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Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | MECHANISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | C-RAF | B-RAF | MUTATIONS | PROTEINS | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 14, pp. 5299 - 5304
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 232 - 236
KRAS and BRAF activating mutations drive tumorigenesis through constitutive activation of the MAPK pathway. As these tumours represent an area of high unmet... 
PATHWAYS | WILD-TYPE | ACTIVATION | PI3K | MULTIDISCIPLINARY SCIENCES | C-RAF | MAP KINASE KINASE-1 | B-RAF | MUTATIONS | TUMOR-GROWTH INHIBITION | RAF PROTEINS | Niacinamide - analogs & derivatives | Humans | Crystallography, X-Ray | Azetidines - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Piperidines - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Genes, ras - genetics | Allosteric Regulation - drug effects | Cell Survival - drug effects | HCT116 Cells | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Clinical Trials as Topic | Imidazoles - pharmacology | Enzyme Activation - drug effects | Phosphoserine - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Feedback, Physiological - drug effects | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Neoplasms - pathology | Oncogene Protein p21(ras) - genetics | Gene mutations | Cancer cells | Cellular control mechanisms | Physiological aspects | Properties | Phosphotransferases | Mitogen-activated protein kinases | Studies | Phosphorylation | Hydrogen bonds | Melanoma | Kinases | Tumors | Cancer
Journal Article
Journal Article
Cell, ISSN 0092-8674, 1998, Volume 95, Issue 6, pp. 759 - 770
IκBα regulates the transcription factor NF-κB through the formation of stable IκBα/NF-κB complexes. Prior to induction, IκBα retains NF-κB in the cytoplasm... 
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2016, Volume 64, Issue 5, pp. 854 - 855
In this issue of , describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib... 
CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Signal Transduction - drug effects | Proto-Oncogene Proteins c-raf | ras Proteins
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, ISSN 2157-1422, 11/2018, Volume 8, Issue 11
Despite decades of extensive drug discovery efforts, there are currently no targeted therapies approved to treat KRAS mutant cancers. In this review, we... 
SIGNAL-TRANSDUCTION | MEDICINE, RESEARCH & EXPERIMENTAL | WILD-TYPE | METASTATIC MELANOMA | MEK INHIBITION | ONCOGENIC RAS | C-RAF | KSR-1 GENE ENCODES | B-RAF | SQUAMOUS-CELL CARCINOMAS | DEPENDENT MECHANISM
Journal Article
ISSN 1144-0546, 3/2015, Volume 39, Issue 4, pp. 335 - 342
Ancillary ligand substitution in the new series [Ru(dicnq)(pyTz)(X)] + {dicnq = 6,7-dicyanodipyrido[2,2- d :2′,3′- f ]quinoxaline and X = 2,2-bipyridine (bpy),... 
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 2013, Volume 12, Issue 11, pp. 2285 - 2295
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-020 - LB-020
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 04/2015, Volume 39, Issue 4, pp. 3035 - 3042
Ancillary ligand substitution in the new series [Ru(dicnq)(pyTz)(X)](+) {dicnq = 6,7-dicyanodipyrido[2,2-d: 2',3'-f] quinoxaline and X = 2,2-bipyridine (bpy),... 
RED ELECTROLUMINESCENCE | TRANSITION-METAL-COMPLEXES | LIGANDS | OPTICAL-PROPERTIES | STRUCTURAL-CHARACTERIZATION | DEVICES | PHOTOPHYSICAL PROPERTIES | EXCIPLEX | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | HOLE-TRANSPORT MATERIALS
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 477 - 493
Journal Article
Iranian Journal of Blood and Cancer, 2016, Volume 8, Issue 3, pp. 86 - 87
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2001, Volume 276, Issue 48, pp. 45225 - 45235
NF-kappaB dimers, inhibitor I kappaB proteins, and NF-kappaB .I kappaB complexes exhibit distinct patterns in partitioning between nuclear and cytoplasmic... 
P50/P65 HETERODIMER | DNA-BINDING | MECHANISM | EXPORT SIGNAL | PHOSPHORYLATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEST DOMAIN | C-REL | P50 | PROTEINS
Journal Article
ISSN 1144-0546, 10/2014, Volume 38, Issue 11, pp. 5312 - 5323
The synthesis, characterization and electrochemical, photoluminescence and electroluminescence properties of new ruthenium( ii ) polypyridyl complexes bearing... 
Journal Article