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1. Full Text Neurotrophic Factors and Their Receptors Are Altered by the Mere Partial IGF-1 Deficiency
by Castilla-Cortázar, Inma and Iturrieta, Ignacio and García-Magariño, Mariano and Puche, Juan E and Martín-Estal, Irene and Aguirre, Gabriel A and Femat-Roldan, Giovana and Cantu-Martinez, Leonel and Muñoz, Úrsula
Neuroscience, ISSN 0306-4522, 04/2019, Volume 404, pp. 445 - 458
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons, playing a role in... 
gene ontology | IGF-1 | RT-qPCR | neurotrophic factors | neuroprotection | microarrays | GDNF FAMILY | INSULIN-LIKE-GROWTH-FACTOR-1 | OXIDATIVE DAMAGE | SYNAPTIC-TRANSMISSION | NEUROSCIENCES | CIRRHOTIC RATS | DATABASE | FACTOR CNTF | DIFFERENTIATION | GROWTH-FACTOR-I | PLASTICITY | Proteins | Somatotropin | Nervous system diseases | Neurons | Analysis | Leukemia | Genes | Development and progression | Nerve growth factor | Genetic transcription | Ciliary neurotrophic factor | Growth factors
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2. Full Text Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins
by González-Guerra, José Luis and Castilla-Cortazar, Inma and Aguirre, Gabriel A and Muñoz, Úrsula and Martín-Estal, Irene and Ávila-Gallego, Elena and Granado, Miriam and Puche, Juan E and García-Villalón, Ángel Luis
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0181760
Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with... 
G(BETA-GAMMA) SUBUNITS | MYOCARDIAL-INFARCTION | HSP47 | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | RECEPTOR | MICE | ISCHEMIA-REPERFUSION | INSULIN SENSITIVITY | GROWTH-FACTOR-I | DIASTOLIC DYSFUNCTION | Angiotensin II - pharmacology | Extracellular Matrix - drug effects | Body Weight - drug effects | Extracellular Matrix - metabolism | Insulin-Like Growth Factor I - deficiency | Myocardial Contraction - drug effects | Mice, Transgenic | Myocardium - pathology | Vasoconstriction - drug effects | Gene Expression Regulation - drug effects | Myocardial Contraction - genetics | Organ Size - drug effects | Animals | Perfusion | Myocardium - metabolism | Hemodynamics - drug effects | Vasodilation - drug effects | Real-Time Polymerase Chain Reaction | Bradykinin - pharmacology | Insulin-Like Growth Factor I - metabolism | Type 2 diabetes | Dyslipidemias | Angiotensin | Insulin resistance | Development and progression | Research | Gene expression | Cardiovascular diseases | Risk factors | Heart | Calcium | Peptides | Insulin-like growth factor I | Dyslipidemia | Insulin-like growth factors | Kinases | Proteins | Calcium signalling | Reduction | Reperfusion | Ischemia | Vasoactive agents | Rodents | Extracellular matrix | Angiotensin II | Heart diseases | Diabetes mellitus | Health risks | Contractility | Coronary circulation | Histology | Insulin | Muscle contraction | Coronary artery disease | Cirrhosis | DNA microarrays | Fibrosis | Metabolic disorders | Circulation | Calcium (extracellular) | Structure-function relationships
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3. Full Text The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy
by Olleros Santos-Ruiz, M and Sádaba, M.C and Martín-Estal, I and Muñoz, U and Sebal Neira, C and Castilla-Cortázar, I
Growth Hormone and IGF Research, ISSN 1096-6374, 2017, Volume 35, pp. 21 - 32
Abstract Background & aims We previously described in cirrhosis and aging, both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with... 
Endocrinology & Metabolism | Advanced Basic Science | Mitochondria | IGF-1 | Free radicals | Cellular protection | Oxidative damage | INVOLVEMENT | RATS | CELL BIOLOGY | LIVER-CIRRHOSIS | METABOLISM | PROTON LEAK | ENDOCRINOLOGY & METABOLISM | MICE | BCL-2 FAMILY-MEMBERS | EXPRESSION | GROWTH-FACTOR-I | Mitochondrial Diseases - genetics | Mitochondrial Diseases - drug therapy | Mitochondria, Liver - pathology | Mitochondria, Liver - metabolism | Liver - metabolism | Oxidative Stress - genetics | Insulin-Like Growth Factor I - deficiency | Apoptosis - genetics | Male | Mice, Transgenic | Treatment Outcome | Insulin-Like Growth Factor I - genetics | Loss of Heterozygosity | Hormone Replacement Therapy | Animals | Mice | Insulin-Like Growth Factor I - therapeutic use
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4. Full Text Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment
by de la Garza, Rocio G and Morales-Garza, Luis Alonso and Martin-Estal, Irene and Castilla-Cortazar, Inma
Journal of clinical medicine research, ISSN 1918-3003, 04/2017, Volume 9, Issue 4, pp. 233 - 247
Cirrhosis represents the final stage of chronic liver damage, which can be due to different factors such as alcohol, metabolic syndrome with liver steatosis,... 
