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Lancet Oncology, The, ISSN 1470-2045, 2011, Volume 12, Issue 13, pp. 1195 - 1203
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 18, Issue 1, pp. 75 - 87
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1... 
Hematology, Oncology and Palliative Medicine | BRCA MUTATION | POLY(ADP-RIBOSE) POLYMERASE | RANDOMIZED PHASE-2 | ONCOLOGY | HOMOLOGOUS RECOMBINATION DEFICIENCY | MUTANT-CELLS | PROSTATE-CANCER | INHIBITORS | DNA-REPAIR | NEGATIVE BREAST-CANCER | GENOMIC LOSS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Germ-Line Mutation - genetics | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Poly(ADP-ribose) Polymerases - chemistry | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Fallopian Tube Neoplasms - pathology | Survival Rate | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | BRCA1 Protein - genetics | International Agencies | Peritoneal Neoplasms - genetics | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indoles - therapeutic use | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Sugars | Monosaccharides | Ovarian cancer | Analysis | Carcinoma | Cancer | Index Medicus
Journal Article
by Coleman, Robert L and Coleman, R L and Oza, Amit M and Oza, A M and Lorusso, D and Lorusso, Domenica and Aghajanian, C and Aghajanian, Carol and Oaknin, A and Oaknin, Ana and Dean, A and Dean, Andrew and Colombo, N and Colombo, Nicoletta and Weberpals, Johanne I and Weberpals, J I and Clamp, Andrew and Clamp, A and Scambia, Giovanni and Scambia, G and Leary, A and Leary, Alexandra and Holloway, Robert W and Holloway, R W and Gancedo, M Amenedo and Gancedo, Margarita Amenedo and Fong, Peter C and Fong, P C and Goh, Jeffrey C and Goh, J C and O'Malley, David M and O'Malley, D M and Armstrong, Deborah K and Armstrong, D K and Garcia-Donas, Jesus and Garcia-Donas, J and Swisher, E M and Swisher, Elizabeth M and Floquet, A and Floquet, Anne and Konecny, Gottfried E and Konecny, G E and McNeish, I A and McNeish, Iain A and Scott, C L and Scott, Clare L and Cameron, Terri and Maloney, Lara and Isaacson, Jeff and Goble, Sandra and Grace, Caroline and Harding, Thomas C and Raponi, Mitch and Sun, James and Lin, Kevin K and Giordano, Heidi and Ledermann, J A and Ledermann, Jonathan A and Buck, M and Friedlander, M L and Harnett, P and Kichenadasse, G and Denys, H and Dirix, L and Vergote, I and Elit, L and Ghatage, P and Plante, M and Provencher, D and Welch, S and Gladieff, L and Joly, F and Lortholary, A and Lotz, J and Medioni, J and Tredan, O and You, B and El-Balat, A and Hänle, C and Krabisch, P and Neunhöffer, T and Pölcher, M and Wimberger, P and Amit, A and Kovel, S and Leviov, M and Safra, T and Shapira-Frommer, R and Stemmer, S and Bologna, A and Pignata, S and Sabbatini, R F and Tamberi, S and Zamagni, C and O'Donnell, A and Herraez, A Casado and Guerra, E M and Palacio, I and Romero, I and Sanchez, A and ... and ARIEL3 Investigators and ARIEL3 investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10106, pp. 1949 - 1961
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a mutation or high percentage of... 
MEDICINE, GENERAL & INTERNAL | MULTICENTER | SOLID TUMORS | BEVACIZUMAB | OPEN-LABEL | CANCER | HETEROZYGOSITY | EPITHELIAL OVARIAN | CHEMOTHERAPY | Double-Blind Method | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Survival Rate | Treatment Outcome | Ovarian Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Indoles - administration & dosage | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Maintenance Chemotherapy - methods | Internationality | Ovarian Neoplasms - therapy | Female | Aged | Molecular Targeted Therapy - methods | Clinical trials | Care and treatment | Carcinoma | Drug therapy | Ovarian cancer | Cancer | Analysis | Chemotherapy | Ovarian carcinoma | Platinum | Biomarkers | Mutation | Cancer therapies | Tumors | Homologous recombination | Central nervous system | Poly(ADP-ribose) | Homology | Genomes | Fallopian tube | ADP | Anticancer properties | Metastases | Homologous recombination repair | Randomization | Pain | Motivation | Ribose | Hemoglobin | Alanine | Anemia | Poly(ADP-ribose) polymerase | Breast cancer | Patients | Survival | Heterozygosity | Abdomen | Polymerase | Inhibitors | Point mutation | Loss of heterozygosity | Antitumor activity | Aspartate aminotransferase | Peritoneum | Index Medicus | Abridged Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2017, Volume 31, Issue 7, pp. 2771 - 2784
Journal Article
Protein Science, ISSN 0961-8368, 09/2005, Volume 14, Issue 9, pp. 2246 - 2257
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 05/2016, Volume 55, Issue 5, pp. 688 - 704
The apurinic/apyrimidinic endonuclease 1 (APE1) is a protein central to the base excision DNA repair pathway and operates in the modulation of gene expression... 
