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Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 15, pp. 6217 - 6222
Journal Article
Immunity, ISSN 1074-7613, 04/2012, Volume 36, Issue 4, pp. 646 - 657
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2008, Volume 180, Issue 2, pp. 341 - 355
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 261 - 266
The B-cell CLL/lymphoma 2 (Bcl2) relative Myeloid cell leukemia sequence 1 (Mcl1) is essential for cell survival during development and for tissue homeostasis... 
Proteins | Germ cells | Thymocytes | Spermatogenesis | Myeloid leukemia | Alleles | Cell lines | Gene expression regulation | Cells | Apoptosis | Programmed cell death | Protein turnover | SURVIVAL | SPERMATOGENESIS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL MATRIX | DEFICIENT MICE | CELL-DEATH | protein turnover | DESTRUCTION | LEUKEMIA | programmed cell death | ANTAGONISTS | PROTEINS | TRANSGENIC MICE | Humans | Leukemia, Myeloid, Acute - metabolism | Male | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Infertility, Male - genetics | Ultraviolet Rays | Time Factors | Cell Transformation, Neoplastic - genetics | Cell Death | HEK293 Cells | Female | Fibroblasts - metabolism | Protein Structure, Tertiary | Polycystic Kidney Diseases - metabolism | Cell Survival | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins c-myc - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Animals | Testis - pathology | Infertility, Male - metabolism | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell death | Leukemia | Oncology, Experimental | Physiological aspects | Lymphomas | Research | Cancer | Infertility | Rodents | Homeostasis | Tumorigenesis | Males | Stress | Index Medicus | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4976 - 13
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2007, Volume 104, Issue 15, p. 6217
  Apoptosis is held in check by prosurvival proteins of the Bc1-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby... 
Proteins | Cell growth | Biochemistry | Binding sites | Apoptosis
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 389 - 399
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might... 
CELLCYCLE | SURVIVAL | SELICICLIB CYC202 | R-ROSCOVITINE | ONCOLOGY | SMALL-MOLECULE INHIBITORS | DOWN-REGULATION | DEATH | KINASE INHIBITOR | FAMILY PROTEINS | MULTIPLE-MYELOMA CELLS | BH3-ONLY PROTEINS | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Male | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Nitrophenols - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Fibroblasts - metabolism | Protein Structure, Tertiary | Cytokines - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mice, Transgenic | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Proteins | Lymphomas | Analysis | Index Medicus
Journal Article