X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (34) 34
animals (32) 32
index medicus (27) 27
pharmacology & pharmacy (22) 22
chemistry, medicinal (14) 14
male (14) 14
mice (14) 14
rats (12) 12
biochemistry & molecular biology (9) 9
pharmacokinetics (9) 9
drug interactions (8) 8
kinetics (8) 8
mitogen-activated protein kinases - metabolism (7) 7
phenolic antioxidants (7) 7
rats, sprague-dawley (7) 7
apoptosis (6) 6
apoptosis - drug effects (6) 6
drugs (6) 6
metabolism (6) 6
metabolites (6) 6
oncology (6) 6
structure-activity relationship (6) 6
tumor cells, cultured (6) 6
ya-subunit gene (6) 6
anticarcinogenic agents - pharmacology (5) 5
chemistry, analytical (5) 5
identification (5) 5
mapk (5) 5
mass spectrometry (5) 5
microsomes, liver - metabolism (5) 5
p-glycoprotein (5) 5
tissue distribution (5) 5
absorption (4) 4
biochemical research methods (4) 4
c-jun (4) 4
caspases (4) 4
caspases - metabolism (4) 4
chemopreventive agents (4) 4
chromatography, liquid (4) 4
discovery (4) 4
disease (4) 4
enzyme activation - drug effects (4) 4
gpcr (4) 4
human liver-microsomes (4) 4
in-vitro (4) 4
liver (4) 4
map kinase (4) 4
mice, inbred balb c (4) 4
n-terminal kinase-1 (4) 4
pharmaceutical preparations - metabolism (4) 4
phase ii drug metabolizing enzymes (4) 4
receptors, ccr2 - antagonists & inhibitors (4) 4
signal transduction (4) 4
administration, oral (3) 3
adult (3) 3
algorithms (3) 3
area under curve (3) 3
biological transport - drug effects (3) 3
biomedicine (3) 3
biotransformation (3) 3
breast neoplasms - pathology (3) 3
butylated hydroxyanisole (3) 3
calcium - metabolism (3) 3
calcium-calmodulin-dependent protein kinases - metabolism (3) 3
cancer resistance protein (3) 3
ccr2 (3) 3
chemistry, organic (3) 3
chemokine (3) 3
crma-inhibitable protease (3) 3
death (3) 3
design (3) 3
disposition (3) 3
dogs (3) 3
dose-response relationship, drug (3) 3
enzyme activation (3) 3
enzyme induction (3) 3
enzyme induction - drug effects (3) 3
enzyme inhibitors - pharmacology (3) 3
glutathione-s-transferase (3) 3
green tea polyphenols (3) 3
hek293 cells (3) 3
hurdles (3) 3
inducible expression (3) 3
inhibition (3) 3
isothiocyanates (3) 3
jnk activation (3) 3
jnk mitogen-activated protein kinases (3) 3
kappa-b (3) 3
liver - metabolism (3) 3
microsomes (3) 3
microsomes, liver - drug effects (3) 3
model (3) 3
monocyte chemoattractant protein-1 (3) 3
ms/ms (3) 3
n-terminal kinase (3) 3
neoplasms - prevention & control (3) 3
nf-kappa-b (3) 3
oxidative stress (3) 3
p38 mitogen-activated protein kinases (3) 3
permeability (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Drug Metabolism and Disposition, ISSN 0090-9556, 06/2017, Volume 45, Issue 6, p. 676
Ortho Tri-Cyclen, a two-drug cocktail comprised of ethinylestradiol and norgestimate (13-ethyl-17-acetoxy-18, 19-dinor-17α-pregn-4-en-20yn-3 oxime), is... 
Ethinylestradiol | Cytochrome | Liver | Cytochrome P450 | Drug interactions | Metabolism | Modulators | Microsomes | Metabolites | Deacetylation | Biotransformation | Phenotyping | Predictions | Uridine | Drug interaction | Static models | Recombinant
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 06/2017, Volume 45, Issue 6, p. 604
Inside-out–oriented membrane vesicles are useful tools to investigate whether a compound can be an inhibitor of efflux transporters such as multidrug... 
Efflux | Multidrug resistance | Fluorescence | Membrane vesicles | Estradiol | Substrates | Proteins | Stimulators | Sex hormones | Vesicles | Kinetics | Inhibition | Transport | Binding sites | Steroid hormones | Steroids
Journal Article
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 09/2015, Volume 36, Issue 6, pp. 385 - 397
In recent years prodrug strategy has been used extensively to improve the pharmacokinetic properties of compounds exhibiting poor bioavailability. Mechanistic... 
intestinal S9 | in situ perfusion model | absorption | portal vein cannulation | carboxylesterase | prodrugs | intestinal metabolism | ANIMALS | DESIGN | ORAL ABSORPTION | DISPOSITION | ISOZYMES | DIFFERENCE | METABOLISM | CATALYTIC-PROPERTIES | LIVER | PHARMACOLOGY & PHARMACY | MALEATE | Enalapril | Enalaprilat
Journal Article
Bioanalysis, 10/2017, Volume 9, Issue 19, p. 1441
Dried blood spots (DBS) offer significant ethical and scientific advantages; however preparation of calibration curves often times, off-sets some of these... 
Reference Standards | Animals | Health Resources - supply & distribution | Male | Mice | Mice, Inbred BALB C | Calibration | Hydroxychloroquine - blood | Dried Blood Spot Testing - standards | Hydroxychloroquine - pharmacokinetics
Journal Article
Bioanalysis, 07/2017, Volume 9, Issue 13, p. 987
The objective of this study was to develop a LC-MS/MS method for the simultaneous determination of triazolam (TRZ) and its two hydroxy metabolites in... 
Triazolam - blood | Limit of Detection | Animals | Triazolam - metabolism | Dried Blood Spot Testing - methods | Mass Spectrometry | Triazolam - pharmacokinetics | Chromatography, Liquid | Mice, Transgenic | Mice | Mice, Inbred BALB C
Journal Article
Bioanalysis, ISSN 1757-6180, 10/2017, Volume 9, Issue 19, pp. 1441 - 1450
Aim: Dried blood spots (DBS) offer significant ethical and scientific advantages; however preparation of calibration curves often times, off-sets some of these... 
pharmacokinetics | hematocrit | blank DBS cards spiked with standard | dried blood spots | internal standards | HCQ | CHEMISTRY, ANALYTICAL | FUTURE-DIRECTIONS | BIOCHEMICAL RESEARCH METHODS | VALIDATION | MS/MS | STRATEGIES | INTERNAL STANDARD | DATE | PROGRESS | SAMPLES | BIOANALYSIS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2000, Volume 275, Issue 4, pp. 2322 - 2327
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 07/2001, Volume 60, Issue 1, pp. 217 - 224
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.