Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6100, pp. 1343 - 1348
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody—based immunotherapy...
H1N1 subtype influenza A virus | Polysaccharides | Databases | Influenza A virus | Vaccination | REPORTS | Antibodies | Viruses | Epitopes | H3N2 subtype influenza A virus | Crystal structure | HIV-1 | CELLS | HEMAGGLUTININ | A VIRUSES | MULTIDISCIPLINARY SCIENCES | ANTIBODY | BROAD | NEUTRALIZATION | RECOGNIZES | LINEAGES | Immunodominant Epitopes - immunology | Orthomyxoviridae Infections - prevention & control | Amino Acid Sequence | Immunodominant Epitopes - chemistry | Humans | Molecular Sequence Data | Neutralization Tests | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Neutralizing - immunology | Animals | Influenza Vaccines - immunology | Antibodies, Neutralizing - chemistry | Conserved Sequence | Protein Conformation | Influenza B virus - immunology | Mice | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Influenza viruses | Influenza vaccines | Monoclonal antibodies | Care and treatment | Immunology | Research | Antigens | Influenza | Immunotherapy | Human | Pigs | Hydroxyapatite | Vaccines | Strain
H1N1 subtype influenza A virus | Polysaccharides | Databases | Influenza A virus | Vaccination | REPORTS | Antibodies | Viruses | Epitopes | H3N2 subtype influenza A virus | Crystal structure | HIV-1 | CELLS | HEMAGGLUTININ | A VIRUSES | MULTIDISCIPLINARY SCIENCES | ANTIBODY | BROAD | NEUTRALIZATION | RECOGNIZES | LINEAGES | Immunodominant Epitopes - immunology | Orthomyxoviridae Infections - prevention & control | Amino Acid Sequence | Immunodominant Epitopes - chemistry | Humans | Molecular Sequence Data | Neutralization Tests | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Neutralizing - immunology | Animals | Influenza Vaccines - immunology | Antibodies, Neutralizing - chemistry | Conserved Sequence | Protein Conformation | Influenza B virus - immunology | Mice | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Influenza viruses | Influenza vaccines | Monoclonal antibodies | Care and treatment | Immunology | Research | Antigens | Influenza | Immunotherapy | Human | Pigs | Hydroxyapatite | Vaccines | Strain
Journal Article
European Urology, ISSN 0302-2838, 2015, Volume 68, Issue 6, pp. 939 - 945
Abstract Background Androgen receptor splice variant 7 ( AR-V7 ) in circulating tumor cells (CTCs) from patients with metastatic castration-resistant prostate...
Urology | Castration-resistant prostate cancer | AR-V7 | Androgen receptor | Metastatic prostate cancer | Circulating tumor cells | CellSearch | Cabazitaxel | SURVIVAL | ENZALUTAMIDE MDV3100 | CROSS-RESISTANCE | ABIRATERONE TREATMENT | DOCETAXEL | CHEMOTHERAPY | TRIAL | PREDNISONE | UROLOGY & NEPHROLOGY | END-POINTS | CLINICAL ACTIVITY | Taxoids - therapeutic use | Receptors, Androgen - analysis | Humans | Male | Neoplastic Cells, Circulating - chemistry | Aged | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - pathology | Prostate cancer | Hospitals | Metastasis
Urology | Castration-resistant prostate cancer | AR-V7 | Androgen receptor | Metastatic prostate cancer | Circulating tumor cells | CellSearch | Cabazitaxel | SURVIVAL | ENZALUTAMIDE MDV3100 | CROSS-RESISTANCE | ABIRATERONE TREATMENT | DOCETAXEL | CHEMOTHERAPY | TRIAL | PREDNISONE | UROLOGY & NEPHROLOGY | END-POINTS | CLINICAL ACTIVITY | Taxoids - therapeutic use | Receptors, Androgen - analysis | Humans | Male | Neoplastic Cells, Circulating - chemistry | Aged | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - pathology | Prostate cancer | Hospitals | Metastasis
Journal Article
Cancers, ISSN 2072-6694, 08/2019, Volume 11, Issue 8, p. 1212
markdownabstract(1) Background: Markers identifying which patients with metastatic, castration-resistant prostate cancer (mCRPC) will benefit from cabazitaxel...
