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Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7709, pp. 307 - 312
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies(1-3). In this strategy, the T cell genome... 
B-CELL | 5-METHYLCYTOSINE | CONVERSION | MULTIDISCIPLINARY SCIENCES | 5-HYDROXYMETHYLCYTOSINE | MUTATIONS | PROTEINS | CD28 COSTIMULATION | DNA INTEGRATION | 5-FORMYLCYTOSINE | LYMPHOCYTES | Clone Cells - cytology | Dioxygenases - metabolism | Immunotherapy - methods | Epigenesis, Genetic | Humans | Male | Adoptive Transfer | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Recombinant Fusion Proteins - metabolism | T-Lymphocytes - transplantation | T-Lymphocytes - metabolism | Clone Cells - immunology | HEK293 Cells | Cell Differentiation | Transgenes | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Clinical Trials as Topic | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Dioxygenases - genetics | 5-Methylcytosine - metabolism | T-Lymphocytes - cytology | Alleles | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | Mutation | Genetic engineering | Research | T cells | Immunotherapy | Oncology, Experimental | Cancer | Leukemia | Differentiation (biology) | Insertion | Genomes | Lymphocytes T | Lymph nodes | Anticancer properties | Proteins | Infusion | Receptors | Lymphocytes | Peripheral blood | Bone marrow | Remission | Oxidation | Bioinformatics | Deoxyribonucleic acid--DNA | Dioxygenase | Antigens | Chronic lymphatic leukemia | Phenotypes | Transposons | CD19 antigen | Cloning | T cell receptors | Cell differentiation | Patients | Progeny | Lymphocytes B | Stem cells | Epigenetics | Tumors
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1100 - 1100
Abstract BACKGROUND: Patients (pts) with follicular lymphoma (FL) who have progression of disease within 2 years of immunochemotherapy have poor outcomes and... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 217 - 217
Abstract Background Targeted immunotherapy with CTL019, CD19-specific chimeric antigen receptor (CAR)-modified T cells, can produce potent and sustained... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 220 - 220
Abstract Introduction CTL019 is a novel, investigational, chimeric antigen receptor (CAR) immunotherapy whereby autologous T cells are genetically modified... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 183 - 183
Abstract BACKGROUND: Autologous T cells genetically modified to express a chimeric antigen receptor consisting of an external anti-CD19 single chain antibody... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 683 - 683
Background Targeted immunotherapy with T cells expressing a chimeric antigen receptor (CAR) can produce dramatic anti-tumor responses. We previously... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 1982 - 1982
Abstract BACKGROUND: We have shown that infusion of autologous T cells genetically modified to express a chimeric antigen receptor (CAR) consisting of an... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 3087 - 3087
Abstract BACKGROUND: Autologous T cells genetically modified to express a chimeric antigen receptor consisting of an external anti-CD19 single chain antibody... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 1983 - 1983
Abstract CTL019 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) consisting of an external anti-CD19 domain with the... 
Journal Article
Journal Article
01/2008, ISBN 0549750622
Porcine Endogenous Retrovirus (PERV) is Porcine Endogenous Retrovirus (PERV) is a gammaretrovirus whose closest relatives include Murine Leukemia Virus (MLV)... 
Virology
Dissertation
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 900 - 900
Abstract Background: MLL partial tandem duplication (MLL PTD) occurs in approximately 5-8% of patients with acute myeloid leukemia (AML) and is associated with... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 3616 - 3616
Abstract Abstract 3616 We recently reported that in addition to down-regulating DMNT1 mRNA and inducing DNA hypomethylation, AZA has the ability to reduce the... 
Journal Article