IGF-1 axis | Mitochondrial protection | Oxidative damage | IGF-1 | Review | Non-alcoholic fatty liver disease | Acute liver damage | Fibrogenesis | Steatosis
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5. Full Text Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: An experimental approach to metabolic syndrome
by Ita, J.Rodríguez and Castilla-Cortázar, I and Aguirre, G.A and Sánchez-Yago, C and Santos-Ruiz, M.Olleros and Guerra-Menéndez, L and Martín-Estal, I and García-Magariño, M and Lara-Díaz, V.J and Puche, J.E and Muñoz, U
Journal of Translational Medicine, ISSN 1479-5876, 10/2015, Volume 13, Issue 1, p. 326
Background: Insulin growth factor 1 (IGF-1) has multiple effects on metabolism. Much evidence suggests that the deficiency of this hormone increases insulin... 
Type 2 diabetes | Oxidative damage | Dyslipidemia | IGF-1 | Metabolic syndrome | Metabolism | ATP-citrate lyase (Acly) | Glucogenolysis | Acetyl-CoA acyltransferase (Acaa1b) | Glucose-6-phosphate (G6P) | Insulin resistance | Phosphoenolpyruvate carboxykinase (PEPCK) | Growth hormone | Gluconeogenesis | MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR AXIS | LARON-SYNDROME | DIABETES-MELLITUS | INSULIN-RESISTANCE | CARDIOVASCULAR-DISEASE | GROWTH-FACTOR-I | HOMEOSTASIS | COENZYME-A | HORMONE | AGING RATS | Insulin-Like Growth Factor Binding Proteins - genetics | Body Weight | Liver - metabolism | Carbohydrate Metabolism - genetics | Organ Size | Male | Insulin-Like Growth Factor I - genetics | Mice, Knockout | Triglycerides - metabolism | Animals | Metabolic Syndrome - genetics | Glucose - metabolism | Lipid Metabolism - genetics | Mice | Fatty Acids - metabolism | Insulin-Like Growth Factor I - metabolism | Disease Models, Animal | Somatotropin | Genes | Liver | Genetic research | Triglycerides | Glucose | Insulin | Dextrose
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6. Full Text IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture
by Lara-Diaz, Vj and Castilla-Cortazar, I and Martín-Estal, I and García-Magariño, M and Aguirre, Ga and Puche, Je and de la Garza, Rg and Morales, La and Muñoz, U
Journal of Physiology and Biochemistry, ISSN 1138-7548, 05/2017, Volume 73, Issue 2, pp. 245 - 258
Even though the liver synthesizes most of circulating IGF-1, it lacks its receptor under physiological conditions. However, according to previous studies, a... 
