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NATURE GENETICS, ISSN 1061-4036, 09/2015, Volume 47, Issue 9, pp. 1020 - 1020
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and... 
PROGENITOR CELLS | CHROMOSOMAL TRANSLOCATIONS | SET ENRICHMENT ANALYSIS | RAS PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | B-CELL DIFFERENTIATION | SEQUENCING DATA | CHAIN REARRANGEMENT | TRANSCRIPTION FACTOR | HEMATOPOIETIC STEM | Sequence Deletion | Oncogene Proteins, Fusion - metabolism | Coculture Techniques | Genomics | Humans | Drug Resistance, Neoplasm | Male | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | Antineoplastic Agents - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | DNA Mutational Analysis | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Immunoglobulin Light Chains, Surrogate - genetics | Gene Expression | Genetic Association Studies | Kaplan-Meier Estimate | PAX5 Transcription Factor - genetics | Mice, SCID | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Oncogene Proteins, Fusion - genetics | Mice, Inbred NOD | Mutation | Cohort Studies | Gene mutations | Genetic aspects | Acute lymphocytic leukemia | Research | Identification and classification | Health aspects | Risk factors | Bone marrow | Genes | Leukemia | cytarabine | integrative | leukemic stem cell | drug activity profiling | panobinostat | mTOR inhibitor | genomics | glucocorticoids | bortezomib | ABT-199 | dexamethasone | HSP90 | TCF3-PBX1 | vincristine | BH3-mimetics | leukemia xenograft model | next generation sequencing | TCF3-HLF | venetoclax | anthracycline | acute lymphoblastic leukemia | AUY922 | BCL2 | drug resistance | prednisone
Journal Article
Journal Article
Blood, ISSN 0006-4971, 03/2017, Volume 129, Issue 11, pp. e26 - e37
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 12/2018, Volume 10, Issue 12
We compared 24 primary pediatric T-cell acute lymphoblastic leukemias (T-ALL) collected at the time of initial diagnosis and relapse from 12 patients and 24... 
MEDICINE, RESEARCH & EXPERIMENTAL | XENOGRAFT MODELS | READ ALIGNMENT | T-cell leukemia | DNA METHYLATION | MECHANISM | PDX stability | PATTERNS | CANCER | DISCOVERY | ATAC-Seq | CLONAL SELECTION | ACUTE LYMPHOBLASTIC-LEUKEMIA | MUTATIONS | T-ALL
Journal Article
HemaSphere, ISSN 2572-9241, 06/2019, Volume 3, p. 16
Journal Article
ONCOTARGET, 11/2014, Volume 5, Issue 22, pp. 11501 - 11512
Interactions with the bone marrow microenvironment are essential for leukemia survival and disease progression. We developed an imaging-based RNAi platform to... 
SURVIVAL | DRUG | RNAi screen | BONE-MARROW NICHE | PROLIFERATION | bone marrow stroma | COMPARTMENT | CANCER | CELL BIOLOGY | microenvironment | acute lymphoblastic leukemia | HEMATOPOIETIC STEM-CELLS | DISEASE | EXPRESSION | oxidative stress
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 1283 - 1283
Abstract Dysregulation of apoptotic pathways provides an indiscriminate mechanism for refractory acute lymphoblastic leukemia (ALL) to escape cell death... 
Journal Article
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