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Movement Disorders, ISSN 0885-3185, 09/2014, Volume 29, Issue 11, pp. 1455 - 1461
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46834
Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and... 
PEPTIDE SEQUENCES | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | SELECTIVE UPTAKE | DISEASE | NEURODEGENERATION | CYTOSOLIC PROTEINS | ALPHA-SYNUCLEIN | MACROAUTOPHAGY | CELL | RAT-LIVER LYSOSOMES | Molecular Chaperones - metabolism | HSC70 Heat-Shock Proteins - metabolism | Humans | Autophagy | PC12 Cells | Nerve Tissue Proteins - chemistry | Lysosomes - metabolism | RNA Interference | Proteolysis | Peptide Fragments - genetics | Amino Acid Sequence | HSC70 Heat-Shock Proteins - genetics | Peptide Fragments - metabolism | Lysosome-Associated Membrane Glycoproteins - metabolism | Molecular Chaperones - genetics | Rats | Nerve Tissue Proteins - genetics | Blotting, Western | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Lysosome-Associated Membrane Glycoproteins - genetics | Protein Binding | HeLa Cells | Mutation | Amino Acid Motifs - genetics | Lysosomal-Associated Membrane Protein 2 | Microscopy, Fluorescence | Proteins | Brain | Huntington's chorea | Adenoviruses | Heat shock proteins | Genetic aspects | Research | Health aspects | Huntingtons disease | Neurosciences | Huntingtin | Laboratories | Pathogenesis | Parkinsons disease | Lysosomes | Biochemistry | Accumulation | Cell adhesion & migration | Degradation | Neurodegeneration | Neostriatum | Aging | Pharmaceutical sciences | Polyglutamine | Incubation | Cortex | Pharmacology | Huntington's disease | Overexpression | Hsc70 protein | Aberration | Alzheimers disease | Phagocytosis | Apoptosis | Heat shock
Journal Article
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2013, Volume 16, Issue 5, pp. 562 - 570
Huntington's disease is caused by expanded CAG repeats in HTT, conferring toxic gain of function on mutant HTT (mHTT) protein. Reducing mHTT amounts is... 
CELLS | MODIFIERS | PROTEASOMAL DEGRADATION | MOTOR | NEDD8 | IN MOUSE MODEL | NEUROPATHOLOGY | GENE HOMOLOG HDH | EXPRESSION | NEUROSCIENCES | DISEASE PROGRESSION | Physiological aspects | Genetic aspects | Research | Gene mutations | Huntington's chorea | Genomics
Journal Article
PLOS ONE, ISSN 1932-6203, 02/2019, Volume 14, Issue 2, p. e0212337
One response of cells to growth factor stimulus involves changes in morphology driven by the actin cytoskeleton and actin associated proteins which regulate... 
WILD-TYPE | TARGETED DISRUPTION | PROTEIN | LACKING HUNTINGTIN | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | CROSS-LINKING | EMBRYONIC LETHALITY | INTERFERENCE-REFLECTION | ARP2/3 COMPLEX | CELL | Neurons - pathology | Actin Cytoskeleton - metabolism | Huntingtin Protein - antagonists & inhibitors | Humans | Huntingtin Protein - metabolism | Huntington Disease - pathology | Cells, Cultured | Actin Cytoskeleton - chemistry | Platelet-Derived Growth Factor - pharmacology | Cell Adhesion - drug effects | Fibroblasts - pathology | Huntington Disease - metabolism | Microscopy, Confocal | Protein Isoforms - metabolism | RNA Interference | Cell Membrane - metabolism | Fibroblasts - cytology | Neurons - metabolism | Huntingtin Protein - genetics | Actinin - metabolism | RNA, Small Interfering - metabolism | Neurosciences | Phosphorylation | Membranes | Motility | Actinin | Huntingtin | Disease | Laboratories | Neurobiology | Mapping | Kinases | Cell adhesion & migration | Fibers | Proteins | Filaments | Actin | Cell adhesion | Fibroblasts | Contact stresses | Localization | Growth factors | Phenotypes | Neurons | Molecular interactions | siRNA | Adhesion | Neurology | Hospitals | Plasticity (synaptic) | Depletion | Microscopy | Vinculin | Morphology | Isoforms | Cytoskeleton | Mutation | Immunoreactivity | Immunofluorescence
Journal Article