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1. Full Text A structural model for multimodular NRPS assembly lines
by Marahiel, Mohamed A
Natural Product Reports, ISSN 0265-0568, 2/2016, Volume 33, Issue 2, pp. 136 - 14
This viewpoint article focuses on the structures of the dissected catalytic domains of non-ribosomal peptide synthetases (NRPSs) associated with substrate... 
CHEMISTRY, MEDICINAL | PROTOTYPE | CRYSTAL-STRUCTURE | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACTIN | CHEMISTRY, ORGANIC | ADENYLATION DOMAINS | CYCLIZATION | Models, Molecular | Catalytic Domain | Molecular Structure | Peptide Synthases - metabolism
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2. Full Text Siderophore-Based Iron Acquisition and Pathogen Control
by Marcus Miethke and Mohamed A. Marahiel
Microbiology and Molecular Biology Reviews, ISSN 1092-2172, 09/2007, Volume 71, Issue 3, pp. 413 - 451
Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ATP-BINDING CASSETTE | FERRIC ENTEROBACTIN RECEPTOR | NONRIBOSOMAL PEPTIDE SYNTHETASE | BIOSYNTHETIC GENE-CLUSTER | OUTER-MEMBRANE RECEPTOR | ESCHERICHIA-COLI K-12 | MICROBIOLOGY | MAJOR FACILITATOR SUPERFAMILY | CHORISMATE-UTILIZING ENZYMES | GELATINASE-ASSOCIATED LIPOCALIN | STREPTOMYCES-COELICOLOR GENOME | Amino Acid Sequence | Bacteria - metabolism | Signal Transduction | Siderophores - metabolism | Humans | Anti-Infective Agents - therapeutic use | Molecular Sequence Data | Iron - metabolism | Peptide Synthases - metabolism | Siderophores - chemistry | Sequence Alignment | Animals | Peptide Synthases - chemistry | Models, Biological | Bacteria - pathogenicity | Gene Expression Regulation, Bacterial | Siderophores - antagonists & inhibitors | Homeostasis | Sideroblastic anemia | Iron compounds | Research | Chemical properties | Iron bacteria | Reviews
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3. Full Text Nonribosomal peptide synthetases: structures and dynamics
by Strieker, Matthias and Tanović, Alan and Marahiel, Mohamed A
Current Opinion in Structural Biology, ISSN 0959-440X, 2010, Volume 20, Issue 2, pp. 234 - 240
Nonribosomal peptide synthetases (NRPSs) are large multimodular biocatalysts that utilize complex regiospecific and stereospecific reactions to assemble... 
ANTIBIOTICS | CRYSTAL-STRUCTURE | BIOSYNTHESIS | THIOESTERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYKETIDE | SUPERFAMILY | FATTY-ACID SYNTHASE | ADENYLATION DOMAINS | SURFACTIN SYNTHETASE | CYCLIZATION | CELL BIOLOGY | Catalytic Domain | Animals | Peptides - metabolism | Peptide Synthases - chemistry | Peptides - chemistry | Models, Biological | Humans | Substrate Specificity | Protein Conformation | Peptide Biosynthesis, Nucleic Acid-Independent - physiology
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4. Full Text Working outside the protein‐synthesis rules: insights into non‐ribosomal peptide synthesis
by Marahiel, Mohamed A
Journal of Peptide Science, ISSN 1075-2617, 12/2009, Volume 15, Issue 12, pp. 799 - 807
Non‐ribosomally synthesized microbial peptides show remarkable structural diversity and constitute a widespread class of the most potent antibiotics and other... 
non‐ribosomal peptide synthetases | NRPS | structures of NRPS‐domains and modules | peptide antibiotics | protein dynamics | Peptide antibiotics | Non-ribosomal peptide synthetases | Protein dynamics | Structures of NRPS-domains and modules | CYTOCHROME-P450 | CHEMISTRY, ANALYTICAL | ANTIBIOTICS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | non-ribosomal peptide synthetases | structures of NRPS-domains and modules | THIOESTERASE DOMAIN | VANCOMYCIN | BIOSYNTHESIS | POLYKETIDE | CONDENSATION DOMAIN | MACROCYCLIZATION | CYCLIZATION | Protein Biosynthesis | Peptides - chemistry | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Peptide Biosynthesis, Nucleic Acid-Independent | Peptides - genetics | Amino Acids - chemistry | Models, Molecular | Molecular Sequence Data | Ribosomes - metabolism | Amino Acids - genetics | Peptide Synthases - metabolism | Amino Acids - metabolism | Peptides - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Molecular Structure
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5. Full Text Biosynthesis of nonribosomal peptides
by Finking, R and Marahiel, MA
ANNUAL REVIEW OF MICROBIOLOGY, ISSN 0066-4227, 2004, Volume 58, Issue 1, pp. 453 - 488
Bacteria and fungi use large multifunctional enzymes, the so-called nonribosomal peptide synthetases (NRPSs), to produce peptides of broad structural and... 
