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2014, ISBN 3319029304, Volume 247, 8
Reference
Reference
Journal Article
Cancer Science, ISSN 1347-9032, 09/2014, Volume 105, Issue 9, pp. 1142 - 1151
We previously established that COX ‐2 overexpression promotes breast cancer progression and metastasis. As long‐term use of COX ‐2 inhibitors ( COX ‐2i) can... 
macrophages | cyclooxygenase 2 | 00015986 | Cancer stem cells | 4 subtype | prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Macrophages | RQ-00015986 | Cyclooxygenase 2 | FACTOR VEGF | ANTAGONIST | prostaglandin E2 receptor EP4 subtype | HUMAN BREAST-CANCER | MURINE | PROSTANOID RECEPTORS | ONCOLOGY | GROWTH | TUMOR-ASSOCIATED MACROPHAGES | CYCLOOXYGENASE-2 EXPRESSION | UP-REGULATION | PROGRESSION | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Pyrazoles - therapeutic use | Cell Proliferation | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Molecular Targeted Therapy | Benzamides - therapeutic use | Lung Neoplasms - secondary | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Mammary Neoplasms, Experimental - pathology | Female | Mammary Neoplasms, Experimental - blood supply | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Lymphangiogenesis | Lung Neoplasms - blood supply | Mammary Neoplasms, Experimental - drug therapy | Pyrazoles - pharmacology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Lymphatic Metastasis | Neoplastic Stem Cells | Celecoxib | Tumor Burden | Sulfonamides - pharmacology | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Mice, Inbred C3H | Adenocarcinoma - blood supply | Macrophages - metabolism | Animals | Sulfonamides - therapeutic use | Neovascularization, Pathologic - drug therapy | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Mice | Apoptosis | Drug Screening Assays, Antitumor | Original
Journal Article
STEM CELLS, ISSN 1066-5099, 09/2016, Volume 34, Issue 9, pp. 2290 - 2305
Cancer stem‐like cells (SLC) resist conventional therapies, necessitating searches for SLC‐specific targets. We established that cyclo‐oxygenase(COX)‐2... 
EP4 | NOTCH/WNT | Breast cancer | Stem‐like cell | Cyclo‐oxygenase‐2 | Cyclo-oxygenase-2 | Stem-like cell | MIGRATION | TARGET | CYCLOOXYGENASE-2 | ANGIOGENESIS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PROSTANOID RECEPTORS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | LYMPHANGIOGENESIS | INHIBITORS | HEMATOLOGY | EXPRESSION | Signal Transduction | Neoplasm Invasiveness | Receptors, Notch - metabolism | Humans | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Breast Neoplasms - enzymology | Phenotype | Animals | Breast Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Female | Mice | Proto-Oncogene Proteins c-akt - metabolism | Neoplasm Micrometastasis - pathology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | COX-2 inhibitors | Prostaglandins | DNA microarrays | Endothelial growth factors | RNA | Analysis | Stem cells | Development and progression | Transplantation | Metastasis | Intermediate filament proteins | Genes | Rodents | Regulations | Severe combined immunodeficiency | Leukocyte migration | Mesenchyme | Oct-4 protein | Gene regulation | AKT protein | E-cadherin | Prostaglandin endoperoxide synthase | Metastases | Allografts | CD44 antigen | Animal tissues | Down-regulation | Localization | Vascular endothelial growth factor | Interleukin 2 receptors | Gene expression | Spheroids | 1-Phosphatidylinositol 3-kinase | Oxygenase | Overexpression | Inhibitors | Lungs | Cell lines | Breast | Biomarkers | Cyclooxygenase-2 | Colonization | Cell migration | Tumors | Cancer
Journal Article
Laboratory Investigation, ISSN 0023-6837, 08/2012, Volume 92, Issue 8, pp. 1115 - 1128
Journal Article
Cancer Research, ISSN 0008-5472, 05/2015, Volume 75, Issue 9 Supplement, pp. P1 - P1-07-29
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 327 - 15
We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression... 
STEM-CELLS | PROSTANOID RECEPTORS | TGF-BETA | METASTASIS | TUMOR PROGRESSION | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | EP4 | CYCLOOXYGENASE-2 EXPRESSION | MESENCHYMAL TRANSITION | Phosphorylation | Prognosis | Humans | Lung Neoplasms - pathology | NF-kappa B - metabolism | Smad3 Protein - metabolism | Cell Movement - genetics | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Lung Neoplasms - secondary | MCF-7 Cells | Neoplastic Stem Cells - metabolism | RNA Interference | Cyclooxygenase 2 - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - genetics | Cell Proliferation - genetics | Cyclooxygenase 2 Inhibitors - pharmacology | Dinoprostone - metabolism | Phenotype | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Breast Neoplasms - mortality | Mice | MicroRNAs - genetics | Transforming Growth Factor beta - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cell proliferation | Spleen | NF-κB protein | Severe combined immunodeficiency | Wnt protein | Liver | MiRNA | Extracellular signal-regulated kinase | AKT protein | Smad3 protein | Breast cancer | Tumor cell lines | Spheroids | 1-Phosphatidylinositol 3-kinase | Prostaglandin endoperoxide synthase | Overexpression | Cell lines | Cyclooxygenase-2 | Cell migration | Tumors
Journal Article
BMC Cancer, ISSN 1471-2407, 06/2019, Volume 19, Issue 1, pp. 561 - 16
Journal Article
Cancers, ISSN 2072-6694, 07/2019, Volume 11, Issue 7, p. 938
MicroRNAs (miRNAs) are small endogenously produced RNAs, which regulate growth and development, and oncogenic miRNA regulate tumor growth and metastasis.... 
angiogenesis | lymphangiogenesis | EP4 | breast cancer | miR655 | miR526b | PI3K/Akt
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 08/2019, Volume 20, Issue 16, p. 4039
In eukaryotes, overproduction of reactive oxygen species (ROS) causes oxidative stress, which contributes to chronic inflammation and cancer. MicroRNAs... 
CELLS | SUPEROXIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | breast cancer | TCF21 | superoxide (SO) | reactive oxygen species (ROS) | Thioredoxin Reductase 1 (TXNRD1) | miR655 | CHEMISTRY, MULTIDISCIPLINARY | miR526b | INACTIVATION | INFLAMMATION | THIOREDOXIN | MicroRNA (miRNA) | TUMOR-SUPPRESSOR | INHIBITOR | EXPRESSION | oxidative stress | PROGRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4464 - 4464
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 04/2018, Volume 19, Issue 4, p. 1019
Journal Article