Cytoskeleton | Extracellular matrix | IGF-1 | Hepatocytes | Tight junctions | Gene expression | PHYSIOLOGY | ATROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SOMATOMEDIN-C | FACTOR-BINDING-PROTEINS | TRANSPORT | CIRRHOTIC RATS | METABOLISM | OSTEOPENIA | MITOCHONDRIAL PROTECTION | HEPATOMA | GROWTH-FACTOR-I | Liver - pathology | Tight Junction Proteins - genetics | Cadherins - metabolism | Oxidative Stress | Cytoskeletal Proteins - genetics | Male | Gene Expression Profiling | Insulin-Like Growth Factor I - genetics | Acute-Phase Proteins - genetics | Desmosomes - pathology | Hepatitis - prevention & control | Liver - immunology | Injections, Subcutaneous | Desmosomes - immunology | Hepatitis - metabolism | Inflammation Mediators - metabolism | Insulin-Like Growth Factor I - administration & dosage | Cytoskeletal Proteins - metabolism | Cadherins - genetics | Insulin-Like Growth Factor I - therapeutic use | Extracellular Matrix Proteins - metabolism | Tight Junction Proteins - metabolism | Desmosomes - metabolism | Acute-Phase Proteins - metabolism | Extracellular Matrix Proteins - genetics | Liver - metabolism | Gene Expression Regulation | Hepatitis - pathology | Mice, Transgenic | Animals | Receptors, Somatomedin - metabolism | Hepatitis - immunology | Receptors, Somatomedin - genetics | Mice | Lipid Peroxidation | Insulin-Like Growth Factor I - metabolism | Crosses, Genetic | Original
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7. Full Text Clinical and molecular diagnosis of a cartilage‐hair hypoplasia with IGF‐1 deficiency
by Castilla‐Cortázar, Inma and Rodríguez De Ita, Julieta and Martín‐Estal, Irene and Castorena, Fabiola and Aguirre, Gabriel A and García de la Garza, Rocío and Elizondo, Martha I
American Journal of Medical Genetics Part A, ISSN 1552-4825, 02/2017, Volume 173, Issue 2, pp. 537 - 540
Cartilage‐hair hypoplasia syndrome (CHH) is a rare autosomal recessive condition characterized by metaphyseal chondrodysplasia and characteristic hair,... 
IGF‐1 | RMRP gene | GHR | cartilage‐hair hypoplasia | IGF-1 | cartilage-hair hypoplasia | SYSTEM | VITRO | COMPLEX | RNA | CIRRHOTIC RATS | DISEASES | GENETICS & HEREDITY | MUTATIONS | IMMUNE FUNCTION | GROWTH-FACTOR-I | AGING RATS | Genetic Testing | Genetic Association Studies | Hair - abnormalities | Humans | Hirschsprung Disease - genetics | Janus Kinase 2 - genetics | Insulin-Like Growth Factor I - deficiency | Genotype | Male | Insulin-Like Growth Factor I - genetics | Osteochondrodysplasias - diagnosis | Radiography | Hirschsprung Disease - diagnosis | Phenotype | Osteochondrodysplasias - genetics | Osteochondrodysplasias - congenital | Adolescent | Biomarkers | Immunologic Deficiency Syndromes - genetics | Physical Examination | Polymorphism, Single Nucleotide | Immunologic Deficiency Syndromes - diagnosis | Gastrointestinal diseases | Immunodeficiency | Hypoplasia | Hair | Hirschsprung's disease | Cartilage | Immune response | Insulin-like growth factors | Hemopoiesis | Chondrodystrophy | Clinical Report | Clinical Reports
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8. Full Text Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases
by Sádaba, M.C and Martín-Estal, I and Puche, J.E and Castilla-Cortázar, I
BBA - Molecular Basis of Disease, ISSN 0925-4439, 07/2016, Volume 1862, Issue 7, pp. 1267 - 1278
This review resumes the association between mitochondrial function and diseases, especially neurodegenerative diseases. Additionally, it summarizes the major... 
Oxidative stress | Mitochondria | Free radicals | Neurodegenerative diseases | Hepatic cirrhosis | Aging | IGF-1 | Mitochondrial diseases | OXIDATIVE DAMAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-I | ALPHA-SYNUCLEIN | CYTOCHROME-C-OXIDASE | BIOPHYSICS | MULTIPLE-SCLEROSIS | ATP SYNTHASE | COMPLEX-I | GENE-EXPRESSION | ALZHEIMERS | PARKINSONS-DISEASE | Type 2 diabetes | Diabetics | Nervous system diseases | DNA microarrays | Analysis | Genes | Physiological aspects | Insulin resistance | Gene expression | Diabetes therapy | Mitochondrial DNA | Superoxide | Antioxidants | Somatotropin | Liver cirrhosis
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9. Intrauterine growth retardation (IUGR) as a novel condition of insulin-like growth factor-1 (IGF-1) deficiency
by Martín-Estal, I and De La Garza, R.G and Castilla-Cortázar, I
Reviews of Physiology, Biochemistry and Pharmacology, ISSN 0303-4240, 2016, Volume 170, pp. 1 - 35
Insulin-like growth factor 1 (IGF-1) is an anabolic hormone with several biological activities, such as proliferation, mitochondrial protection, cell survival,... 
