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1. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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2. Full Text Epigenetic germline inheritance of diet-induced obesity and insulin resistance
by Huypens, Peter and Sass, Steffen and Wu, Moya and Dyckhoff, Daniela and Tschöp, Matthias and Theis, Fabian and Marschall, Susan and De Angelis, Martin Hrabě and Beckers, Johannes
Nature Genetics, ISSN 1061-4036, 05/2016, Volume 48, Issue 5, pp. 497 - 499
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the... 
Inheritance Patterns | Genetic Predisposition to Disease | Animals | Fertilization in Vitro | Diet, High-Fat | Epigenesis, Genetic | Mice, Inbred C57BL | Insulin Resistance - genetics | Female | Male | Germ Cells | Obesity - genetics | Obesity | Epigenetic inheritance | Genetic susceptibility | Genetic research | Insulin resistance | Genetic aspects | Research | Observations | In vitro fertilization | Diet | Sperm | Epigenetics | Glucose | Insulin | Metabolic disorders | Index Medicus
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3. Full Text A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
by Bowl, Michael R and Simon, Michelle M and Ingham, Neil J and Greenaway, Simon and Santos, Luis and Cater, Heather and Taylor, Sarah and Mason, Jeremy and Kurbatova, Natalja and Pearson, Selina and Bower, Lynette R and Clary, Dave A and Meziane, Hamid and Reilly, Patrick and Minowa, Osamu and Kelsey, Lois and Allen, Sue and Clementson-Mobbs, Sharon and Codner, Gemma and Fray, Martin and Gardiner, Wendy and Joynson, Russell and Kenyon, Janet and Loeffler, Jorik and Nell, Barbara and Parker, Andrew and Quwailid, Deen and Stewart, Michelle and Walling, Alison and Zaman, Rumana and Chen, Chao-Kung and Conte, Nathalie and Matthews, Peter and Relac, Mike and Tudose, Ilinca and Warren, Jonathan and Le Marchand, Elise and El Amri, Amal and El Fertak, Leila and Ennah, Hamid and Ali-Hadji, Dalila and Ayadi, Abdel and Wattenhofer-Donze, Marie and Moulaert, David and Jacquot, Sylvie and André, Philippe and Birling, Marie-Christine and Pavlovic, Guillaume and Lalanne, Valérie and Lux, Aline and Riet, Fabrice and Mittelhaeuser, Christophe and Bour, Raphael and Guimond, Alain and Bam'Hamed, Chaouki and Leblanc, Sophie and Vasseur, Laurent and Selloum, Mohammed and Sorg, Tania and Ayabe, Shinya and Furuse, Tamio and Kaneda, Hideki and Kobayashi, Kimio and Masuya, Hiroshi and Miura, Ikuo and Obata, Yuichi and Suzuki, Tomohiro and Tamura, Masaru and Tanaka, Nobuhiko and Yamada, Ikuko and Yoshiki, Atsushi and Berberovic, Zorana and Bubshait, Mohammed and Cabezas, Jorge and Carroll, Tracy and Clark, Greg and Clarke, Shannon and Creighton, Amie and Danisment, Ozge and Eskandarian, Mohammad and Feugas, Patricia and Gertsenstein, Marina and Guo, Ruolin and Hunter, Jane and Jacob, Elsa and Lan, Qing and Laurin, Valerie and Law, Napoleon and MacMaster, Sue and Miller, David and Morikawa, Lily and Newbigging, Susan and Owen, Celeste and Penton, Patricia and Pereira, Monica and Qu, Dawei and Shang, Xueyuan and Sleep, Gillian and Sohel, Khondoker and Tondat, Sandra and ... and Int Mouse Phenotyping Consortium and International Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 886 - 11
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In... 