Biomarker | MCRPC | Circulating tumor cells | Prostate cancer | CTCs | PLUS PREDNISONE | PERIPHERAL-BLOOD | EXPRESSION PROFILES | circulating tumor cells | biomarker | PROGNOSTIC MODEL | mCRPC | WHOLE-BLOOD | prostate cancer | MESSENGER-RNA | ONCOLOGY | POOR SURVIVAL | INCREASED SURVIVAL | ENZALUTAMIDE | ABIRATERONE
Biomarker | MCRPC | Circulating tumor cells | Prostate cancer | CTCs | PLUS PREDNISONE | PERIPHERAL-BLOOD | EXPRESSION PROFILES | circulating tumor cells | biomarker | PROGNOSTIC MODEL | mCRPC | WHOLE-BLOOD | prostate cancer | MESSENGER-RNA | ONCOLOGY | POOR SURVIVAL | INCREASED SURVIVAL | ENZALUTAMIDE | ABIRATERONE
Journal Article
European Journal of Cancer, ISSN 0959-8049, 11/2019, Volume 121, pp. 48 - 54
The interpretation of the presence of in circulating tumour cells (CTCs) in men with metastatic castration-resistant prostate cancer (mCRPC) remains to be...
Biomarker | AR-V7 | Metastatic castration-resistant prostate cancer | Circulating tumour cells | ONCOLOGY | Prostate cancer | Analysis | Metastasis
Biomarker | AR-V7 | Metastatic castration-resistant prostate cancer | Circulating tumour cells | ONCOLOGY | Prostate cancer | Analysis | Metastasis
Journal Article
Journal of Virology, ISSN 0022-538X, 12/2004, Volume 78, Issue 23, pp. 13207 - 13215
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
MULTIPLE ISOFORMS | NEUTRALIZING ANTIBODIES | VIROLOGY | SPECIES-B | IMMUNE-RESPONSES | IN-VIVO | CELLULAR RECEPTOR | CYSTIC-FIBROSIS | CD46 | MEMBRANE COFACTOR PROTEIN | GENOME ORGANIZATION | Membrane Glycoproteins - analysis | Tropism | Genetic Therapy | Genetic Vectors - immunology | Adenoviruses, Human - immunology | Humans | Middle Aged | Vaccination | Seroepidemiologic Studies | Antibodies, Viral - blood | Genetic Vectors - genetics | Antigens, CD - analysis | Cross Reactions | Animals | Virus Replication | Adult | Adenoviruses, Human - genetics | Aged | Mice | Mice, Inbred BALB C | Membrane Cofactor Protein | Gene Therapy
MULTIPLE ISOFORMS | NEUTRALIZING ANTIBODIES | VIROLOGY | SPECIES-B | IMMUNE-RESPONSES | IN-VIVO | CELLULAR RECEPTOR | CYSTIC-FIBROSIS | CD46 | MEMBRANE COFACTOR PROTEIN | GENOME ORGANIZATION | Membrane Glycoproteins - analysis | Tropism | Genetic Therapy | Genetic Vectors - immunology | Adenoviruses, Human - immunology | Humans | Middle Aged | Vaccination | Seroepidemiologic Studies | Antibodies, Viral - blood | Genetic Vectors - genetics | Antigens, CD - analysis | Cross Reactions | Animals | Virus Replication | Adult | Adenoviruses, Human - genetics | Aged | Mice | Mice, Inbred BALB C | Membrane Cofactor Protein | Gene Therapy
Journal Article
The Journal of Molecular Diagnostics, ISSN 1525-1578, 05/2018, Volume 20, Issue 3, pp. 316 - 325
Recent reports have emphasized the clinical relevance of detecting in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to...
PATHOLOGY | RESISTANT PROSTATE-CANCER | MEN | ENZALUTAMIDE | ABIRATERONE
PATHOLOGY | RESISTANT PROSTATE-CANCER | MEN | ENZALUTAMIDE | ABIRATERONE
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 2617 - 2617
Journal Article
Journal of Virology, ISSN 0022-538X, 12/2004, Volume 78, Issue 23, pp. 13207 - 13215
A novel plasmid-based adenovirus vector system that enables manufacturing of replication-incompetent ( delta E1) adenovirus type 11 (Ad11)-based vectors is...
