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Cancer Cell, ISSN 1535-6108, 2009, Volume 15, Issue 2, pp. 135 - 147
The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing... 
STEMCELL | CELLCYCLE | PROGENITOR CELLS | EXTERNAL GRANULAR LAYER | ONCOLOGY | NEURONAL PRECURSORS | GENE-EXPRESSION | MYELOID-LEUKEMIA | CENTRAL-NERVOUS-SYSTEM | MONOCLONAL-ANTIBODIES | HUMAN HOMOLOG | CANCER STEM-CELLS | BRAIN-TUMORS | CELL BIOLOGY | Neoplasm Transplantation | Lewis X Antigen - genetics | Humans | Brain Neoplasms - pathology | Brain Neoplasms - physiopathology | Glycoproteins - metabolism | Hedgehog Proteins - metabolism | Molecular Sequence Data | Neurons - cytology | Gene Expression Profiling | Stem Cells - cytology | Lewis X Antigen - metabolism | Stem Cells - metabolism | Biomarkers, Tumor | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Peptides - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Mice, Mutant Strains | Microarray Analysis | Medulloblastoma - pathology | Neoplastic Stem Cells - pathology | Neurons - metabolism | Patched Receptors | Tumor Cells, Cultured | Disease Models, Animal | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptors, Cell Surface - metabolism | Medulloblastoma - physiopathology | Survival Rate | Mice, SCID | AC133 Antigen | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice | Receptors, Cell Surface - genetics | Analysis | Medulloblastoma | Brain tumors | Stem cells | Index Medicus
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
Development, ISSN 0950-1991, 05/2012, Volume 139, Issue 10, pp. 1724 - 1733
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 3443 - 3443
Journal Article
Oncogene, ISSN 0950-9232, 07/2015, Volume 34, Issue 29, pp. 3770 - 3779
Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to... 
APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | DRUG-RESISTANCE | MOUSE MODELS | CELL BIOLOGY | CELL LUNG-CANCER | MALIGNANT GLIOMA | YM155 | ONCOLOGY | GENETICS & HEREDITY | PEDIATRIC MEDULLOBLASTOMA | INHIBITOR | EXPRESSION | Apoptosis - drug effects | Apoptosis - radiation effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Hedgehog Proteins - metabolism | Ki-67 Antigen - metabolism | Chemoradiotherapy | Repressor Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - deficiency | Biphenyl Compounds - pharmacology | Repressor Proteins - deficiency | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Tumor Cells, Cultured | Medulloblastoma - genetics | Child | Cerebellar Neoplasms - metabolism | Cerebellar Neoplasms - drug therapy | Cell Cycle - radiation effects | Mice, Inbred C57BL | Repressor Proteins - genetics | Naphthoquinones - pharmacology | Imidazoles - pharmacology | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Hedgehog Proteins - antagonists & inhibitors | Mice, SCID | Interleukin Receptor Common gamma Subunit - genetics | Blotting, Western | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Xenograft Model Antitumor Assays | Microscopy, Confocal | Animals | Mice, Nude | Mice, Inbred NOD | Cell Proliferation - drug effects | Pyridines - pharmacology | Cell Cycle - drug effects | Medulloblastoma - drug therapy | Cell Proliferation - radiation effects | Oncology | Brain cancer | Cell cycle | Tumors | Apoptosis | Index Medicus | sonic hedgehog | survivin | targeted therapy | brain tumor | animal model | medulloblastoma
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 20, pp. 6310 - 6322
Journal Article
Journal Article
Journal Article
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