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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2015, Volume 112, Issue 18, pp. E2395 - E2402
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 06/2016, Volume 134, Issue 6, p. 697
  Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) of cellular... 
Macular degeneration | Medical imaging | Blindness | Tomography | Pigments
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 06/2015, Volume 133, Issue 6, p. 653
  The patients evaluated in this study, to our knowledge, represent the first complete clinical description of a family with an autosomal dominant inheritance... 
Genotype & phenotype | Genetics | Mutation | Patients
Journal Article
Journal Article
American Journal of Ophthalmology, ISSN 0002-9394, 08/2019, Volume 204, pp. 70 - 79
To use projection-resolved optical coherence tomographic angiography (PR-OCTA) to characterize the microvascular changes in 3 distinct retinal plexuses in... 
DENSITY | VARIABILITY | ABNORMALITIES | QUANTIFICATION | MOUSE MODEL | SENSITIVITY | OPHTHALMOLOGY | PREVALENCE | CHOROIDAL BLOOD-FLOW | FLUORESCEIN ANGIOGRAPHY | THICKNESS | Development and progression | Algorithms | Angiography | Retinitis pigmentosa | Retina | Medical imaging | Mutation | Ophthalmology | Patients | Surgery
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 06/2019, Volume 303, pp. 91 - 100
Retinal gene therapy has had unprecedented success in generating treatments that can halt vision loss. However, immunogenic response and long-term toxicity... 
Eye | Retinal degeneration | Retina | mRNA | Transfection efficiency | Lipid nanoparticle | CELLS | EFFICACY | OPEN-LABEL | SIRNA DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | CHALLENGES | CATIONIC LIPIDS | IMMUNOGENICITY | DNA NANOPARTICLES | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | EFFICIENT | Nanoparticles | Anopheles | Messenger RNA | Genes | Genomics | World health | Lipids | Gene therapy | Gene expression
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0159776 - e0159776
Purpose To assess the neuroprotective effects of flibanserin (formerly BIMT-17), a dual 5-HT1A agonist and 5-HT2A antagonist, in a light-induced retinopathy... 
PHOTORECEPTOR CELL-DEATH | GREEN FLUORESCENT PROTEIN | OXIDATIVE STRESS | SEXUAL DESIRE DISORDER | ADENOVIRUS-MEDIATED DELIVERY | OPTICAL COHERENCE TOMOGRAPHY | RABBIT RETINA | MULTIDISCIPLINARY SCIENCES | PREMENOPAUSAL WOMEN EFFICACY | LIGHT-INDUCED RETINOPATHY | LEBERS CONGENITAL AMAUROSIS | Retina - drug effects | Retina - metabolism | Receptor, Serotonin, 5-HT2A - genetics | Apoptosis - drug effects | Apoptosis - radiation effects | Receptor, Serotonin, 5-HT1A - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | Retinal Diseases - metabolism | Antioxidants | Neuroprotective Agents - pharmacology | Retinal Diseases - etiology | Receptor, Serotonin, 5-HT1A - metabolism | Electroretinography | Retina - radiation effects | Cell Survival - drug effects | Retinal Diseases - diagnosis | Tomography, Optical Coherence | Light - adverse effects | Gene Knockout Techniques | Cell Survival - radiation effects | Animals | Serotonin Agents - pharmacology | Benzimidazoles - pharmacology | Mice | Retinal Diseases - drug therapy | Receptor, Serotonin, 5-HT2A - metabolism | Dose-Response Relationship, Radiation | Retina - pathology | Genetically modified mice | Care and treatment | Usage | Retinal degeneration | Research | Diagnosis | Gene expression | Neuroprotection | Oxidative stress | Transcription factors | Retinopathy | Bcl-2 protein | Science | Retina | Superoxide dismutase | Serotonin S1 receptors | Receptors | Mitochondria | Fos protein | Rodents | Light | Localization | c-Fos protein | Serotonin | Albinism | c-Jun protein | Federal regulation | Exposure | FDA approval | Serotonin S2 receptors | Cyclic AMP response element-binding protein | Luminous intensity | Optical Coherence Tomography | Photoreceptors | Apoptosis | Structure-function relationships | Index Medicus
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 01/2018, Volume 59, Issue 1, pp. 462 - 471
PURPOSE. To characterize the mediators of 5-HT2A serotonin receptor-driven retinal neuroprotection. METHODS. Albino mice were treated intraperitoneally with... 
Retinal degeneration | Light damage | MAPK/ERK | Sarpogrelate | 5-HT2A | PATHWAYS | APOPTOSIS | retinal degeneration | ANTAGONIST | PROTECTION | PHOSPHORYLATION | G-PROTEINS | MAP KINASES | MECHANISMS | light damage | DEGENERATION | PHOTORECEPTOR CELL-DEATH | sarpogrelate | OPHTHALMOLOGY | Index Medicus | Retina | MAPK | ERK
Journal Article
Retina (Philadelphia, Pa.), ISSN 0275-004X, 04/2019, p. 1
Choroideremia is an incurable, X-linked, recessive retinal dystrophy caused by loss of function mutations in the CHM gene. It is estimated to affect... 
Journal Article