HAIR-CELLS | MUTAGENESIS | PROJECT | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | MOUSE | MUTATION | DISEASE | GENOME-WIDE | IMPAIRMENT | RESOURCE | Consortia | Genes | Phenotyping | Auditory system | Hearing protection | Hearing impairment | Hearing loss
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4. Full Text Identification of genetic elements in metabolism by high-throughput mouse phenotyping
by Rozman, Jan and Rathkolb, Birgit and Oestereicher, Manuela A and Schütt, Christine and Ravindranath, Aakash Chavan and Leuchtenberger, Stefanie and Sharma, Sapna and Kistler, Martin and Willershäuser, Monja and Brommage, Robert and Meehan, Terrence F and Mason, Jeremy and Haselimashhadi, Hamed and Aguilar-Pimentel, Antonio and Becker, Lore and Treise, Irina and Moreth, Kristin and Garrett, Lillian and Hölter, Sabine M and Zimprich, Annemarie and Marschall, Susan and Amarie, Oana V and Calzada-Wack, Julia and Neff, Frauke and Brachthäuser, Laura and Lengger, Christoph and Stoeger, Claudia and Zapf, Lilly and Cho, Yi-Li and Da Silva-Buttkus, Patricia and Kraiger, Markus J and Mayer-Kuckuk, Philipp and Gampe, Karen Kristine and Wu, Moya and Conte, Nathalie and Warren, Jonathan and Chen, Chao-Kung and Tudose, Ilinca and Relac, Mike and Matthews, Peter and Cater, Heather L and Natukunda, Helen P and Cleak, James and Teboul, Lydia M and Clementson-Mobbs, Sharon and Szoke-Kovacs, Zsombor and Walling, Alison P and Johnson, Sara J and Codner, Gemma F and Fiegel, Tanja and Ring, Natalie and Westerberg, Henrik and Greenaway, Simon and Sneddon, Duncan and Morgan, Hugh and Loeffler, Jorik and Stewart, Michelle E and Ramirez-Solis, Ramiro and Bradley, Allan and Skarnes, William C and Steel, Karen P and Maguire, Simon A and Dench, Joshua and Lafont, David and Vancollie, Valerie E and Pearson, Selina A and Gates, Amy S and Sanderson, Mark and Shannon, Carl and Anthony, Lauren F. E and Sumowski, Maksymilian T and McLaren, Robbie S. B and Doe, Brendan and Wardle-Jones, Hannah and Griffiths, Mark N. D and Galli, Antonella and Swiatkowska, Agnieszka and Isherwood, Christopher M and Speak, Anneliese O and Cambridge, Emma L and Wilson, Heather M and Caetano, Susana S and Maguire, Anna Karin B and Adams, David J and Bottomley, Joanna and Ryder, Ed and Gleeson, Diane and Pouilly, Laurent and Rousseau, Stephane and Auburtin, Aurélie and Reilly, Patrick and Ayadi, Abdel and Selloum, Mohammed and Wood, Joshua A and Clary, Dave and Havel, Peter and Tolentino, Todd and Tolentino, Heather and Schuchbauer, Mike and Pedroia, Sheryl and ... and IMPC Consortium
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 288 - 16
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood.... 
DIABETES-MELLITUS | CONSORTIUM | PATHWAYS | VARIANTS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | DISEASE | BIOLOGY | GLYCEMIC TRAITS | ARCHITECTURE | ASSOCIATION | Genome-Wide Association Study | Basal Metabolism - genetics | Area Under Curve | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Regulatory Networks | Body Weight - genetics | Obesity - genetics | Mice, Knockout | Triglycerides - metabolism | Phenotype | Animals | High-Throughput Screening Assays | Oxygen Consumption - genetics | Metabolic Diseases - genetics | Mice | Blood Glucose - metabolism | Consortia | Annotations | Genes | Phenotyping | Data processing | Genomes | Regulatory sequences | Genetic factors | Metabolism | Binding sites | Metabolic disorders
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5. Full Text Strategies to Prevent Surgical Site Infections in Acute Care Hospitals
by Deverick J. Anderson and Keith S. Kaye and David Classen and Kathleen M. Arias and Kelly Podgorny and Helen Burstin and David P. Calfee and Susan E. Coffin and Erik R. Dubberke and Victoria Fraser and Dale N. Gerding and Frances A. Griffin and Peter Gross and Michael Klompas and Evelyn Lo and Jonas Marschall and Leonard A. Mermel and Lindsay Nicolle and David A. Pegues and Trish M. Perl and Sanjay Saint and Cassandra D. Salgado and Robert A. Weinstein and Robert Wise and Deborah S. Yokoe
Infection Control and Hospital Epidemiology, ISSN 0899-823X, 09/2008, Volume 29, Issue S1, pp. S51 - S61
