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1. Full Text A Susceptibility Locus for Myopia in the Normal Population Is Linked to the PAX6 Gene Region on Chromosome 11: A Genomewide Scan of Dizygotic Twins
by Hammond, Christopher J and Andrew, Toby and Tat Mak, Ying and Spector, Tim D
The American Journal of Human Genetics, ISSN 0002-9297, 2004, Volume 75, Issue 2, pp. 294 - 304
Myopia is a common, complex trait with considerable economic and social impact and, in highly affected individuals, ocular morbidity. We performed a classic... 
REFRACTIVE ERROR | EYE | QUANTITATIVE TRAITS | DISEQUILIBRIUM | MAPS | GROWTH | ENVIRONMENT | GENETICS & HEREDITY | LINKAGE ANALYSIS | BLINDNESS | Genetic Predisposition to Disease | Paired Box Transcription Factors | Humans | Middle Aged | Repressor Proteins | Genotype | PAX6 Transcription Factor | Homeodomain Proteins - genetics | Lod Score | Myopia - genetics | Aged | Chromosomes, Human, Pair 11 | Polymorphism, Single Nucleotide | Eye Proteins | Genetic Linkage | Genetic research | Genetic aspects | Research | Twins | Myopia
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2. Full Text Heterozygous familial hypercholesterolemia in Hong Kong Chinese. Study of 252 cases
by Hu, Miao and Lan, Wei and Lam, Christopher W.K and Mak, Ying Tat and Pang, Chi Pui and Tomlinson, Brian
International Journal of Cardiology, ISSN 0167-5273, 2012, Volume 167, Issue 3, pp. 762 - 767
Abstract Background Earlier studies reported that Chinese subjects with heterozygous familial hypercholesterolemia (heFH) living in Mainland China or in... 
Cardiovascular | Chinese | Coronary heart disease | Familial hypercholesterolemia | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | CHINA | GUIDELINES | CLINICAL-FEATURES | RISK-FACTOR | CARDIOVASCULAR-DISEASE | LIPOPROTEIN RECEPTOR GENE | MUTATIONS | CORONARY-HEART-DISEASE | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Child, Preschool | Male | Biomarkers - blood | Hyperlipoproteinemia Type II - ethnology | Asian Continental Ancestry Group - ethnology | Young Adult | Hyperlipoproteinemia Type II - epidemiology | Hong Kong - epidemiology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Hong Kong - ethnology | Child | Genetic Carrier Screening | Hyperlipoproteinemia Type II - genetics | Genetic aspects | Hypercholesterolemia | Low density lipoproteins | Cholesterol
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3. Full Text Genotype‐phenotype studies of six novel LPL mutations in Chinese patients with hypertriglyceridemia
by Chan, Lisa Y.S and Lam, Ching‐Wan and Mak, Ying‐Tat and Tomlinson, Brian and Tsang, Man‐Woo and Baum, Larry and Masarei, John R.L and Pang, Chi‐Pui
Human Mutation, ISSN 1059-7794, 09/2002, Volume 20, Issue 3, pp. 232 - 233
We screened 160 unrelated Chinese hypertriglyceridemic subjects for sequence alterations in the promoter and the 10 exons of the lipoprotein lipase (LPL) gene.... 
hypertriglyceridemia | LPL | Chinese | lipoprotein lipase | GENETICS & HEREDITY | Hypertriglyceridemia - genetics | Lipoprotein Lipase - genetics | Humans | Genotype | Male | Hypertriglyceridemia - blood | DNA - genetics | DNA - chemistry | Phenotype | DNA Mutational Analysis | China | Lipids - blood | Female | Catalysis | Mutation | Lipoprotein Lipase - metabolism
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4. Full Text Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8
by Lu, Gang and Wu, Yan and Mak, Ying Tat and Wai, Sen Mun and Feng, Zhong Tang and Rudd, John A and Yew, David Tai Wai
Brain Research, ISSN 0006-8993, 2006, Volume 1090, Issue 1, pp. 23 - 28
In the present studies, we investigated the molecular mechanism of one of the active ingredients of , EGb761, to affect the levels of several apoptotic markers... 
