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1. Full Text Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
by Dastani, Zari and Hivert, Marie-France and Timpson, Nicholas and Perry, John R. B and Yuan, Xin and Scott, Robert A and Henneman, Peter and Heid, Iris M and Kizer, Jorge R and Lyytikäinen, Leo-Pekka and Fuchsberger, Christian and Tanaka, Toshiko and Morris, Anew P and Small, Kerrin and Isaacs, Aaron and Beekman, Marian and Coassin, Stefan and Lohman, Kurt and Qi, Lu and Kanoni, Stavroula and Pankow, James S and Uh, Hae-Won and Wu, Ying and Bidulescu, Aurelian and Rasmussen-Torvik, Laura J and Greenwood, Celia M. T and Ladouceur, Martin and Grimsby, Jonna and Manning, Alisa K and Liu, Ching-Ti and Kooner, Jaspal and Mooser, Vincent E and Vollenweider, Peter and Kapur, Karen A and Chambers, John and Wareham, Nicholas J and Langenberg, Claudia and Frants, Rune and Willems-Vandijk, Ko and Oostra, Ben A and Willems, Sara M and Lamina, Claudia and Winkler, Thomas W and Psaty, Bruce M and Tracy, Russell P and Brody, Jennifer and Chen, Ida and Viikari, Jorma and Kähönen, Mika and Pramstaller, Peter P and Evans, David M and St Pourcain, Beate and Sattar, Naveed and Wood, Anew R and Bandinelli, Stefania and Carlson, Olga D and Egan, Josephine M and Böhringer, Stefan and van Heemst, Diana and Kedenko, Lyudmyla and Kristiansson, Kati and Nuotio, Marja-Liisa and Loo, Britt-Marie and Harris, Tamara and Garcia, Melissa and Kanaya, Alka and Haun, Margot and Klopp, Norman and Wichmann, H.-Erich and Deloukas, Panos and Katsareli, Efi and Couper, David J and Duncan, Bruce B and Kloppenburg, Margreet and Adair, Linda S and Borja, Judith B and Wilson, James G and Musani, Solomon and Guo, Xiuqing and Johnson, Toby and Semple, Robert and Teslovich, Tanya M and Allison, Matthew A and Redline, Susan and Buxbaum, Sarah G and Mohlke, Karen L and Meulenbelt, Ingrid and Ballantyne, Christie M and Dedoussis, George V and Hu, Frank B and Liu, Yongmei and Paulweber, Bernhard and Spector, Timothy D and Slagboom, P. Eline and Ferrucci, Luigi and Jula, Antti and Perola, Markus and Raitakari, Olli and Florez, Jose C and Salomaa, Veikko and ... and GLGC Investigators and DIAGRAM Consortium and MAGIC Consortium and MuTHER Consortium and Global B Pgen Consortium and MAGIC investigators and Procardis Consortium and DIAGRAM+ Consortium and GLGC Consortium and GIANT Consortium
PLoS genetics, ISSN 1553-7390, 2012, Volume 8, Issue 3, pp. e1002607 - e1002607
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes... 