Recommendations | Supplement Article: SHEA/IDSA Practice Recommendation | Antimicrobials | Cardiac surgical procedures | Disease risk | Health care industry | Infections | Computer surveillance | Patient surveillance | Surgical procedures | Surgical specialties | INFECTIOUS DISEASES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Surgical Wound Infection - prevention & control | Hospitals - standards | Infection Control - standards | Critical Care - standards | Cross Infection - prevention & control | Humans | Surgical Procedures, Operative - adverse effects
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6. Full Text Strategies to Prevent Central Line–Associated Bloodstream Infections in Acute Care Hospitals
by Jonas Marschall and Leonard A. Mermel and David Classen and Kathleen M. Arias and Kelly Podgorny and Deverick J. Anderson and Helen Burstin and David P. Calfee and Susan E. Coffin and Erik R. Dubberke and Victoria Fraser and Dale N. Gerding and Frances A. Griffin and Peter Gross and Keith S. Kaye and Michael Klompas and Evelyn Lo and Lindsay Nicolle and David A. Pegues and Trish M. Perl and Sanjay Saint and Cassandra D. Salgado and Robert A. Weinstein and Robert Wise and Deborah S. Yokoe
Infection Control and Hospital Epidemiology, ISSN 0899-823X, 09/2008, Volume 29, Issue S1, pp. S22 - S30
Recommendations | Intensive care units | Supplement Article: SHEA/IDSA Practice Recommendation | Medical practice | Health care industry | Hospital units | Infections | Compliance certificates | Patient compliance | Catheters | Central venous catheterization | INFECTIOUS DISEASES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Bacteremia - prevention & control | Hospitals - standards | Critical Care - standards | Cross Infection - prevention & control | Humans | Infection Control | Anti-Infective Agents - therapeutic use | Catheterization, Central Venous - adverse effects
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7. Full Text Strategies to Prevent Ventilator‐Associated Pneumonia in Acute Care Hospitals
by Susan E. Coffin and Michael Klompas and David Classen and Kathleen M. Arias and Kelly Podgorny and Deverick J. Anderson and Helen Burstin and David P. Calfee and Erik R. Dubberke and Victoria Fraser and Dale N. Gerding and Frances A. Griffin and Peter Gross and Keith S. Kaye and Evelyn Lo and Jonas Marschall and Leonard A. Mermel and Lindsay Nicolle and David A. Pegues and Trish M. Perl and Sanjay Saint and Cassandra D. Salgado and Robert A. Weinstein and Robert Wise and Deborah S. Yokoe
Infection Control and Hospital Epidemiology, ISSN 0899-823X, 09/2008, Volume 29, Issue S1, pp. S31 - S40
Recommendations | Supplement Article: SHEA/IDSA Practice Recommendation | Medical practice | Ventilation systems | Disease risk | Health care industry | Infections | Compliance certificates | Surveillance equipment | Patient surveillance | Patient compliance | URINARY-TRACT-INFECTION | SURGERY | INFECTIOUS DISEASES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MANAGEMENT | RANDOMIZED-TRIAL | SILICONE | CATHETER | PHYSICIANS | EPIDEMIOLOGY | BACTERIURIA | FEEDBACK | Critical Care - methods | Hospitals - standards | Infection Control - standards | Critical Care - standards | Respiration, Artificial - adverse effects | Humans | Pneumonia, Ventilator-Associated - prevention & control | Infection Control - methods
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8. Full Text Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
by Essig, Katharina and Hu, Desheng and Guimaraes, Joao C and Alterauge, Dominik and Edelmann, Stephanie and Raj, Timsse and Kranich, Jan and Behrens, Gesine and Heiseke, Alexander and Floess, Stefan and Klein, Juliane and Maiser, Andreas and Marschall, Susan and Hrabĕ de Angelis, Martin and Leonhardt, Heinrich and Calkhoven, Cornelis F and Noessner, Elfriede and Brocker, Thomas and Huehn, Jochen and Krug, Anne B and Zavolan, Mihaela and Baumjohann, Dirk and Heissmeyer, Vigo
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1067 - 1082.e12
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. Here we showed... 
