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life sciences & biomedicine (27) 27
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1. Full Text Synaptic energy metabolism and neuronal excitability, in sickness and health
by Oyarzabal, Alfonso and Marin‐Valencia, Isaac
Journal of inherited metabolic disease, ISSN 0141-8955, 03/2019, Volume 42, Issue 2, pp. 220 - 236
epilepsy | seizures | glucose | neurotransmission | synapse | energy metabolism | Endocrinology & Metabolism | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Brain - metabolism | Animals | Synapses - metabolism | Energy Metabolism | Oxidation-Reduction | Humans | Glucose - metabolism | Epilepsy - metabolism | Seizures - metabolism | Neurons - metabolism | Synaptic Transmission | Astrocytes - metabolism | Energy metabolism | Neurons | Astrocytes | Epilepsy | Excitability | Glucose | Metabolism | Neurological diseases | Glucose metabolism | Synaptic transmission | Neurological complications | Oxidation | Seizures | Index Medicus
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2. Full Text Pathogenetic mechanisms of focal cortical dysplasia
by Marin‐Valencia, Isaac and Guerrini, Renzo and Gleeson, Joseph G
Epilepsia (Copenhagen), ISSN 0013-9580, 07/2014, Volume 55, Issue 7, pp. 970 - 978
mTOR | Focal cortical dysplasia | Mammalian target of rapamycin | PMSE syndrome | Giant cell | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Gene Targeting - methods | Humans | Anticonvulsants - administration & dosage | Signal Transduction - genetics | Malformations of Cortical Development - genetics | Epilepsy - epidemiology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | TOR Serine-Threonine Kinases - genetics | Signal Transduction - drug effects | Malformations of Cortical Development - epidemiology | Epilepsy - drug therapy | Epilepsy - genetics | Malformations of Cortical Development - drug therapy | Drug Delivery Systems - methods | Dysplasia | Head injuries | Analysis | Epilepsy | Medical research | Index Medicus
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3. Full Text Decreased carbon shunting from glucose toward oxidative metabolism in diet‐induced ketotic rat brain
by Zhang, Yifan and Zhang, Shenghui and Marin‐Valencia, Isaac and Puchowicz, Michelle A
Journal of neurochemistry, ISSN 0022-3042, 02/2015, Volume 132, Issue 3, pp. 301 - 312
oxidative metabolism | GABA | citric acid cycle | glucose | ketone bodies | brain amino acids | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Carbon - metabolism | Oxidation-Reduction | Rats, Wistar | Diet, Ketogenic | Ketone Bodies - metabolism | Propionic Acidemia - metabolism | Rats | Male | Animals | Energy Metabolism | gamma-Aminobutyric Acid - biosynthesis | Acetoacetates - metabolism | Glucose - metabolism | Brain Chemistry | Physiological aspects | Brain | Glucose | Dextrose | Citric acid | Neurochemistry | Amino acids | Metabolism | Rodents | Index Medicus
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4. Full Text 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
by Choi, Changho and Ganji, Sandeep K and DeBerardinis, Ralph J and Hatanpaa, Kimmo J and Rakheja, Dinesh and Kovacs, Zoltan and Yang, Xiao-Li and Mashimo, Tomoyuki and Raisanen, Jack M and Marin-Valencia, Isaac and Pascual, Juan M and Madden, Christopher J and Mickey, Bruce E and Malloy, Craig R and Bachoo, Robert M and Maher, Elizabeth A
Nature medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 624 - 629
Choline - metabolism | Magnetic Resonance Spectroscopy | Glutarates | Humans | Brain - enzymology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Statistics as Topic | Mutation - genetics | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Algorithms | Creatine - metabolism | Brain Mapping | Aspartic Acid - metabolism | Female | Aspartic Acid - analogs & derivatives | Enzymes | Medical imaging | Mutation | Gene expression | Brain cancer | Spectrum analysis | Index Medicus
