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ISSN 1999-4915, 2018
The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, p. 10014
  Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates... 
Enzymes | Signal transduction | Cytokines | Sensors | Catalysis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2014, Volume 111, Issue 37, p. 13463
  IgA is the most prevalent antibody type on mucosal surfaces and the second most prevalent antibody in circulation, yet its role in immune defense is not... 
Signal transduction | Rodents | T cell receptors | Gene expression | Cells | Binding sites
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 48, p. 19733
  Blood plasma viral loads and the time to progress to AIDS differ widely among untreated HIV-infected humans. Although people with certain HLA (HLA-I) alleles... 
Plasma | Evolutionary biology | Lymphocytes | Human immunodeficiency virus--HIV | Cytotoxicity | Gene loci | Mutation
Journal Article
BioEssays, ISSN 0265-9247, 11/2011, Volume 33, Issue 11, pp. 803 - 809
Journal Article
Cell Reports, ISSN 2211-1247, 08/2014, Volume 8, Issue 4, pp. 999 - 1005
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2019, Volume 10, Issue 1, pp. 1 - 13
The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein... 
E3 LIGASE | CATALYSIS | ACTIVATION | STRUCTURAL BASIS | COMPLEX REVEALS | RING | ENZYMES | MULTIDISCIPLINARY SCIENCES | UBIQUITYLATION | MODEL | TRIM5-ALPHA | Ubiquitin | Anchors | Ubiquitination | Depletion | Human immunodeficiency virus--HIV | Antibodies | Chains | Catalysis | Mutation | Protein structure | Neutralization | Locking
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 37, pp. 13463 - 13468
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, p. 19985
  Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain... 
Proteins | Cellular biology | Physiology | Experiments | Viral infections | Binding sites | Immune system
Journal Article
Viruses, ISSN 1999-4915, 11/2018, Volume 10, Issue 11, p. 640
The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent... 
AIDS | infection | uncoating | HIV | IP6 | capsid | CELLS | PROTEIN | PHOSPHATIDYLINOSITOL-(4,5)-BISPHOSPHATE | PLASMA-MEMBRANE | IMPORT | IN-VITRO | VIROLOGY | GAG MOLECULES | DNA | ROUS-SARCOMA-VIRUS | REQUIREMENT | HIV-1 - physiology | Phytic Acid - metabolism | Capsid - metabolism | Virus Assembly | Virus Uncoating
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 09/2014, Volume 111, Issue 37, pp. 13463 - 13463
IgA is the most prevalent antibody type on mucosal surfaces and the second most prevalent antibody in circulation, yet its role in immune defense is not fully... 
Journal Article