Cell proliferation | Intrauterine growth restriction | Placental lactogen | Foetal/placental growth | Somatostatinergic tone | IGFBP-rPs | IGFBPs | IGF-1 | IGF-2 | GH/IGF-1 axis | IGF-1R | COHORT PROFILE | PHYSIOLOGY | LOW-BIRTH-WEIGHT | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | HUMAN-PLACENTA | HUMAN FETAL-GROWTH | HORMONE RECEPTORS | FACTOR-BINDING-PROTEINS | lacental lactogen | MITOCHONDRIAL PROTECTION | FACTOR SYSTEM | PHARMACOLOGY & PHARMACY | FOR-GESTATIONAL-AGE | Fetal Growth Retardation - blood | Pregnancy | Animals | Fetal Growth Retardation - etiology | Humans | Insulin-Like Growth Factor I - deficiency | Female
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10. Erratum: Intrauterine growth retardation (IUGR) as a novel condition of insulin-like growth factor-1 (IGF-1) deficiency (Rev Physiol Biochem Pharmacol, 10.1007/112_2015_5001)
by Martín-Estal, Irene and de la Garza, R.G and Castilla-Cortázar, I
Reviews of Physiology, Biochemistry and Pharmacology, ISSN 0303-4240, 2016, Volume 170, p. 129
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11. Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases
by Sádaba, M C and Martín-Estal, I and Puche, J E and Castilla-Cortázar, I
Biochimica et biophysica acta, ISSN 0006-3002, 07/2016, Volume 1862, Issue 7, p. 1267
This review resumes the association between mitochondrial function and diseases, especially neurodegenerative diseases. Additionally, it summarizes the major... 
Mitochondrial Diseases - pathology | Mitochondrial Diseases - drug therapy | Humans | Insulin Resistance | Mitochondrial Diseases - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Protective Agents - therapeutic use | Insulin - metabolism | Animals | Insulin-Like Growth Factor I - administration & dosage | Oxidative Stress - drug effects | Protective Agents - administration & dosage | Insulin-Like Growth Factor I - therapeutic use
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12. Full Text Primary growth hormone insensitivity and psychomotor delay
by Castilla‐Cortazar, Inma and De Ita, Julieta Rodríguez and Aguirre, Gabriel A and Rodríguez‐Rivera, Joel and García‐Magariño, Mariano and Martín‐Estal, Irene and Flores‐Caloca, Óscar and Diaz‐Olachea, Carlos
Clinical Case Reports, ISSN 2050-0904, 02/2018, Volume 6, Issue 2, pp. 426 - 431
Key Clinical Message We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and... 
IGF‐1 | GH insensitivity | GH resistance | Laron Syndrome | GH/IGF‐1 axis | IGF-1 | GH/IGF-1 axis
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13. Full Text Mexican case report of a never‐treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke
by Castilla‐Cortazar, Inma and Femat‐Roldán, Giovana and Rodríguez‐Rivera, Joel and Aguirre, Gabriel A and García‐Magariño, Mariano and Martín‐Estal, Irene and Espinosa, Luis and Díaz‐Olachea, Carlos
Clinical Case Reports, ISSN 2050-0904, 11/2017, Volume 5, Issue 11, pp. 1852 - 1855
Key Clinical Message Glucose and lipid profile together with blood pressure should always be considered for low sera‐IGF‐1 patients. Even when adulthood is... 
GHR | IGF‐1 | metabolic syndrome | GH insensitivity | type 2 diabetes | GH/IGF‐1 axis | Laron syndrome | stroke | obesity | IGF-1 | GH/IGF-1 axis | Metabolism | Diabetes
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14. Full Text Growth hormone insensitivity: Mexican case report
by Castilla-Cortazar, I and De Ita, J R and Aguirre, G A and García-Magariño, M and Martín-Estal, I and Lara-Diaz, V J and Elizondo, M I
Endocrinology, diabetes & metabolism case reports, ISSN 2052-0573, 2017, Volume 2017, Issue 1, pp. 1 - 5
Herein, we present a 14-year-old patient with short stature (134 cm) referred from Paediatrics to our department for complementary evaluation since growth... 
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15. Intrauterine Growth Retardation (IUGR) as a Novel Condition of Insulin-Like Growth Factor-1 (IGF-1) Deficiency (vol 170, pg 1, 2016)
by Martin-Estal, I and de la Garza, RG and Castilla-Cortazar, I
2016, Reviews of Physiology Biochemistry and Pharmacology, Volume 170, 1
PHYSIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHARMACOLOGY & PHARMACY
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