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Journal Article
Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6319, pp. aaf6814 - aaf6814
Journal Article
by Flannick, Jason and Mercader, Josep M and Fuchsberger, Christian and Udler, Miriam S and Mahajan, Anubha and Wessel, Jennifer and Teslovich, Tanya M and Caulkins, Lizz and Koesterer, Ryan and Barajas-Olmos, Francisco and Blackwell, Thomas W and Boerwinkle, Eric and Brody, Jennifer A and Centeno-Cruz, Federico and Chen, Ling and Chen, Siying and Contreras-Cubas, Cecilia and Córdova, Emilio and Correa, Adolfo and Cortes, Maria and DeFronzo, Ralph A and Dolan, Lawrence and Drews, Kimberly L and Elliott, Amanda and Floyd, James S and Gabriel, Stacey and Garay-Sevilla, Maria Eugenia and García-Ortiz, Humberto and Gross, Myron and Han, Sohee and Heard-Costa, Nancy L and Jackson, Anne U and Jørgensen, Marit E and Kang, Hyun Min and Kelsey, Megan and Kim, Bong-Jo and Koistinen, Heikki A and Kuusisto, Johanna and Leader, Joseph B and Linneberg, Allan and Liu, Ching-Ti and Liu, Jianjun and Lyssenko, Valeriya and Manning, Alisa K and Marcketta, Anthony and Malacara-Hernandez, Juan Manuel and Martínez-Hernández, Angélica and Matsuo, Karen and Mayer-Davis, Elizabeth and Mendoza-Caamal, Elvia and Mohlke, Karen L and Morrison, Alanna C and Ndungu, Anne and Ng, Maggie C. Y and O’Dushlaine, Colm and Payne, Anthony J and Pihoker, Catherine and Post, Wendy S and Preuss, Michael and Psaty, Bruce M and Vasan, Ramachandran S and Rayner, N. William and Reiner, Alexander P and Revilla-Monsalve, Cristina and Robertson, Neil R and Santoro, Nicola and Schurmann, Claudia and So, Wing Yee and Soberón, Xavier and Stringham, Heather M and Strom, Tim M and Tam, Claudia H. T and Thameem, Farook and Tomlinson, Brian and Torres, Jason M and Tracy, Russell P and van Dam, Rob M and Vujkovic, Marijana and Wang, Shuai and Welch, Ryan P and Witte, Daniel R and Wong, Tien-Yin and Atzmon, Gil and Barzilai, Nir and Blangero, John and Bonnycastle, Lori L and Bowden, Donald W and Chambers, John C and Chan, Edmund and Cheng, Ching-Yu and Cho, Yoon Shin and Collins, Francis S and de Vries, Paul S and Duggirala, Ravindranath and Glaser, Benjamin and Gonzalez, Clicerio and Gonzalez, Ma Elena and Groop, Leif and Kooner, Jaspal Singh and Kwak, Soo Heon and ... and DiscovEHR Collaboration and ESP and GoT2D and SIGMA-T2D and Broad Genomics Platform and AMP-T2D-GENES and LuCamp and T2D-GENES and CHARGE and ProDiGY
Nature, ISSN 0028-0836, 06/2019, Volume 570, Issue 7759, pp. 71 - 76
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of... 
Type 2 diabetes | Genetic research | Genetic aspects | Research | Exome sequencing | Medical colleges | Analysis | Diabetes therapy | Sequences | Disease | Pathogenesis | Genes | Diabetes mellitus | Hispanic Americans | Health risks | Genomes | Epidemiology | Disease control | Studies | Proteins | Genetic variance | Gene frequency | Alleles | Heritability | Gene loci | Diabetes | Diabetes mellitus (non-insulin dependent) | Power
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H. Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca A and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas J and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper and Diabetes - Cardiovascular Disease and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and Diabetes - kardiovaskulär sjukdom and Lund University and Genomics, Diabetes and Endocrinology and EpiHealth: Epidemiology for Health and Genomik, diabetes och endokrinologi and Institutionen för kliniska vetenskaper, Malmö and Lunds universitet and Department of Clinical Sciences, Malmö
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2252 - 11
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient... 
HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | MULTIDISCIPLINARY SCIENCES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | HAN CHINESE | CHINESE POPULATION | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - genetics | Humans | Homeostasis | Male | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Genetic Variation | Diabetes Mellitus, Type 2 - etiology | Female | Lipoprotein Lipase - metabolism | Genetic Association Studies | Mice, Inbred C57BL | Risk Factors | Gene Silencing | Angiopoietin-like 4 Protein - deficiency | Mice, Knockout | Whole Exome Sequencing | Animals | Insulin Resistance - genetics | Angiopoietin-like 4 Protein - metabolism | Heterozygote | Mice | Blood Glucose - metabolism | Amino Acid Substitution | Angiopoietin-like 4 Protein - genetics | Deactivation | Angiopoietin | Diabetes mellitus | Health risks | Risk reduction | Risk | Lipoprotein lipase | Glucose | Lipase | Inactivation | Insulin | Proteins | Confidence intervals | Sensitivity | Nutrient loss | Rodents | Arteriosclerosis | Atherosclerosis | Genetics | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 01/2018, Volume 102, Issue 1, pp. 103 - 115
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca Andrea and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas John and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper
ISSN 2041-1723, 2018
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2016, Volume 48, Issue 6, pp. 593 - 599
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than... 
GENETIC-VARIATION | AFRICA | EVOLUTION | VARIANTS | EXPANSION | GENETICS & HEREDITY | FRAMEWORK | ANCESTOR | COPY NUMBER VARIATION | INFERENCE | ASSOCIATION | Haplotypes | Chromosomes, Human, Y | Demography | Humans | Male | Polymorphism, Single Nucleotide | Mutation | Phylogeny | Research | Genetic variation | Analysis | Y chromosome | Studies | Genotype & phenotype | Laboratories | Genomes | Grants | Molecular biology | Chromosomes | Index Medicus
Journal Article