POPULATION | GENETIC-BASIS | VARIANTS | INSULIN-RESISTANCE | LIPID CONCENTRATIONS | GENETICS & HEREDITY | RISK | RECEPTOR | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Glucose Tolerance Test | Diabetes Mellitus, Type 2 - genetics | Humans | African Americans | European Continental Ancestry Group | Male | Cholesterol, HDL - genetics | Adiponectin - blood | Asian Continental Ancestry Group | Metabolic Networks and Pathways | Adiponectin - genetics | Insulin Resistance - genetics | Female | Polymorphism, Single Nucleotide | Waist-Hip Ratio | Type 2 diabetes | Physiological aspects | Development and progression | Genetic aspects | Research | Metabolism | Health aspects | Blood proteins | Meta-analysis | Medical research | Cardiovascular disease | Drug therapy | Insulin | Metabolic disorders | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
by Dupuis, Josée and Langenberg, Claudia and Prokopenko, Inga and Saxena, Richa and Soranzo, Nicole and Jackson, Anne and Wheeler, Eleanor and Glazer, Nicole and Bouatia-Naji, Nabila and Gloyn, Anna and Lindgren, Cecilia and Mägi, Reedik and Morris, Anew and Randall, Joshua and Johnson, Toby and Elliott, Paul and Rybin, Denis and Thorleifsson, Gudmar and Steinthorsdottir, Valgerdur and Henneman, Peter and Grallert, Harald and Dehghan, Abbas and JanHottenga, Jouke and Franklin, Christopher and Navarro, Pau and Song, Kijoung and Goel, Anuj and Perry, John and Egan, Josephine and Lajunen, Taina and Grarup, Niels and Sparsø, Thomas and Doney, Alex and Voight, Benjamin and Stringham, Heather and Li, Man and Kanoni, Stavroula and Shrader, Peter and Cavalcanti-Proença, Christine and Kumari, Meena and Qi, Lu and Timpson, Nicholas and Gieger, Christian and Zabena, Carina and Rocheleau, Ghislain and Ingelsson, Erik and An, Ping and O´Connell, J.R and Luan, J and McCarroll, Steven and Payne, Felicity and Roccasecca, R.M and Pattou, François and Sethupathy, Praveen and Ardlie, Kristin and Ariyurek, Yavuz and Balkau, Beverley and Barter, Phil and Beilby, John and Ben-Shlomo, Y and Benediktsson, Rafn and Bennett, Amanda and Bergmann, Sven and Bochud, Murielle and Boerwinkle, Eric and Bonnefond, Amélie and Bonnycastle, Lori and Borch-Johnsen, K and Böttcher, Yvonne and Brunner, Eric and Bumpstead, Suzannah and Charpentier, Guillaume and IdaChen, Yii and Chines, Peter and Clarke, R and McOin, Lachlan and Cooper, Matthew and Cornelis, Marilyn and Crawford, Gabe and Crisponi, Laura and Day, Ian and Geus, Eco and Delplanque, Jerome and Dina, Christian and Erdos, Michael and Fedson, Annette and Fischer-Rosinsky, Antje and Forouhi, Nita and Fox, Caroline and Frants, Rune and GraziaFranzosi, Maria and Galan, Pilar and Goodarzi, Mark and Graessler, Jürgen and Groves, Christopher and Grundy, Scott and Gwilliam, Rhian and Gyllensten, Ulf and Hadjadj, Samy and Hallmans, Göran and ... and DIAGRAM Consortium and Global BPgen Consortium and Anders Hamsten Procardis Consortiu and GIANT Consortium and MAGIC Investigators and Anders Hamsten on behalf of Procardis Consortium and MAGIC investigators and the MAGIC investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Näringsforskning and Umeå universitet and Medicin
Nature Genetics, ISSN 1061-4036, 02/2010, Volume 42, Issue 2, pp. 105 - 116
textabstractLevels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide... 
CIRCADIAN CLOCK | DISEASE RISK | TRIGLYCERIDE LEVELS | INSULIN-RESISTANCE | GENETICS & HEREDITY | BETA-CELL DYSFUNCTION | PLASMA-GLUCOSE | MODEL ASSESSMENT | FOLLOW-UP | GENOME-WIDE ASSOCIATION | ESSENTIAL COMPONENTS | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Reproducibility of Results | Quantitative Trait, Heritable | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Regulation | Genetic Loci - genetics | Databases, Genetic | DNA Copy Number Variations - genetics | Fasting - blood | Adolescent | Alleles | Polymorphism, Single Nucleotide - genetics | Adult | Blood Glucose - genetics | Blood Glucose - metabolism | Child | Homeostasis - genetics | Quantitative Trait Loci - genetics | Type 2 diabetes | Homeostasis | Physiological aspects | Genetic aspects | Research | Insulin | Health aspects | Risk factors | Studies | Hyperglycemia | Diabetes | Sample size | Meta-analysis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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3. Full Text LDL-cholesterol concentrations: a genome-wide association study
by Sandhu, Manjinder S, Dr and Waterworth, Dawn M, PhD and Debenham, Sally L, PhD and Wheeler, Eleanor, PhD and Papadakis, Konstantinos, MSc and Zhao, Jing Hua, PhD and Song, Kijoung, PhD and Yuan, Xin, PhD and Johnson, Toby, PhD and Ashford, Sofie, BSc and Inouye, Michael, MSc and Luben, Robert, BSc and Sims, Matthew, BSc and Hadley, David, MSc and McArdle, Wendy, PhD and Barter, Philip, Prof and Kesäniemi, Y Antero, Prof and Mahley, Robert W, Prof and McPherson, Ruth, Prof and Grundy, Scott M, Prof and Bingham, Sheila A, Prof and Khaw, Kay-Tee, Prof and Loos, Ruth JF, PhD and Waeber, Gérard, Prof and Barroso, Inês, PhD and Strachan, David P, Prof and Deloukas, Panagiotis, PhD and Vollenweider, Peter, MD and Wareham, Nicholas J, Prof and Mooser, Vincent, MD and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium
Lancet, The, ISSN 0140-6736, 2008, Volume 371, Issue 9611, pp. 483 - 491
Summary Background LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that... 
