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Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7447, pp. 108 - 112
Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection(1,2). Repeat biopsies to study genomic evolution as a result of... 
HETEROGENEITY | LUNG-CANCER | ACTIVATION | EVOLUTION | VARIANTS | AXL | MULTIDISCIPLINARY SCIENCES | TAMOXIFEN RESISTANCE | TUMOR-CELLS | MUTATIONS | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Genomics | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Ovarian Neoplasms - genetics | Neoplasms - genetics | DNA Mutational Analysis | Female | Antineoplastic Agents - pharmacology | DNA, Neoplasm - analysis | Ovarian Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Intercellular Signaling Peptides and Proteins - genetics | Breast Neoplasms - drug therapy | Genome, Human - genetics | Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Plasma - chemistry | Alleles | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Neoplasms - pathology | Mediator Complex Subunit 1 - genetics | Drug Resistance, Neoplasm - drug effects | Evolution, Molecular | Antimitotic agents | Care and treatment | Physiological aspects | Dosage and administration | Genetic aspects | Research | Nucleotide sequencing | Drug resistance | Antineoplastic agents | DNA sequencing | Blood plasma | Cancer | Plasma | Biopsy | Breast cancer | Genomes | Mutation | Patients | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, p. 8760
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic... 
HETEROGENEITY | ACTIVATION | VARIANTS | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | ACQUIRED-RESISTANCE | SEQUENCING DATA | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Humans | Receptor, ErbB-2 - metabolism | Clonal Evolution - genetics | Tamoxifen - administration & dosage | Case-Control Studies | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Carcinoma, Ductal, Breast - drug therapy | Neoplasm Metastasis | Lung Neoplasms - secondary | Adult | Carcinoma, Ductal, Breast - pathology | Female | Quinazolines - administration & dosage | Lapatinib | Liver Neoplasms - secondary | Carcinoma, Ductal, Breast - metabolism | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Deoxycytidine - administration & dosage | Brain Neoplasms - genetics | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Sequence Analysis, DNA | Spinal Neoplasms - secondary | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Spinal Neoplasms - genetics | Bayes Theorem | DNA, Neoplasm - genetics | Mutation | Deoxycytidine - analogs & derivatives | Biological evolution | Breast cancer | Genomes | Metastasis | ErbB-2 protein | Patients | Metastases | Heterogeneity | Biopsy | Breast | Evolution | Deoxyribonucleic acid--DNA | Cancer | Tumors
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 9, pp. 1055 - 1060
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2017, Volume 389, pp. S99 - S99
Abstract Background Circulating tumour DNA (ctDNA) is released by cancer cells into the bloodstream, which can be analysed via liquid biopsy. Analysis of... 
Internal Medicine | Metastasis | Analysis | DNA | Melanoma | Gene mutations | Oncology, Experimental | Research | Cancer
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2018, Volume 10, Issue 12, pp. e9323 - n/a
Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell-free tumor DNA (cftDNA) in cerebrospinal fluid (CSF)... 
cell-free DNA | shallow WGS | glioma | fragmentation | cerebrospinal fluid | MEDICINE, RESEARCH & EXPERIMENTAL | Gene mutations | Gliomas | Genomics | DNA | Genetic research | Genetic aspects | Genomes | Cancer | Body fluids | Glioma | Biopsy | Copy number | Fluid | DNA fragmentation | Cerebrospinal fluid | Deoxyribonucleic acid--DNA | DNA sequencing | Tumors | Report | Biomarkers & Diagnostic Imaging | cell‐free DNA
Journal Article
BMC Medical Genomics, ISSN 1755-8794, 05/2017, Volume 10, Issue 1, pp. 1 - 12
Background An increasing number of precision oncology programmes are being launched world-wide. To support this development, we present the Cancer Variant... 
