolecular Substances - administration & dosage | Antineoplastic Agents - administration & dosage | Permeability | Drug Delivery Systems | Neoplasms - drug therapy | Animals | Micelles | Macromolecular Substances - pharmacokinetics | Drug Liberation | Antineoplastic Agents - pharmacokinetics | Liposomes | Neoplasms - pathology | Nanomedicine | Drugs | Drug delivery systems | Metastasis | Vehicles | Index Medicus
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2. Full Text Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
by Maeda, Hiroshi
Bioconjugate chemistry, ISSN 1043-1802, 05/2010, Volume 21, Issue 5, pp. 797 - 802
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Multidisciplinary | Science & Technology | Animals | Capillary Permeability | Humans | Macromolecular Substances - administration & dosage | Macromolecular Substances - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - administration & dosage | Drug Delivery Systems - trends | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Drug Delivery Systems - methods | Neoplasms - drug therapy | Drugs | Pharmacology | Molecular chemistry | Bacterial infections | Tumors | Index Medicus
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3. Full Text Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
by Maeda, Hiroshi
Journal of controlled release, ISSN 0168-3659, 12/2012, Volume 164, Issue 2, pp. 138 - 144
SMANCS | Heterogeneity of EPR effect | EPR-effect | Tumor targeting | Vascular permeability | Augmentation of EPR effect | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Ethiodized Oil - administration & dosage | Neoplasms - metabolism | Polymers - administration & dosage | Animals | Humans | Antineoplastic Agents - administration & dosage | Permeability | Drug and Narcotic Control | Drug Delivery Systems | Marketing | Neoplasms - drug therapy | Care and treatment | Cancer | Index Medicus | Antitumor agents | Macromolecules | nanotechnology | Drug delivery | Hepatoma | hepatic artery | Drug development | Controlled release | Feeding | Tumors
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4. Full Text The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect
by Maeda, Hiroshi
Cancer science, ISSN 1347-9032, 07/2013, Volume 104, Issue 7, pp. 779 - 789
Life Sciences & Biomedicine | Oncology | Science & Technology | Guanosine - analogs & derivatives | Neoplasms - metabolism | Nitric Oxide - pharmacology | Humans | Neoplasms - microbiology | Capillary Permeability - drug effects | Neoplasms - blood supply | Infection - microbiology | Neoplasms - drug therapy | Infection - metabolism | Animals | Nanomedicine - methods | Free Radicals - metabolism | Guanosine - pharmacology | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Oxidases | Drugs | Drug delivery systems | Care and treatment | Endothelial growth factors | RNA | Kallikrein | Development and progression | Superoxide | Permeability | Vehicles | Molybdenum compounds | Nitric oxide | Drug therapy | Health aspects | Cancer | Plasma | Soybeans | Infections | Drug delivery | Hepatoma | Drug development | Cancer therapies | Carcinogenesis | Proteins | Maleic acid | Carbon monoxide | Superoxide anions | Polymers | Vascular endothelial growth factor | Lavage | Enzymes | Adenosine | Lymphatic system | Peroxynitrite | Free radicals | Bacterial infections | Macromolecules | Xanthine | Ribonucleic acid--RNA | Nitric-oxide synthase | Influenza | Styrene | Xanthine oxidase | Solid tumors | Viral infections | Peritoneum | Tumors | Index Medicus | Review
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5. Full Text Polymer therapeutics and the EPR effect
by Maeda, Hiroshi
Journal of drug targeting, ISSN 1061-186X, 11/2017, Volume 25, Issue 9-10, pp. 781 - 785
tumor vascular permeability | history of EPR effect | time and MW dependent | inflammation/infection | EPR effect | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neoplasms - metabolism | Humans | Drug Delivery Systems - standards | Antineoplastic Agents - therapeutic use | Permeability | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Polymers - therapeutic use | Animals | Polymers - chemistry | Drug Delivery Systems - methods | Polymers - metabolism | Index Medicus
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6. Full Text Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease
