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ACS Chemical Neuroscience, ISSN 1948-7193, 01/2012, Volume 3, Issue 1, pp. 50 - 68
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2012, Volume 340, Issue 1, pp. 124 - 133
CEP-26401 [irdabisant; 6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2H-pyridazin-3-one HCl] is a novel, potent histamine H-3 receptor (H3R)... 
RAT | PREPULSE INHIBITION | ALZHEIMERS-DISEASE | INVERSE AGONIST | CONSTITUTIVE ACTIVITY | CIPROXIFAN | PHARMACOLOGY & PHARMACY | SOCIAL MEMORY | H-3-RECEPTOR | BRAIN | PHARMACOLOGICAL-PROPERTIES
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2012, Volume 55, Issue 2, pp. 903 - 913
A substantial body of evidence supports the utility of antiangiogenesis inhibitors as a strategy to block or attenuate tumor-induced angiogenesis and... 
VEGF-R2 | CHEMISTRY, MEDICINAL | RECEPTOR TYROSINE KINASES | TIE-2 | EFFICACY | MODELS | IN-VIVO | TUMOR ANGIOGENESIS | DUAL INHIBITORS | CANCER | DISCOVERY | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Indazoles - chemical synthesis | Humans | Macaca fascicularis | Biological Availability | Male | Carbazoles - chemical synthesis | Receptor, TIE-2 - chemistry | Structure-Activity Relationship | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Angiogenesis Inhibitors - chemical synthesis | Receptor, TIE-2 - antagonists & inhibitors | Recombinant Proteins - antagonists & inhibitors | Administration, Oral | Angiogenesis Inhibitors - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Angiogenesis Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Indazoles - pharmacokinetics | Mice, Nude | Carbazoles - pharmacokinetics | Mice | Carbazoles - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 8, pp. 2158 - 2162
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2004, Volume 14, Issue 4, pp. 1035 - 1038
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 05/2002, Volume 67, Issue 10, pp. 3235 - 3241
Tandem alkylation/cyclization of indenopyrrolocarbazole 4a, a C12 carbon analogue of indolocarbazole K252c, was carried out by general solid-phase and... 
ROUTE | POTENT | STAUROSPORINE | MODE | CHEMISTRY, ORGANIC | DERIVATIVES | PROTEIN-KINASE INHIBITORS | STRUCTURE-BASED DESIGN | Solid state chemistry | Chemical inhibitors | Chemistry, Organic | Heterocyclic compounds | Solution (Chemistry) | Physiological aspects | Research | Ring formation (Chemistry) | Carbon | Alkylation | Adenosine triphosphate
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2004, Volume 14, Issue 4, p. 1035
A series of potent 1,2-benzothiazine 1,1-dioxide [alpha]-ketoamide inhibitors of calpain I is described. 
Calpain
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1999, Volume 9, Issue 16, pp. 2371 - 2374
A series of potent P-2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I is described. (C) 1999 Elsevier Science Ltd. All rights reserved. 
SYSTEM | ESTER | FLUOROMETHYL KETONE INHIBITORS | CHEMISTRY, MEDICINAL | ACID | AMIDE | CHEMISTRY, ORGANIC | CYSTEINE PROTEASES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2002, Volume 43, Issue 2, pp. 217 - 220
A modified core structure of indolo[2, 3-a]carbazole template has been immobilized. EtMgBr was identified as a substrate compatible base providing solid-phase... 
COMPREHENSIVE SURVEY | PHASE SYNTHESIS | POTENT | DESIGN | MICROBIAL ORIGIN | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | K-252A
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2003, Volume 46, Issue 25, pp. 5375 - 5388
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 08/1999, Volume 9, Issue 16, pp. 2371 - 2374
Journal Article
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