Organic Letters, ISSN 1523-7060, 05/2015, Volume 17, Issue 10, pp. 2442 - 2445
Tris(2,2,2-trifluoroethyl)borate [B(OCH2CF3)3] was found to be a mild and general reagent for the formation of a variety of imines by condensation of amides or...
Hydrocarbons, Fluorinated - chemistry | Molecular Structure | Imines - chemical synthesis | Borates - chemistry | Imines - chemistry
Hydrocarbons, Fluorinated - chemistry | Molecular Structure | Imines - chemical synthesis | Borates - chemistry | Imines - chemistry
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 08/2018, Volume 61, Issue 10, pp. 764 - 772
1‐(4‐Fluorophenyl)‐1H‐pyrazolo[3,4‐c]pyridine‐4‐carboxylic acid (2‐methanesulfonyl‐pyridin‐4‐ylmethyl)‐amide (1) and its analogs (2) and (3) are potent CCR1...
radiosynthesis | tritium | carbon‐13 | carbon‐14 | CCR1 antagonists | carbon-14 | carbon-13 | RHEUMATOID-ARTHRITIS | CHEMISTRY, ANALYTICAL | CHEMISTRY, MEDICINAL | BIOCHEMICAL RESEARCH METHODS
radiosynthesis | tritium | carbon‐13 | carbon‐14 | CCR1 antagonists | carbon-14 | carbon-13 | RHEUMATOID-ARTHRITIS | CHEMISTRY, ANALYTICAL | CHEMISTRY, MEDICINAL | BIOCHEMICAL RESEARCH METHODS
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 29, pp. 9481 - 9488
An electrophilic cyanation of aryl Grignard or lithium reagents, generated in situ from the corresponding aryl bromides or iodides, by a transnitrilation with...
HALIDES | C-H CYANATION | EXCHANGE-REACTION | MOLECULAR CALCULATIONS | HYDROGENATION | EFFECTIVE CORE POTENTIALS | TERTIARY AMIDE | POTASSIUM HEXACYANOFERRATE(II) | HALOGEN | PALLADIUM-CATALYZED CYANATION | CHEMISTRY, MULTIDISCIPLINARY | Chemistry Techniques, Synthetic | Lithium - chemistry | Nitriles - chemistry | Nitriles - chemical synthesis | Organometallic Compounds - chemistry | Catalysis | Indicators and Reagents - chemistry | Nitriles | Lithium | Research | Chemical properties | Chemical synthesis | Index Medicus
HALIDES | C-H CYANATION | EXCHANGE-REACTION | MOLECULAR CALCULATIONS | HYDROGENATION | EFFECTIVE CORE POTENTIALS | TERTIARY AMIDE | POTASSIUM HEXACYANOFERRATE(II) | HALOGEN | PALLADIUM-CATALYZED CYANATION | CHEMISTRY, MULTIDISCIPLINARY | Chemistry Techniques, Synthetic | Lithium - chemistry | Nitriles - chemistry | Nitriles - chemical synthesis | Organometallic Compounds - chemistry | Catalysis | Indicators and Reagents - chemistry | Nitriles | Lithium | Research | Chemical properties | Chemical synthesis | Index Medicus
Journal Article
4.
Full Text
A Practical Procedure for Reduction of Primary, Secondary and Tertiary Amides to Amines
Advanced Synthesis & Catalysis, ISSN 1615-4150, 01/2013, Volume 355, Issue 1, pp. 47 - 52
A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and...
silanes | ruthenium | amides | reduction | SYSTEM | SELF-ENCAPSULATION | COMPLEX | SILANE REDUCTION | HYDROSILANES | CHEMISTRY, ORGANIC | CONVENIENT | CARBOXAMIDES | CHEMOSELECTIVE REDUCTION | CHIMIE ORGANIQUE | CATALYZED REDUCTION | CHEMISTRY, APPLIED | Amides | Amines | Ruthenium | Silane | Silanes | Reduction | Catalysts | Accessibility | Crystallization | Catalysis
silanes | ruthenium | amides | reduction | SYSTEM | SELF-ENCAPSULATION | COMPLEX | SILANE REDUCTION | HYDROSILANES | CHEMISTRY, ORGANIC | CONVENIENT | CARBOXAMIDES | CHEMOSELECTIVE REDUCTION | CHIMIE ORGANIQUE | CATALYZED REDUCTION | CHEMISTRY, APPLIED | Amides | Amines | Ruthenium | Silane | Silanes | Reduction | Catalysts | Accessibility | Crystallization | Catalysis
Journal Article
Organic Letters, ISSN 1523-7060, 01/2011, Volume 13, Issue 1, pp. 118 - 121
A formal synthesis of berkelic acid is reported. The strategy employs the combination of a chiral exocyclic enol ether and an achiral isochromanone to afford...