Brain | bax/bcl-2 ratio | Ginkgo | Ischemia/reperfusion | SAMP8 | ischemia/reperfusion | APOPTOSIS | ACTIVATION | DISEASE | EXTRACT EGB761 | MECHANISMS | brain | NEUROSCIENCES | CELL-DEATH | Brain Chemistry - drug effects | Neuroprotective Agents - therapeutic use | Caspase 9 | Apoptosis - drug effects | Plant Extracts - pharmacology | Aging - drug effects | Brain Ischemia - metabolism | Apoptosis - genetics | Male | Mice, Neurologic Mutants | Brain - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Neuroprotective Agents - pharmacology | Aging - genetics | Caspases - drug effects | Genetic Predisposition to Disease - prevention & control | Brain Chemistry - genetics | Disease Models, Animal | Biomarkers - metabolism | Genetic Predisposition to Disease - genetics | bcl-2-Associated X Protein - metabolism | Treatment Outcome | Brain Ischemia - physiopathology | bcl-2-Associated X Protein - drug effects | Aging - pathology | Brain - drug effects | Ginkgo biloba | Animals | Brain Ischemia - drug therapy | Proto-Oncogene Proteins c-bcl-2 - drug effects | Mice | Plant Extracts - therapeutic use | Legislators | Lymphomas | Ischemia | Analysis | Leukemia
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5. Full Text Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke
by Zhang, Lihong and Lam, Wai P and Lü, Lanhai and Wang, Chunmei and Wong, Yeuk W and Lam, Lok H and Tang, Hong C and Wai, Maria S.M and Wang, Mingwei and Kwong, Wing H and Ngai, Sai M and Mak, Ying T and Yew, David T.W
Chinese Medicine, ISSN 1749-8546, 10/2010, Volume 5, Issue 1, pp. 35 - 35
Stroke caused by brain ischemia is the third leading cause of adult disability. Active prevention and early treatment of stroke targeting the causes and risk... 
Free radicals | Mortality | Science | Experiments | Manuscripts | Proteins | Studies | Mitochondria | Ischemia | Rodents | Fatalities | Standard deviation | Laboratory animals | Apoptosis | Veins & arteries
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6. Full Text F049 Familial hypercholesterolaemia in Hong Kong
by Tomlinson, Brian and Lan, Wei and Mak, Ying-Tat and Mak, Tony W.-L and Chan, Yuen-Shan and Critchley, Julian A.J.H and Maserei, John R.L and Pang, Chi-Pui
Atherosclerosis, ISSN 0021-9150, 1998, Volume 136, pp. S59 - S59
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7. Full Text Mutations in the Low-Density Lipoprotein Receptor Gene in Chinese Familial Hypercholesterolemia Patients
by Mak, Ying-Tat and Pang, Chi-Pui and Tomlinson, Brian and Zhang, Jun and Chan, Yuen-Shan and Mak, Tony W.L and Masarei, John R.L
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/1998, Volume 18, Issue 10, pp. 1600 - 1605
It has been reported that in China, patients with heterozygous familial hypercholesterolemia (FH) may go unrecognized because they do not have xanthomata or... 
Chinese | LDL receptor gene | Familial hypercholesterolemia | POPULATION | RECURRENT | familial hypercholesterolemia | SEQUENCE | PERIPHERAL VASCULAR DISEASE | POLYMORPHISM METHOD | DNA POLYMORPHISMS | IDENTIFICATION | HEMATOLOGY | BINDING
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8. Full Text F082 Investigation of mutations and polymorphisms in the lipoprotein lipase gene
by Chan, Yuen-Shan and Tomlinson, Brian and Mak, Ying-Tat and Mak, Tony W.-L and Pang, Chi-Pui
Atherosclerosis, ISSN 0021-9150, 1998, Volume 136, pp. S67 - S67
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9. Full Text Mutations in the low-density lipoprotein receptor gene in Chinese familial hypercholesterolemia patients
by Mak, Y T and Pang, C P and Tomlinson, B and Zhang, J and Chan, Y S and Mak, T W and Masarei, J R
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 10/1998, Volume 18, Issue 10, p. 1600
It has been reported that in China, patients with heterozygous familial hypercholesterolemia (FH) may go unrecognized because they do not have xanthomata or... 
