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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
by Bougouin, Wulfran and Marijon, Eloi and Planquette, Benjamin and Karam, Nicole and Dumas, Florence and Celermajer, David and Jost, Daniel and Lamhaut, Lionel and Beganton, Frankie and Cariou, Alain and Meyer, Guy and Jouven, Xavier and Bureau, Côme and Charpentier, Julien and Salem, Omar Ben Hadj and Guillemet, Lucie and Arnaout, Michel and Ferre, Alexis and Geri, Guillaume and Mongardon, Nicolas and Pène, Frédéric and Chiche, Jean-Daniel and Mira, Jean-Paul and Labro, Guylaine and Belon, François and Luu, Vinh-Phuc and Chenet, Julien and Besch, Guillaume and Puyraveau, Marc and Piton, Gaël and Capellier, Gilles and Martin, Maëlle and Lascarrou, Jean-Baptiste and Le Thuaut, Aurélie and Lacherade, Jean-Claude and Martin-Lefèvre, Laurent and Fiancette, Maud and Vinatier, Isabelle and Lebert, Christine and Bachoumas, Konstantinos and Yehia, Aihem and Henry-Laguarrigue, Matthieu and Colin, Gwenhaël and Reignier, Jean and Privat, Elodie and Escutnaire, Joséphine and Dumont, Cyrielle and Baert, Valentine and Vilhelm, Christian and Hubert, Hervé and Robert-Edan, Vincent and Lakhal, Karim and Quartin, Andrew and Hobbs, Brian and Cely, Cynthia and Bell, Cynthia and Pham, Tai and Schein, Roland and Geng, Yimin and Ng, Chaan and Ehrmann, Stephan and Gandonnière, Charlotte Salmon and Boisramé-Helms, Julie and Le Tilly, Olivier and De Bretagne, Isabelle Benz and Mercier, Emmanuelle and Mankikian, Julie and Bretagnol, Anne and Meziani, Ferhat and Halimi, Jean Michel and Le Guellec, Chantal Barin and Gaudry, Stéphane and Hajage, David and Tubach, Florence and Pons, Bertrand and Boulet, Eric and Boyer, Alexandre and Chevrel, Guillaume and Lerolle, Nicolas and Carpentier, Dorothée and de Prost, Nicolas and Lautrette, Alexandre and Mayaux, Julien and Nseir, Saad and Ricard, Jean-Damien and Dreyfuss, Didier and Robert, René and Garzotto, Franscesco and Kipnis, Eric and Tetta, Ciro and Ronco, Claudio and Schnell, David and Aurelie, Bourmaud and Reynaud, Marie and Clec’h, Christophe and Benyamina, Mourad and Vincent, François and Mariat, Christophe and Bornstain, Caroline and Rouleau, Stephane and ... and ENCEPHALITICA Study Group and GFRUP RMEF and for the EurêClark Study Group and REVA ECMOnet and REA-RAISIN Study Group and Sudden Death Expertise Center and for the HYPER2S Investigators and REVA Research Network and for the Purpura Fulminans Study Group and DO-RE-MI-FA Group and AKIKI Study Group and Groupe Communication et Simulation en Pédiatrie
Annals of Intensive Care, ISSN 2110-5820, 1/2017, Volume 7, Issue S1, pp. 1 - 104
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2018, Volume 24, Issue 12, pp. 1877 - 1886
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNA HELICASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | BRAF | MICE LACKING | CELL BIOLOGY | ONCOGENIC RAS | RESISTANCE | PD-L1 | EIF4F | INHIBITOR | INITIATION COMPLEX | Tumor Escape - drug effects | Protein Biosynthesis | Humans | B7-H1 Antigen - therapeutic use | Eukaryotic Initiation Factor-4F - genetics | Gene Expression Regulation, Neoplastic - immunology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Melanoma - pathology | STAT1 Transcription Factor - genetics | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Melanoma - genetics | Melanoma - immunology | Immunotherapy | Interferon-gamma - immunology | Cell Line, Tumor | Mice | Programmed Cell Death 1 Receptor - therapeutic use | Interferon-gamma - genetics | Melanoma - therapy | Tumor Escape - immunology | Prevention | Usage | Care and treatment | Analysis | Oncology, Experimental | Melanoma | Research | Biological response modifiers | Apoptosis | Cancer | RNA | Interferon | T cells | Genetic translation | Complex formation | PD-1 protein | Drug development | Immunosuppressive agents | Anticancer properties | DNA helicase | Antitumor agents | Bioindicators | Stat1 protein | Initiation complex | Translation | Tumor cells | Translation initiation | Pharmacology | Ribonucleic acid--RNA | Immune checkpoint | PD-L1 protein | Biomarkers | Antitumor activity | RNA helicase | Tumors | Index Medicus
Journal Article