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2009, Volume 302, Issue 1, pp. 58 - 64
Worldwide, breast cancer is the most frequently occurring malignancy in women. Early age at full term pregnancy has a protective effect against breast cancer....
LH receptor | Breast cancer | Prognosis | qRT-PCR | CANCER PATIENTS | CELLS | STATISTICS | CHORIONIC-GONADOTROPIN HCG | RISK | OVARIAN-CANCER | CELL BIOLOGY | IN-VITRO | CG-BETA CONJUGATE | MUTATION | ENDOCRINOLOGY & METABOLISM | ESTROGEN | Reproducibility of Results | Signal Transduction | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptors, LH - metabolism | Male | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Receptors, LH - genetics | Cell Line, Tumor | Adult | Female | Aged | Messenger RNA | Chorionic gonadotropin | Oncology, Experimental | Analysis | Genetic research | Development and progression | Research | Drug therapy | Gene expression | Steroid hormones | Cancer | Pregnancy | Receptors | Breast | Ovaries | Hormones | Assaying | Tumors | breast cancer | prognosis
LH receptor | Breast cancer | Prognosis | qRT-PCR | CANCER PATIENTS | CELLS | STATISTICS | CHORIONIC-GONADOTROPIN HCG | RISK | OVARIAN-CANCER | CELL BIOLOGY | IN-VITRO | CG-BETA CONJUGATE | MUTATION | ENDOCRINOLOGY & METABOLISM | ESTROGEN | Reproducibility of Results | Signal Transduction | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptors, LH - metabolism | Male | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Receptors, LH - genetics | Cell Line, Tumor | Adult | Female | Aged | Messenger RNA | Chorionic gonadotropin | Oncology, Experimental | Analysis | Genetic research | Development and progression | Research | Drug therapy | Gene expression | Steroid hormones | Cancer | Pregnancy | Receptors | Breast | Ovaries | Hormones | Assaying | Tumors | breast cancer | prognosis
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2016, Volume 46, pp. 42 - 50
Highlights • Tools to guide treatment sequencing for mCRPC patients are urgently needed. • The CellSearch CTC count from peripheral blood is a strong...
Hematology, Oncology and Palliative Medicine | Characterization | Circulating tumor cells | Metastatic castration-resistant prostate cancer | CellSearch | Prognostic | Predictive | SURVIVAL | ANDROGEN RECEPTOR | BIOMARKER | CROSS-RESISTANCE | PERIPHERAL-BLOOD | DOCETAXEL | GENE STATUS | ONCOLOGY | EXPRESSION | ABIRATERONE | ENZALUTAMIDE | Prognosis | Neoplastic Cells, Circulating - pathology | Prostatic Neoplasms, Castration-Resistant - blood | Humans | Decision Support Techniques | Male | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - pathology | Usage | Metastasis | Drug therapy | Prostate cancer | Development and progression | Prostate-specific antigen
Hematology, Oncology and Palliative Medicine | Characterization | Circulating tumor cells | Metastatic castration-resistant prostate cancer | CellSearch | Prognostic | Predictive | SURVIVAL | ANDROGEN RECEPTOR | BIOMARKER | CROSS-RESISTANCE | PERIPHERAL-BLOOD | DOCETAXEL | GENE STATUS | ONCOLOGY | EXPRESSION | ABIRATERONE | ENZALUTAMIDE | Prognosis | Neoplastic Cells, Circulating - pathology | Prostatic Neoplasms, Castration-Resistant - blood | Humans | Decision Support Techniques | Male | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - pathology | Usage | Metastasis | Drug therapy | Prostate cancer | Development and progression | Prostate-specific antigen
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 2008, Volume 129, Issue 4, pp. 175 - 182
In mice, genetic modification of the gene encoding p53 affects both cancer incidence and longevity. In humans, we recently found that a codon 72 Arginine ( )...