Receptors, LDL - genetics | Humans | Middle Aged | Male | Asian Continental Ancestry Group | Pedigree | Adolescent | Aged, 80 and over | Adult | Female | Aged | Mutation | Child | Hyperlipoproteinemia Type II - genetics
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10. Full Text Molecular genetic analysis of a Chinese patient with Fabry disease
by Lam, Ching-Wan and Mak, Ying-Tat and Lo, Yuk-Ming Dennis and Tong, Sui-Fan and To, Ka-Fai and Lai, Fernand Mac-Moune
Chinese Medical Journal, ISSN 0366-6999, 02/2000, Volume 113, Issue 2, pp. 186 - 188
GALACTOSIDASE-A-GENE | MEDICINE, GENERAL & INTERNAL | POINT MUTATION | DNA - genetics | alpha-Galactosidase - genetics | DNA - chemistry | DNA Mutational Analysis | Fabry Disease - genetics | Base Sequence | China | Humans | Adolescent | Male | Fabry Disease - enzymology | Mutation, Missense
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11. Full Text Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese
by Baum, Larry and Chen, Lan and Ng, Ho-Keung and Chan, Yuen Shan and Mak, Ying Tat and Woo, Jean and Chiu, Helen F.K and Pang, Chi Pui
Neuroscience Letters, ISSN 0304-3940, 1998, Volume 247, Issue 1, pp. 33 - 36
Since apolipoprotein E4 (apoE4) is the major genetic risk for late onset Alzheimer's disease (AD), proteins that interact with apoE might be involved in AD... 
apoE | Lipoprotein receptor related protein | Low density lipoprotein receptor related protein | Apolipoprotein E | Alzheimer's disease | low density lipoprotein receptor related protein | DIAGNOSIS | lipoprotein receptor related protein | LIGANDS | apolipoprotein E | LRP | EXPRESSION | NEUROSCIENCES | APOLIPOPROTEIN-E | Receptors, LDL - genetics | Hong Kong | Humans | Risk Factors | Asian Continental Ancestry Group - genetics | Exons - genetics | Apolipoproteins E - metabolism | Case-Control Studies | Polymorphism, Single-Stranded Conformational | Apolipoproteins E - genetics | Polymerase Chain Reaction | Aged, 80 and over | Low Density Lipoprotein Receptor-Related Protein-1 | Polymorphism, Genetic - genetics | Aged | Alzheimer Disease - genetics | Receptors, Immunologic - genetics
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12. Full Text Genotype-phenotype studies of six novelLPL mutations in Chinese patients with hypertriglyceridemia
by Chan, Lisa Y.S and Lam, Ching-Wan and Mak, Ying-Tat and Tomlinson, Brian and Tsang, Man-Woo and Baum, Larry and Masarei, John R.L and Pang, Chi-Pui
Human Mutation, ISSN 1059-7794, 09/2002, Volume 20, Issue 3, pp. 232 - 233
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13. Full Text Different Aging Patterns of the Neuronal and Inducible Isoforms of Nitric Oxide Synthase in Mouse Hippocampus by Immunohistochemistry
by Wong, Ho Wai and Mak, Ying Tat and Yu, Mang Chung and Yew, David Tai Wai
Neuroembryology and Aging, ISSN 1661-3406, 11/2005, Volume 3, Issue 2, pp. 92 - 98
Background: Nitric oxide synthase (NOS) produces nitric oxide (NO) from arginine, and both NOS and NO play important roles in the normal aging of the... 
Original Paper | Nitric oxide synthase isoform | Long-term potentiation | Nitric oxide | Apoptosis
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14. Prevalence of pyruvate kinase deficiency among the Chinese: Determination by the quantitative assay
by Feng, Chi-Shun and Tsang, SS and Mak, Ying-Tat
American Journal of Hematology, ISSN 0361-8609, 01/1993, Volume 43, Issue 4, pp. 271 - 273
The prevalence of pyruvate kinase (PK) deficiency among the Chinese population has not been established. Fung et al. and Wu et al. indicate 3.4% and 2.1% PK... 