by Howard, James F and Utsugisawa, Kimiaki and Benatar, Michael and Murai, Hiroyuki and Barohn, Richard J and Illa, Isabel and Jacob, Saiju and Vissing, John and Burns, Ted M and Kissel, John T and Muppidi, Srikanth and Nowak, Richard J and O'Brien, Fanny and Wang, Jing-Jing and Mantegazza, Renato and Mazia, Claudio Gabriel and Wilken, Miguel and Ortea, Carolina and Saba, Juliet and Rugiero, Marcelo and Bettini, Mariela and Vidal, Gonzalo and Vidal, Nuria and Garcia, Rebekah and Garcia, Sonia and Garcia, Alejandra Dalila and Lamont, Phillipa and Leong, Wai-Kuen and Boterhoven, Heidi and Fyfe, Beverly and Roberts, Leslie and Jasinarachchi, Mahi and Willlems, Natasha and Wanschitz, Julia and Löscher, Wolfgang and De Bleecker, Jan and Van den Abeele, Guy and de Koning, Kathy and De Mey, Katrien and Mercelis, Rudy and Wagemaekers, Linda and Mahieu, Delphine and Van Damme, Philip and Smetcoren, Charlotte and Stevens, Olivier and Verjans, Sarah and D'Hondt, Ann and Tilkin, Petra and Alves de Siqueira Carvalho, Alzira and Hasan, Rosa and Dias Brockhausen, Igor and Feder, David and Ambrosio, Daniel and Melo, Ana Paula and Rocha, Rosana and Rosa, Bruno and Veiga, Thabata and Augusto da Silva, Luiz and Gonçalves Geraldo, Jordana and da Penha Morita Ananias, Maria and Nogueira Coelho, Erica and Paiva, Gabriel and Pozo, Marina and Prando, Natalia and Dada Martineli Torres, Debora and Fernanda Butinhao, Cristiani and Coelho, Erica and Renata Cubas Volpe, Luciana and Duran, Gustavo and Gomes da Silva, Tamires Cristina and Otavio Maia Gonçalves, Luiz and Pazetto, Lucas Eduardo and Souza Duca, Luciana and Suriane Fialho, Tomás Augusto and Gheller Friedrich, Maurício André and Guerreiro, Alexandre and Mohr, Henrique and Pereira Martins, Maurer and da Cruz Pacheco, Daiane and Macagnan, Ana Paula and de Cassia Santos, Aline and Bulle Oliveira, Acary Souza and Amaral de Andrade, Ana Carolina and Annes, Marcelo and Cavalcante Lino, Valeria and Pinto, Wladimir and Miranda, Carolina and Carrara, Fernanda and Souza, Iandra and Genge, Angela and Massie, Rami and Campbell, Natasha and Bril, Vera and Katzberg, Hans and Soltani, Mehran and Ng, Eduardo and Siddiqi, Zaeem and Phan, Celile and Blackmore, Derrick and Vohanka, Stanislav and ... and REGAIN Study Grp and REGAIN Study Group
The Lancet Neurology, ISSN 1474-4422, 12/2017, Volume 16, Issue 12, pp. 976 - 986
Journal Article
British Journal of Ophthalmology, ISSN 0007-1161, 06/2018, Volume 102, Issue 6, pp. 808 - 813
Journal Article
International Journal of Infectious Diseases, ISSN 1201-9712, 04/2019, Volume 81, pp. 52 - 56
The aim was to characterize the clinical features, outcomes, and strain diversity of laboratory-confirmed (group A , GAS) infections among inpatients... 
Homeless persons | Streptococcus pyogenes | Skin infections | Epidemiology | Streptococcal m protein | INFECTIOUS DISEASES | Homelessness | Medical research | Analysis | Abscess | Medicine, Experimental | Skin | Health aspects | Index Medicus
Journal Article
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 10/2017, Volume 101, Issue 4, pp. 630 - 637
Hearing loss and visual impairment in childhood have mostly genetic origins, some of them being related to sensorial neuronal defects. Here, we report on eight... 
optic atrophy | iron overload | ARH1 | Auditory neuropathy | iron-sulfur cluster | mitochondria | FDXR | Fe-S cluster synthesis | CLUSTER BIOGENESIS | FRATAXIN | DOMINANT OPTIC ATROPHY | PROTEIN | ADRENODOXIN REDUCTASE | IRON HOMEOSTASIS | GENE | GENETICS & HEREDITY | MECHANISMS | AUDITORY NEUROPATHY | FERREDOXINS | Ferredoxin-NADP Reductase - metabolism | Mitochondrial Diseases - pathology | Mitochondria - enzymology | Saccharomyces cerevisiae - genetics | Humans | Child, Preschool | Iron-Sulfur Proteins - genetics | Male | Hearing Loss, Central - genetics | Genetic Complementation Test | Optic Atrophy - pathology | Saccharomyces cerevisiae - metabolism | Young Adult | Hearing Loss, Central - enzymology | Mitochondria - genetics | Ferredoxin-NADP Reductase - genetics | Adult | Female | Optic Atrophy - genetics | Mitochondrial Diseases - genetics | Amino Acid Sequence | Mitochondria - pathology | Saccharomyces cerevisiae Proteins - genetics | Iron - metabolism | Mitochondrial Diseases - enzymology | Sequence Alignment | Pedigree | Adolescent | Saccharomyces cerevisiae Proteins - metabolism | Iron-Sulfur Proteins - metabolism | Ferredoxin-NADP Reductase - chemistry | Mutation | Hearing Loss, Central - pathology | Optic Atrophy - enzymology | Saccharomyces cerevisiae - growth & development | Usage | Gene mutations | Analysis | Genetic aspects | Nucleotide sequencing | Research | Children | Gene expression | Health aspects | DNA sequencing | Hearing loss | Index Medicus | Report
Journal Article
Pharmaceuticals, ISSN 1424-8247, 07/2013, Volume 6, Issue 7, pp. 837 - 850
Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6... 
Diamidine | Pentamidine | Pneumocystis | pentamidine | diamidine
Journal Article
Revue Neurologique, ISSN 0035-3787, 04/2015, Volume 171, pp. A181 - A181
Journal Article