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Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 452 - 455
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2018, Volume 9, Issue 4, pp. 354 - 358
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening... 
tirasemtiv | imidazo[4,5-b]pyrazin-2-one | troponin | Amyotrophic lateral sclerosis (ALS) | skeletal muscle activator | CHEMISTRY, MEDICINAL | SAFETY | HUMANS | AMYOTROPHIC-LATERAL-SCLEROSIS | POTENTIAL THERAPEUTIC APPROACH | YOUNG | CARDIAC MYOSIN | CONTRACTION | TOLERABILITY | DISEASE
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2010, Volume 1, Issue 9, pp. 472 - 477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit... 
cardiac myosin | small molecule enzyme activator | Omecamtiv mecarbil | systolic heart failure | MORTALITY | CHROMATOGRAPHIC ANALYSIS | CHEMISTRY, MEDICINAL | HUMAN SERUM-ALBUMIN | HEART-FAILURE | PROTEIN BINDING | CARBAMAZEPINE BINDING
Journal Article
Science (Washington), ISSN 0036-8075, 03/2011, Volume 331, Issue 6023, pp. 1439 - 1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling... 
Heart | Cascades | Myosin | Activation | Mathematical models | Catalysis | Failure | Ejection
Journal Article
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