The New England Journal of Medicine, ISSN 0028-4793, 03/2007, Volume 356, Issue 12, pp. 1216 - 1225
A region on chromosome 17 has been associated with a range of epidemiologically associated autoimmune and autoinflammatory diseases, including vitiligo. Using...
MEDICINE, GENERAL & INTERNAL | SLEV1 | GENE | SUSCEPTIBILITY LOCI | COLD AUTOINFLAMMATORY SYNDROME | MUTATIONS | HLA | EPIDEMIOLOGY | ONSET | FAMILY | Amino Acid Sequence | Promoter Regions, Genetic | Genetic Predisposition to Disease | Humans | Vitiligo - immunology | Molecular Sequence Data | Genotype | Logistic Models | Sequence Analysis, DNA | Autoimmune Diseases - genetics | Genetic Variation | Inheritance Patterns | Sequence Alignment | Chromosomes, Human, Pair 17 | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - genetics | Polymorphism, Single Nucleotide | Vitiligo - genetics | Genetic Linkage | Care and treatment | Genetic aspects | Diagnosis | Autoimmune diseases | Lupus | Genetics | Thyroid gland | Immune system
MEDICINE, GENERAL & INTERNAL | SLEV1 | GENE | SUSCEPTIBILITY LOCI | COLD AUTOINFLAMMATORY SYNDROME | MUTATIONS | HLA | EPIDEMIOLOGY | ONSET | FAMILY | Amino Acid Sequence | Promoter Regions, Genetic | Genetic Predisposition to Disease | Humans | Vitiligo - immunology | Molecular Sequence Data | Genotype | Logistic Models | Sequence Analysis, DNA | Autoimmune Diseases - genetics | Genetic Variation | Inheritance Patterns | Sequence Alignment | Chromosomes, Human, Pair 17 | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - genetics | Polymorphism, Single Nucleotide | Vitiligo - genetics | Genetic Linkage | Care and treatment | Genetic aspects | Diagnosis | Autoimmune diseases | Lupus | Genetics | Thyroid gland | Immune system
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2010, Volume 362, Issue 18, pp. 1686 - 1697
The results of a genomewide association study of generalized vitiligo implicate genes involved in the immune response and also a variant of TYR, which encodes...
RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | GENE | HAPLOTYPE MAP | TYROSINASE | DISEASE | RISK | HLA | GRANZYME-B | PIGMENTATION | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Major Histocompatibility Complex - genetics | Melanoma - genetics | Humans | Vitiligo - immunology | Genotype | Monophenol Monooxygenase - genetics | Polymorphism, Single Nucleotide | Genetic Markers | Vitiligo - genetics | Vitiligo | Major histocompatibility complex | Analysis | Melanoma | Genetic aspects | Research | Single nucleotide polymorphisms | Diagnosis | Genetics | Autoimmune diseases | Rheumatoid arthritis | Thyroid diseases
RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | GENE | HAPLOTYPE MAP | TYROSINASE | DISEASE | RISK | HLA | GRANZYME-B | PIGMENTATION | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Major Histocompatibility Complex - genetics | Melanoma - genetics | Humans | Vitiligo - immunology | Genotype | Monophenol Monooxygenase - genetics | Polymorphism, Single Nucleotide | Genetic Markers | Vitiligo - genetics | Vitiligo | Major histocompatibility complex | Analysis | Melanoma | Genetic aspects | Research | Single nucleotide polymorphisms | Diagnosis | Genetics | Autoimmune diseases | Rheumatoid arthritis | Thyroid diseases
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 8, pp. 2952 - 2956
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to...
Haplotypes | Homozygotes | Celiac disease | Monocytes | Vitiligo | Addison disease | Systemic lupus erythematosus | Disease risk | Mucocutaneous lymph node syndrome | Autoimmune diseases | Interleukin-1beta | Cytokine | DNA sequencing | cytokine | NALP1 | GWAS | GENERALIZED VITILIGO | GENE | MULTIDISCIPLINARY SCIENCES | DISEASE | RISK | POLYMORPHISM | interleukin-1beta | ONSET | Apoptosis Regulatory Proteins - immunology | Interleukin-1beta - metabolism | Humans | Inflammasomes - immunology | Vitiligo - immunology | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Biological Sciences
Haplotypes | Homozygotes | Celiac disease | Monocytes | Vitiligo | Addison disease | Systemic lupus erythematosus | Disease risk | Mucocutaneous lymph node syndrome | Autoimmune diseases | Interleukin-1beta | Cytokine | DNA sequencing | cytokine | NALP1 | GWAS | GENERALIZED VITILIGO | GENE | MULTIDISCIPLINARY SCIENCES | DISEASE | RISK | POLYMORPHISM | interleukin-1beta | ONSET | Apoptosis Regulatory Proteins - immunology | Interleukin-1beta - metabolism | Humans | Inflammasomes - immunology | Vitiligo - immunology | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2013, Volume 110, Issue 8, p. 2952
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to...
