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Glia, ISSN 0894-1491, 09/2018, Volume 66, Issue 9, pp. 1881 - 1895
Microglia show a rich repertoire of activation patterns regulated by a complex ensemble of surface ion channels, receptors, and transporters. We and others... 
PAP‐1 | potassium channel | pro‐inflammatory | Kv1.3 | microglia | Kir2.1 | PAP-1 | pro-inflammatory | TARGET | STIMULATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | AMYLOID-BETA | MICE | LONG-TERM POTENTIATION | K+ CHANNEL | MEMORY T-CELLS | EXPRESSION | BLOCKER | Calcium-Binding Proteins - metabolism | Microglia - metabolism | Cytokines - metabolism | Immunity, Innate - drug effects | Microglia - drug effects | Tissue Culture Techniques | Escherichia coli | Mice, Inbred C57BL | Kv1.3 Potassium Channel - antagonists & inhibitors | Kv1.3 Potassium Channel - genetics | Long-Term Potentiation - immunology | Lipopolysaccharides | Mice, Knockout | Brain - drug effects | Brain - metabolism | Inflammation - metabolism | Animals | Kv1.3 Potassium Channel - metabolism | Microfilament Proteins - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Nervous system diseases | Analysis | Potassium channels | Potentiation | Cell culture | Brain | Animal models | Pathogenesis | Brain slice preparation | Activation | Neurotoxicity | Receptors | Rodents | Ion channels | Potassium channels (voltage-gated) | Immune response | Potassium channels (inwardly-rectifying) | Pharmacology | Inflammation | Gene expression | Ribonucleic acid--RNA | Nitric-oxide synthase | Microglia | Neurological diseases | Tumor necrosis factor | Immunoreactivity | Potassium | Hippocampus | Index Medicus
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 02/2017, Volume 60, pp. 106 - 116
Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding MeCP2, an epigenetic modulator that binds the... 
CX3CR1 | MeCP2 | Rett syndrome | Microglia | Index Medicus | ett syndrome
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 02/2017, Volume 60, p. 106
* CX.sub.3CR1 ablation improves the life span, body weight, and symptomatic scores of Mecp2KO mice. * CX.sub.3CR1 ablation improves the respiratory parameters... 
Glutamate | Neurons | Analysis | Body weight
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, p. 246
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 203a - 203a
Journal Article
Glia, ISSN 0894-1491, 01/2017, Volume 65, Issue 1, pp. 106 - 121
Microglia are highly plastic cells that can assume different phenotypes in response to microenvironmental signals. Lipopolysaccharide (LPS) and interferon‐γ... 
KCa3.1 | Kir2.1 | potassium channel | PAP‐1 | Kv1.3 | microglia | TRAM‐34 | TRAM-34 | PAP-1
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 02/2017, Volume 60, pp. 106 - 116
Journal Article
Molecules, ISSN 1420-3049, 08/2018, Volume 23, Issue 8, p. 2010
There is growing recognition regarding the role of intracellular amyloid beta (A beta) in the Alzheimer's disease process, which has been linked with aberrant... 
Nitroxide antioxidant | Intraneuronal Aβ | Oxidative stress | Amyloid beta | Spin label | Bifunctional drug | Intracellular Aβ | Oligomer | Alzheimer's disease | intracellular A beta | ACTIVATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | spin label | TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | amyloid beta | OLIGOMERS | nitroxide antioxidant | A beta oligomer | INTRACELLULAR ACCUMULATION | A-BETA | intraneuronal A beta | PRECURSOR PROTEIN | INHIBITORS | bifunctional drug | DERIVATIVES | oxidative stress | AGGREGATION | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - pharmacology | Amyloid beta-Protein Precursor - chemistry | Humans | Protein Multimerization | Fluorenes - pharmacology | Spin Labels | Alzheimer Disease - pathology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Neurons - metabolism | Neurons - drug effects | Protein Aggregates - drug effects | Cell Line | Gene Expression | Signal Transduction | Models, Molecular | Amyloid beta-Protein Precursor - genetics | Fluorenes - chemistry | Alzheimer Disease - metabolism | Protein Conformation | Amyloid beta-Peptides - chemistry | Oxidative Stress - drug effects | Alzheimer Disease - genetics | Protein Aggregation, Pathological - metabolism | Fluorene | Image resolution | Toxicity | Fluorescence | Confocal microscopy | Nitroxide | Metabolism | Amyloid precursor protein | Accumulation | Proteins | Mitochondria | Microscopy | Disruption | Synergistic effect | Intracellular | intracellular Aβ | Alzheimer’s disease | intraneuronal Aβ | Aβ oligomer
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2016
Highlights • CX3CR1 ablation improves the life span, body weight, and symptomatic scores of Mecp2KO mice. • CX3CR1 ablation improves the respiratory parameters... 
Allergy and Immunology | Psychiatry
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2017, Volume 58, Issue 2, pp. 559 - 574
There is an urgent unmet need for new therapeutics for Alzheimer's disease (AD), the most common cause of dementia in the elderly. Therapeutic approaches... 
NMDA | amyloid | neurotoxicity | hippocampus | Alzheimer's disease | neuroprotection | PROTEIN | PROTECTION | NEURONAL CELL-DEATH | SYNAPTIC PLASTICITY | NEUROSCIENCES | IN-VITRO | INHIBITION | TREATMENT STRATEGIES | FAMILIAL ALZHEIMERS-DISEASE | CYTOTOXICITY | BRAIN | Neuroprotective Agents - therapeutic use | Locomotion - genetics | Humans | Motor Activity - drug effects | Male | Excitatory Postsynaptic Potentials - drug effects | Alzheimer Disease - pathology | Brain - metabolism | Pyrones - chemistry | Excitatory Postsynaptic Potentials - genetics | Neuroblastoma - pathology | Disease Models, Animal | Locomotion - drug effects | Alzheimer Disease - physiopathology | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Amyloidogenic Proteins - toxicity | Mutation - genetics | Brain - drug effects | Motor Activity - genetics | Amyloidogenic Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Brain - pathology | Cell Line, Tumor | Pyrones - therapeutic use | Drinking Behavior - drug effects | Mice | Pyrones - chemical synthesis | Potentiation | Elderly people | Neuroprotection | Brain | Oxidative stress | Animal models | Toxicity | Glutamic acid receptors (ionotropic) | Memory | Glutamic acid receptors | Drug development | ABCA1 protein | Learning | Rodents | Dementia disorders | Coenzyme A | Amyloid | Neurodegenerative diseases | Long-term potentiation | N-Methyl-D-aspartic acid receptors | Pharmacology | Plasticity (hippocampal) | Acyltransferase | Cholesterol | Properties (attributes) | Excitatory postsynaptic potentials | ATP-binding protein | Elderly | Hippocampus | Sterol O-acyltransferase | Geriatrics
Journal Article
MOLECULAR AUTISM, ISSN 2040-2392, 01/2013, Volume 4, Issue 1, pp. 3 - 3
Journal Article
International Journal of Alzheimer's Disease, ISSN 2090-8024, 2012, Volume 2012, p. 868972
There exists an urgent need for new target discovery to treat Alzheimer's disease (AD); however, recent clinical trials based on anti-Aβ and anti-inflammatory... 
Studies | Clinical trials | Pathology | Alzheimers disease | Sickle cell disease | Memory | Review
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 527a - 528a
Journal Article