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index medicus (17) 17
chemistry, medicinal (16) 16
humans (14) 14
pyridines - pharmacology (13) 13
structure-activity relationship (13) 13
anticancer agents (12) 12
cell line, tumor (12) 12
derivatives (12) 12
pyridine (12) 12
antineoplastic agents - chemical synthesis (11) 11
antineoplastic agents - pharmacology (11) 11
chemistry, organic (10) 10
cytotoxicity (10) 10
pyridines - chemical synthesis (10) 10
pyridines - chemistry (10) 10
cell proliferation - drug effects (9) 9
design (9) 9
topoisomerase ii inhibitors - chemical synthesis (9) 9
topoisomerase ii inhibitors - pharmacology (9) 9
antineoplastic agents - chemistry (8) 8
dna topoisomerases (8) 8
pharmacy (8) 8
dna topoisomerases, type ii - metabolism (7) 7
drugstores (7) 7
2,4,6-triphenyl pyridines (6) 6
alkaloids (6) 6
analysis (6) 6
biochemistry & molecular biology (6) 6
dna topoisomerases, type i - metabolism (6) 6
molecular structure (6) 6
potent (6) 6
topoisomerase i inhibitors - chemical synthesis (6) 6
topoisomerase i inhibitors - pharmacology (6) 6
antiproliferative activity (5) 5
cancer (5) 5
dose-response relationship, drug (5) 5
drug design (5) 5
drug screening assays, antitumor (5) 5
topoisomerase ii inhibitors - chemistry (5) 5
animals (4) 4
cell survival - drug effects (4) 4
discovery (4) 4
dna topoisomerases, type i - chemistry (4) 4
halogenation (4) 4
hydroxides (4) 4
hydroxylation (4) 4
topoisomerase i inhibitors - chemistry (4) 4
2,4-diaryl (3) 3
benzofurans - chemistry (3) 3
biological evaluation (3) 3
cells (3) 3
dna (3) 3
dna topoisomerases, type ii - chemistry (3) 3
dna-binding proteins - antagonists & inhibitors (3) 3
etoposide (3) 3
expression (3) 3
in-vitro (3) 3
indenes - chemistry (3) 3
indenes - pharmacology (3) 3
nadph oxidase (3) 3
poisons (3) 3
topoisomerase i and ii inhibition (3) 3
2,4,6-trisubstituted pyridine (2) 2
anticancer activity (2) 2
antiinflammatory agents (2) 2
antiproliferative agents (2) 2
antitumor agents (2) 2
apoptosis (2) 2
benzofurans - chemical synthesis (2) 2
benzofurans - pharmacology (2) 2
biocatalysis (2) 2
biphenyl compounds - chemistry (2) 2
biphenyl compounds - pharmacology (2) 2
cancer-chemotherapy (2) 2
cell-cycle (2) 2
chalcone (2) 2
chalcones (2) 2
colitis (2) 2
colitis - chemically induced (2) 2
colitis - drug therapy (2) 2
complexes (2) 2
disease models, animal (2) 2
dna - metabolism (2) 2
dual topoisomerase i and ii inhibition (2) 2
female (2) 2
gastrointestinal diseases (2) 2
hela cells (2) 2
homeopathy (2) 2
ht29 cells (2) 2
hydroxylated 2,4-diphenyl indenopyridine (2) 2
i inhibitors (2) 2
indans - pharmacology (2) 2
indenes - chemical synthesis (2) 2
inflammatory bowel disease (2) 2
inflammatory bowel diseases - drug therapy (2) 2
jnk (2) 2
macrophages (2) 2
materia medica and therapeutics (2) 2
mechanism (2) 2
medicinal chemistry (2) 2
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European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2017, Volume 133, p. 69
With the aim to develop novel antiproliferative agents, a new series of eighteen dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines were systematically... 
Etoposide | Drugstores | Alkaloids | Pyridine | Pharmacy | DNA
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3499 - 3512
Journal Article
Journal Article
Bulletin of the Korean Chemical Society, ISSN 1229-5949, 06/2017, Volume 38, Issue 6, pp. 665 - 670
Chromanone‐containing compounds have been reported to possess several important biological activities. As a part of our continuing effort for discovering... 
4‐Chromanone | RAW 264.7 macrophages | ROS production | Inhibitory activity | 4-Chromanone | OXIDATIVE STRESS | DESIGN | TOXICITY | CAESALPINIA-SAPPAN | CHEMISTRY, MULTIDISCIPLINARY | MEDICINAL CHEMISTRY | HOMOISOFLAVONOIDS | CHALCONES | DERIVATIVES | BRAZILIN
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2015, Volume 90, pp. 302 - 314
For the development of novel anticancer agents, we designed and synthesized hydroxylated 2,4-diphenyl indenopyridines, and evaluated their topoisomerase... 
Topoisomerase IIa non-intercalative | catalytic inhibitorAntiproliferative activity | Anticancer agents | Hydroxylated 2,4-diphenyl indenopyridine | Terpyridine
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, p. 1909
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmc.2018.02.035 As part... 
Antimitotic agents | Care and treatment | Hydroxides | Pyridine | Antineoplastic agents | Cancer
Journal Article
Biomolecules and Therapeutics, ISSN 1976-9148, 03/2018, Volume 26, Issue 2, pp. 191 - 200
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present... 
Reactive oxygen species | JNK | NADPH oxidase | P38MAPK | Chalcone | TRANSCRIPTION FACTORS | CELLS | APOPTOSIS | RECRUITMENT | OXIDATIVE STRESS | ACTIVATION | INVOLVEMENT | MECHANISMS | CHALCONES | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | p38MAPK | Original
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2017, Volume 133, pp. 69 - 84
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 137, pp. 575 - 597
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 318 - 333
Novel series of conformationally constrained 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines were rationally designed and synthesized.... 
Dual topoisomerase I and II inhibition | Non-intercalative catalytic inhibiton | Anticancer agent | 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines | Antiproliferative activity | APOPTOSIS | CHEMISTRY, MEDICINAL | PROLIFERATION | 2,4-chloro- and hydroxy-substituted | diphenyl benzofuro[3,2-b]pyridines | CANCER | DISCOVERY | ANTICANCER ACTIVITY | POTENT | BIOLOGICAL EVALUATION | DNA TOPOISOMERASES | CELL-CYCLE | DERIVATIVES | Topoisomerase I Inhibitors - metabolism | Apoptosis - drug effects | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - metabolism | Benzofurans - chemistry | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Topoisomerase I Inhibitors - chemistry | DNA Topoisomerases, Type II - metabolism | Biocatalysis | Chemistry Techniques, Synthetic | DNA Topoisomerases, Type I - metabolism | Pyridines - chemical synthesis | Topoisomerase II Inhibitors - pharmacology | DNA - metabolism | Topoisomerase II Inhibitors - metabolism | Antineoplastic Agents - chemistry | Topoisomerase I Inhibitors - chemical synthesis | Pyridines - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Pyridines - pharmacology | Drugstores | Alkaloids | Pyridine | Design and construction | Analysis | Pharmacy
Journal Article
Biomolecules & Therapeutics(구 응용약물학회지), ISSN 1976-9148, 2018, Volume 26, Issue 2, pp. 191 - 200
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present... 
Reactive oxygen species | NADPH oxidase | JNK | Chalcone | p38MAPK
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 302 - 314
Journal Article