Personalized oncology | Melanoma | Molecular tumor board | Prioritization | Cancer variant explorer | WGCNA | Co-expression network | TCGA | Lung cancer | Genomics | Genes | Exploration | Oncology | Genomes | DNA repair | Data bases | Studies | Proteins | Annotations | Mutation | Bioinformatics | Deoxyribonucleic acid--DNA | Tumors | Cancer
Journal Article
BMC Research Notes, ISSN 1756-0500, 2011, Volume 4, Issue 1, pp. 88 - 88
Atlantic salmon (Salmo salar L.) is an environmentally and economically important organism and its gene content is reasonably well characterized. From a... 
Usage | RNA | Comparative genomic hybridization | Physiological aspects | Atlantic salmon | Genetic aspects | Research | Gene expression | Studies | Fish | Salmon | Aquaculture
Journal Article
The Journal of Urology, ISSN 0022-5347, 04/2018, Volume 199, Issue 4, pp. e1062 - e1063
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 06/2018, Volume 10, Issue 6, p. n/a
Tumour heterogeneity leads to the development of multiple resistance mechanisms during targeted therapies. Identifying the dominant driver(s) is critical for... 
lung cancer | circulating tumour | targeted therapy | resistance mechanisms | DNA | liquid biopsy | circulating tumour DNA | MEDICINE, RESEARCH & EXPERIMENTAL | DIGITAL PCR | GEFITINIB | NSCLC | ADENOCARCINOMAS | ACQUIRED-RESISTANCE | HETEROGENEITY | EVOLUTION | CIRCULATING TUMOR DNA | MUTATIONS | INHIBITOR | Carcinoma, Non-Small-Cell Lung - pathology | Hydroxychloroquine - therapeutic use | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Prognosis | Carcinoma, Non-Small-Cell Lung - genetics | Humans | ErbB Receptors - genetics | Lung Neoplasms - pathology | Treatment Outcome | Antineoplastic Agents - therapeutic use | Gefitinib - therapeutic use | Tumor Suppressor Protein p53 - genetics | DNA Copy Number Variations | Drug Resistance, Neoplasm - genetics | DNA, Neoplasm - blood | DNA Mutational Analysis | Survival Analysis | Tumor Suppressor Protein p53 - chemistry | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Longitudinal Studies | Hydroxychloroquine | Analysis | Genomics | Genetic research | Genomes | Genetic aspects | Nucleotide sequencing | Lung cancer, Non-small cell | Tumor proteins | DNA sequencing | Cancer | Plasma | Transformation | Epidermal growth factor receptors | Copy number | Invasiveness | p53 Protein | Lung cancer | Patients | Medical prognosis | Gefitinib | PTEN protein | Tumors | Respiratory System | Pharmacology & Drug Discovery
Journal Article
Annals of Applied Statistics, ISSN 1932-6157, 12/2016, Volume 10, Issue 4, pp. 2377 - 2404
Tumours develop in an evolutionary process, in which the accumulation of mutations produces subpopulations of cells with distinct mutational profiles, called... 
Tumour heterogeneity | Clonal deconvolution | Phylogeny | Latent feature model | Admixture | EVOLUTION | admixture | RECONSTRUCTION | latent feature model | phylogeny | STATISTICS & PROBABILITY | INFERENCE | CANCER | GENOME | tumour heterogeneity
Journal Article
ISSN 0008-5472, 2018
The factors responsible for the low detection rate of cell-free tumor DNA (ctDNA) in the plasma of glioblastoma (GB) patients are currently unknown. In this... 
Journal Article
Cancer Research, ISSN 0008-5472, 01/2019, Volume 79, Issue 1, pp. 220 - 230
The factors responsible for the low detection rate of cell-free tumor DNA (ctDNA) in the plasma of patients with glioblastoma (GBM) are currently unknown. In... 
ORIGIN | EVOLUTION | ONCOLOGY | CENTRAL-NERVOUS-SYSTEM | SERUM | MICE | CEREBROSPINAL-FLUID | BLOOD-BRAIN-BARRIER | CANCER | CARCINOMA | PUNCTURE | Patient-derived orthotopic xenograft | Blood brain barrier | mitochondrial DNA | Circulating DNA | Glioblastoma
Journal Article