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1. Full Text Optical Correlation Domain Reflectometry Based on Coherence Synchronization: Theoretical Analysis and Proof-of-Concept
by Okamoto, Tatsuya and Iida, Daisuke and Toge, Kunihiro and Manabe, Tetsuya
Journal of Lightwave Technology, ISSN 0733-8724, 09/2016, Volume 34, Issue 18, pp. 4259 - 4265
We describe a novel optical correlation domain reflectometry technique based on coherence synchronization between probe and local lights. Coherence... 
Optical fibers | Low coherence light | Correlation | Phase modulation | Coherence | optical frequency comb | Optical harmonic generation | Delays | optical correlation domain reflectometry | Probes | phase modulation | Lasers | Correlation analysis | Synchronism | Reflectometry | Optical frequency | Synchronization
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2. Full Text Digestion of Ceramide 2-Aminoethylphosphonate, a Sphingolipid from the Jumbo Flying Squid Dosidicus gigas, in Mice
by Tomonaga, Nami and Manabe, Yuki and Sugawara, Tatsuya
Lipids, ISSN 0024-4201, 4/2017, Volume 52, Issue 4, pp. 353 - 362
Ceramide 2-aminoethylphosphonate (CAEP), a sphingophosphonolipid containing a carbon–phosphorus bond, is frequently found in marine organisms and has a unique... 
Life Sciences | Neurochemistry | Medicinal Chemistry | Lipidology | Nutrition | Microbial Genetics and Genomics | Ceramide | Medical Biochemistry | Digestion | Dietary sphingolipids | Sphingoid base | GLUCOSYLCERAMIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPIDS | FATTY-ACIDS | SKIN BARRIER | QUANTITATIVE-ANALYSIS | CANNULATED RATS | DRY-SKIN | TRACT | NUTRITION & DIETETICS | INTESTINAL ALKALINE SPHINGOMYELINASE | CACO-2 CELLS | Ceramides - administration & dosage | Ceramides - pharmacology | Hydrolysis | Aminoethylphosphonic Acid - analogs & derivatives | Aminoethylphosphonic Acid - pharmacology | Animals | Aminoethylphosphonic Acid - administration & dosage | Sphingomyelin Phosphodiesterase - metabolism | Sphingomyelins - chemistry | Mice | Intestine, Small - metabolism | Decapodiformes - chemistry | Dietary Supplements
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3. Full Text Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice
by Komatsu, Toshiyuki and Sasaki, Suguru and Manabe, Yuki and Hirata, Takashi and Sugawara, Tatsuya
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0171178
Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect... 
CHOLESTEROL SULFATE | EXTRACTION | HORMONE | MULTIDISCIPLINARY SCIENCES | HUMAN HEALTH | IN-VIVO | AQUAPORIN-3 | NUTRITION | ULTRAVIOLET-RADIATION | PITUITARY-ADRENAL AXIS | EXPRESSION | Skin Aging - pathology | Gene Expression | Skin - metabolism | RNA, Messenger - genetics | Skin Aging - drug effects | Xanthophylls - pharmacokinetics | Mice, Hairless | Skin Aging - radiation effects | RNA, Messenger - metabolism | Ultraviolet Rays - adverse effects | Animals | Skin - radiation effects | Biomarkers | Female | Xanthophylls - pharmacology | Mice | Skin Aging - genetics | Dietary Supplements | Skin - drug effects | Skin - pathology | Prevention | Aging | Usage | Skin | Health aspects | Astaxanthin | Haematococcus pluvialis | Seafood | Dermis | Filaggrin | Matrix metalloproteinase | Antioxidants | Water loss | Steroid sulfatase | Rodents | Fibroblasts | Extracellular matrix | Metalloproteinase | Aquaporin 3 | U.V. radiation | Therapeutic applications | Aquaporins | Epidermis | Liquid chromatography | Metabolism | Hairless | Gene expression | High-performance liquid chromatography | Ultraviolet radiation | Diet | Collagen | Irradiation | Laboratory animals
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4. Full Text Dietary astaxanthin can accumulate in the brain of rats
by Manabe, Yuki and Komatsu, Toshiyuki and Seki, Shinobu and Sugawara, Tatsuya
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 08/2018, Volume 82, Issue 8, pp. 1433 - 1436
We evaluated the distribution of astaxanthin in rat brains after a single dose administration and after feeding 0.1% astaxanthin diet for 5 days. Astaxanthin... 
