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1. Full Text Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study
by Raab, Jennifer and Haupt, Florian and Scholz, Marlon and Matzke, Claudia and Warncke, Katharina and Lange, Karin and Assfalg, Robin and Weininger, Katharina and Wittich, Susanne and Löbner, Stephanie and Beyerlein, Andreas and Nennstiel-Ratzel, Uta and Lang, Martin and Laub, Otto and Dunstheimer, Desiree and Bonifacio, Ezio and Achenbach, Peter and Winkler, Christiane and Ziegler, Anette-G and Fr1da Study Grp and Fr1da Study Group
BMJ Open, ISSN 2044-6055, 05/2016, Volume 6, Issue 5, p. e011144
IntroductionType 1 diabetes can be diagnosed at an early presymptomatic stage by the detection of islet autoantibodies. The Fr1da study aims to assess whether... 
type 1 diabetes | screening | childhood | GLUTAMIC-ACID DECARBOXYLASE | RISK | KETOACIDOSIS | PREVALENCE | islet autoantibodies | ANTIBODY STANDARDIZATION PROGRAM | CHILDREN | MEDICINE, GENERAL & INTERNAL | SCHOOLCHILDREN | ADOLESCENTS | ASSAYS | PSYCHOLOGICAL IMPACT | Prediabetic State - blood | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology | Stress, Psychological - blood | Autoantibodies - blood | Humans | Child, Preschool | Islets of Langerhans - immunology | Male | Directive Counseling | Mass Screening - methods | Zinc Transporter 8 - immunology | Prediabetic State - diagnosis | Caregivers - education | Blood Specimen Collection | Diabetes Mellitus, Type 1 - blood | Preliminary Data | Female | Prediabetic State - psychology | Capillaries | Glutamate Decarboxylase - immunology | Early Diagnosis | Research Design | Stress, Psychological - etiology | Patient Education as Topic
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2. 150 Jahre "Mabinogion" - deutsch-walisische Kulturbeziehungen
by Hrsg.: Maier, Bernhard
2001, 1 Auflage., Buchreihe der Zeitschrift f¿ur celtische Philologie, ISBN 9783484429192, Volume 19
Sprach- und Literaturwissenschaft sonstiger Sprachen | SEL Library selection
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3. Full Text Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this... 
GENOTYPES | COMMON VARIANTS | IMPUTATION | GENETIC RISK | SEQUENCE | GENETICS & HEREDITY | NEURONS | RECEPTOR | MUTATIONS | CD33 | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Case-Control Studies | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Cohort Studies | Quantitative trait loci | Genetic aspects | Research | Genetic susceptibility | Alzheimer's disease | Identification and classification | Genealogy | Genomics | Genes | Quality control | Aging | Genomes | Alzheimers disease | Health risk assessment | Meta-analysis | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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4. Full Text Landscape simplification filters species traits and drives biotic homogenization
by Gámez-Virués, Sagrario and Perović, David J and Gossner, Martin M and Börschig, Carmen and Blüthgen, Nico and De Jong, Heike and Simons, Nadja K and Klein, Alexandra-Maria and Krauss, Jochen and Maier, Gwen and Scherber, Christoph and Steckel, Juliane and Rothenwöhrer, Christoph and Steffan-Dewenter, Ingolf and Weiner, Christiane N and Weisser, Wolfgang and Werner, Michael and Tscharntke, Teja and Westphal, Catrin
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8568
Biodiversity loss can affect the viability of ecosystems by decreasing the ability of communities to respond to environmental change and disturbances.... 
BIODIVERSITY | HETEROGENEITY | BODY-SIZE | LAND-USE INTENSITY | MULTIDISCIPLINARY SCIENCES | BUTTERFLIES | SUSTAINABLE INTENSIFICATION | AGRICULTURAL INTENSIFICATION | DIVERSITY | MANAGED GRASSLANDS | COMMUNITY FUNCTIONAL-RESPONSES | Grassland | Coleoptera | Biota | Biodiversity | Bees | Heteroptera | Arachnida | Animals | Larva | Ecosystem | Lepidoptera | Agriculture | Hemiptera | Diptera | Germany
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5. Full Text Cross-linking oppositely charged oil-in-water emulsions to enhance heteroaggregate stability
by Maier, Christiane and Oechsle, Anja M and Weiss, Jochen
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 11/2015, Volume 135, pp. 525 - 532
The formation and subsequent enzymatic and chemical cross-linking of heteroaggregates from oppositely charged oil-in-water (O/W) emulsions was investigated.... 