by Sone, Jun and Mitsuhashi, Satomi and Fujita, Atsushi and Mizuguchi, Takeshi and Hamanaka, Kohei and Mori, Keiko and Koike, Haruki and Hashiguchi, Akihiro and Takashima, Hiroshi and Sugiyama, Hiroshi and Kohno, Yutaka and Takiyama, Yoshihisa and Maeda, Kengo and Doi, Hiroshi and Koyano, Shigeru and Takeuchi, Hideyuki and Kawamoto, Michi and Kohara, Nobuo and Ando, Tetsuo and Ieda, Toshiaki and Kita, Yasushi and Kokubun, Norito and Tsuboi, Yoshio and Katoh, Kazutaka and Kino, Yoshihiro and Katsuno, Masahisa and Iwasaki, Yasushi and Yoshida, Mari and Tanaka, Fumiaki and Suzuki, Ikuo K and Frith, Martin C and Matsumoto, Naomichi and Sobue, Gen
Nature genetics, ISSN 1061-4036, 08/2019, Volume 51, Issue 8, pp. 1215 - 1221
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Neurodegenerative Diseases - pathology | Receptors, Notch - metabolism | Humans | Middle Aged | Intranuclear Inclusion Bodies - genetics | Male | Neurodegenerative Diseases - genetics | Receptors, Notch - genetics | Case-Control Studies | Intranuclear Inclusion Bodies - pathology | Linkage Disequilibrium | Brain - metabolism | Young Adult | Pedigree | Genetic Markers - genetics | Adolescent | Brain - pathology | Trinucleotide Repeat Expansion - genetics | Adult | Female | Aged | High-Throughput Nucleotide Sequencing - methods | Nervous system | Development and progression | Degeneration | Genetic aspects | Nucleotide sequencing | Diagnosis | Health aspects | DNA sequencing | Nuclear magnetic resonance--NMR | Disease | Neurodegenerative diseases | Leukocytes (eosinophilic) | Genes | Antisense RNA | Mapping | Genomes | Inclusions | Neurogenesis | Neurological diseases | Cytomegalic inclusion disease | Acids | Biopsy | Somatic cells | Inclusion bodies | Fibroblasts | Skin | Gene mapping | Bioinformatics | Dementia | Index Medicus
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7. Full Text The Rise of the Current Mortality Pattern of the United States, 1890–1930
by Maeda, Hiroshi
American journal of epidemiology, ISSN 0002-9262, 04/2018, Volume 187, Issue 4, pp. 639 - 646
urban mortality penalty | 1918 influenza pandemic | urban-rural mortality differentials | historical epidemiology | epidemiologic transition | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Urban Population - history | United States - epidemiology | Mortality - history | Pandemics | Communicable Diseases - epidemiology | History, 20th Century | Humans | Influenza, Human - epidemiology | Cause of Death | Residence Characteristics - statistics & numerical data | Communicable Diseases - history | Noncommunicable Diseases - epidemiology | Rural Population - trends | History, 19th Century | Influenza, Human - history | Rural Population - history | Urban Population - trends | Infectious diseases | Mortality patterns | Rural areas | Urban areas | Influenza | Mortality | Differentials | Death | Epidemiology | Urban environments | Index Medicus | Epidemiology in History
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8. Full Text The shikimate pathway and aromatic amino acid biosynthesis in plants
by Maeda, Hiroshi and Dudareva, Natalia
Annual review of plant biology, ISSN 1543-5008, 06/2012, Volume 63, Issue 1, pp. 73 - 105
metabolite transport | metabolic engineering | subcellular localization | plant metabolism | metabolic regulation | Phenylalanine - biosynthesis | Tyrosine - biosynthesis | Amino Acids, Aromatic - biosynthesis | Humans | Alkyl and Aryl Transferases - metabolism | 3-Deoxy-7-Phosphoheptulonate Synthase - genetics | Shikimic Acid - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Tryptophan - biosynthesis | Biological Transport | Plants - genetics | Alkyl and Aryl Transferases - genetics | Transcription, Genetic | Hydro-Lyases - metabolism | Anthranilate Synthase - metabolism | Phosphorus-Oxygen Lyases - metabolism | Physiological aspects | Amino acids | Biosynthesis | Research | Phytochemistry | Plant metabolites | Herbicides | Enzymes | Flowers & plants | Metabolism | Index Medicus | Space life sciences
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9. Full Text Nationwide Post Event Survey and Analysis of the 2011 Tohoku Earthquake Tsunami
by Mori, Nobuhito and Takahashi, Tomoyuki and 2011 Tohoku Earthquake Tsunami Joint Survey Group and THE 2011 TOHOKU EARTHQUAKE TSUNAMI JOINT SURVEY GROUP
Coastal engineering journal, ISSN 2166-4250, 03/2012, Volume 54, Issue 1, pp. 1250001-1 - 1250001-27
inundation height | Tsunami | run-up height | post event survey | Engineering, Ocean | Engineering | Technology | Engineering, Civil | Science & Technology | Surveys | Tsunamis | Earthquakes | Japan | Databases | Earthquake engineering | Satellite navigation systems | Coastal environments | Seismic phenomena | Inundation | Global Positioning System
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