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1. Full Text Innate immunity in diabetes and diabetic nephropathy
by Wada, Jun and Makino, Hirofumi
Nature Reviews Nephrology, ISSN 1759-5061, 01/2016, Volume 12, Issue 1, pp. 13 - 26
The innate immune system includes several classes of pattern recognition receptors (PRRs), including membrane-bound Toll-like receptors (TLRs) and... 
HUMAN ADIPOSE-TISSUE | METABOLIC SYNDROME | OBESITY-INDUCED INFLAMMATION | NOD-LIKE RECEPTORS | INSULIN-RESISTANCE | TOLL-LIKE RECEPTOR | UROLOGY & NEPHROLOGY | THIOREDOXIN-INTERACTING PROTEIN | NLRP3 INFLAMMASOME | DIET-INDUCED OBESITY | NF-KAPPA-B | Immunity, Innate | Diabetes Mellitus - immunology | Obesity - immunology | Diabetic Nephropathies - immunology | Humans | Complications and side effects | Care and treatment | Analysis | Diabetic nephropathies | Inflammation | Research | Diabetes | Immunity | Risk factors
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2. Full Text Inflammation and the pathogenesis of diabetic nephropathy
by Wada, Jun and Makino, Hirofumi
Clinical Science, ISSN 0143-5221, 02/2013, Volume 124, Issue 3, pp. 139 - 152
The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The... 
Chemokine | Nuclear receptor | Cytokine | Diabetic nephropathy | Adhesion molecule | Adipokine | Transcription factor | cytokine | C-REACTIVE PROTEIN | MEDICINE, RESEARCH & EXPERIMENTAL | transcription factor | chemokine | ACTIVATED RECEPTOR-GAMMA | adipokine | adhesion molecule | JAK/STAT SIGNALING PATHWAY | VITAMIN-D ANALOG | GLOMERULAR MESANGIAL CELLS | TUMOR-NECROSIS-FACTOR | CHEMOATTRACTANT PROTEIN-1 EXPRESSION | HIGH GLUCOSE | nuclear receptor | NF-KAPPA-B | ADHESION MOLECULE-1 ICAM-1 | diabetic nephropathy | Kidney Failure, Chronic - physiopathology | Diabetic Nephropathies - pathology | Cytokines - metabolism | Signal Transduction | Diabetic Nephropathies - etiology | Humans | Disease Progression | Inflammation - complications | Inflammation - metabolism | Diabetic Nephropathies - physiopathology | Kidney Failure, Chronic - pathology | Models, Biological | Inflammation Mediators - metabolism | Inflammation - physiopathology
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3. Full Text Proposal for diagnostic criteria for IgG4-related kidney disease
by Kawano, Mitsuhiro and Saeki, Takako and Nakashima, Hitoshi and Nishi, Shinichi and Yamaguchi, Yutaka and Hisano, Satoshi and Yamanaka, Nobuaki and Inoue, Dai and Yamamoto, Motohisa and Takahashi, Hiroki and Nomura, Hideki and Taguchi, Takashi and Umehara, Hisanori and Makino, Hirofumi and Saito, Takao
Clinical and Experimental Nephrology, ISSN 1342-1751, 10/2011, Volume 15, Issue 5, pp. 615 - 626
IgG4-related disease has attracted wide attention recently. It is characterized by a high level of serum IgG4 and dense infiltration of IgG4-positive plasma... 
Nephrology | Medicine & Public Health | Diagnostic criteria | Tubulointerstitial nephritis | IgG4 | Urology | IgG4-related kidney disease | INFLAMMATORY PSEUDOTUMOR | AUTOIMMUNE PANCREATITIS | EXTRAPANCREATIC LESIONS | CONSENSUS | UROLOGY & NEPHROLOGY | SERUM | IGG4 CONCENTRATIONS | NEPHROPATHY | Immunohistochemistry | Immunoglobulin G - blood | Kidney - pathology | Kidney Diseases - pathology | Nephritis, Interstitial - diagnosis | Humans | Kidney Diseases - diagnosis | Middle Aged | Pancreas - pathology | Male | Tomography, X-Ray Computed | Autoimmune Diseases - diagnosis | Algorithms | Nephritis, Interstitial - pathology | Aged, 80 and over | Adult | Female | Pancreatitis - pathology | Aged | Autoimmune Diseases - pathology | Urine | Medical colleges | CT imaging | Lymphocytes | Analysis | Immunoglobulin G | Pancreatitis | Immunoglobulin E | Kidney diseases | Universities and colleges | Diagnosis
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4. Full Text High Porosity Dpf Design for Integrated Scr Functions
by Kawakami, Akifumi, author and Mizutani, Takashi, author and Shibagaki, Yukinari, author and Yuuki, Kazuya, author and Sakamoto, Hirofumi, author and Vogt, Claus, author and Kuki, Tatsuyuki, author and Heuss, Wolfgang, author and Kattouah, Philipp, author and Makino, Mikio, author
SAE technical paper series, Volume 2012-01-0843.