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15. Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese
by Baum, L and Chen, Lan and Ng, Ho-Keung and Chan, Yuen Shan and Mak, Ying Tat and Woo, Jean and Chiu, HFK and Pang, Chi Pui
Neuroscience Letters, ISSN 0304-3940, 05/1998, Volume 247, Issue 1, pp. 33 - 36
Since apolipoprotein E4 (apoE4) is the major genetic risk for late onset Alzheimer's disease (AD), proteins that interact with apoE might be involved in AD... 
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16. No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese
by Chen, Lan and Baum, L and Ng, Ho Keung and Chan, Yuen Shan and Mak, Ying Tat and Woo, J and Chiu, H and Pang, Chi Pui
Neuroscience Letters, ISSN 0304-3940, 01/1998, Volume 241, Issue 1, pp. 33 - 36
The epsilon 4 allele of apolipoprotein E (ApoE) is a risk factor in late-onset Alzheimer's disease (AD). As a receptor for ApoE, very-low-density lipoprotein... 
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17. Full Text No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese
by Chen, Lan and Baum, Larry and Ng, Ho Keung and Chan, Yuen Shan and Mak, Ying Tat and Woo, Jean and Chiu, Helen and Pang, Chi Pui
Neuroscience Letters, ISSN 0304-3940, 1998, Volume 241, Issue 1, pp. 33 - 36
The ε4 allele of apolipoprotein E (ApoE) is a risk factor in late- onset Alzheimer's disease (AD). As a receptor for ApoE, very-low-density lipoprotein... 
Trinucleotide repeat | Very-low-density lipoprotein receptor (VLDLR) | Alzheimer's disease | Apolipoprotein E receptor | Polymorphism | ALLELE | very-low-density lipoprotein receptor (VLDLR) | apolipoprotein E receptor | polymorphism | trinucleotide repeat | NEUROSCIENCES | GENE POLYMORPHISM | Japan - epidemiology | Receptors, LDL - genetics | European Continental Ancestry Group - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Lipoproteins, VLDL - genetics | Hong Kong - epidemiology | Lipoproteins, VLDL - metabolism | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Aged | Alzheimer Disease - genetics | Japan - ethnology
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18. Full Text Gas chromatographic-mass fragmentographic determination of serum 1α,25 dihydroxyvitamin D3
by Poon, Priscilla M.K and Mak, Ying-Tat and Pang, Chi-Pui
Clinical Biochemistry, ISSN 0009-9120, 12/1993, Volume 26, Issue 6, pp. 461 - 469
We extracted 1α,25-dihydroxyvitamin D [1α,25(OH) D ] from 10 mL serum using Sep-Pak C18 and Sep-Pak Silica mini-columns and normal-phase high performance... 
gas chromatography-mass fragmentography | Serum 1α | 25-dihydroxyvitamin D3 | HUMAN-PLASMA | VITAMIN-D | GAS CHROMATOGRAPHY MASS FRAGMENTOGRAPHY | ASSAY | SERUM 1-ALPHA,25-DIHYDROXYVITAMIN-D3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1-ALPHA,25-DIHYDROXYVITAMIN-D | 1,25-DIHYDROXYCHOLECALCIFEROL | CULTURE | RADIOIMMUNOASSAY | EXTRA-RENAL PRODUCTION | 1,25-DIHYDROXYVITAMIN-D3 | MEDICAL LABORATORY TECHNOLOGY | Chromatography, Gas - methods | Chromatography, High Pressure Liquid | Calcitriol - blood | Humans | Sensitivity and Specificity
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19. Full Text Prevalence of pyruvate kinase deficiency among the chinese: Determination by the quantitative assay
by Feng, Chi‐Shun and Tsang, Sophia S and Mak, Ying‐Tat
American Journal of Hematology, ISSN 0361-8609, 08/1993, Volume 43, Issue 4, pp. 271 - 273
The prevalence of pyruvate kinase (PK) deficiency among the Chinese population has not been established. Fung et al. (Arch Dis Child 44:373–376, 1969) and Wu... 
