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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7559, pp. 183 - 188
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 24, pp. 4112 - 4116
A Rh(III)-catalyzed oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters is achieved to afford benzolactams in up to 93% yields. With the... 
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 24, pp. 4112 - 4116
A Rh(III)-catalyzed oxidative [4 + 1] cycloaddition of benzohydroxamic acids and alpha-diazoesters is achieved to afford benzolactams in up to 93% yields. With... 
ACTIVATION | C-H BOND | CHEMISTRY, ORGANIC | ARYL ACYLPEROXIDES | DIAZO-COMPOUNDS | INTERNAL ALKYNES | CLEAVAGE | REGIOSELECTIVITY | TERT-BUTYL HYDROPEROXIDE | BENZOIC-ACIDS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 492 - 503
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the degradation of GSPT1. We... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 535 - 542
The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | COMPLEX | CHEMISTRY, MEDICINAL | SUSCEPTIBILITY LOCI | LENALIDOMIDE | CHINESE HAN POPULATION | THALIDOMIDE | IDENTIFICATION | MULTIPLE-MYELOMA CELLS | POMALIDOMIDE | CRL4(CRBN) UBIQUITIN LIGASE | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 492 - 503
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the degradation of GSPT1. We... 
Index Medicus
Journal Article
Journal Article
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 02/2016, Volume 223, pp. 318 - 323
This work reports a metal ion-responsive photonic colloidal crystalline (PCC) microspheric material and the convenient, reversible switching of its photonic... 
Metal ions sensing | Electrochemically tunable colours | Photonic crystal beads | Hydrogel particles | Redox reaction | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | INSTRUMENTS & INSTRUMENTATION | EMISSION | SENSORS | Electrochemistry | Batteries | Diffraction | Hydrogels | Colors (materials) | Devices | Coatings | Colour | Photonics | Crystal structure
Journal Article
Microvascular Research, ISSN 0026-2862, 2009, Volume 77, Issue 2, pp. 78 - 86
Lenalidomide (Revlimid®) is approved for the treatment of transfusion-dependent patients with anemia due to low- or intermediate-1-risk Myelodysplastic... 
Angiogenesis | Lenalidomide | HIF-1α | Metastasis | Akt | Cadherin | IMiDs | MIGRATION | HIF-1 alpha | PHOSPHORYLATION | IMiDs (R) | THALIDOMIDE | CANCER | IN-VITRO | THERAPY | PATHWAY | PERIPHERAL VASCULAR DISEASE | TUMOR-GROWTH | PROGRESSION | Cadherins - metabolism | Humans | Melanoma, Experimental - drug therapy | Thalidomide - pharmacology | Microcirculation - drug effects | Antigens, CD - metabolism | Cell Hypoxia | Thalidomide - analogs & derivatives | Basic Helix-Loop-Helix Transcription Factors - metabolism | Lung Neoplasms - secondary | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neoplasm Metastasis - prevention & control | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | beta Catenin - metabolism | Pregnancy | Umbilical Arteries - growth & development | Animals | Lung Neoplasms - prevention & control | Umbilical Arteries - drug effects | Cell Differentiation - drug effects | Adherens Junctions - drug effects | Cell Line, Tumor | Mice | Endothelial Cells - pathology | In Vitro Techniques | Endothelial Cells - drug effects | Care and treatment | Dexamethasone | Analysis | Multiple myeloma | Dimethyl sulfoxide | Melanoma | Fibroblast growth factors | Angiogenesis inhibitors | Vascular endothelial growth factor | Endothelium | Cancer | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2015, Volume 126, Issue 6, pp. 779 - 789
Cereblon (CRBN), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immunomodulatory drugs lenalidomide and... 
B-CELL LYMPHOMA | COMPLEX | IKAROS | PROTEIN EXPRESSION | GENE-EXPRESSION | C-MYC | LENALIDOMIDE | NON-HODGKINS-LYMPHOMA | HEMATOLOGY | T-CELLS | E3 UBIQUITIN LIGASE | RNA, Small Interfering - genetics | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Interferon Regulatory Factor-7 - genetics | Lymphoma, Large B-Cell, Diffuse - metabolism | Thalidomide - pharmacology | Ikaros Transcription Factor - genetics | Lentivirus - metabolism | Proteolysis - drug effects | Thalidomide - analogs & derivatives | Molecular Mimicry | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Lentivirus - genetics | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Ikaros Transcription Factor - metabolism | Interferons - genetics | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Peptide Hydrolases - metabolism | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Piperidones - pharmacology | Interferon Regulatory Factor-7 - metabolism | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Piperidones - chemistry | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Interferons - metabolism | Mice | Quinazolinones - chemistry | Lymphoma, Large B-Cell, Diffuse - genetics | RNA, Small Interfering - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2009, Volume 52, Issue 6, pp. 1522 - 1524
In this communication, we report the discovery of IS (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-alpha... 
OBSTRUCTIVE PULMONARY-DISEASE | CHEMISTRY, MEDICINAL | ANALOGS | PDE4 INHIBITION | ASTHMA | ROFLUMILAST | PSORIASIS
Journal Article
Journal Article