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Advances in experimental medicine and biology, ISSN 0065-2598, 2019, Volume 1159, p. 139
Inflammation is a powerful immune countermeasure to tissue damage and infection. The inflammatory response is complex and requires the involvement of myriad... 
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7771 - 13
Mammalian Sphingosine kinase 2 is the primary enzyme responsible for phosphorylating FTY720 to its active form, FTY720-P. Systemic FTY720 treatment confers... 
APOPTOSIS | ORAL FINGOLIMOD | INHIBITION | 1-PHOSPHATE RECEPTOR | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | SPHINGOSINE-1-PHOSPHATE | EGRESS | IMMUNOSUPPRESSANT | TYPE-2 | DRUG FTY720 | Phosphorylation | Sphingosine kinase | Cell death | Light | FTY720 | Retina | Photoreceptors | Kinases | Apoptosis
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2018, Volume 19, Issue 12, p. 3885
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182390
To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-[beta]) in order to develop... 
Sphingosine | Vitamin C | Sphingolipids | Research | Transforming growth factors | Health aspects
Journal Article
Journal of Diabetes and Its Complications, ISSN 1056-8727, 03/2019, Volume 33, Issue 3, pp. 195 - 201
Sphingolipids have a fundamental role in many cellular processes, and they have been implicated in insulin resistance and Diabetes Mellitus (DM) and its... 
Ceramide | Diabetic retinopathy | Vitreous | Sphingolipids | Diabetes Mellitus | PROFILES | LIPID-PEROXIDATION | AQUEOUS-HUMOR | METABOLISM | CELL-MIGRATION | INSULIN-RESISTANCE | SPHINGOSINE-1-PHOSPHATE | ENDOCRINOLOGY & METABOLISM | RETINOPATHY | INSIGHTS | Type 2 diabetes | Membrane lipids | Analysis | Sphingosine | Ceramides | Insulin resistance | Ophthalmology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2013, Volume 110, Issue 14, p. 5446
  Autosomal-dominant Stargardt-like macular dystrophy [Stargardt3 (STGD3)] results from single allelic mutations in the elongation of very-long-chain fatty... 
Proteins | Pathology | Chemical reactions | Cytotoxicity | Mutation | Fatty acids | Muscular dystrophy
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1609, pp. 267 - 276
The role of sphingolipids, mainly sphingosine 1-phosphate (S1P) and the receptors for which it serves as a ligand, is an interesting and promising area in both... 
Angiogenesis | Cornea | Neovascularization | Sphingosine 1-phosphate | Immunohistochemistry | Lysophospholipids - metabolism | Sphingosine - analogs & derivatives | Animals | Models, Biological | Humans | Cornea - physiology | Sphingosine - metabolism | Wound Healing | Microscopy, Fluorescence | Neovascularization, Physiologic
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2008, Volume 105, Issue 35, p. 12843
  Stargardt-like macular dystrophy (STGD3) is a dominantly inherited juvenile macular degeneration that eventually leads to loss of vision. Three independent... 
Proteins | Macular degeneration | Genotype & phenotype | Rodents | Mutation | Gene expression | Fatty acids
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182390
Purpose To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-beta) in order to... 
HUMAN HEPATIC MYOFIBROBLASTS | GROWTH-FACTOR-BETA | MULLER GLIAL-CELLS | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | IN-VITRO MODEL | ENDOTHELIAL-CELL MIGRATION | EXTRACELLULAR-MATRIX | 1-PHOSPHATE STIMULATES PROLIFERATION | RECEPTOR EXPRESSION PROFILE | SPHINGOSINE 1-PHOSPHATE | Corneal Stroma - drug effects | Corneal Stroma - metabolism | Humans | Sphingolipids - metabolism | Blotting, Western | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Sphingosine - analogs & derivatives | Protein Isoforms - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Fibrosis | Lysophospholipids - pharmacology | Cell Extracts | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Wound Healing - drug effects | Fibroblasts - metabolism | Phosphates | Health sciences | Neurosciences | Cornea | Collagen (type I) | Ascorbic acid | Leukocyte migration | Transforming growth factor-b | Smooth muscle | Stimulation | Sphingolipids | Kinases | Sphingosine 1-phosphate | Cell adhesion & migration | Angiogenesis | Actin | Vitamin C | Fibroblasts | Extracellular matrix | Assembly | Sphingosine kinase | Stroma | Data processing | Gene expression | Antibiotics | Isoforms | Cell migration | Cancer
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2009, Volume 46, Issue 5, pp. 672 - 679
Age-related macular degeneration (AMD) is a complex disease that has potential involvement of inflammatory and oxidative stress-related pathways in its... 
