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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 50, pp. 15438 - 15443
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2017, Volume 127, Issue 9, pp. 3339 - 3352
Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification.... 
PLURIPOTENT STEM-CELLS | PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-CONTROL | I RECEPTOR | DISEASE | BONE MORPHOGENETIC PROTEINS | OSTEOGENIC DIFFERENTIATION | REGULATORS | ALK2 | HETEROTOPIC OSSIFICATION | Lysophospholipids - metabolism | Chondrocytes - cytology | Embryonic Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | TOR Serine-Threonine Kinases - metabolism | Humans | Activins - metabolism | Male | Inhibitory Concentration 50 | Female | Cell Differentiation | Chondrogenesis | Induced Pluripotent Stem Cells - cytology | Recombinant Proteins - metabolism | Myositis Ossificans - metabolism | Phosphoric Diester Hydrolases - metabolism | Signal Transduction | Mice, Inbred C57BL | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Mice, Inbred C3H | Point Mutation | Animals | Mice | Transforming Growth Factor beta - metabolism | Rare diseases | Physiological aspects | Rapamycin | Genetic disorders | Health aspects | TOR protein | Animal models | Mesenchyme | Hyperactivity | Stem cell transplantation | High-throughput screening | Kinases | Signal transduction | Bone growth | Allografts | Bones | Bone morphogenetic proteins | Bone (endochondral) | Myositis ossificans | Patients | Lysophosphatidic acid | Stromal cells | Stem cells | Genetic engineering | Mutation | Activin | Ossification (ectopic) | Osteogenesis | Pluripotency | Inhibitory postsynaptic potentials | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61540 - e61540
The establishment of human induced pluripotent stem cells (hiPSCs) has enabled the production of in vitro, patient-specific cell models of human disease. In... 
PLURIPOTENT STEM-CELLS | SKELETAL-MUSCLE | PROGENITORS | GENE | MULTIDISCIPLINARY SCIENCES | MOUSE | DUCHENNE MUSCULAR-DYSTROPHY | DYSFERLIN | EXPRESSION | FIBROBLASTS | DEFICIENCY | Electric Stimulation | MyoD Protein - genetics | Humans | Gene Expression Profiling | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Cell Differentiation - genetics | Transfection | Muscle Proteins - metabolism | Distal Myopathies - metabolism | Membrane Proteins - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Gene Expression | Induced Pluripotent Stem Cells - drug effects | Muscular Atrophy - metabolism | Membrane Proteins - genetics | Distal Myopathies - pathology | Muscular Atrophy - pathology | Cells, Cultured | Dysferlin | Muscular Atrophy - genetics | MyoD Protein - metabolism | Mice, SCID | Muscle Proteins - genetics | Distal Myopathies - genetics | Animals | Cell Differentiation - drug effects | Models, Biological | Doxycycline - pharmacology | Muscle Fibers, Skeletal - cytology | Mice | Genetic Vectors | Gene expression | Analysis | Genes | Stem cells | Cell culture | Health sciences | Disease | Muscular diseases | Myocytes | Cell fusion | Muscular dystrophy | Defects | Embryology | Immunology | Miyoshi myopathy | Rodents | Fibroblasts | Genetics | Modelling | Repair | Myotubes | Health promotion | Muscles | Twitching | Electrical stimuli | Medicine | Pathology | Musculoskeletal system | Reproducibility | Mutation | Differentiation | Pluripotency | Myopathy | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e112291 - e112291
Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of cell types that contribute to the... 
MAINTENANCE | BRANCHIAL ARCHES | MULTIDISCIPLINARY SCIENCES | MOUSE | PATIENT-SPECIFIC IPSCS | GENERATION | DIFFERENTIATION | INDUCTION | SPECIFICATION | PARAXIAL MESODERM | MELANOCYTES | Chondrocytes - cytology | Neural Crest - cytology | Cell Proliferation | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Cells, Cultured - cytology | Humans | Cell Lineage | Cornea - metabolism | Bone Morphogenetic Proteins - metabolism | Insulin - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Endothelial Cells - cytology | Melanocytes - cytology | Cell Differentiation | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | DNA, Complementary - metabolism | Transforming Growth Factor beta - metabolism | Osteogenesis | Fibroblasts - metabolism | Fibroblast growth factors | Skin | Transforming growth factors | Gene expression | Embryonic stem cells | Biopharmaceutics | Cell culture | Pediatrics | Cornea | Media (culture) | Mesenchyme | Embryo cells | Melanocytes | Nervous system | Neuronal-glial interactions | Cell growth | Epidermal growth factor | Surgery | Growth factors | Biomedical engineering | Fibroblast growth factor 2 | Peripheral nervous system | Tissue engineering | Insulin | Neural crest | Embryos | Pigmentation | Endothelial cells | Medicine | Organic chemistry | Inhibitors | Animal behavior | Stromal cells | Stem cells | Differentiation | Pluripotency | Cell migration | Inhibitory postsynaptic potentials | Index Medicus
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 3068 - 17
The mechanical properties of the extracellular microenvironment, including its stiffness, play a crucial role in stem cell fate determination. Although... 