Internal Medicine | GENOTYPES | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | PLASMA | RANDOMIZED-TRIALS | LIPID-LEVELS | COMMON DISEASES | RISK | HYPERCHOLESTEROLEMIA | CORONARY-ARTERY-DISEASE | APOLIPOPROTEIN-E | European Continental Ancestry Group - genetics | Humans | Middle Aged | Europe - epidemiology | Linear Models | Male | Seroepidemiologic Studies | Cholesterol, LDL - physiology | Cardiovascular Diseases - genetics | Linkage Disequilibrium | Cholesterol, LDL - genetics | Cardiovascular Diseases - epidemiology | Adult | Cholesterol, LDL - blood | Female | Aged | Genetic Variation - genetics | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 1 - genetics | Genome, Human | Cohort Studies | Studies | Medical research | Cardiovascular disease | Diet | Genomics | Cholesterol | Index Medicus | Abridged Index Medicus | Fast track
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4. Full Text Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
by Speliotes, E.K and Yerges-Armstrong, L.M and Wu, J and Hernaez, R and Kim, L.J and Palmer, C.D and Gudnason, V and Eiriksdottir, G and Garcia, M.E and Launer, L.J and Nalls, M.A and Clark, J.M and Mitchell, B.D and Shuldiner, A.R and Butler, J.L and Tomas, M and Hoffmann, U and Hwang, S.J and Massaro, J.M and O'Donnell, C.J and Sahani, D.V and Salomaa, V and Schadt, E.E and Schwartz, S.M and Siscovick, D.S and Voight, B.F and Carr, J.J and Feitosa, M.F and Harris, T.B and Fox, C.S and Smith, A.V and Kao, W.H and Hirschhorn, J.N and Borecki, I.B and Heijer, M. den and GOLD Consortium and NASH CRN and GIANT Consortium and MAGIC Investigators and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Physiology and Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi and Sahlgrenska Academy
PLOS Genetics, ISSN 1553-7390, 2011, Volume 7, Issue 3, pp. e1001324 - e1001324
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to... 
HEART | DESIGN | TRIGLYCERIDE LEVELS | SUSCEPTIBILITY | GENETICS & HEREDITY | ADULTS | PNPLA3 | RISK | LOCI | STEATOHEPATITIS | CORONARY-ARTERY-DISEASE | Chondroitin Sulfate Proteoglycans - genetics | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Mutation, Missense | Insulin - blood | Lectins, C-Type - genetics | Case-Control Studies | Non-alcoholic Fatty Liver Disease | Aged, 80 and over | Adult | Fatty Liver - genetics | Genome-Wide Association Study | Fatty Liver - metabolism | Blood Glucose - analysis | Membrane Proteins - genetics | Nerve Tissue Proteins - genetics | Fatty Liver - diagnostic imaging | Adaptor Proteins, Signal Transducing - genetics | Aged | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Cohort Studies | Lipase - genetics | CT imaging | Usage | Fatty liver | Development and progression | Genetic aspects | Research | Diagnosis | Single nucleotide polymorphisms | Risk factors | Index Medicus | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES | Studies | Diet | Liver cirrhosis | Rodents
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5. Full Text Apolipoprotein E: Remarkable protein sheds light on cardiovascular and neurological diseases
by Mahley, Robert W
Clinical Chemistry, ISSN 0009-9147, 01/2017, Volume 63, Issue 1, pp. 14 - 20
  Apolipoprotein E (apoE)6 is a relatively small protein (34 kDa, 299 amino acids) that has been slowly revealing its biologic secrets in cardiovascular and... 