Diesel engines are more fuel efficient due to their high thermal efficiency, compared to gasoline engines and therefore, have a higher potential to reduce CO2... 
Particulate filters | Diesel exhaust emissions control | Selective catalytic reduction
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5. Full Text Potential of a Low Pressure Drop Filter Concept for Direct Injection Gasoline Engines to Reduce Particulate Number Emission
by Shimoda, Takehide, author and Ito, Yoshitaka, author and Saito, Chika, author and Nakatani, Takahiko, author and Shibagaki, Yukinari, author and Yuuki, Kazuya, author and Sakamoto, Hirofumi, author and Vogt, Claus, author and Matsumoto, Tasuku, author and Furuta, Yasuyuki, author and Heuss, Wolfgang, author and Kattouah, Philipp, author and Makino, Mikio, author
SAE technical paper series, Volume 2012-01-1241.
The automotive industry is currently evaluating the gasoline particulate filter (GPF) as a potential technology to reduce particulate emissions from gasoline... 
Particulate matter (PM) | Particulate filters | Diesel particulate filters
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6. Full Text Advanced Ceramic Wall Flow Filter for Reduction of Particulate Number Emission of Direct Injection Gasoline Engines
by Ito, Yoshitaka, author and Shimoda, Takehide, author and Aoki, Takashi, author and Shibagaki, Yukinari, author and Yuuki, Kazuya, author and Sakamoto, Hirofumi, author and Vogt, Claus, author and Matsumoto, Tasuku, author and Heuss, Wolfgang, author and Kattouah, Philipp, author and Makino, Mikio, author and Kato, Kyohei, author
SAE technical paper series, Volume 2013-01-0836.
Low fuel consumption and improved power output are the main market drivers in the automotive industry. For these challenges, Gasoline Direct Injection (GDI)... 
Particulate matter (PM) | Downsizing | Particulate filters
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7. Full Text Advanced Ceramic Wall Flow Filter for Reduction of Particulate Number Emission of Direct Injection Gasoline Engines
by Ito, Yoshitaka, author and Shimoda, Takehide, author and Aoki, Takashi, author and Shibagaki, Yukinari, author and Yuuki, Kazuya, author and Sakamoto, Hirofumi, author and Vogt, Claus, author and Matsumoto, Tasuku, author and Heuss, Wolfgang, author and Kattouah, Philipp, author and Makino, Mikio, author and Kato, Kyohei, author
SAE technical paper series, Volume 2013-01-0836.
Low fuel consumption and improved power output are the main market drivers in the automotive industry. For these challenges, Gasoline Direct Injection (GDI)... 
Particulate matter (PM) | Downsizing | Particulate filters
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8. Full Text Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
by Heerspink, Hiddo J L and Parving, Hans-Henrik and Andress, Dennis L and Bakris, George and Correa-Rotter, Ricardo and Hou, Fan-Fan and Hou, Fanfan and Kitzman, Dalane W and Kohan, Donald and Makino, Shinya and Makino, Hirofumi and McMurray, John J V and Melnick, Joel Z and Miller, Michael G and Miller, Alan and Miller, Steven and Pergola, Pablo E and Pergola, Pablo and Perkovic, Vlado and Tobe, Sheldon and Yi, Joo Hark and Yi, Tingting and Wigderson, Melissa and de Zeeuw, Dick and Elbert, Alicia and Vallejos, Augusto and Alvarisqueta, Andres and Maffei, Laura and Juncos, Luis and de Arteaga, Javier and Greloni, Gustavo and Farias, Eduardo and Zucchini, Alfredo and Vogel, Daniel and Cusumano, Ana and Santos, Juan and Fraenkel, Margaret and Gallagher, Martin and Davis, Tim and Acharya, Shamasunder and Cooke, Duncan and Suranyi, Michael and Roger, Simon and Toussaint, Nigel and Pollock, Carol and Chan, Doris and Stranks, Stephen and MacIsaac, Richard and Endre, Zoltan and Schmidt, Alice and Schmidt, Rebecca and Prager, Rudolf and Mayer, Gert and Warling, Xavier and Jadoul, Michel and Hougardy, Jean and Vercammen, Chris and Van Vlem, Bruno and Gillard, Pieter and Costa e Forti, Adriana and Borges, Joao Lindolfo and Santos Canani, Luis and Eliaschewitz, Freddy and Leite, Silmara and Fraige Filho, Fadlo and Paschoalin, Raphael and Moura Neto, Jose Andrade and Deboni, Luciane and de Lourdes Noronha, Irene and Cercato, Cintia and Prompt, Carlos Alberto and Zanella, Maria and Rassi, Nelson and D'Avila, Domingos and Milagres, Rosangela and Felicio, Joao and Pecoits Filho, Roberto and Riella, Miguel Carlos and Salles, Joao and Keitel, Elizete and Draibe, Sergio and Amodeo, Celso and Youmbissi, Joseph and Roy, Louise and Cournoyer, Serge and Jolly, Shivinder and Pichette, Vincent and Nesrallah, Gihad and Bajaj, Harpreet Singh and Khandwala, Hasnain and Aronson, Ronnie and Goluch, Richard and Tam, Paul and Rabbat, Christian and Bailey, Gordon and Chow, Stephen and Castillo, Alvaro and Danin Vargas, Alfredo and Gonzalez, Fernando and Munoz, Rodrigo and ... and SONAR Committees and Investigators and SONAR Comm Investigators
The Lancet, ISSN 0140-6736, 05/2019, Volume 393, Issue 10184, pp. 1937 - 1947
Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without... 
