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Angewandte Chemie International Edition, ISSN 1433-7851, 05/2012, Volume 51, Issue 21, pp. 5244 - 5246
Better fit, less effort: An easy‐to‐synthesize ruthenium phthalimide complex (tan‐colored carbon atoms in the picture) was designed to bind within the active... 
protein kinases | ruthenium | bioorganometallic chemistry | enzyme inhibitors | PAK1 | RUTHENIUM COMPLEXES | KINASE INHIBITORS | CHEMICAL SPACE | CONFORMATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Metals - chemistry | Models, Molecular | Proteins - physiology | Proteins | Pictures | Pocket | Ruthenium | Phthalimides | Carbon
Journal Article
eLife, ISSN 2050-084X, 05/2016, Volume 5, Issue 2016
Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple... 
INDUCIBLE CYCLOOXYGENASE | ACTIVATED PROTEIN-KINASE | TRANSCRIPTIONAL COACTIVATOR P300 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SODIUM-SALICYLATE | G1/S TRANSITION | BIOLOGY | RANDOMIZED-TRIAL | HISTONE ACETYLTRANSFERASE | NF-KAPPA-B | TERMINAL KINASE | Leukocytes - pathology | Oncogene Proteins, Fusion - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Humans | Structure-Activity Relationship | Leukocytes - enzymology | Salicylic Acid - chemistry | Leukemia, Myeloid, Acute - enzymology | Salicylic Acid - pharmacology | p300-CBP Transcription Factors - genetics | Enzyme Inhibitors - chemistry | HEK293 Cells | Leukemia, Myeloid, Acute - drug therapy | RUNX1 Translocation Partner 1 Protein - genetics | Antineoplastic Agents - pharmacology | RUNX1 Translocation Partner 1 Protein - metabolism | Binding, Competitive | Catalytic Domain | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Diflunisal - pharmacology | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Mice, SCID | Acetyl Coenzyme A - metabolism | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Diflunisal - chemistry | Animals | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Leukocytes - drug effects | Acetyl Coenzyme A - antagonists & inhibitors | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Metabolites | Salicylic acid | Health aspects | Event-related potentials | Acetylsalicylic acid | Cell fusion | Kinases | Confidence intervals | Proteins | Coenzyme A | Acetyltransferase | Acetylation | Fusion protein | Drug dosages | NF-κB protein | Medical research | Immunoglobulins | Antiinflammatory agents | Oral administration | Inflammation | Tumor cell lines | Medicine | AML1 protein | Acids | Sodium | Lysine | Cell lines | Insulin resistance | Antitumor activity | Software | Cancer | Apoptosis
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 29105 - 29114
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 10/2016, Volume 11, Issue 10, pp. 2876 - 2888
The BRAF kinase, within the mitogen activated protein kinase (MAPK) signaling pathway, harbors activating mutations in about half of melanomas and to a... 
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 10/2016, Volume 11, Issue 10, pp. 2876 - 2888
The BRAF kinase, within the mitogen activated protein kinase (MAPK) signaling pathway, harbors activating mutations in about half of melanomas and to a... 
SELECTIVE INHIBITOR | MELANOMA | MEK INHIBITION | MUTANT BRAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | ACQUIRED-RESISTANCE | RAF INHIBITORS | B-RAF | MAPK PATHWAY | COMBINED BRAF
Journal Article
Synlett, ISSN 0936-5214, 5/2007, Volume 2007, Issue 8, pp. 1177 - 1189
Abstract Complementing organic elements with a metal center provides new opportunities for building three-dimensional structures with unique and defined... 
account | Bioorganometallic chemistry | Inhibitors | Ruthenium | Protein kinases | Mammalian cells | inhibitors | ZEBRAFISH | STAUROSPORINE | ACTIVE-SITE | protein kinases | CHEMISTRY, ORGANIC | bioorganometallic chemistry | POTENT INHIBITORS | CELL BIOLOGY | P53 | GLYCOGEN-SYNTHASE KINASE-3-BETA | ruthenium | PATHWAY | mammalian cells | LITHIUM
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 5/2012, Volume 51, Issue 21, pp. 5244 - 5246
Journal Article
ChemBioChem, ISSN 1439-4227, 12/2008, Volume 9, Issue 18, pp. 2933 - 2936
Perfect match: An organoruthenium complex with at most a low picomolar binding constant for glycogen synthase kinases 3 is reported, whose binding to the...