PHYSICOCHEMICAL PROPERTIES | FIBRIL FORMATION | EXCITATORY NEURONS | MULTIDISCIPLINARY SCIENCES | TISSUE | CROSS-LINKING | EFFICIENT GENERATION | SUBSTRATE STIFFNESS | DIFFERENTIATION | FATE | BIOPHYSICAL REGULATION | Cell culture | Cell fate | Gels | Collagen | Cortex | Stem cells | Mechanical properties | Neural stem cells | Neurogenesis | Pluripotency | Mimicry
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0131998 - e0131998
Somatic mutations in the isocitrate dehydrogenase (IDH) 1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite,... 
MAFFUCCI SYNDROME | OLLIER DISEASE | GLIOBLASTOMA | COL2A1 | MULTIDISCIPLINARY SCIENCES | MYELOPROLIFERATIVE NEOPLASMS | MUTATIONS | PROMOTER | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CANCER | EXPRESSION | Mesenchymal Stromal Cells - enzymology | Genetic Predisposition to Disease | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Enchondromatosis - enzymology | Genetic Association Studies | Epigenesis, Genetic | Humans | Cells, Cultured | Gene Expression Regulation, Neoplastic | Isocitrate Dehydrogenase - genetics | Mutation, Missense | Chondrosarcoma - enzymology | Chondrosarcoma - genetics | Bone Neoplasms - genetics | Cell Differentiation | Protein Processing, Post-Translational | Histones - metabolism | Osteosarcoma - genetics | Methylation | Enchondromatosis - genetics | Mesenchymal Stromal Cells - physiology | Histones | Stem cells | Mesenchyme | Leukemia | Genes | Sox9 protein | Central nervous system | Proteins | Cartilage | Biomedical materials | Cell growth | Osteosarcoma | Surgery | DNA methylation | Bone marrow | Biocompatibility | Inhibition | Isocitrate dehydrogenase | Deoxyribonucleic acid--DNA | Enzymes | Tissue engineering | Osteosarcoma cells | Gene expression | Medicine | Properties (attributes) | Animal behavior | Epigenetics | Mutation | Differentiation | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Visualized Experiments, ISSN 1940-087X, 04/2019, Volume 2019, Issue 146
In response to signals such as WNTs, bone morphogenetic proteins (BMPs), and sonic hedgehog (SHH) secreted from surrounding tissues, somites (SMs) give rise to... 
Dermatome | Issue 146 | Paraxial mesoderm | Induced pluripotent stem cell | Somite | Syndetome | Myotome | Developmental Biology | Differentiation | Sclerotome | TENDON | myotome | differentiation | VIVO | somite | MULTIDISCIPLINARY SCIENCES | INDUCTION | induced pluripotent stem cell | paraxial mesoderm | sclerotome | dermatome | syndetome
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142991 - e0142991
The prevalence and specificity of unique fusion oncogenes are high in a number of soft tissue sarcomas (STSs). The close relationship between fusion genes and... 
TRANSLOCATION | SOFT-TISSUE SARCOMAS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SSX | CLASSIFICATION | TRANSCRIPT | INDUCTION | MESENCHYMAL STEM-CELLS | SYT | Oncogene Proteins, Fusion - metabolism | Epigenesis, Genetic | Humans | Transcriptome | Genetic Loci | Neural Crest - metabolism | DNA-Binding Proteins - metabolism | SMARCB1 Protein | Mesenchymal Stromal Cells - cytology | RNA Interference | Cell Differentiation | Cell Line | Neural Crest - cytology | Pluripotent Stem Cells - cytology | Chromosomal Proteins, Non-Histone - metabolism | Frizzled Receptors - metabolism | Mesenchymal Stromal Cells - metabolism | Sarcoma, Synovial - metabolism | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Frizzled Receptors - genetics | Sarcoma, Synovial - genetics | Oncogene Proteins, Fusion - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Histones - metabolism | Sarcoma, Synovial - pathology | RNA, Small Interfering - metabolism | Epigenetic inheritance | Care and treatment | Sarcoma | Patient outcomes | Development and progression | Research | Gene expression | Risk factors | Mesenchyme | Tissue engineering | Synovial sarcoma | Genomes | Kinases | Neural crest | Chromatin remodeling | Proteins | Biological effects | Cell growth | Animal behavior | Stromal cells | Surgery | Cell lines | Stem cells | Epigenetics | Life sciences | Mutation | Fusion protein | Pluripotency | Cancer | Tumors | Index Medicus
Journal Article