Proteins | Haplotypes | Polypeptides | Risk assessment | T cell receptors | Ribonucleic acid--RNA | Immune system
Proteins | Haplotypes | Polypeptides | Risk assessment | T cell receptors | Ribonucleic acid--RNA | Immune system
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2104 - 2115
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
TARGET | COACTIVATOR | ELEMENT | BIOINFORMATICS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | TRANSCRIPTION FACTOR | BINDING | DISCOVERY | FAMILY | CELL BIOLOGY | Promoter Regions, Genetic | Response Elements | Mice, Inbred C57BL | Gene Expression Regulation | Male | Receptors, Glucocorticoid - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lung - physiology | Mice, Knockout | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Dexamethasone - pharmacology | Chromatin Immunoprecipitation | Lung - drug effects | Receptors, Glucocorticoid - genetics | Female | Mice | Proline Oxidase - metabolism
TARGET | COACTIVATOR | ELEMENT | BIOINFORMATICS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | TRANSCRIPTION FACTOR | BINDING | DISCOVERY | FAMILY | CELL BIOLOGY | Promoter Regions, Genetic | Response Elements | Mice, Inbred C57BL | Gene Expression Regulation | Male | Receptors, Glucocorticoid - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lung - physiology | Mice, Knockout | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Dexamethasone - pharmacology | Chromatin Immunoprecipitation | Lung - drug effects | Receptors, Glucocorticoid - genetics | Female | Mice | Proline Oxidase - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2007, Volume 104, Issue 32, pp. 13182 - 13186
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture....
Cerebellum | Cell growth | Messenger RNA | Purkinje cells | Neurons | Stem cells | Cell cycle | Mice | Embryos | Cellular differentiation | Development | CNS | Embryo | Mouse | Transcription | development | GRANULE NEURON PRECURSORS | transcription | HOMEOBOX GENE LIM1 | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | embryo | RECEPTOR ROR-ALPHA | SPINAL-CORD | PROLIFERATION | DEVELOPING BRAIN | mouse | IN-VIVO | MICE | EXPRESSION | DNA-Binding Proteins - physiology | Nerve Tissue Proteins - physiology | Transcription Factors - physiology | LIM Domain Proteins | Mice, Inbred C57BL | Cerebellum - embryology | Pregnancy | Animals | Purkinje Cells - cytology | Female | LIM-Homeodomain Proteins | Cell Differentiation | Homeodomain Proteins - physiology | Biological Sciences
Cerebellum | Cell growth | Messenger RNA | Purkinje cells | Neurons | Stem cells | Cell cycle | Mice | Embryos | Cellular differentiation | Development | CNS | Embryo | Mouse | Transcription | development | GRANULE NEURON PRECURSORS | transcription | HOMEOBOX GENE LIM1 | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | embryo | RECEPTOR ROR-ALPHA | SPINAL-CORD | PROLIFERATION | DEVELOPING BRAIN | mouse | IN-VIVO | MICE | EXPRESSION | DNA-Binding Proteins - physiology | Nerve Tissue Proteins - physiology | Transcription Factors - physiology | LIM Domain Proteins | Mice, Inbred C57BL | Cerebellum - embryology | Pregnancy | Animals | Purkinje Cells - cytology | Female | LIM-Homeodomain Proteins | Cell Differentiation | Homeodomain Proteins - physiology | Biological Sciences
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 09/2011, Volume 45, Issue 3, pp. 642 - 649
Glucocorticoids (GCs), which activate GC receptor (GR) signaling and thus modulate gene expression, are widely used to treat asthma. GCs exert their...