hybrid genes | COLI ENTEROBACTIN SYNTHETASE | OPEN READING FRAME | ASSEMBLY-LINE ENZYMOLOGY | MICROBIOLOGY | biosynthetic strategies | SITE-DIRECTED MUTAGENESIS | GRAMICIDIN-S SYNTHETASE | COENZYME-A CARBOXYLASE | 4 '-phosphopantetheinyl transferases | ACYL CARRIER PROTEIN | ADENYLATE-FORMING ENZYMES | FATTY-ACID SYNTHASE | nonribosomal peptide synthetases | IN-VITRO RECONSTITUTION | tailoring enzymes | 4′- phosphopantetheinyl transferases | Biosynthetic strategies | Tailoring enzymes | Hybrid genes | Nonribosomal peptide synthetases | Biosynthesis | Synthesis | Research | Peptides
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6. Full Text Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
by Arnison, Paul G and Bibb, Mervyn J and Bierbaum, Gabriele and Bowers, Albert A and Bugni, Tim S and Bulaj, Grzegorz and Camarero, Julio A and Campopiano, Dominic J and Challis, Gregory L and Clardy, Jon and Cotter, Paul D and Craik, David J and Dawson, Michael and Dittmann, Elke and Donadio, Stefano and Dorrestein, Pieter C and Entian, Karl-Dieter and Fischbach, Michael A and Garavelli, John S and Göransson, Ulf and Gruber, Christian W and Haft, Daniel H and Hemscheidt, Thomas K and Hertweck, Christian and Hill, Colin and Horswill, Alexander R and Jaspars, Marcel and Kelly, Wendy L and Klinman, Judith P and Kuipers, Oscar P and Link, A. James and Liu, Wen and Marahiel, Mohamed A and Mitchell, Douglas A and Moll, Gert N and Moore, Bradley S and Müller, Rolf and Nair, Satish K and Nes, Ingolf F and Norris, Gillian E and Olivera, Baldomero M and Onaka, Hiroyasu and Patchett, Mark L and Piel, Joern and Reaney, Martin J. T and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W and Selsted, Michael E and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Süssmuth, Roderich D and Tagg, John R and Tang, Gong-Li and Truman, Andrew W and Vederas, John C and Walsh, Christopher T and Walton, Jonathan D and Wenzel, Silke C and Willey, Joanne M and van der Donk, Wilfred A
ISSN 0265-0568, 12/2012, Volume 3, Issue 1, pp. 18 - 16
Covering: 1988 to 2012 This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides... 
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7. Full Text Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature
by Arnison, Paul G and Bibb, Mervyn J and Bierbaum, Gabriele and Bowers, Albert A and Bugni, Tim S and Bulaj, Grzegorz and Camarero, Julio A and Campopiano, Dominic J and Challis, Gregory L and Clardy, Jon and Cotter, Paul D and Craik, David J and Dawson, Michael and Dittmann, Elke and Donadio, Stefano and Dorrestein, Pieter C and Entian, Karl-Dieter and Fischbach, Michael A and Garavelli, John S and Göransson, Ulf and Gruber, Christian W and Haft, Daniel H and Hemscheidt, Thomas K and Hertweck, Christian and Hill, Colin and Horswill, Alexander R and Jaspars, Marcel and Kelly, Wendy L and Klinman, Judith P and Kuipers, Oscar P and Link, A. James and Liu, Wen and Marahiel, Mohamed A and Mitchell, Douglas A and Moll, Gert N and Moore, Bradley S and Müller, Rolf and Nair, Satish K and Nes, Ingolf F and Norris, Gillian E and Olivera, Baldomero M and Onaka, Hiroyasu and Patchett, Mark L and Piel, Joern and Reaney, Martin J. T and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W and Selsted, Michael E and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Süssmuth, Roderich D and Tagg, John R and Tang, Gong-Li and Truman, Andrew W and Vederas, John C and Walsh, Christopher T and Walton, Jonathan D and Wenzel, Silke C and Willey, Joanne M and Van Der Donk, Wilfred A and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för läkemedelskemi and Uppsala universitet and Farmaceutiska fakulteten and Avdelningen för farmakognosi
Natural Product Reports, ISSN 0265-0568, 2013, Volume 30, Issue 1, pp. 108 - 160
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly... 