cerebral cortex | hippocampus | brain | absorption | Astaxanthin | Brain | Cerebral cortex | Absorption | Hippocampus | OXIDATIVE STRESS | TEMPORAL-LOBE EPILEPSY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | COGNITIVE FUNCTION | IMPAIRMENT | SUPPLEMENTATION | METABOLISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TISSUE DISTRIBUTION | DOUBLE-BLIND | SPATIAL MEMORY | MICE | CHEMISTRY, APPLIED | Xanthophylls - administration & dosage | Antioxidants - metabolism | Male | Antioxidants - pharmacology | Rats, Sprague-Dawley | Cerebral Cortex - metabolism | Hippocampus - metabolism | Xanthophylls - blood | Animals | Diet | Antioxidants - administration & dosage | Xanthophylls - metabolism | Xanthophylls - pharmacology | Oxidative Stress - drug effects
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5. Full Text Robust Laser Phase Noise Reduction by Tracking Frequency Discrimination Change of Interferometer
by Okamoto, Tatsuya and Toge, Kunihiro and Manabe, Tetsuya
Journal of Lightwave Technology, ISSN 0733-8724, 08/2016, Volume 34, Issue 16, pp. 3908 - 3913
We present a robust interferometer-based laser phase noise reduction technique that can easily be tuned to apply phase corrections at frequencies at which the... 
Phase noise | Optical fibers | Optical filters | FM noise spectrum | Optical interferometry | frequency discrimination | laser phase noise reduction | Optical feedback | lissajous figure | mach-zehnder interferometer | Optical noise | Mach-Zehnder interferometer | STABILIZATION | CAVITY | TELECOMMUNICATIONS | RESONATOR | ENGINEERING, ELECTRICAL & ELECTRONIC | REFLECTOMETRY | OPTICS | MODULATION
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6. Full Text Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer–stromal interactions in a mouse xenograft model
by Yoshida, Masaki and Miyasaka, Yoshihiro and Ohuchida, Kenoki and Okumura, Takashi and Zheng, Biao and Torata, Nobuhiro and Fujita, Hayato and Nabae, Toshinaga and Manabe, Tatsuya and Shimamoto, Masaya and Ohtsuka, Takao and Mizumoto, Kazuhiro and Nakamura, Masafumi
Cancer Science, ISSN 1347-9032, 10/2016, Volume 107, Issue 10, pp. 1443 - 1452
Desmoplasia contributes to the aggressive behavior of pancreatic cancer. However, recent clinical trials testing several antifibrotic agents on pancreatic... 
pancreatic stellate cells | Calpeptin | pancreatic cancer | cancer–stromal interaction | desmoplasia | METASTASIS | SOLID TUMORS | ADENOCARCINOMA | STELLATE CELLS | GEMCITABINE | OVEREXPRESSION | ONCOLOGY | cancer-stromal interaction | FOCAL ADHESION KINASE | NF-KAPPA-B | CARCINOMA | PROGRESSION | Gene Expression | Calpain - metabolism | Pancreatic Neoplasms - metabolism | Dipeptides - pharmacology | Humans | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Stromal Cells - metabolism | Pancreatic Neoplasms - genetics | Calpain - genetics | RNA, Messenger - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Cell Communication - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Calpain - antagonists & inhibitors | Disease Models, Animal | Pancreatic Stellate Cells - metabolism | Calpain | RNA | Pancreatic cancer | Analysis | Cell proliferation | Stellate cells | Aggressive behavior | Clinical trials | mRNA | Metastasis | Kinases | Cancer therapies | Cell adhesion & migration | Studies | Liver cancer | Chemotherapy | Medical prognosis | Fibrosis | Xenografts | Growth factors | Cell migration | Tumors | Apoptosis | Original
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7. Full Text Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells)
by Ravi, Hindupur and Kurrey, Nawneet and Manabe, Yuki and Sugawara, Tatsuya and Baskaran, Vallikannan
Materials Science & Engineering C, ISSN 0928-4931, 10/2018, Volume 91, pp. 785 - 795
Fucoxanthin (FUCO), a marine carotenoid is photo-, and thermo-labile and poorly bioavailable due to its lipophilicity. Hence, we developed a chitosan... 