(-)-BERKELIC ACID | CYCLOADDITION | REAGENTS | LACTONES | NATURAL-PRODUCTS | O-QUINONE METHIDES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | SPIROKETAL | CANCER | Molecular Structure | Cyclization | Oxidation-Reduction | Stereoisomerism | Spiro Compounds - chemical synthesis
(-)-BERKELIC ACID | CYCLOADDITION | REAGENTS | LACTONES | NATURAL-PRODUCTS | O-QUINONE METHIDES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | SPIROKETAL | CANCER | Molecular Structure | Cyclization | Oxidation-Reduction | Stereoisomerism | Spiro Compounds - chemical synthesis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2015, Volume 54, Issue 18, pp. 5474 - 5477
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a...
phosphinamides | asymmetric catalysis | organocatalyst | chirality | nucleophilic substitution | Nucleophilic substitution | Organocatalyst | Phosphinamides | Asymmetric catalysis | Chirality | BRONSTED ACID | REAGENTS | AMINOPHOSPHINES | ALDOL REACTIONS | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY | ORGANOCATALYSTS | BLOCKS | OXIDES | Phosphines - chemical synthesis | Chemistry Techniques, Synthetic | Phosphines - chemistry | Phosphinic Acids - chemistry | Amides - chemical synthesis | Stereoisomerism | Amides - chemistry | Molecular Structure | Lewis Bases - chemistry | Synthesis | Catalysis | Enantiomers | Organic compounds | Asymmetry | Catalysts | Lewis base
phosphinamides | asymmetric catalysis | organocatalyst | chirality | nucleophilic substitution | Nucleophilic substitution | Organocatalyst | Phosphinamides | Asymmetric catalysis | Chirality | BRONSTED ACID | REAGENTS | AMINOPHOSPHINES | ALDOL REACTIONS | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY | ORGANOCATALYSTS | BLOCKS | OXIDES | Phosphines - chemical synthesis | Chemistry Techniques, Synthetic | Phosphines - chemistry | Phosphinic Acids - chemistry | Amides - chemical synthesis | Stereoisomerism | Amides - chemistry | Molecular Structure | Lewis Bases - chemistry | Synthesis | Catalysis | Enantiomers | Organic compounds | Asymmetry | Catalysts | Lewis base
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2016, Volume 72, Issue 26, pp. 3713 - 3717
The hydrindane (bicyclo[4.3.0]nonane) structural motif ( ) and related -1-hydrindanone skeleton ( ) are common substructures in many natural products. Herein,...
Hydrindanone | Conjugate addition | Olefin cross metathesis | Michael reaction | 1,4-Addition | Linchpin | MUKAIYAMA | SILYLATED KETENE ACETALS | CHEMISTRY, ORGANIC | DECARBOXYLATION | ANTI-MESO-ACETYLMETHYLDIVINYLCYCLOPENTANE | SILYLKETENE ACETALS | CONSTRUCTION | ANNELATION | BETA-KETO | DERIVATIVES | ACCESS | Chemical industry | Herbicides | Pesticides industry | Incorporation | Copper | Construction standards | Substructures | Construction | Natural products | Tetrahedrons | Strategy | Ketenes | linchpin | olefin cross metathesis | hydrindanone | 1,4-addition | conjugate addition
Hydrindanone | Conjugate addition | Olefin cross metathesis | Michael reaction | 1,4-Addition | Linchpin | MUKAIYAMA | SILYLATED KETENE ACETALS | CHEMISTRY, ORGANIC | DECARBOXYLATION | ANTI-MESO-ACETYLMETHYLDIVINYLCYCLOPENTANE | SILYLKETENE ACETALS | CONSTRUCTION | ANNELATION | BETA-KETO | DERIVATIVES | ACCESS | Chemical industry | Herbicides | Pesticides industry | Incorporation | Copper | Construction standards | Substructures | Construction | Natural products | Tetrahedrons | Strategy | Ketenes | linchpin | olefin cross metathesis | hydrindanone | 1,4-addition | conjugate addition
Journal Article
Organic Letters, ISSN 1523-7060, 11/2015, Volume 17, Issue 22, pp. 5614 - 5617
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to...
Stereoisomerism | Aza Compounds - chemistry | Esters | Molecular Structure | Catalysis | Aziridines - chemistry | Aziridines - chemical synthesis
Stereoisomerism | Aza Compounds - chemistry | Esters | Molecular Structure | Catalysis | Aziridines - chemistry | Aziridines - chemical synthesis
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 04/2016, Volume 57, Issue 17, pp. 1903 - 1905
Triisopropyl borate effects the condensation of aldehydes with sulfinamides to give -sulfinyl imines. The reaction is amenable to 1°, 2°, and 3° alkyl...
