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Cell and Tissue Research, ISSN 0302-766X, 4/2014, Volume 356, Issue 1, pp. 15 - 27
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2016, Volume 25, Issue 17, pp. 921 - 935
Aims: Sickle retinopathy (SR) is a major cause of blindness in sickle cell disease (SCD). The genetic mutation responsible for SCD is known, however; oxidative... 
Original Research Communications | fetal hemoglobin induction | inflammation | Nrf2 | retina | monomethyl fumarate | oxidative stress | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROXYUREA | ELECTRORETINOGRAPHIC FINDINGS | PROTECTIVE ROLE | FETAL-HEMOGLOBIN | ENDOCRINOLOGY & METABOLISM | MICE | ANEMIA | ISCHEMIA-REPERFUSION | RETINAL-PIGMENT EPITHELIUM | Retina - drug effects | Retinal Pigment Epithelium - metabolism | Retina - metabolism | Humans | Neovascularization, Pathologic | Fumarates - administration & dosage | Retinal Diseases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Retinal Pigment Epithelium - pathology | Retinal Diseases - etiology | gamma-Globulins - metabolism | Retinal Diseases - pathology | Retinal Neurons - drug effects | Nuclear Proteins - genetics | Disease Models, Animal | Retinal Pigment Epithelium - drug effects | Electroretinography | Gene Expression | Administration, Oral | Anemia, Sickle Cell - complications | Gene Expression Regulation | Nuclear Proteins - metabolism | Blood-Retinal Barrier - pathology | Blood-Retinal Barrier - metabolism | Carrier Proteins - genetics | Intercellular Adhesion Molecule-1 - metabolism | Animals | Carrier Proteins - metabolism | Retinal Neurons - metabolism | Intercellular Adhesion Molecule-1 - genetics | NF-E2-Related Factor 2 - metabolism | gamma-Globulins - genetics | Mice | Retinal Neurons - pathology | Anemia, Sickle Cell - blood | Anemia, Sickle Cell - diagnosis | Oxidative Stress - drug effects | Retinal Diseases - drug therapy | Retina - pathology | Antioxidants | Complications and side effects | Care and treatment | Sickle cell anemia | Retinal diseases | Health aspects | Risk factors | Oxidative stress | Animal models | Multiple sclerosis | Drug delivery systems | Retinopathy | Medical services | Innovations | Retina | Drug delivery | Proteins | Autopsy | Hemoglobin | Sickle cell disease | Formulations | Hematology | Complications | Fetuses | Abnormalities | Oral administration | Inflammation | Ribonucleic acid--RNA | Pathology | Fumaric acid | Blindness
Journal Article
Documenta Ophthalmologica, ISSN 0012-4486, 06/2017, Volume 134, Issue 3, pp. 195 - 203
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2015, Volume 86, p. 25
Oxidative stress figures prominently in retinal diseases, including diabetic retinopathy, and glaucoma. Ligands for [sigma]1R, a unique transmembrane protein... 
Glaucoma | Antioxidants | Oxidative stress | Diabetic retinopathy | Cysteine | Analysis | Mitochondrial DNA | Ophthalmology | Glutamate | Cystine
Journal Article
Experimental Eye Research, ISSN 0014-4835, 04/2016, Volume 145, pp. 164 - 172
Mutations in crumb homologue 1 ( ) in humans are associated with Leber's congenital amaurosis (LCA) and retinitis pigmentosa (RP). There is no clear... 
CRB1 | Mouse | rd8 | Retina | MTHFR | LCA | Homocysteine | Rd8 | homocysteine | mouse | retina
Journal Article
Experimental Eye Research, ISSN 0014-4835, 04/2016, Volume 145, p. 164
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.exer.2015.11.013 
Enzymes | Analysis | Physiological aspects | Genetic aspects | Homocysteine
Journal Article
Experimental Eye Research, ISSN 0014-4835, 04/2016, Volume 145, p. 164
Journal Article
Experimental Eye Research, ISSN 0014-4835, 04/2016, Volume 145, pp. 164 - 172
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2015, Volume 56, Issue 4, pp. 2684 - 2695
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2015, Volume 132, Issue 5, p. 546
  The high-affinity sigma receptor 1 (σR1) ligand (+)-pentazocine ((+)-PTZ) affords profound retinal neuroprotection in vitro and in vivo by a yet-unknown... 