combination therapy | NPM1 | small molecule | protein/protein interaction | APE1 | Protein/protein interaction | Small molecule | Combination therapy | APE1/REF-1 | CRITICAL LYSINE RESIDUES | protein interaction | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOCELLULAR-CARCINOMA | PROTEIN INTERACTIONS | NUCLEOPHOSMIN | ONCOLOGY | protein | N-TERMINAL DOMAIN | DNA-REPAIR | EXPRESSION | Neoplasms - metabolism | Cell Survival - drug effects | Small Molecule Libraries - pharmacology | Humans | Nuclear Proteins - metabolism | High-Throughput Screening Assays | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | MCF-7 Cells | Nuclear Proteins - antagonists & inhibitors | Protein Binding - drug effects | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | HeLa Cells | Neoplasms - pathology | Proteins | Chemotherapy | Pharmacology | DNA repair | Tumors | Cell proliferation | Drugs | Surgical implants | Ovarian carcinoma | Liver | High-throughput screening | Genomes | Drug development | Assaying | Ovarian cancer | Anticancer properties | Biomedical materials | Antitumor agents | Bioactive compounds | Modulation | Biocompatibility | Localization | Deoxyribonucleic acid--DNA | Cell survival | Aggressive behavior | Preservation | Maturation | Tumor cells | rRNA | Light emitting diodes | Chemiluminescence | Gene expression | Screening | Inhibitors | Medical prognosis | Cells (biology) | Aberration | Position (location) | Protein interaction | Endonuclease | Cancer | Index Medicus
Journal Article
1994, Research studies of the Fair Tax Commission of Ontario., ISBN 0802076033, xiv, 260
Book
NATURAL PRODUCT REPORTS, ISSN 0265-0568, 10/2018, Volume 35, Issue 1, pp. 182 - 196
Covering: up to the end of 2018 Polyketides are a valuable source of bioactive and clinically important molecules. The biosynthesis of these chemically complex... 
CHEMISTRY, MEDICINAL | 6-DEOXYERYTHRONOLIDE B SYNTHASE | ACTIVE-SITE | CRYSTAL-STRUCTURE | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOCKING DOMAINS | CHEMISTRY, ORGANIC | ACYL CARRIER PROTEIN | STRUCTURAL BASIS | MOLECULAR RECOGNITION | FATTY-ACID SYNTHASE | ENZYME-SUBSTRATE INTERACTIONS
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 6, pp. 1404 - 1414.e6
Mutations of the transcriptional regulator PHF6 cause the X-linked intellectual disability disorder Börjeson-Forssman-Lehmann syndrome (BFLS), but the... 
mouse models | X-linked intellectual disability | PHF6 | gene expression | neuronal excitability | ENTORHINAL CORTEX | MAMMALIAN BRAIN | OFF-TARGET | AUTISM | PROTEIN | CONNECTIVITY | MICE | EPILEPSY | INSIGHTS | CELL BIOLOGY | Index Medicus
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 09/2011, Volume 301, Issue 3, pp. R791 - R800
Marais M, Maloney SK, Gray DA. Brain IL-6- and PG-dependent actions of IL-1 beta and lipopolysaccharide in avian fever. Am J Physiol Regul Integr Comp Physiol... 
Pekin duck | Prostaglandin E | Interleukin-1β | Interleukin-6 | FEBRILE RESPONSE | PHYSIOLOGY | SALMONELLA-TYPHIMURIUM LIPOPOLYSACCHARIDE | SENSORY CIRCUMVENTRICULAR ORGANS | INTERLEUKIN (IL)-6 | BROILER-CHICKENS | SICKNESS BEHAVIOR | BODY-TEMPERATURE | interleukin-6 | prostaglandin E-2 | interleukin-1 beta | PEKIN DUCKS | CENTRAL-NERVOUS-SYSTEM | Fever - veterinary | Lipopolysaccharides - administration & dosage | Injections, Intraventricular | Male | Reaction Time | Fever - chemically induced | Ducks | Fever - physiopathology | Poultry Diseases - physiopathology | Time Factors | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Body Temperature Regulation - drug effects | Female | Fever - immunology | Interleukin-6 - administration & dosage | Interleukin-6 - metabolism | Poultry Diseases - chemically induced | Brain - physiopathology | Cyclooxygenase Inhibitors - administration & dosage | Poultry Diseases - drug therapy | Recombinant Proteins - administration & dosage | Dinoprostone - metabolism | Antibodies - administration & dosage | Animals | Interleukin-1beta - administration & dosage | Analysis of Variance | Prostaglandin-Endoperoxide Synthases - metabolism | Interleukin-6 - immunology | Poultry Diseases - immunology | Diclofenac - administration & dosage | Brain - immunology | Fever - drug therapy | Prostaglandins - metabolism | Index Medicus
Journal Article