FAT TRANSPORT | LOW-DENSITY LIPOPROTEINS | CHOLESTEROL TRANSPORT | ALZHEIMERS-DISEASE | REGENERATION | DISORDERS | MECHANISMS | NEUROPATHOLOGY | MEDICAL LABORATORY TECHNOLOGY | INTEGRATED APPROACH | CELL BIOLOGY | Nervous system diseases | Amino acids | Genetic aspects | Blood lipids | Apolipoproteins | Genetic polymorphisms | Neurophysiology | Physiological aspects | Cardiovascular diseases | Health aspects | Laboratories | Colleges & universities | Cardiovascular disease | Lipids | Metabolism | Cholesterol | Proteins | Lipoproteins | Neurotoxicity | Hospitals | Rodents | Atherosclerosis | Ligands | Index Medicus
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6. Full Text A genome-wide association study reveals variants in ARL15 that influence adiponectin levels
by Richards, Brent and Waterworth, Dawn and O'Rahilly, Stephen and Hivert, Marie-France and Loos, Ruth and Perry, John and Tanaka, Toshiko and Timpson, Nicholas and Semple, Robert and Soranzo, Nicole and Song, Kijoung and Rocha, Nuno and Grundberg, Elin and Dupuis, Josée and Florez, Jose and Langenberg, Claudia and Prokopenko, Inga and Saxena, Richa and Sladek, Rob and Aulchenko, Yurii and Evans, David and Waeber, Gérard and Burnett, M.S and Sattar, Naveed and Devaney, Joseph and Willenborg, Christina and Hingorani, Aroon and Witteman, Jacqueline and Vollenweider, Peter and Glaser, Beate and Hengstenberg, Christian and Ferrucci, Luigi and Melzer, David and Stark, Klaus and Deanfield, John and Winogradow, Janina and Grassl, Martina and Hall, Alistair and Egan, Josephine and Thompson, John and Ricketts, Sally and König, Inke and Reinhard, Wibke and Grundy, Scott and Wichmann, Heinz Erich and Barter, Phil and Mahley, Robert and Kesaniemi, Antero and Rader, Daniel and Reilly, Muredach and Epstein, Stephen and Stewart, Alexane and Tikka-Kleemola, Päivi and Schunkert, Heribert and Burling, Keith and Erdmann, Jeanette and Deloukas, Panagiotis and Pastinen, Tomi and Samani, Nilesh and McPherson, Ruth and Smith, G.D and Frayling, Timothy and Wareham, Nick and Meigs, James and Mooser, Vincent and Spector, Tim and GIANT Consortium
P L o S Genetics (Print), ISSN 1553-7390, 12/2009, Volume 5, Issue 12, pp. e1000768 - e1000768
textabstractThe adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary... 
SERUM CONCENTRATION | METABOLIC SYNDROME | PLASMA ADIPONECTIN | BONE-MINERAL DENSITY | MYOCARDIAL-INFARCTION | INSULIN-RESISTANCE | GENETICS & HEREDITY | SMALL G-PROTEINS | MOLECULAR-WEIGHT ADIPONECTIN | CIRCULATING ADIPONECTIN | APM1 GENE | Adiponectin - blood | Genetic Predisposition to Disease | Genome-Wide Association Study | Coronary Disease - genetics | Adiponectin - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Female | Male | Polymorphism, Single Nucleotide | Adiponectin - physiology | Index Medicus | Heart | Medical research | Biomedical research | Cardiovascular disease | Genomes | Grants | Gene expression | Recruitment | Proteins | Councils | Influence | Diabetes | Metabolic disorders
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