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eLife, ISSN 2050-084X, 12/2012, Volume 2012, Issue 1, p. e00047
Innate immunity is the first immunological defence against pathogens. During virus infection detection of nucleic acids is crucial for the inflammatory... 
NEUTROPHIL EXTRACELLULAR TRAPS | INTRACELLULAR DNA | DAI DLM-1/ZBP1 | MAMMALIAN DNA | IN-VIVO | BIOLOGY | V(D)J RECOMBINATION | DEPENDENT PROTEIN-KINASE | CYTOSOLIC DNA | AUTOIMMUNE-DISEASE | CYTOPLASMIC DNA | Embryo, Mammalian | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | DNA-Binding Proteins - deficiency | Vaccinia virus - immunology | DNA-Activated Protein Kinase - genetics | Nuclear Proteins - deficiency | Herpesvirus 1, Human - immunology | Influenza A virus - immunology | Nuclear Proteins - genetics | DNA-Activated Protein Kinase - deficiency | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Fibroblasts - virology | DNA-Binding Proteins - immunology | Signal Transduction | Gene Expression Regulation - immunology | Membrane Proteins - genetics | DNA, Viral - metabolism | Protein-Serine-Threonine Kinases - genetics | V(D)J Recombination | Membrane Proteins - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | DNA, Viral - immunology | Animals | DNA Repair - immunology | Interferon Type I - genetics | Fibroblasts - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Primary Cell Culture | DNA-Activated Protein Kinase - immunology | Cytokines - biosynthesis | Protein kinase C | Severe combined immunodeficiency | Transcription | Genes | Viruses | Innate immunity | Infections | Kinases | DNA repair | Proteins | Fibroblasts | Sensors | Localization | Deoxyribonucleic acid--DNA | RNA viruses | Fractionation | Statistical analysis | Cytokines | V(D)J recombination | Inflammation | RNA polymerase | Pattern recognition | DNA viruses | DNA-dependent protein kinase | Interferon regulatory factor 3 | Cytoplasm | Chemokines
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2011, Volume 7, Issue 9, p. e1002247
Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-beta (IFN-beta) induction, a key event in the antiviral innate immune... 
KAPPA-B KINASE | RNA | RIG-I | MICROBIOLOGY | INDUCTION | CYTOPLASMIC DNA | ANTIVIRAL RESPONSES | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | HOST-DEFENSE | INTERFERONS | PARASITOLOGY | Phosphorylation | Protein Binding - genetics | Virulence Factors - genetics | Humans | Open Reading Frames | NF-kappa B - metabolism | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Receptors, Pattern Recognition - metabolism | I-kappa B Kinase - metabolism | HEK293 Cells | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Viral Proteins - genetics | I-kappa B Kinase - genetics | Immunity, Innate | Interferon Regulatory Factor-7 - metabolism | Immune Evasion | Interferon-beta - metabolism | NF-kappa B - genetics | Virus Replication | Gene Expression Regulation, Viral | Plasmids | Genes, Regulator | Interferon Regulatory Factor-3 - metabolism | Virulence Factors - metabolism | Vaccinia virus - physiology | Physiological aspects | Immune response | Research | Viral proteins | DNA viruses | Health aspects | Cell culture | Genes | Colleges & universities | Viruses | Pattern recognition | RNA polymerase | Kinases | Experiments | Proteins | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 06/2018, Volume 46, Issue 10, pp. 5269 - 5285
Abstract Interferon-induced proteins with tetratricopeptide repeats (IFITs) are highly expressed during the cell-intrinsic immune response to viral infection.... 
VIRUS | PROTEIN | MEMBERS | MESSENGER-RNA | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELECTROSTATICS | PDB2PQR | INTERFERONS | REVEALS | RNA and RNA-protein complexes
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 10, pp. 5991 - 6002
Background: Poxviruses contain several virulence factors with no identifiable cellular homologues. Results: Vaccinia virus immunomodulatory protein A49 adopts... 
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 05/2019, Volume 202, Issue 9, pp. 2671 - 2681
Brucella abortus is a facultative intracellular bacterium that causes brucellosis, a prevalent zoonosis that leads to abortion and infertility in cattle, and... 
SUBTILASE CYTOTOXIN | ACTIVATION | PATHWAY | DNA | SENSOR | DEGRADATION | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | IFN-BETA INDUCTION | LINKS ER STRESS
Journal Article
ISSN 1999-4915, 2017
Herpes simplex virus 1 (HSV-1) has extensive interactions with the host DNA damage response (DDR) machinery that can be either detrimental or beneficial to the... 
Cell Line | Genome, Viral | Interferons | Humans | Viral Proteins | Herpesvirus 1, Human | Herpes Simplex | Animals | Virion | Virus Replication | DNA End-Joining Repair | Genes, Viral | Mice | DNA-Binding Proteins
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, p. 36339
Targeting regions of proteins that show a high degree of structural conservation has been proposed as a method of developing immunotherapies and vaccines that... 
DESIGN | E-GLYCOPROTEIN | PROTEIN | NEUTRALIZING ANTIBODY | FLAVIVIRUS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | MUTATION | INFLUENZA-A VIRUSES | MONOCLONAL-ANTIBODY | INFECTION | RNA viruses | Conserved sequence | Antigenicity | Peptides | Dengue fever | Dengue | Antibodies | Serotypes | Envelope protein | Viruses | Genomes | Vaccines
Journal Article
Phytotherapy Research, ISSN 0951-418X, 10/2015, Volume 29, Issue 10, p. 1509
  Several plant species are used in Brazil to treat inflammatory diseases and associated conditions. TNF-[alpha] plays a pivotal role on inflammation, and... 
Medicinal plants | Medicine, Herbal | Tumor necrosis factor | Medicine, Botanic
Journal Article