Imine | Borate | Condensation | Sulfinamide | KETONES | ASYMMETRIC-SYNTHESIS | AMINES | TERT-BUTANESULFINYL KETIMINES | CHEMISTRY, ORGANIC | ALDEHYDES | Aldehydes | Schiff bases | Borates | Filtration | Imines | Reagents | Tetrahedrons | Byproducts
Imine | Borate | Condensation | Sulfinamide | KETONES | ASYMMETRIC-SYNTHESIS | AMINES | TERT-BUTANESULFINYL KETIMINES | CHEMISTRY, ORGANIC | ALDEHYDES | Aldehydes | Schiff bases | Borates | Filtration | Imines | Reagents | Tetrahedrons | Byproducts
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2016, Volume 138, Issue 47, pp. 15473 - 15481
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst...
MECHANISTIC INVESTIGATIONS | MOLECULAR CALCULATIONS | LIGANDS | IRIDIUM COMPLEXES | BOND FORMATION | PYRIDINIUM SALTS | SUBSTITUTED PIPERIDINES | MULTIPLE STEREOGENIC CENTERS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | CATALYZED DIRECT ARYLATION | Piperidines - chemistry | Stereoisomerism | Humans | Molecular Conformation | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - chemical synthesis | Piperidines - chemical synthesis | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | Hydrogenation | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Piperidines - pharmacology | Enzyme Inhibitors - chemistry | Catalysis | Iridium - chemistry | Palladium - chemistry
MECHANISTIC INVESTIGATIONS | MOLECULAR CALCULATIONS | LIGANDS | IRIDIUM COMPLEXES | BOND FORMATION | PYRIDINIUM SALTS | SUBSTITUTED PIPERIDINES | MULTIPLE STEREOGENIC CENTERS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | CATALYZED DIRECT ARYLATION | Piperidines - chemistry | Stereoisomerism | Humans | Molecular Conformation | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - chemical synthesis | Piperidines - chemical synthesis | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | Hydrogenation | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Piperidines - pharmacology | Enzyme Inhibitors - chemistry | Catalysis | Iridium - chemistry | Palladium - chemistry
Journal Article
Green Chemistry, ISSN 1463-9262, 2017, Volume 19, Issue 6, pp. 1454 - 1461
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following...
Journal Article
GREEN CHEMISTRY, ISSN 1463-9262, 03/2017, Volume 19, Issue 6, pp. 1454 - 1461
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following...
RHEUMATOID-ARTHRITIS | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | SCALE-UP | ALPHA-ARYLATION | HOFMANN REARRANGEMENT | GREEN CHEMISTRY | EFFICIENT SYNTHESIS | COUPLING REAGENTS | AMIDE BOND FORMATION | PEPTIDE-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | CARBOXYLIC-ACIDS | Coupling (molecular) | Trapping | Synthesis | Cyclopropane | Transformations | Robustness | Continuous flow | Extreme values
RHEUMATOID-ARTHRITIS | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | SCALE-UP | ALPHA-ARYLATION | HOFMANN REARRANGEMENT | GREEN CHEMISTRY | EFFICIENT SYNTHESIS | COUPLING REAGENTS | AMIDE BOND FORMATION | PEPTIDE-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | CARBOXYLIC-ACIDS | Coupling (molecular) | Trapping | Synthesis | Cyclopropane | Transformations | Robustness | Continuous flow | Extreme values
Journal Article
Organic Letters, ISSN 1523-7060, 04/2008, Volume 10, Issue 7, pp. 1477 - 1480
A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature...
CHEMISTRY, ORGANIC | ACID | RUBROMYCINS | NITRILES | COMPLEXES | Biological Products - chemical synthesis | Stereoisomerism | Spiro Compounds - chemical synthesis | Chromans - chemical synthesis | Ethers - chemistry | Indolequinones - chemistry | Molecular Structure | Furans - chemical synthesis
CHEMISTRY, ORGANIC | ACID | RUBROMYCINS | NITRILES | COMPLEXES | Biological Products - chemical synthesis | Stereoisomerism | Spiro Compounds - chemical synthesis | Chromans - chemical synthesis | Ethers - chemistry | Indolequinones - chemistry | Molecular Structure | Furans - chemical synthesis
Journal Article
ISSN 1463-9262, 3/2017, Volume 19, Issue 6, pp. 1454 - 1461
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following...
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2013, Volume 135, Issue 15, pp. 5565 - 5568
Carbamoyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high diastereoselectivity to chiral N-sulfinyl aldimines...