CHEMISTRY, MEDICINAL | AMINOACYL-TRANSFER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELONGATION-FACTOR-G | CHEMISTRY, ORGANIC | PROMOTES SECONDARY METABOLISM | STREPTOMYCES SP RE-701 | NATRIURETIC-FACTOR ANF | LASSO PEPTIDE | BIOSYNTHETIC GENE-CLUSTER | CYCLOTIDE CYCLOVIOLACIN O2 | GENOME-MINING APPROACH | IN-VITRO RECONSTITUTION | Amino Acid Sequence | Biological Products - classification | Peptides - chemistry | Humans | Molecular Sequence Data | Ribosomes - metabolism | Biological Products - pharmacology | Peptides - pharmacology | Biological Products - chemical synthesis | Biological Products - chemistry | Peptides - chemical synthesis | Ribosomes - genetics | Molecular Structure | Peptides - classification | Protein Processing, Post-Translational | Naturvetenskap | Natural Sciences | Medical and Health Sciences | Medicin och hälsovetenskap
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8. Full Text Lasso Peptides: An Intriguing Class of Bacterial Natural Products
by Hegemann, Julian D and Zimmermann, Marcel and Xie, Xiulan and Marahiel, Mohamed A
Accounts of Chemical Research, ISSN 0001-4842, 07/2015, Volume 48, Issue 7, pp. 1909 - 1919
CONSPECTUS: Natural products of peptidic origin often represent a rich source of medically relevant compounds. The synthesis of such polypeptides in nature is... 
STREPTOMYCES SP | SEQUENCE-ANALYSIS | LEADER PEPTIDE | ANTIBIOTIC MICROCIN J25 | SIAMYCIN-II | ESCHERICHIA-COLI | GENOME-MINING APPROACH | BIOLOGICAL-PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | RNA-POLYMERASE | Biological Products - metabolism | Models, Molecular | Bacteria - metabolism | Biological Products - chemistry | Peptides - metabolism | Peptides - chemistry | Research | Chemical properties | Peptides | Ribosomal proteins | Natural products
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9. Full Text Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis:  Approaches to New Antibiotics
by Sieber, Stephan A and Marahiel, Mohamed A
Chemical Reviews, ISSN 0009-2665, 02/2005, Volume 105, Issue 2, pp. 715 - 738
ACYL CARRIER PROTEIN | ANTITUMOR DRUG BLEOMYCIN | MICROTUBULE-STABILIZING AGENTS | ADENYLATE-FORMING ENZYMES | BIOSYNTHETIC GENE-CLUSTER | INITIATION MODULE PHEATE | STREPTOMYCES-VERTICILLUS ATCC15003 | ASSEMBLY-LINE ENZYMOLOGY | FATTY-ACID SYNTHASE | GRAMICIDIN-S SYNTHETASE | CHEMISTRY, MULTIDISCIPLINARY | Animals | Genetic Engineering | Peptide Biosynthesis | Cyclization | Anti-Bacterial Agents - chemistry | Models, Molecular | Anti-Bacterial Agents - biosynthesis | Molecular Structure | Peptides, Cyclic - biosynthesis | Peptide Synthases - genetics | Peptides, Cyclic - chemistry | Peptide Synthases - metabolism
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10. Full Text Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery
by Robbel, Lars and Marahiel, Mohamed A
Journal of Biological Chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 36, pp. 27501 - 27508
Daptomycin (Cubicin (R)) is a branched cyclic lipopeptide antibiotic of nonribosomal origin and the prototype of the acidic lipopeptide family. It was approved... 
PEPTIDE ANTIBIOTICS | COMBINATORIAL BIOSYNTHESIS | GENE-CLUSTER | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | STREPTOMYCES-ROSEOSPORUS | STAPHYLOCOCCUS-AUREUS | DOMAINS | A21978C | ANTIBIOTIC DAPTOMYCIN | Daptomycin - pharmacology | Bacteria - metabolism | Daptomycin - chemistry | Genetic Engineering | Daptomycin - biosynthesis | Anti-Bacterial Agents - chemistry | Bacteria - cytology | Bacteria - drug effects | Ribosomes | Anti-Bacterial Agents - biosynthesis | Anti-Bacterial Agents - pharmacology | Infection | Pathogens | Antibiotics | lipopeptides | daptomycin | Skin | Drug resistance | Bacteremia | Pharmaceuticals | Antibiotic | Peptide Biosynthesis | NRPS | Enzyme Catalysis | MRSA | Daptomycin | Minireviews | Drug Action | Multifunctional Enzymes | Metabolism | Combinatorial Biosynthesis | Drug Resistance
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