AMD | Photoreceptors | Retina | Curcumin | Light-induced retinal degeneration | OXIDATIVE DAMAGE | LIPID-PEROXIDATION | ALBINO-RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | TRANSGENIC RATS | RESPONSIVE ELEMENT | COLON-CANCER CELLS | TRANSCRIPTION FACTOR EGR-1 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NF-KAPPA-B | Rats, Wistar | Apoptosis - drug effects | Humans | Oxidative Stress - physiology | Transcriptional Activation - drug effects | Gene Expression Profiling | Cytoprotection - physiology | Curcumin - administration & dosage | Macular Degeneration - drug therapy | Protein Processing, Post-Translational - drug effects | Retinal Cone Photoreceptor Cells - pathology | Macular Degeneration - enzymology | Phytotherapy | Disease Models, Animal | Electroretinography | Macular Degeneration - etiology | NF-kappa B - antagonists & inhibitors | Light - adverse effects | Cells, Cultured | Curcumin - pharmacology | Retinal Cone Photoreceptor Cells - physiology | Rats | Animals | Retinal Cone Photoreceptor Cells - drug effects | Mice | Apoptosis - physiology | Dietary Supplements | Macular Degeneration - pathology | Antigens | Diabetic retinopathy | Hydrogen peroxide | RNA | Streptozocin | Lactate dehydrogenase | Superoxide dismutase | Superoxide | Macular degeneration | Proteins | Methyl aspartate | Cell death | Analysis | Heme | Ophthalmology | Vascular endothelial growth factor | photoreceptors | light-induced retinal degeneration
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38616
Damage to the retinal pigment epithelium (RPE) is an early event in the pathogenesis of age-related macular degeneration (AMD). X-box binding protein 1 (XBP1)... 
ACTIVATION | LIGHT DAMAGE | SOD1-DEFICIENT MICE | ER STRESS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TRANSCRIPTION FACTOR XBP-1 | MACULAR DEGENERATION | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | EXPRESSION | Retinal Pigment Epithelium - metabolism | Superoxide Dismutase - genetics | Superoxide Dismutase - biosynthesis | Antioxidants - metabolism | Glutathione Synthase - biosynthesis | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Retinal Pigment Epithelium - ultrastructure | Glutathione Synthase - genetics | Eye Proteins - genetics | Transcription Factors - immunology | DNA-Binding Proteins - immunology | Catalase - genetics | Cell Survival | Rats | Rats, Sprague-Dawley | Regulatory Factor X Transcription Factors | Mice, Knockout | Transcription Factors - metabolism | Macular Degeneration - metabolism | Animals | Eye Proteins - metabolism | Macular Degeneration - genetics | Mice | Superoxide Dismutase-1 | Catalase - biosynthesis | Macular Degeneration - pathology | Macular degeneration | Epithelium | Cell death | Analysis | Genes | Protein binding | Health sciences | Oxidative stress | Neurosciences | Laboratories | Pathogenesis | Leukemia | Homeostasis | Retina | Superoxide dismutase | Activation | Retinal pigment epithelium | Glutathione synthase | Proteins | Catalase | Neurodegeneration | Ultrastructure | Rodents | Light | Activating transcription factor 1 | Vascular endothelial growth factor | Glutathione | Thickening | Binding | Enzymes | Cell survival | siRNA | Gene expression | Electron microscopy | Survival | Light effects | Medicine | Retinal degeneration | Photoreceptors | Diabetes | Endoplasmic reticulum | Endocrinology | Apoptosis
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 4, pp. 636 - 648
The pathophysiology of human keratoconus (KC), a bilateral progressive corneal disease leading to protrusion of the cornea, stromal thinning, and scarring, is... 
Lipidomics | Cornea | Transforming growth factor-β | RETINAL DEGENERATION | FIBROSIS | OXIDATIVE STRESS | cornea | BIOCHEMISTRY & MOLECULAR BIOLOGY | PENETRATING KERATOPLASTY | SPHINGOSINE 1-PHOSPHATE | CERAMIDE SYNTHASES | CELL-DEATH | transforming growth factor-beta | IN-VITRO MODEL | THERAPEUTIC TARGETS | LIGHT-INDUCED DEGENERATION | lipidomics | Lysophospholipids - administration & dosage | Transforming Growth Factor beta1 - administration & dosage | Fibroblasts - physiology | Humans | Transforming Growth Factor beta2 - administration & dosage | Sphingosine - administration & dosage | Keratoconus - genetics | Lysophospholipids - biosynthesis | Cornea - pathology | Keratoconus - pathology | Transforming Growth Factor beta3 - administration & dosage | Fibroblasts - metabolism | Fingolimod Hydrochloride - administration & dosage | Ceramides - administration & dosage | Cell Line | Signal Transduction | RNA, Messenger - genetics | Sphingolipids - metabolism | Sphingolipids - isolation & purification | Ceramides - genetics | Cornea - metabolism | Sphingosine - analogs & derivatives | Sphingolipids - genetics | Sphingosine - biosynthesis | Fibroblasts - drug effects | Collagen (type III) | Smooth muscle | mRNA | Sphingolipids | Sphingosine 1-phosphate | Signal transduction | Actin | Keratoconus | FTY720 | Isoforms | Fibroblasts | Ceramide | transforming growth factor-β
Journal Article