Fucoxanthin | Nanocarrier | Chitosan | Caco-2 | Glycolipid | Apoptosis | Chemotherapy | Chromatin | Colon cancer | Analysis | Lipids | Cancer
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8. Full Text A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity
by TSUZUKI, Satoshi and KIMOTO, Yusaku and LEE, Shinhye and SUGAWARA, Tatsuya and MANABE, Yuki and INOUE, Kazuo
Biomedical Research, ISSN 0388-6107, 2018, Volume 39, Issue 3, pp. 117 - 129
Class B scavenger receptors, scavenger receptor B1 (SR-B1) and cluster of differentiation 36 (CD36), are broadly expressed cell-surface proteins and are... 
Reverse transcription | Lipids | CD36 antigen | Mammals | Metabolism | Gene expression | Aldehydes | Epithelium | Cell surface | Odorants | Aliphatic compounds | Polymerase chain reaction | Proteins | Receptors | Nose | Scavenger receptors | Volatile compounds | Lipid metabolism | Olfactory epithelium | Surface layers | Odor compounds
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9. Full Text Effects of feeding on plasma concentrations of vitamin A in captive African penguins (Spheniscus demersus)
by UEDA, Kentaro and AKASHI, Fumiko and KAWASAKI, Motoki and SUGAWARA, Tatsuya and MANABE, Yuki and MATSUI, Tohru
Journal of Veterinary Medical Science, ISSN 0916-7250, 2019, Volume 81, Issue 11, pp. 1580 - 1585
Vitamin A comprises vitamin A1 and vitamin A2; vitamin A1 is retinol and its fatty-acid esters and vitamin A2 is 3,4-didehydroretinol and its fatty-acid... 
Plasma | Esters | Birds | Bioavailability | Palmitic acid | Rapid flow | Feeding | Blood levels | Vitamin A | Acids | Retinene | Vitamin E | Fish | Portal vein
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10. Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells)
by Hindupur Ravi and Nawneet Kurrey and Yuki Manabe and Tatsuya Sugawara and Vallikannan Baskaran
Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, ISSN 0928-4931, 10/2018, Volume 91, p. 785
Fucoxanthin (FUCO), a marine carotenoid is photo-, and thermo-labile and poorly bioavailable due to its lipophilicity. Hence, we developed a chitosan... 
Chromatin | Bax protein | Bcl-2 protein | Medical treatment | Colorectal cancer | Caspase | Fucoxanthin | Bioavailability | Caspase-3 | Anticancer properties | Mitochondria | Carotenoids | Colon cancer | Micelles | DNA fragmentation | Colon | Chitosan | Viability | Lipophilicity | Deoxyribonucleic acid--DNA | Apoptosis | Cancer
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11. Full Text Biodegradable Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanocapsules: An Efficient Carrier for Improved Solubility, Bioavailability, and Anticancer Property of Lutein
by Arunkumar, Ranganathan and Prashanth, Keelara Veerappa Harish and Manabe, Yuki and Hirata, Takashi and Sugawara, Tatsuya and Dharmesh, Shylaja Mallaiah and Baskaran, Vallikannan
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 06/2015, Volume 104, Issue 6, pp. 2085 - 2093
Lutein bioavailability is limited because of its poor aqueous solubility. In this study, lutein-poly (lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)... 
