X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, organic (118) 118
index medicus (102) 102
chemistry, medicinal (89) 89
alzheimer's disease (76) 76
derivatives (74) 74
humans (68) 68
alzheimer disease - drug therapy (46) 46
animals (44) 44
biochemistry & molecular biology (42) 42
chemistry, multidisciplinary (42) 42
neuroprotection (42) 42
carbohydrates (41) 41
analysis (39) 39
cholinesterase inhibitors - pharmacology (39) 39
cyclization (38) 38
cholinesterase inhibitors - chemistry (37) 37
alzheimer’s disease (35) 35
inhibitors (35) 35
cholinesterase inhibitors - chemical synthesis (34) 34
antioxidants (33) 33
models, molecular (33) 33
alzheimers-disease (31) 31
oxidative stress (31) 31
acetylcholinesterase - metabolism (30) 30
acetylcholinesterase (29) 29
acetylcholinesterase inhibitors (28) 28
neuroprotective agents - pharmacology (28) 28
neurosciences (28) 28
structure-activity relationship (27) 27
molecular structure (26) 26
molecular modeling (24) 24
drug therapy (23) 23
pharmacology & pharmacy (23) 23
stereoisomerism (23) 23
tacrine (23) 23
drugs (22) 22
neuroprotective agents - chemistry (22) 22
carbocycles (21) 21
ring closure reactions (21) 21
analogs (20) 20
rats (20) 20
biological evaluation (19) 19
donepezil (18) 18
ligands (18) 18
neuroprotective agents - chemical synthesis (18) 18
route (18) 18
synthesis (18) 18
cholinesterase inhibitors - therapeutic use (17) 17
design (17) 17
butyrylcholinesterase - metabolism (16) 16
research (16) 16
tacrine - chemistry (16) 16
target-directed ligands (16) 16
acetylcholinesterase - chemistry (15) 15
antioxidants - pharmacology (15) 15
butyrylcholinesterase (15) 15
cholinesterases (15) 15
enzyme inhibitors (15) 15
hep g2 cells (15) 15
antioxidant (14) 14
antioxidants - chemistry (14) 14
catalysis (14) 14
cell line, tumor (14) 14
cell survival - drug effects (14) 14
hepatotoxicity (14) 14
hybrids (14) 14
tacrine - pharmacology (14) 14
ache (13) 13
antioxidants - chemical synthesis (13) 13
chemistry (13) 13
binding sites (12) 12
models (12) 12
monoamine oxidase (12) 12
neurodegenerative diseases (12) 12
potent (12) 12
stereochemistry (12) 12
alzheimer disease - metabolism (11) 11
buche (11) 11
chemical properties (11) 11
chemistry, applied (11) 11
cholinesterase inhibitors (11) 11
cholinesterase-inhibitors (11) 11
drug design (11) 11
male (11) 11
molecular conformation (11) 11
monoamine oxidase - metabolism (11) 11
pharmacology (11) 11
beta-amyloid aggregation (10) 10
calcium - metabolism (10) 10
cholinesterases - metabolism (10) 10
directed ligands (10) 10
dose-response relationship, drug (10) 10
dual inhibitors (10) 10
enynes (10) 10
in-vitro (10) 10
inhibition (10) 10
inhibition mechanism (10) 10
kinetic analysis (10) 10
kinetics (10) 10
mao-a (10) 10
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 10/2019, Volume 10, Issue 10, pp. 1361 - 1362
A recent review from Prof. Garrett on the causes and cures of Alzheimer's disease prompts the author to insist in that beyond the "A beta Tau" praxis other... 
CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2017, Volume 17, Issue 31, pp. 3318 - 3318
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 11/2011, Volume 11, Issue 22, pp. 2714 - 2715
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 15, pp. 6937 - 6943
Contilisant, a permeable, antioxidant, and neuroprotectant agent, showing high nM affinity at H3R and excellent inhibition of the monoamine oxidases and... 
IN-VITRO | POTENT | CHEMISTRY, MEDICINAL | H-3 RECEPTOR ANTAGONISTS | LIGANDS | MEMORY | BIOLOGICAL EVALUATION | SIGMA RECEPTOR | ACETYLCHOLINESTERASE INHIBITORS | IDENTIFICATION | DERIVATIVES
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 03/2018, Volume 9, Issue 3, pp. 401 - 403
No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal... 
CHEMISTRY, MEDICINAL | multitarget-small molecules | selective drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | DESIGNED MULTIPLE LIGANDS | Alzheimer's disease | NEUROSCIENCES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8251 - 8270
Journal Article
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 08/2009, Volume 42, Issue 8, pp. 1026 - 1036
Organometallic chemistry provides powerful tools for the stereocontrolled synthesis of heterocycles and carbocycles. The electrophilic transition metals Pt(II)... 
REARRANGEMENT | ACTIVATION | SKELETAL REORGANIZATION | POLYFUNCTIONALIZED 1,6-ENYNES | CYCLOPROPANATION | PTCL2-CATALYZED CYCLOISOMERIZATIONS | ALKYNES | CHEMISTRY, MULTIDISCIPLINARY | PTCL2-MEDIATED CYCLOISOMERIZATION | HYDROARYLATION | ENYNES
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 2184 - 2201
We describe herein the synthesis and neuroprotective capacity of an array of 31 compounds comprising quinolyloximes, quinolylhydrazones, quinolylimines, QNs,... 
DESIGN | CHEMISTRY, MEDICINAL | NITRONE | TRAPS | FOCAL CEREBRAL-ISCHEMIA | N-TERT-BUTYL | NITRIC-OXIDE | AGENTS | RADICALS | NXY-059 | DERIVATIVES
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2013, Volume 13, Issue 15, pp. 1745 - 1770
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | Ca2+ dyshomeostasis | BACE‐1 inhibitors | amyloid–β antiaggregating agents | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | Ca2+ overload | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | overload | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | dyshomeostasis | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | GSK-3 ss inhibitors | anti-inflammatory drugs | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | NMDA RECEPTOR ANTAGONIST | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article