Tfr | Itch | T cell differentiation | Tfh | Roquin | RNA-binding proteins | CD25 | Pten | Akt mTOR | Foxo1 | TH17 DIFFERENTIATION | AUTOIMMUNITY | GERMINAL CENTER REACTION | INFLAMMATION | ROR-GAMMA | COSTIMULATOR MESSENGER-RNA | RECEPTOR | IMMUNOLOGY | EXPRESSION | MTOR | EFFECTOR LINEAGE | Autoimmunity | Ligases | Protein biosynthesis | T cells | Binding proteins | Cell differentiation | Protein binding | TOR protein | Ubiquitin | Cytokines | Helper cells | AKT protein | T cell receptors | Lymphocytes T | Kinases | Cells | 1-Phosphatidylinositol 3-kinase | Proteins | Signal transduction | Specialization | Cell activation | Clonal deletion | FOXO1 protein | Lymphocytes | CD25 antigen | Colitis | Ubiquitin-protein ligase
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9. Full Text Strategies to Prevent Catheter‐Associated Urinary Tract Infections in Acute Care Hospitals
by Evelyn Lo and Lindsay Nicolle and David Classen and Kathleen M. Arias and Kelly Podgorny and Deverick J. Anderson and Helen Burstin and David P. Calfee and Susan E. Coffin and Erik R. Dubberke and Victoria Fraser and Dale N. Gerding and Frances A. Griffin and Peter Gross and Keith S. Kaye and Michael Klompas and Jonas Marschall and Leonard A. Mermel and David A. Pegues and Trish M. Perl and Sanjay Saint and Cassandra D. Salgado and Robert A. Weinstein and Robert Wise and Deborah S. Yokoe
Infection Control and Hospital Epidemiology, ISSN 0899-823X, 09/2008, Volume 29, Issue S1, pp. S41 - S50
Recommendations | Urine | Indwelling catheters | Supplement Article: SHEA/IDSA Practice Recommendation | Health outcomes | Catheterization | Predisposing factors | Health care industry | Infections | Patient surveillance | Catheters | Hospitals - standards | Infection Control - standards | Urinary Catheterization - standards | Humans | Urinary Tract Infections - prevention & control | Infection Control - methods | Urinary Catheterization - adverse effects | Urinary Tract Infections - drug therapy
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10. Full Text Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
by De Angelis, Martin Hrabě and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and Adams, David J and Adams, Niels C and Adler, Thure and Aguilar-Pimentel, Antonio and Ali-Hadji, Dalila and Amann, Gregory and André, Philippe and Atkins, Sarah and Auburtin, Aurelie and Ayadi, Abdel and Becker, Julien and Becker, Lore and Bedu, Elodie and Bekeredjian, Raffi and Birling, Marie-Christine and Blake, Andrew and Bottomley, Joanna and Bowl, Michael R and Brault, Véronique and Busch, Dirk H and Bussell, James N and Calzada-Wack, Julia and Cater, Heather and Champy, Marie-France and Charles, Philippe and Chevalier, Claire and Chiani, Francesco and Codner, Gemma F and Combe, Roy and Cox, Roger and Dalloneau, Emilie and Dierich, André and Di Fenza, Armida and Doe, Brendan and Duchon, Arnaud and Eickelberg, Oliver and Esapa, Chris T and Fertak, Lahcen El and Feigel, Tanja and Emelyanova, Irina and Estabel, Jeanne and Favor, Jack and Flenniken, Ann and Gambadoro, Alessia and Garrett, Lilian and Gates, Hilary and Gerdin, Anna-Karin and Gkoutos, George and Greenaway, Simon and Glasl, Lisa and Goetz, Patrice and Da Cruz, Isabelle Goncalves and Götz, Alexander and Graw, Jochen and Guimond, Alain and Hans, Wolfgang and Hicks, Geoff and Hölter, Sabine M and Höfler, Heinz and Hancock, John M and Hoehndorf, Robert and Hough, Tertius and Houghton, Richard and Hurt, Anja and Ivandic, Boris and Jacobs, Hughes and Jacquot, Sylvie and Jones, Nora and Karp, Natasha A and Katus, Hugo A and Kitchen, Sharon and Klein-Rodewald, Tanja and Klingenspor, Martin and Klopstock, Thomas and Lalanne, Valerie and Leblanc, Sophie and Lengger, Christoph and Le Marchand, Elise and Ludwig, Tonia and Lux, Aline and McKerlie, Colin and Maier, Holger and Mandel, Jean-Louis and Marschall, Susan and Mark, Manuel and Melvin, David G and Meziane, Hamid and Micklich, Kateryna and Mittelhauser, Christophe and Monassier, Laurent and ... and EUMODIC Consortium
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 969 - 978
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the... 
EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | GENOME-WIDE | EMPRESS | KNOCKOUT MICE | ACCESS | RESOURCE | Homozygote | Phenotype | Animals | Genetic Association Studies | Humans | Mice, Inbred C57BL | Molecular Sequence Annotation | Female | Heterozygote | Male | Mutation | Mice, Knockout | Research | Gene mutations | Human genome | Identification and classification | Health aspects | Consortia | Genotype & phenotype | Physiology | Genomes | Metabolism | Power
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