Glucocorticoid | Klf15 | Asthma | TO-MODERATE ASTHMA | glucocorticoid | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | asthma | CELL BIOLOGY | MURINE MODEL | INHALED BUDESONIDE | RETINOBLASTOMA PROTEIN | RESPIRATORY SYSTEM | ALLERGIC-ASTHMA | MOUSE MODEL | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | TNF-ALPHA | Cell Line | Asthma - metabolism | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Male | Mice, Transgenic | Nuclear Proteins - metabolism | DNA-Binding Proteins - metabolism | Ovalbumin - metabolism | Transcription Factors - metabolism | Animals | Dexamethasone - pharmacology | Glucocorticoids - metabolism | Kruppel-Like Transcription Factors - metabolism | Bronchial Hyperreactivity - metabolism | Female | Mice
Glucocorticoid | Klf15 | Asthma | TO-MODERATE ASTHMA | glucocorticoid | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | asthma | CELL BIOLOGY | MURINE MODEL | INHALED BUDESONIDE | RETINOBLASTOMA PROTEIN | RESPIRATORY SYSTEM | ALLERGIC-ASTHMA | MOUSE MODEL | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | TNF-ALPHA | Cell Line | Asthma - metabolism | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Male | Mice, Transgenic | Nuclear Proteins - metabolism | DNA-Binding Proteins - metabolism | Ovalbumin - metabolism | Transcription Factors - metabolism | Animals | Dexamethasone - pharmacology | Glucocorticoids - metabolism | Kruppel-Like Transcription Factors - metabolism | Bronchial Hyperreactivity - metabolism | Female | Mice
Journal Article
Developmental Biology, ISSN 0012-1606, 01/2010, Volume 337, Issue 2, pp. 313 - 323
The mammalian pituitary gland originates from two separate germinal tissues during embryonic development. The anterior and intermediate lobes of the pituitary...
Cell proliferation | Lhx2 | Pituitary | Endocrine cell lineages | Transgenic | Rathke's pouch | LIM-homeobox | Transcription factor | Differentiation | Infundibulum | Organogenesis | Apoptosis | PROGENITOR CELLS | ANTERIOR-PITUITARY | DEVELOPMENTAL BIOLOGY | LINEAGE DETERMINATION | SPECIFICATION | BINDING PROTEIN | CEREBRAL-CORTEX | CELL DIFFERENTIATION | EXPRESSION | RATHKES POUCH | Diencephalon - metabolism | Cell Proliferation | Pituitary Gland - metabolism | Homeodomain Proteins - metabolism | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Gene Expression Regulation, Developmental | Genes, Homeobox | Diencephalon - pathology | Embryo, Mammalian - pathology | Pituitary Gland - pathology | RNA, Messenger - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Mutation - genetics | Pituitary Gland, Posterior - embryology | Homeodomain Proteins - genetics | Pituitary Gland - embryology | Transcription Factors - metabolism | Cell Lineage | Diencephalon - embryology | Animals | Models, Biological | LIM-Homeodomain Proteins | Pituitary Gland, Posterior - metabolism | Mice | Pituitary Gland, Posterior - pathology | Body Patterning - genetics | Animal genetics | Genetic research | Embryonic development | Developmental biology | Genes
Cell proliferation | Lhx2 | Pituitary | Endocrine cell lineages | Transgenic | Rathke's pouch | LIM-homeobox | Transcription factor | Differentiation | Infundibulum | Organogenesis | Apoptosis | PROGENITOR CELLS | ANTERIOR-PITUITARY | DEVELOPMENTAL BIOLOGY | LINEAGE DETERMINATION | SPECIFICATION | BINDING PROTEIN | CEREBRAL-CORTEX | CELL DIFFERENTIATION | EXPRESSION | RATHKES POUCH | Diencephalon - metabolism | Cell Proliferation | Pituitary Gland - metabolism | Homeodomain Proteins - metabolism | RNA, Messenger - metabolism | Embryo, Mammalian - metabolism | Gene Expression Regulation, Developmental | Genes, Homeobox | Diencephalon - pathology | Embryo, Mammalian - pathology | Pituitary Gland - pathology | RNA, Messenger - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Mutation - genetics | Pituitary Gland, Posterior - embryology | Homeodomain Proteins - genetics | Pituitary Gland - embryology | Transcription Factors - metabolism | Cell Lineage | Diencephalon - embryology | Animals | Models, Biological | LIM-Homeodomain Proteins | Pituitary Gland, Posterior - metabolism | Mice | Pituitary Gland, Posterior - pathology | Body Patterning - genetics | Animal genetics | Genetic research | Embryonic development | Developmental biology | Genes
Journal Article
Nature Genetics, ISSN 1061-4036, 07/2010, Volume 42, Issue 7, pp. 576 - 578
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed...
