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Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 147 - 148
A study in mouse models of allogeneic stem cell transplantation with donor-derived CD19 chimeric antigen receptor (CAR) T cells for the treatment of relapsed B... 
MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANCIES | CHIMERIC ANTIGEN RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Cell receptors | Patient outcomes | Genetic aspects | Transplantation | T cells | Gene expression | Health aspects | Hematopoietic stem cells | Methods | Lymphomas | Transplants & implants | Lymphocytes | Stem cells
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2202 - 2213
The successful immunotherapy of acute myeloid leukemia (AML) has been hampered because most potential antigenic targets are shared with normal hematopoietic... 
AML | CLL-1 | CAR | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | SUICIDE GENE | PERSISTENCE | BISPECIFIC ANTIBODY | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EXPANSION | GENETICS & HEREDITY | RESISTANCE | SAFETY SWITCH | LYMPHOCYTES | Humans | Middle Aged | Male | Leukemia, Myeloid, Acute - immunology | Recombinant Fusion Proteins | Young Adult | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Inflammation Mediators - metabolism | Aged, 80 and over | Adult | Female | Child | Leukemia, Myeloid, Acute - therapy | Disease Models, Animal | Gene Expression | Cytokines - metabolism | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Xenograft Model Antitumor Assays | Animals | Leukemia, Myeloid, Acute - diagnosis | Adolescent | Cell Line, Tumor | Myeloid Cells - metabolism | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | Aged | Mice | Receptors, Antigen, T-Cell - genetics | Lectins, C-Type - antagonists & inhibitors | Cytotoxicity, Immunologic | Leukemia, Myeloid, Acute - genetics | Leukemia | Stem cell transplantation | Cytotoxicity | Leukocytes (mononuclear) | Lymphocytes T | Suicide | Cancer therapies | Hematopoietic stem cells | Lymphocytes | Immunotherapy | Xenografts | Peripheral blood mononuclear cells | Conflicts of interest | Tumor necrosis factor-TNF | Suicide genes | Antigens | Myeloid cells | Chronic lymphatic leukemia | Cell survival | Statistical analysis | Cytokines | Colonies | Myeloid leukemia | Caspase | Patients | Progenitor cells | Hemopoiesis | Chemotherapy | Stem cells | Caspase-9 | Software | Acute myeloid leukemia | Original
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.... 
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | ACTIVATION | LIGAND EXPRESSION | CAR | EFFECTOR FUNCTION | GENE-EXPRESSION | FAS | DEATH | ANTITUMOR-ACTIVITY | NF-KAPPA-B | SIGNALING COMPLEX | CELL BIOLOGY | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Chimeric antigen receptor
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2015, Volume 23, pp. S162 - S163
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2014, Volume 44, Issue 3, pp. 715 - 727
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2014, Volume 44, Issue 3, pp. 715 - 727
Most differentiated CD8 super(+) T cells die off at the end of an infection, revealing two main subsets of memory T cells - central and effector memory - which... 
Journal Article
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, pp. 3036 - 3052
In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single... 
REGRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | RECOGNITION | GLIOBLASTOMA-MULTIFORME | PERSISTENCE | RECEPTOR | ANTITUMOR-ACTIVITY | EXPRESSION | ADOPTIVE IMMUNOTHERAPY | LYMPHOCYTES | EPHA2
Journal Article