Humans | Middle Aged | Male | Diabetic Nephropathies - blood | Serum Albumin, Human - urine | Young Adult | Aged, 80 and over | Adult | Female | Diabetic Nephropathies - prevention & control | Endothelin A Receptor Antagonists - therapeutic use | Diabetic Nephropathies - urine | Glomerular Filtration Rate | Double-Blind Method | Endothelin A Receptor Antagonists - administration & dosage | Administration, Oral | Treatment Outcome | Creatinine - urine | Renal Insufficiency, Chronic - blood | Renal Insufficiency, Chronic - prevention & control | Atrasentan - therapeutic use | Creatinine - blood | Aged | Atrasentan - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Renal Insufficiency, Chronic - urine | MEDICINE, GENERAL & INTERNAL | INHIBITION | ENDOTHELIN | ALBUMINURIA | NEPHROPATHY | Short term | Enrichment | End-stage renal disease | Renal function | Endothelin | Heart attacks | Peptides | Clinical trials | Cardiovascular disease | Transplantation | Retention | Randomization | Renin | Motivation | Hemoglobin | Blood pressure | Safety | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Heart failure | Urine | Creatinine | Enzymes | Kidneys | Epidermal growth factor receptors | Anemia | Diabetes mellitus | Health risks | Patients | Disease control | Glomerular filtration rate | Sodium | Angiotensin | Renal failure | Dialysis | Kidney diseases | Diabetes | Surface area | Potassium | Kidney transplantation | Long-term effects
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9. Full Text Single Adult Kidney Stem/Progenitor Cells Reconstitute Three‐Dimensional Nephron Structures In Vitro
by Kitamura, Shinji and Sakurai, Hiroyuki and Makino, Hirofumi
STEM CELLS, ISSN 1066-5099, 03/2015, Volume 33, Issue 3, pp. 774 - 784
The kidneys are formed during development from two distinct primordial tissues, the metanephric mesenchyme and the ureteric bud. The metanephric mesenchyme... 
Adult kidney tissue stem cells | Three‐dimensional nephron structures in vitro | Organogenesis | Three-dimensional nephron structures in vitro | RAT-KIDNEY | REGENERATION | MAMMALIAN KIDNEY | IDENTIFICATION | CULTURE | PROGENITOR-LIKE CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | MORPHOGENESIS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | WATER CHANNEL | GROWTH-FACTOR | HEMATOLOGY | Nephrons - cytology | Adult Stem Cells - cytology | Animals | Signal Transduction | Rats | Kidney - cytology | Stem Cells - cytology | In Vitro Techniques | Cell Differentiation - physiology | Rats, Sprague-Dawley | Embryonic development | Aquaporins | Analysis | Stem cells | Rodents | Kidneys
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10. Full Text Prevalence of chronic kidney disease in the Japanese general population
by Imai, Enyu and Horio, Masaru and Watanabe, Tsuyoshi and Iseki, Kunitoshi and Yamagata, Kunihiro and Hara, Shigeko and Ura, Nobuyuki and Kiyohara, Yutaka and Moriyama, Toshiki and Ando, Yasuhiro and Fujimoto, Shoichi and Konta, Tsuneo and Yokoyama, Hitoshi and Makino, Hirofumi and Hishida, Akira and Matsuo, Seiichi
Clinical and Experimental Nephrology, ISSN 1342-1751, 12/2009, Volume 13, Issue 6, pp. 621 - 630
We previously estimated the prevalence of chronic kidney disease (CKD) stages 3–5 at 19.1 million based on data from the Japanese annual health check program... 