quantitative assay | prevalence in Chinese | pyruvate kinase deficiency | PREVALENCE IN CHINESE | HEMATOLOGY | PYRUVATE KINASE DEFICIENCY | QUANTITATIVE ASSAY | China - ethnology | Pyruvate Kinase - analysis | Humans | Middle Aged | Male | Pyruvate Kinase - deficiency | Reference Standards | Hong Kong - epidemiology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Erythrocytes - enzymology | Child
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20. Full Text Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
by Wilson, Duncan and Ambler, Gareth and Lee, Keon-Joo and Lim, Jae-Sung and Shiozawa, Masayuki and Koga, Masatoshi and Li, Richard and Li, Siu Hung and Li, Linxin and Lovelock, Caroline and Chabriat, Hugues and Hennerici, Michael and Wong, Lawrence and Wong, Adrian and Wong, Edmund Ka Ming and Wong, Yuen Kwun and Wong, Kwok Kui and Mak, Henry Ka Fung and Prats-Sánchez, Luis and Martínez-Domeño, Alejandro and Inamura, Shigeru and Yoshifuji, Kazuhisa and Arsava, Ethem Murat and Horstmann, Solveig and Purrucker, Jan and Lam, Bonnie Yin Ka and Kim, Beom Joon and Kim, Young Dae and Song, Tae-Jin and Schrooten, Maarten and Lemmens, Robin and Eppinger, Sebastian and Gattringer, Thomas and Uysal, Ender and Tanriverdi, Zeynep and Bornstein, Natan M and Assayag, Einor Ben and Hallevi, Hen and Tanaka, Jun and Hara, Hideo and Coutts, Shelagh B and Hert, Lisa and Polymeris, Alexandros and Seiffge, David J and Lyrer, Philippe and Algra, Ale and Kappelle, Jaap and Al-Shahi Salman, Rustam and Jäger, Hans R and Lip, Gregory Y H and Mattle, Heinrich P and Panos, Leonidas D and Mas, Jean-Louis and Legrand, Laurence and Karayiannis, Christopher and Phan, Thanh and Gunkel, Sarah and Christ, Nicolas and Abrigo, Jill and Leung, Thomas and Leung, Kam Tat and Chu, Winnie and Chappell, Francesca and Makin, Stephen and Hayden, Derek and Williams, David J and Kooi, M Eline and van Dam-Nolen, Dianne H K and Barbato, Carmen and Browning, Simone and Wiegertjes, Kim and Tuladhar, Anil M and Maaijwee, Noortje and Guevarra, Christine and Yatawara, Chathuri and Mendyk, Anne-Marie and Delmaire, Christine and Köhler, Sebastian and van Oostenbrugge, Robert and Zhou, Ying and Xu, Chao and Hilal, Saima and Gyanwali, Bibek and Chen, Christopher and Lou, Min and Staals, Julie and Bordet, Régis and Kandiah, Nagaendran and de Leeuw, Frank-Erik and Simister, Robert and van der Lugt, Aad and Kelly, Peter J and Kelly, Deborah and Wardlaw, Joanna M and Soo, Yannie and Fluri, Felix and Srikanth, Velandai and Calvet, David and Jung, Simon and Kwa, Vincent I H and ... and Microbleeds Int Collaborative Net and Microbleeds International Collaborative Network
The Lancet Neurology, ISSN 1474-4422, 07/2019, Volume 18, Issue 7, pp. 653 - 665
Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent... 
SMALL VESSEL DISEASE | DEMENTIA | WARFARIN | AMYLOID ANGIOPATHY | T2-ASTERISK-WEIGHTED MR-IMAGES | INTRACEREBRAL HEMORRHAGE | RECURRENT STROKE | CHINESE PATIENTS | ASSOCIATION | CLINICAL NEUROLOGY | ATRIAL-FIBRILLATION | Drugs | Studies | Neuroimaging | Anticoagulants | Stroke | Transient ischemic attack | Magnetic resonance imaging | Collaboration | Bias | Patients | Hemorrhage | Magnetic susceptibility
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