Aggregation | Stability | Glutaraldehyde | Emulsifier | Oil-in-water emulsion | Laccase | Whey Proteins - chemistry | Cross-Linking Reagents - chemistry | Emulsions | Drug Stability | Emulsifying Agents - chemistry | Water - chemistry | Laccase - chemistry | Oils - chemistry | Glutaral - chemistry | Arginine - analogs & derivatives | Gelatin - chemistry | Saponins - chemistry | Saponins | Charging | Aggregates | Crosslinking | Emulsifiers | Whey
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6. Full Text Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus
by Ziegler, Anette-G and Wallner, Maike and Kaiser, Imme and Rossbauer, Michaela and Harsunen, Minna H and Lachmann, Lorenz and Maier, Jörg and Winkler, Christiane and Hummel, Sandra
Diabetes, ISSN 0012-1797, 12/2012, Volume 61, Issue 12, pp. 3167 - 3171
Women with gestational diabetes mellitus (GDM) have a high risk of developing postpartum type 2 diabetes. Strategies to prevent postpartum type 2 diabetes are... 
PREDICTORS | GLUCOSE-TOLERANCE | DURATION | POSTPARTUM | ENDOCRINOLOGY & METABOLISM | Body Mass Index | Pregnancy | Multivariate Analysis | Prospective Studies | Humans | Breast Feeding | Diabetes Mellitus, Type 2 - prevention & control | Diabetes, Gestational - physiopathology | Adult | Female | Lactation - physiology | Type 2 diabetes | Complications and side effects | Prognosis | Lactation | Development and progression | Diabetes in pregnancy | Research | Health aspects | Risk factors | Metabolism
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7. Full Text Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... 
COMMON VARIANTS | IDENTIFIES VARIANTS | METAANALYSIS | GENOTYPE IMPUTATION | LOW-FREQUENCY | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | LOCI | WAVE2 COMPLEX | GENOME-WIDE ASSOCIATION | Amino Acid Sequence | Microglia - metabolism | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Immunity, Innate - genetics | Genotype | Gene Expression Profiling | Case-Control Studies | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Protein Interaction Maps - genetics | Adaptor Proteins, Signal Transducing - genetics | Phospholipase C gamma - genetics | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Receptors, Immunologic - genetics | Immune response | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neurodegenerative diseases | Genes | Genomics | Health risks | Innate immunity | Genomes | Disease control | Immunity | Microglia | Proteins | Studies | Consortia | DNA microarrays | Genotyping | Gene frequency | DNA methylation | Alzheimers disease | Protein interaction | Bioinformatics | Genotypes | Immune system | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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8. Full Text Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis
by Huang, Jingang and Maier, Christiane and Zhang, Yun and Soare, Alina and Dees, Clara and Beyer, Christian and Harre, Ulrike and Chen, Chih-Wei and Distler, Oliver and Schett, Georg and Wollin, Lutz and Distler, Jörg H W
Annals of the Rheumatic Diseases, ISSN 0003-4967, 11/2017, Volume 76, Issue 11, pp. 1941 - 1948
BackgroundNintedanib is an inhibitor targeting platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth... 
macrophages | endothelial | scleroderma | VEGF | CSF | PULMONARY-HYPERTENSION | EFFICACY | EXTRACELLULAR-MATRIX | TUMOR ANGIOGENESIS | RHEUMATOLOGY | VASCULOPATHIES | EXPRESSION | DERMAL FIBROSIS | ENDOTHELIAL GROWTH-FACTOR | TRANSGENIC MICE | TOCILIZUMAB | Enzyme Inhibitors - pharmacology | Scleroderma, Systemic - pathology | Vascular Endothelial Growth Factor A - blood | Fos-Related Antigen-2 | Mice, Transgenic | Pulmonary Artery - drug effects | Muscle, Smooth, Vascular - cytology | Animals | Scleroderma, Systemic - complications | Fibrosis | Indoles - pharmacology | Cell Proliferation - drug effects | Hypertension, Pulmonary - drug therapy | Mice | Macrophage Activation - drug effects | Hypertension, Pulmonary - etiology | Scleroderma, Systemic - drug therapy | Disease Models, Animal | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Sclerosis | Pulmonary fibrosis | Cell proliferation | Occlusion | Polarization | Fibroblast growth factor | Fos-related antigen | Platelet-derived growth factor | Smooth muscle | Arthritis | Kinases | Macrophages | Angiogenesis | Cell activation | Fos protein | Transgenic animals | Rodents | Extracellular matrix | Vascular endothelial growth factor | Tyrosine | Hypertension | Pulmonary arteries | Lung diseases | Transgenic mice | Endothelial cells | Pulmonary artery | Serum levels | Monocytes | Systemic sclerosis | Skin | Microvasculature | Apoptosis | Veins & arteries
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