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American Journal of Physiology-Gastrointestinal and Liver Physiology, ISSN 0193-1857, 11/2019, Volume 317, Issue 5, pp. G739 - G749
Extracellular vesicles (EVs) are membrane-defined nanoparticles released by most cell types. The EVs released by cells may differ quantitatively and... 
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 11/2019, Volume 203, p. 107401
Nonalcoholic fatty liver disease is a major public health burden. Although many features of nonalcoholic fatty liver disease pathogenesis are known, the... 
Sphingolipids | Nonalcoholic steatohepatitis | Lipotoxicity | Palmitate | Endoplasmic reticulum stress
Journal Article
Alimentary pharmacology & therapeutics, ISSN 0269-2813, 9/2016, Volume 44, Issue 5, pp. 533 - 534
Journal Article
Hepatology, ISSN 0270-9139, 01/2018, Volume 67, Issue 1, pp. 10 - 12
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 795 - 809
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sensed by the binding... 
Gastroenterology and Hepatology | Hepatosteatosis | Endoplasmic reticulum stress | Unfolded protein response | Liver injury | MESSENGER-RNA TRANSLATION | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | NECROSIS-FACTOR-ALPHA | ISCHEMIA-REPERFUSION INJURY | PROGRAMMED CELL-DEATH | GLUCOSE-REGULATED PROTEINS | HEPATITIS-C VIRUS | HUMAN HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | Hepatitis C, Chronic - metabolism | Fatty Liver - metabolism | Cholestasis - metabolism | eIF-2 Kinase - metabolism | Humans | Liver Diseases - pathology | Stress, Physiological | Endoplasmic Reticulum - metabolism | Hyperhomocysteinemia - metabolism | Hepatocytes - pathology | Hepatocytes - metabolism | Unfolded Protein Response | Liver Diseases, Alcoholic - metabolism | Activating Transcription Factor 6 - metabolism | Inflammation - metabolism | Animals | Models, Biological | Liver Neoplasms - metabolism | Non-alcoholic Fatty Liver Disease | Protein Conformation | Liver Diseases - metabolism | Reperfusion Injury - metabolism | Apoptosis | Carcinoma, Hepatocellular - metabolism | Inositol | Immunoglobulins | Stress (Physiology) | Ribonuclease | Glucose | Genetic translation | Dextrose | Messenger RNA | Proteases | Proteolysis | Analysis | Hepatitis C | Adenylic acid | Hepatitis C virus | Health aspects | Protein binding | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 17, pp. 12093 - 12101
Elevated serum free fatty acids (FFAs) and hepatocyte lipoapoptosis are features of non-alcoholic fatty liver disease. However, the mechanism by which FFAs... 
PROGRAMMED CELL-DEATH | OXIDATIVE STRESS | RAT HEPATOCYTES | INDUCED APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | ENDOTHELIAL-CELLS | SYMPATHETIC NEURONS | NONALCOHOLIC STEATOHEPATITIS | DIRECT ACTIVATION | Cathepsin B - physiology | Cathepsin B - genetics | Fatty Acids, Nonesterified - pharmacology | Hepatocytes - metabolism | Hepatocytes - cytology | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Membrane Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Hepatocytes - drug effects | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | bcl-2-Associated X Protein - metabolism | Rats | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Fatty Liver | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | JNK Mitogen-Activated Protein Kinases - physiology | Liver Neoplasms - metabolism | Mice | Apoptosis - physiology | Carcinoma, Hepatocellular - metabolism
Journal Article