poly(lactic/glycolic) acid (PLGA or PLA) | poorly water-soluble drugs | polymeric drug carrier | bioavailability | antioxidants | biodegradable polymers | nanocapsules | pharmacokinetics | X-ray powder diffractometry | X‐ray powder diffractometry | poorly water‐soluble drugs | DRUG | poly(lactic | CHEMISTRY, MEDICINAL | VIVO | ENCAPSULATION | CURCUMIN-LOADED PLGA | MODEL | FORMULATION | CHEMISTRY, MULTIDISCIPLINARY | glycolic) acid (PLGA or PLA | DELIVERY | NANOPARTICLES | IN-VITRO | ORAL BIOAVAILABILITY | PHARMACOLOGY & PHARMACY | Lactic Acid - chemistry | Drug Stability | Humans | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Biological Availability | Male | Polyethylene Glycols - chemistry | Lutein - chemistry | Nanocapsules - chemistry | Hep G2 Cells | Lutein - pharmacokinetics | Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Lutein - administration & dosage | Polyglycolic Acid - chemistry | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - pharmacokinetics | Lutein - pharmacology | Tagetes - chemistry | Antioxidants | Drugs | Drug delivery systems | Care and treatment | Hydrogen | Polyethylene glycol | Analysis | Pharmacists | Cancer | Vehicles
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12. Full Text Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy
by Fujita, Hayato and Ohuchida, Kenoki and Mizumoto, Kazuhiro and Itaba, Soichi and Ito, Tetsuhide and Nakata, Kohei and Yu, Jun and Kayashima, Tadashi and Souzaki, Ryota and Tajiri, Tatsuro and Manabe, Tatsuya and Ohtsuka, Takao and Tanaka, Masao
Neoplasia, ISSN 1476-5586, 10/2010, Volume 12, Issue 10, pp. 807,IN7 - 817,IN8
The standard palliative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) is gemcitabine-based chemotherapy; however, PDAC still presents a major... 
CELL LUNG-CANCER | SURVIVAL | DEOXYCYTIDINE KINASE | ONCOLOGY | RESECTION | ADENOCARCINOMA | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1 | RESISTANCE | RANDOMIZED-TRIAL | CYTIDINE DEAMINASE | MESSENGER-RNA LEVELS | Humans | Middle Aged | Carcinoma, Adenosquamous - drug therapy | Male | Gene Expression Profiling | Immunoenzyme Techniques | Feasibility Studies | Deoxycytidine Kinase - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Deoxycytidine Kinase - genetics | Ribonucleoside Diphosphate Reductase - metabolism | Tumor Cells, Cultured | Gene Expression Regulation, Neoplastic - physiology | Tumor Suppressor Proteins - metabolism | Cytidine Deaminase - genetics | RNA, Messenger - genetics | Equilibrative Nucleoside Transporter 1 - genetics | Pancreatic Neoplasms - genetics | Ribonucleoside Diphosphate Reductase - genetics | Survival Rate | Treatment Outcome | Equilibrative Nucleoside Transporter 1 - metabolism | Carcinoma, Adenosquamous - genetics | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Biopsy, Fine-Needle | Antimetabolites, Antineoplastic - therapeutic use | Cytidine Deaminase - metabolism | Aged | Biomarkers, Tumor - genetics | Deoxycytidine - analogs & derivatives
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13. Full Text A role for scavenger receptor B1 as a captor of specific fatty acids in taste buds of circumvallate papillae
by TSUZUKI, Satoshi and LEE, Shinhye and KIMOTO, Yusaku and SUGAWARA, Tatsuya and MANABE, Yuki and INOUE, Kazuo
Biomedical Research, ISSN 0388-6107, 2018, Volume 39, Issue 6, pp. 295 - 300
Class B scavenger receptor family members, scavenger receptor B1 (SR-B1) and cluster of differentiation 36 (CD36), are broadly expressed cell-surface proteins,... 
MEDICINE, RESEARCH & EXPERIMENTAL | SR-BI | RECOGNITION | LIGANDS | LOW-DENSITY-LIPOPROTEIN | OXIDIZED PHOSPHOLIPIDS | CD36 | IDENTIFICATION | BINDING | EXPRESSION | INHIBIT | Oleic Acids - metabolism | Taste Buds - metabolism | Tongue | Animals | CD36 Antigens - metabolism | Mice, Inbred C57BL | Taste Buds - cytology | Mice | Fatty Acids, Unsaturated - metabolism | RNA, Messenger - metabolism | Taste buds | Taste receptor neurons | Reverse transcription | Lipids | CD36 antigen | Mammals | Metabolism | Fatty acids | Cell surface | Polymerase chain reaction | Proteins | Oral cavity | Oleic acid | Taste | Lipid metabolism | Papillae
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14. Full Text Vascular anatomy of the transverse mesocolon and bidirectional laparoscopic D3 lymph node dissection for patients with advanced transverse colon cancer
by Ueki, Takashi and Ueki, Takashi and Nagai, Shuntato and Nagai, Shuntato and Manabe, Tatsuya and Manabe, Tatsuya and Koba, Ryo and Koba, Ryo and Nagayoshi, Kinuko and Nagayoshi, Kinuko and Nakamura, Masafumi and Nakamura, Masafumi and Tanaka, Masao and Tanaka, Masao
Surgical Endoscopy, ISSN 0930-2794, 7/2019, Volume 33, Issue 7, pp. 2257 - 2266
Laparoscopic D3 lymph node dissection for transverse colon cancer is technically demanding because of complicated anatomy. Here, we reviewed the vascular... 