Cytokines | Rodents | Ligands | Cell adhesion & migration
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2015, Volume 132, Issue 5, pp. 546 - 558
The high-affinity sigma receptor 1 ( sigma R1) ligand (+)-pentazocine ((+)-PTZ) affords profound retinal neuroprotection in vitro and in vivo by a yet-unknown... 
Journal Article
01/2015, ISBN 9781339156415
Homocysteine (hcy), a sulfur containing amino acid, is an integral part of methionine metabolism. Elevated plasma level of hcy (Hhcy) is identified as a risk... 
Molecular biology
Dissertation
American Journal of Pathology, The, ISSN 0002-9440, 2014, Volume 184, Issue 9, pp. 2573 - 2585
Mild to moderate hyperhomocysteinemia is prevalent in humans and is implicated in neurovascular diseases, including recently in certain retinal diseases.... 
Pathology
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 03/2015, Volume 1851, Issue 3, pp. 290 - 298
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via... 
Diabetic retinopathy | PEDF | 12/15 HETEs | 12/15-Lipoxygenase | Retinal vascular leakage | Retinal inflammation | DIABETIC-RETINOPATHY | NADPH OXIDASE | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AQUEOUS-HUMOR | FACTOR-KAPPA-B | CELL BIOLOGY | BIOPHYSICS | FACTOR PEDF | INFLAMMATION | VITREOUS LEVELS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Retina - drug effects | Intravitreal Injections | Membrane Glycoproteins - metabolism | Hydroxyeicosatetraenoic Acids - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Diabetes Mellitus, Experimental - genetics | NADPH Oxidases - metabolism | NF-kappa B - metabolism | Retinal Neovascularization - metabolism | Nerve Growth Factors - pharmacology | Membrane Glycoproteins - antagonists & inhibitors | Hydroxyeicosatetraenoic Acids - pharmacology | NADPH Oxidases - genetics | Zonula Occludens-1 Protein - metabolism | Interleukin-6 - metabolism | Zonula Occludens-1 Protein - genetics | Interleukin-6 - genetics | Signal Transduction | Endothelial Cells - metabolism | NADPH Oxidases - antagonists & inhibitors | Serpins - pharmacology | Diabetic Retinopathy - genetics | Mice, Knockout | Intercellular Adhesion Molecule-1 - metabolism | Intercellular Adhesion Molecule-1 - genetics | Mice | Retinal Neovascularization - drug therapy | Endothelial Cells - pathology | Vascular Cell Adhesion Molecule-1 - metabolism | Retina - pathology | Retinal Neovascularization - pathology | Eye Proteins - pharmacology | Tumor Necrosis Factor-alpha - metabolism | Diabetic Retinopathy - drug therapy | Retina - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Ependymoglial Cells - metabolism | Diabetic Retinopathy - pathology | Acetophenones - pharmacology | Retinal Neovascularization - genetics | Vascular Cell Adhesion Molecule-1 - genetics | Diabetes Mellitus, Experimental - metabolism | Ependymoglial Cells - pathology | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology | Arachidonate 12-Lipoxygenase - genetics | 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - antagonists & inhibitors | Cells, Cultured | Gene Expression Regulation | Arachidonate 15-Lipoxygenase - metabolism | Ependymoglial Cells - drug effects | NADPH Oxidase 2 | Diabetic Retinopathy - metabolism | Membrane Glycoproteins - genetics | Animals | Arachidonate 15-Lipoxygenase - genetics | NF-kappa B - genetics | Diabetes Mellitus, Experimental - pathology | Endothelial Cells - drug effects | Oxidases | Analysis | Permeability | Neovascularization | Epithelium | Vascular endothelial growth factor
Journal Article