Codon 72 | Human aging | TP53 | Cellular senescence | Apoptosis | Cancer | Ageing | Biochemistry | Developmental Biology | Developmental Neuroscience | SURVIVAL | MITOTIC CATASTROPHE | DNA-DAMAGE | apoptosis | DEATH | P53 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | SENESCENT HUMAN-CELLS | cellular senescence | human aging | IN-VIVO | cancer | RADIOSENSITIVITY | codon 72 | Apoptosis - radiation effects | Humans | Cells, Cultured | Genotype | Polymorphism, Genetic - radiation effects | Tumor Suppressor Protein p53 - genetics | Fibroblasts - radiation effects | Cell Nucleus - radiation effects | Cellular Senescence - radiation effects | Cloning, Molecular | beta-Galactosidase - metabolism | Aged, 80 and over | Polymorphism, Genetic - genetics | Codon - genetics | Fibroblasts - metabolism | Codon | Nuclear radiation | Genetically modified organisms | Proline | Genetic aspects | Tumor proteins | Cells
Codon 72 | Human aging | TP53 | Cellular senescence | Apoptosis | Cancer | Ageing | Biochemistry | Developmental Biology | Developmental Neuroscience | SURVIVAL | MITOTIC CATASTROPHE | DNA-DAMAGE | apoptosis | DEATH | P53 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | SENESCENT HUMAN-CELLS | cellular senescence | human aging | IN-VIVO | cancer | RADIOSENSITIVITY | codon 72 | Apoptosis - radiation effects | Humans | Cells, Cultured | Genotype | Polymorphism, Genetic - radiation effects | Tumor Suppressor Protein p53 - genetics | Fibroblasts - radiation effects | Cell Nucleus - radiation effects | Cellular Senescence - radiation effects | Cloning, Molecular | beta-Galactosidase - metabolism | Aged, 80 and over | Polymorphism, Genetic - genetics | Codon - genetics | Fibroblasts - metabolism | Codon | Nuclear radiation | Genetically modified organisms | Proline | Genetic aspects | Tumor proteins | Cells
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 26, pp. 18198 - 18213
Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and...
Fanconi anemia | DNA repair | HNSCC | Homologous recombination | Gene variants
Fanconi anemia | DNA repair | HNSCC | Homologous recombination | Gene variants
Journal Article
PROTEOMICS, ISSN 1615-9853, 05/2016, Volume 16, Issue 10, pp. 1474 - 1485
Laser‐capture microdissection (LCM) offers a reliable cell population enrichment tool and has been successfully coupled to MS analysis. Despite this, most...
Biomarker | Orbitrap mass spectrometry | Tissue heterogeneity | Laser‐capture microdissection | Bioinformatics | Label‐free quantification | Laser-capture microdissection | Label-free quantification | CANCER TISSUES | DRAFT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | COLON | HUMAN PLASMA PROTEOME | Breast Neoplasms - surgery | Humans | Laser Capture Microdissection | Treatment Outcome | Biomarkers, Tumor - isolation & purification | Breast Neoplasms - metabolism | Tandem Mass Spectrometry | Breast Neoplasms - pathology | Biomarkers, Tumor - metabolism | Estrogen Receptor alpha - metabolism | Female | Proteomics - methods | Estrogen Receptor alpha - isolation & purification | Proteome - isolation & purification | Proteome - metabolism | Proteins | Physiological aspects | Mass spectrometry | Analysis | Enrichment | Profiling | Epithelial cells | Tissue analysis | Breast cancer | Tissues | Impact analysis | Missing data | Biomarkers | Two dimensional analysis | Tumors | Immune system
Biomarker | Orbitrap mass spectrometry | Tissue heterogeneity | Laser‐capture microdissection | Bioinformatics | Label‐free quantification | Laser-capture microdissection | Label-free quantification | CANCER TISSUES | DRAFT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | COLON | HUMAN PLASMA PROTEOME | Breast Neoplasms - surgery | Humans | Laser Capture Microdissection | Treatment Outcome | Biomarkers, Tumor - isolation & purification | Breast Neoplasms - metabolism | Tandem Mass Spectrometry | Breast Neoplasms - pathology | Biomarkers, Tumor - metabolism | Estrogen Receptor alpha - metabolism | Female | Proteomics - methods | Estrogen Receptor alpha - isolation & purification | Proteome - isolation & purification | Proteome - metabolism | Proteins | Physiological aspects | Mass spectrometry | Analysis | Enrichment | Profiling | Epithelial cells | Tissue analysis | Breast cancer | Tissues | Impact analysis | Missing data | Biomarkers | Two dimensional analysis | Tumors | Immune system
Journal Article
Breast Cancer Research (Print), ISSN 1465-5411, 11/2011, Volume 13, Issue 6, pp. R110 - R110
textabstractIntroduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer...