Vascular anatomy | Medicine & Public Health | Surgery | Gynecology | Hepatology | D3 lymph node dissection | Gastroenterology | Abdominal Surgery | Transverse colon cancer | Laparoscopic surgery | Proctology | SURGERY | SURVIVAL | SHORT-TERM OUTCOMES | RESECTION | LIGATION | COLECTOMY | EXCISION | CARCINOMA | METACHRONOUS COLORECTAL-CANCER | Care and treatment | Cancer patients | Laparoscopy | Colon cancer
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15. Full Text The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse
by Kiyama, Yuji and Kikkawa, Yayoi S and Kinoshita, Makoto and Matsumoto, Yu and Kondo, Kenji and Fujimoto, Chisato and Iwasaki, Shinichi and Yamasoba, Tatsuya and Manabe, Toshiya
Laboratory Investigation, ISSN 0023-6837, 11/2018, Volume 98, Issue 11, pp. 1364 - 1374
Cadherin 11 (Cdh11), a member of the cadherin adhesion molecule family, is expressed in various regions of the brain as well as the head and ear. To gain... 
MEDICINE, RESEARCH & EXPERIMENTAL | ANXIETY | CAVITATION | TIP-LINK | TEMPORAL BONES | MICE | MECHANISMS | CLASSIC CADHERINS | PATHOLOGY | MESENCHYME | EXPRESSION | STARTLE | Brain | Head | Mesenchyme | Brain stem | Inflammation | Geographical variations | Hearing impairment | Cadherin | Cavitation | Neural crest | Adhesion | Hearing loss | Rodents | Ear | Otitis media | Mice | Middle ear
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16. Full Text Phosphatidic Acid Produced by Phospholipase D Promotes RNA Replication of a Plant RNA Virus
by Hyodo, Kiwamu and Taniguchi, Takako and Manabe, Yuki and Kaido, Masanori and Mise, Kazuyuki and Sugawara, Tatsuya and Taniguchi, Hisaaki and Okuno, Tetsuro
PLoS Pathogens, ISSN 1553-7366, 05/2015, Volume 11, Issue 5, p. e1004909
Eukaryotic positive-strand RNA [(+) RNA] viruses are intracellular obligate parasites replicate using the membrane-bound replicase complexes that contain... 
DEFENSE RESPONSES | ACTIVATION | VIRAL-RNA | PROTEIN | MICROBIOLOGY | MOSAIC-VIRUS | UNTRANSLATED REGION | CAP-INDEPENDENT TRANSLATION | VIROLOGY | ARABIDOPSIS | BINDING | DISEASE RESISTANCE | PARASITOLOGY | RNA, Small Interfering - genetics | Immunoprecipitation | RNA, Messenger - genetics | Gene Silencing | Plant Leaves - virology | RNA, Plant - genetics | Phospholipase D - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Phospholipase D - metabolism | Blotting, Western | RNA, Viral - genetics | Virus Replication | Tobacco - virology | Phosphatidic Acids - metabolism | Phospholipase D - genetics | Real-Time Polymerase Chain Reaction | Tombusviridae - physiology | RNA viruses | Virus diseases of plants | Genetic aspects | Phospholipases | Health aspects | Plant viruses | Enzymes | Membranes | Lipids | Viruses | Infections | Genomes | RNA polymerase | Kinases | Metabolism | Mammals | Experiments | Proteins | Acids | Metabolites | Red clover | Flowers & plants
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