ORGANIC-SYNTHESIS | KETONES | ASYMMETRIC-SYNTHESIS | ORGANOMETALLIC REAGENTS | NUCLEOPHILIC ACYLATION | ALDEHYDE IMINES | REACTIVITY | MAIN-GROUP METAL | CARBONYL-COMPOUNDS | UMPOLUNG | CHEMISTRY, MULTIDISCIPLINARY | Chemistry Techniques, Synthetic | Amides - chemical synthesis | Stereoisomerism | Molecular Conformation | Imines - chemistry | Amides - chemistry | Models, Molecular | Substrate Specificity | Dipeptides - chemical synthesis | Dipeptides - chemistry
ORGANIC-SYNTHESIS | KETONES | ASYMMETRIC-SYNTHESIS | ORGANOMETALLIC REAGENTS | NUCLEOPHILIC ACYLATION | ALDEHYDE IMINES | REACTIVITY | MAIN-GROUP METAL | CARBONYL-COMPOUNDS | UMPOLUNG | CHEMISTRY, MULTIDISCIPLINARY | Chemistry Techniques, Synthetic | Amides - chemical synthesis | Stereoisomerism | Molecular Conformation | Imines - chemistry | Amides - chemistry | Models, Molecular | Substrate Specificity | Dipeptides - chemical synthesis | Dipeptides - chemistry
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2016, Volume 138, Issue 47, p. 15473
Journal Article
Organic Letters, ISSN 1523-7060, 08/2006, Volume 8, Issue 16, pp. 3481 - 3483
(±)-Mitorubrinic acid, a member of the azaphilone family of natural products, has been constructed in 12 steps. Key aspects of the synthesis include...
FUNGI | PENICILLIUM-FUNICULOSUM | AZAPHILONES | CHEMISTRY, ORGANIC | CYCLOISOMERIZATION | MITORUBRIN | METABOLITE | DEAROMATIZATION
FUNGI | PENICILLIUM-FUNICULOSUM | AZAPHILONES | CHEMISTRY, ORGANIC | CYCLOISOMERIZATION | MITORUBRIN | METABOLITE | DEAROMATIZATION
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2010, Volume 75, Issue 21, pp. 7479 - 7482
An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant...
MYCOBACTERIUM-TUBERCULOSIS | CHEMISTRY, ORGANIC | MURINE MODEL | NITROIMIDAZOPYRAN DRUG CANDIDATE | VOLTAMMETRIC DETERMINATION | REDUCTION | Hydrolysis | Antitubercular Agents - chemical synthesis | Nitroimidazoles - chemical synthesis | Antitubercular Agents - chemistry | Nitroimidazoles - pharmacology | Stereoisomerism | Drug Resistance, Multiple - drug effects | Antitubercular Agents - pharmacology | Kinetics | Nitroimidazoles - chemistry | Antitubercular agents | Chemical properties | Research | Pharmaceutical chemistry
MYCOBACTERIUM-TUBERCULOSIS | CHEMISTRY, ORGANIC | MURINE MODEL | NITROIMIDAZOPYRAN DRUG CANDIDATE | VOLTAMMETRIC DETERMINATION | REDUCTION | Hydrolysis | Antitubercular Agents - chemical synthesis | Nitroimidazoles - chemical synthesis | Antitubercular Agents - chemistry | Nitroimidazoles - pharmacology | Stereoisomerism | Drug Resistance, Multiple - drug effects | Antitubercular Agents - pharmacology | Kinetics | Nitroimidazoles - chemistry | Antitubercular agents | Chemical properties | Research | Pharmaceutical chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 05/2009, Volume 11, Issue 9, pp. 1955 - 1958
Chemoselective additions of organometallic reagents to 3-benzyloxy-1,2-o-quinone are described. Various nucleophiles are shown to undergo selective...
OXIDATION | ORTHO-QUINONES | CYCLOADDITION | DIELS-ALDER REACTIONS | ENANTIOSELECTIVE SYNTHESIS | O-BENZOQUINONES | REDUCTION | LEWIS-ACID | ALLYLATION | CHEMISTRY, ORGANIC | DERIVATIVES
OXIDATION | ORTHO-QUINONES | CYCLOADDITION | DIELS-ALDER REACTIONS | ENANTIOSELECTIVE SYNTHESIS | O-BENZOQUINONES | REDUCTION | LEWIS-ACID | ALLYLATION | CHEMISTRY, ORGANIC | DERIVATIVES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2013, Volume 135, Issue 15, pp. 5565 - 5568
Journal Article
No results were found for your search.
Cannot display more than 1000 results, please narrow the terms of your search.