eGFR | Nephrology | Medicine & Public Health | Serum creatinine | Chronic kidney disease | Japanese | Urology | MORTALITY | ADULTS | RISK | PROTEINURIA | BLOOD-PRESSURE | GLOMERULAR-FILTRATION-RATE | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | STAGE RENAL-DISEASE | Japan - epidemiology | United States - epidemiology | Proteinuria - epidemiology | Glomerular Filtration Rate | Prevalence | Humans | Middle Aged | Male | Asian Continental Ancestry Group | Aging - physiology | Kidney Failure, Chronic - epidemiology | Diabetes Mellitus - physiopathology | Diabetes Mellitus - epidemiology | Creatinine - blood | Adult | Female | Aged | Hypertension - epidemiology | Hypertension | Medical colleges | Diabetes | Chronic kidney failure | Prevalence studies (Epidemiology)
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11. Full Text Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
by Terami, Naoto and Ogawa, Daisuke and Tachibana, Hiromi and Hatanaka, Takashi and Wada, Jun and Nakatsuka, Atsuko and Eguchi, Jun and Sato Horiguchi, Chikage and Nishii, Naoko and Yamada, Hiroshi and Takei, Kohji and Makino, Hirofumi
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e100777
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been reported as a new therapeutic strategy for treating diabetes. However, the effect of SGLT2... 
OXIDATIVE STRESS | ACTIVATION | HYPERGLYCEMIA | SGLT2 INHIBITOR | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RATS | COMPLICATIONS | MELLITUS | PANCREATIC-FUNCTION | RENAL INJURY | Inflammation - pathology | Oxidative Stress | Kidney Cortex - metabolism | Body Weight - drug effects | Diabetic Nephropathies - drug therapy | Male | Kidney Function Tests | Inflammation - metabolism | Kidney - metabolism | Glomerular Mesangium - metabolism | Glomerular Mesangium - drug effects | Homeostasis - drug effects | Kidney - physiopathology | Disease Models, Animal | Diabetic Nephropathies - pathology | Gene Expression | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Kidney - drug effects | Macrophages - pathology | Diabetic Nephropathies - metabolism | Cells, Cultured | Diabetic Nephropathies - genetics | Kidney Cortex - pathology | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Blood Glucose - drug effects | Glomerular Mesangium - pathology | Macrophages - metabolism | Animals | Insulin-Secreting Cells - drug effects | Kidney Tubules, Proximal - metabolism | Glucose - metabolism | Inflammation - genetics | Benzhydryl Compounds - pharmacology | Mice | Apoptosis | Oxidases | Type 2 diabetes | Blood sugar | Analysis | Body weight | Diabetic nephropathies | Hemoglobin | DNA polymerases | Gene expression | Health aspects | Oxidative stress | RNA-directed DNA polymerase | Syngeneic grafts | Homeostasis | Glucose | Macrophages | Blood | NAD(P)H oxidase | Biomedical materials | Hyperglycemia | Rodents | Biocompatibility | Blood pressure | Inhibition | Pancreas | Pharmaceutical sciences | Age | University graduates | Neurochemistry | Creatinine | Kidneys | Cytokines | Diabetes mellitus | Osteopontin | Inflammation | Dentistry | Metabolism | Medicine | Studies | Inhibitors | Nephropathy | Sodium | Monocyte chemoattractant protein | Fibrosis | Infiltration | Diabetes | Monocyte chemoattractant protein 1
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12. Full Text The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2014)
by Shimamoto, Kazuaki and Ando, Katsuyuki and Fujita, Toshiro and Hasebe, Naoyuki and Higaki, Jitsuo and Horiuchi, Masatsugu and Imai, Yutaka and Imaizumi, Tsutomu and Ishimitsu, Toshihiko and Ito, Masaaki and Ito, Sadayoshi and Itoh, Hiroshi and Iwao, Hiroshi and Kai, Hisashi and Kario, Kazuomi and Kashihara, Naok and Kawano, Yuhei and Kim-Mitsuyama, Shokei and Kimura, Genjiro and Kohara, Katsuhiko and Komuro, Issei and Kumagai, Hiroo and Matsuura, Hideo and Miura, Katsuyuki and Morishita, Ryuichi and Naruse, Mitsuhide and Node, Koichi and Ohya, Yusuke and Rakugi, Hiromi and Saito, Ikuo and Saitoh, Shigeyuki and Shimada, Kazuyuki and Shimosawa, Tatsuo and Suzuki, Hiromichi and Tamura, Kouichi and Tanahashi, Norio and Tsuchihashi, Takuya and Uchiyama, Makoto and Ueda, Shinichiro and Umemura, Satoshi and Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Hypertension Research, ISSN 0916-9636, 2014, Volume 37, Issue 4, pp. 253 - 390
Hypertension - drug therapy | Hypertension - therapy | Antihypertensive Agents - therapeutic use | Humans
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