GENETIC SUSCEPTIBILITY | POPULATION | RISK PREDICTION | VARIANTS | ONCOLOGY | PHENOTYPE | CONFER SUSCEPTIBILITY | LOCI | OVARIAN-CANCER | ESTROGEN-RECEPTOR | GENOME-WIDE ASSOCIATION | Reports | Breast cancer | Genetic aspects | Research | BRCA mutations | Allelomorphism | Gene mutations | Oncology, Experimental | Disease susceptibility | Single nucleotide polymorphisms | Progesterone | Health aspects | Cancer | Life Sciences | Obstetrics, Gynecology and Reproductive Medicine | Reproduktionsmedicin och gynekologi | Cancer and Oncology | Cancer och onkologi
GENETIC SUSCEPTIBILITY | POPULATION | RISK PREDICTION | VARIANTS | ONCOLOGY | PHENOTYPE | CONFER SUSCEPTIBILITY | LOCI | OVARIAN-CANCER | ESTROGEN-RECEPTOR | GENOME-WIDE ASSOCIATION | Reports | Breast cancer | Genetic aspects | Research | BRCA mutations | Allelomorphism | Gene mutations | Oncology, Experimental | Disease susceptibility | Single nucleotide polymorphisms | Progesterone | Health aspects | Cancer | Life Sciences | Obstetrics, Gynecology and Reproductive Medicine | Reproduktionsmedicin och gynekologi | Cancer and Oncology | Cancer och onkologi
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2012, Volume 51, Issue 10, pp. 807 - 815
We and others have identified FGFR4 as a direct transcriptional target of the alveolar rhabdomyosarcoma (ARMS) specific fusion protein, PAX3‐FOXO1. We...
PAX3‐FOXO1 | FGFR4 | alveolar rhabdomyosarcoma | PAX3-FOXO1 | Alveolar rhabdomyosarcoma | CHILDHOOD RHABDOMYOSARCOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-LINES | CHILDRENS ONCOLOGY GROUP | PAX3-FKHR FUSION PROTEIN | BREAST-CANCER | GENE FUSIONS | ONCOLOGY | EMBRYONAL RHABDOMYOSARCOMA | PROSTATE-CANCER | GROWTH-FACTOR RECEPTOR-4 | UP-REGULATION | Paired Box Transcription Factors - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Up-Regulation | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Humans | Molecular Sequence Data | Myoblasts - metabolism | Rhabdomyosarcoma, Alveolar - metabolism | Mice, Mutant Strains | Rhabdomyosarcoma, Alveolar - pathology | Cell Differentiation | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Rhabdomyosarcoma, Alveolar - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Myoblasts - pathology | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Polymorphism, Single Nucleotide | Mutation | Paired Box Transcription Factors - metabolism | Fibroblast growth factors | Messenger RNA | Proteins | Genotype & phenotype | Gene expression | Lung cancer
PAX3‐FOXO1 | FGFR4 | alveolar rhabdomyosarcoma | PAX3-FOXO1 | Alveolar rhabdomyosarcoma | CHILDHOOD RHABDOMYOSARCOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-LINES | CHILDRENS ONCOLOGY GROUP | PAX3-FKHR FUSION PROTEIN | BREAST-CANCER | GENE FUSIONS | ONCOLOGY | EMBRYONAL RHABDOMYOSARCOMA | PROSTATE-CANCER | GROWTH-FACTOR RECEPTOR-4 | UP-REGULATION | Paired Box Transcription Factors - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Up-Regulation | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Humans | Molecular Sequence Data | Myoblasts - metabolism | Rhabdomyosarcoma, Alveolar - metabolism | Mice, Mutant Strains | Rhabdomyosarcoma, Alveolar - pathology | Cell Differentiation | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Rhabdomyosarcoma, Alveolar - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Myoblasts - pathology | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Polymorphism, Single Nucleotide | Mutation | Paired Box Transcription Factors - metabolism | Fibroblast growth factors | Messenger RNA | Proteins | Genotype & phenotype | Gene expression | Lung cancer
Journal Article