IDDM8 | DISEASES | AUTOIMMUNITY | GENETICS | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | ESSENTIAL TRANSCRIPTIONAL REGULATOR | T-CELLS | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Gene Frequency | Humans | Repressor Proteins - genetics | Family Health | Genotype | Forkhead Transcription Factors - genetics | Linkage Disequilibrium | Genetic Variation | Polymorphism, Single Nucleotide | Vitiligo - genetics | Chromosomes, Human, Pair 3 - genetics | Quantitative trait loci | Vitiligo | Genetic aspects | Research | Genetic variation | Risk factors | Studies | Regression analysis | Autoimmune diseases
IDDM8 | DISEASES | AUTOIMMUNITY | GENETICS | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | ESSENTIAL TRANSCRIPTIONAL REGULATOR | T-CELLS | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Gene Frequency | Humans | Repressor Proteins - genetics | Family Health | Genotype | Forkhead Transcription Factors - genetics | Linkage Disequilibrium | Genetic Variation | Polymorphism, Single Nucleotide | Vitiligo - genetics | Chromosomes, Human, Pair 3 - genetics | Quantitative trait loci | Vitiligo | Genetic aspects | Research | Genetic variation | Risk factors | Studies | Regression analysis | Autoimmune diseases
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2007, Volume 104, Issue 32, p. 13182
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture....
Proteins | Embryology | Neurosciences | Cellular biology | Rodents | Models | Cells
Proteins | Embryology | Neurosciences | Cellular biology | Rodents | Models | Cells
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2010, Volume 184, Issue 2, pp. 775 - 786
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome I...
PLASMACYTOID DENDRITIC CELLS | SYSTEMIC-LUPUS | CENTER B-CELLS | INDOLEAMINE 2,3-DIOXYGENASE | BONE-MARROW | T-CELL | IMMUNOLOGY | INFLAMMATORY CYTOKINES | PRONE MICE | CONGENIC MOUSE STRAINS | I INTERFERON
PLASMACYTOID DENDRITIC CELLS | SYSTEMIC-LUPUS | CENTER B-CELLS | INDOLEAMINE 2,3-DIOXYGENASE | BONE-MARROW | T-CELL | IMMUNOLOGY | INFLAMMATORY CYTOKINES | PRONE MICE | CONGENIC MOUSE STRAINS | I INTERFERON
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2013, Volume 110, Issue 8, pp. 2952 - 2956
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to...
Haplotypes | Interleukin-1 | Monocytes | Genetic aspects | Properties | Identification and classification | Membrane proteins
Haplotypes | Interleukin-1 | Monocytes | Genetic aspects | Properties | Identification and classification | Membrane proteins
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 09/2011, Volume 45, Issue 3, pp. 642 - 649
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2010, Volume 184, Issue 2, p. 775
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 08/2007, Volume 104, Issue 32, p. 13182
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture....
Cerebellum | Evaluation | Neural circuitry | Purkinje cells | Genetic aspects | Chemical properties | Genetic transcription | Cell differentiation
Cerebellum | Evaluation | Neural circuitry | Purkinje cells | Genetic aspects | Chemical properties | Genetic transcription | Cell differentiation
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 08/2007, Volume 104, Issue 32, pp. 13182 - 13186
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture....
Journal Article
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 11/2016, Volume 4, Issue S1
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 05/2010, Volume 362, Issue 18, pp. 1686 - 1697
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 03/2007, Volume 356, Issue 12, pp. 1216 - 1225
Journal Article
Journal of immunology (Baltimore, Md. : 1950), 01/2010, Volume 184, Issue 2, p. 775
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1...
Kidney Diseases | Genetic Predisposition to Disease - genetics | Autoantibodies - biosynthesis | Antigens, CD - genetics | Cytokines - physiology | Disease Progression | Plasma Cells - pathology | Receptors, IgG - genetics | Animals | Signaling Lymphocytic Activation Molecule Family Member 1 | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Cell Differentiation | Mice | Mice, Congenic | B-Lymphocytes - pathology | Lupus Erythematosus, Systemic - pathology | Apoptosis | Receptors, Cell Surface - genetics
Kidney Diseases | Genetic Predisposition to Disease - genetics | Autoantibodies - biosynthesis | Antigens, CD - genetics | Cytokines - physiology | Disease Progression | Plasma Cells - pathology | Receptors, IgG - genetics | Animals | Signaling Lymphocytic Activation Molecule Family Member 1 | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Cell Differentiation | Mice | Mice, Congenic | B-Lymphocytes - pathology | Lupus Erythematosus, Systemic - pathology | Apoptosis | Receptors, Cell Surface - genetics
Journal Article
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