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5. Full Text Heptanoate as a Neural Fuel: Energetic and Neurotransmitter Precursors in Normal and Glucose Transporter I-Deficient (G1D) Brain
by Marin-Valencia, Isaac and Good, Levi B and Ma, Qian and Malloy, Craig R and Pascual, Juan M
Journal of cerebral blood flow and metabolism, ISSN 0271-678X, 2/2013, Volume 33, Issue 2, pp. 175 - 182
glucose | glutamine | nuclear magnetic resonance | transporter | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Hematology | Science & Technology | Brain Chemistry - drug effects | Heptanoates - pharmacology | Seizures - genetics | Magnetic Resonance Spectroscopy | Seizures - drug therapy | Glutamine - metabolism | Acetyl Coenzyme A - genetics | Glucose - genetics | Glucose Transporter Type 1 | Mice, Transgenic | Seizures - metabolism | Anticonvulsants - pharmacology | Acetyl Coenzyme A - metabolism | Brain - metabolism | Heptanoates - metabolism | Animals | Energy Metabolism | Glutamine - genetics | Glucose - metabolism | Pyruvic Acid - metabolism | Mice | Triglycerides - pharmacology | Brain Chemistry - genetics | Index Medicus | Glucose transporter | Tricarboxylic acid cycle | Brain | Energy metabolism | Ketogenesis | Mass spectroscopy | Pyruvic acid | Fuels | ketones | Magnetic resonance spectroscopy | Gas chromatography | Glucose metabolism | Neurotransmitters | Spectrometry | Motivation | Cerebral blood flow | Neural stem cells | Glutamine | Seizures | Original
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6. Full Text PYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive
by Zaki, Maha S and Bhat, Gifty and Sultan, Tipu and Issa, Mahmoud and Jung, Hea‐Jin and Dikoglu, Esra and Selim, Laila and G. Mahmoud, Imam and Abdel‐Hamid, Mohamed S and Abdel‐Salam, Ghada and Marin‐Valencia, Isaac and Gleeson, Joseph G
Annals of neurology, ISSN 0364-5134, 07/2016, Volume 80, Issue 1, pp. 59 - 70
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microcephaly - genetics | Humans | Failure to Thrive - complications | Child, Preschool | Infant | Male | Mutation, Missense | Young Adult | Transfection | Fibroblasts | Female | Child | Pyrroline Carboxylate Reductases - biosynthesis | Gene Expression | Genetic Predisposition to Disease - genetics | Microcephaly - complications | Failure to Thrive - genetics | Microcephaly - diagnosis | Genotype | Codon, Nonsense | Pyrroline Carboxylate Reductases - genetics | Syndrome | Exome - genetics | Phenotype | Adolescent | Primary Cell Culture | Proteins | Mutation | Index Medicus | microcephaly | PYCR2 | proline metabolism | pyrroline-5-carboxylate reductase 2 | brain atrophy | hypomyelinating leukodystrophy-10
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7. Full Text The ratio of acetate‐to‐glucose oxidation in astrocytes from a single 13C NMR spectrum of cerebral cortex
by Marin‐Valencia, Isaac and Hooshyar, M. Ali and Pichumani, Kumar and Sherry, A. Dean and Malloy, Craig R
Journal of neurochemistry, ISSN 0022-3042, 01/2015, Volume 132, Issue 1, pp. 99 - 109
acetate | neuron | glucose | glia | Cerebral Cortex - chemistry | Magnetic Resonance Spectroscopy | Neurons - chemistry | Oxidation-Reduction | Acetates - metabolism | Mice, Inbred C57BL | Glutamine - metabolism | Cerebral Cortex - cytology | Acetyl Coenzyme A - metabolism | Cerebral Cortex - metabolism | Animals | Astrocytes - chemistry | Glucose - metabolism | Female | Glutamic Acid - metabolism | Mice | Neurons - metabolism | Ketoglutaric Acids - metabolism | Astrocytes - metabolism | Glucose metabolism | Brain | Analysis | Oxidation-reduction reaction | Nuclear magnetic resonance spectroscopy | Glucose | Glutamate | Dextrose | Glutamine | Neurochemistry | Neurotransmitters | Nuclear magnetic resonance--NMR | Index Medicus
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