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BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 06/2018, Volume 29, Issue 6, pp. 2021 - 2027
Serotonin (5-HT) modulates key aspects of the immune system. However, its precise function and the receptors involved in the observed effects have remained... 
HUMAN DENDRITIC CELLS | PROTEIN | 5-HYDROXYTRYPTAMINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | MECHANISMS | REGULATORY T | CHEMISTRY, MULTIDISCIPLINARY | LIGANDS | EXPRESSION | T-CELLS | IL-10 RESPONSES | MYD88
Journal Article
Chemistry: A European Journal, ISSN 0947-6539, 01/2016, Volume 22, Issue 4, pp. 1313 - 1321
Determination of the targets of a compound remains an essential aspect in drug discovery. A complete understanding of all binding interactions is critical to... 
Drugs | Binding | Platforms | Receptors | Serotonin | Methodology | Ligands | Biological
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2011, Volume 54, Issue 23, pp. 7986 - 7999
We report the synthesis of new compounds 4 35 based on structural modifications of different moieties of previously described lead UCM-2550. The new... 
CHEMISTRY, MEDICINAL | TERMINAL AMIDE FRAGMENT | ARYLPIPERAZINES | AMINO-ACIDS | PROTEIN-COUPLED RECEPTORS | NEW-MODEL | COMPUTATIONAL SIMULATION | RAT-BRAIN | 8-OH-DPAT-INDUCED HYPOTHERMIA | CEREBRAL-ISCHEMIA | NR1 SUBUNIT
Journal Article
Allergy, ISSN 0105-4538, 11/2017, Volume 72, Issue 11, pp. 1744 - 1752
Journal Article
Organic Letters, ISSN 1523-7060, 09/2010, Volume 12, Issue 18, pp. 4082 - 4085
SmI2-mediated 3-exo-trig cyclizations of beta,gamma-unsaturated carbonyl compounds to generate cyclopropanols are not generally observed processes. The... 
DIIODIDE | CHEMISTRY | CHEMISTRY, ORGANIC | SAMARIUM(II) IODIDE
Journal Article
Organic Letters, ISSN 1523-7060, 09/2010, Volume 12, Issue 18, pp. 4082 - 4085
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 02/2018, Volume 12, Issue 2, pp. e0006267 - e0006267
Background Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional... 
SWISS-MODEL | 5-HT RECEPTOR | LOCALIZATION | LIVER FLUKE | ACTIVATION | 5-HYDROXYTRYPTAMINE | MUSCLE | IDENTIFICATION | BINDING | MODULATION | PARASITOLOGY | TROPICAL MEDICINE | Cestoda - genetics | Echinococcus granulosus - genetics | Receptors, G-Protein-Coupled - metabolism | Cestode Infections - drug therapy | Computational Biology | Models, Molecular | Phylogeny | Serotonin - pharmacology | Echinococcus granulosus - physiology | Amino Acid Motifs | Sequence Alignment | Animals | Cestoda - growth & development | Mesocestoides - physiology | Cloning, Molecular | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Larva - physiology | Mesocestoides - growth & development | Cestoda - physiology | Receptors, G-Protein-Coupled - chemistry | Mesocestoides - genetics | RNA sequencing | Diphyllobothrium | Analysis | Physiological aspects | Genetic aspects | Cyclic adenylic acid | G proteins | Research | Cestoda | Larvae | Neurosciences | Motility | G protein-coupled receptors | Spatial discrimination | Fluorescent indicators | Parasites | Properties | Serotonin S7 receptors | Proteins | Signal transduction | Receptors | Parasitic diseases | Phylogenetics | Modelling | Localization | Serotonin | Nucleotide sequence | Lysergic acid diethylamide--LSD | Cloning | Agents | Pharmacology | Properties (attributes) | Sensitivity | Molecular modelling | Serotonin receptors | Ligands | Receptor mechanisms | Position (location) | Index Medicus | Lysergic acid diethylamide | LSD
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 01/2017, Volume 23, Issue 7, pp. 1676 - 1685
Despite more than three decades of intense effort, no anti‐Ras therapies have reached clinical application. Contributing to this failure has been an... 
inhibitors | cancer | drug design | proteins | medicinal chemistry | ACTIVATION | EFFECTOR INTERACTIONS | CHEMISTRY, MULTIDISCIPLINARY | K-RAS | LIGANDS | IN-VIVO | MUTATIONS | GTPASE | RENAISSANCE | MODULATION | Molecular dynamics | Nuclear magnetic resonance spectroscopy | Usage | Mitogens | Protein kinases | Analysis | Kinases | Proteins | Inhibitors | Pathways | Pocket | Activation | Failure | Cancer
Journal Article
Genes and Immunity, ISSN 1466-4879, 12/2014, Volume 15, Issue 8, p. 511
The prevalence of allergic diseases has significantly increased in industrialized countries. Allergen-specific immunotherapy (AIT) remains as the only curative... 
Allergy | Immune response | Interleukin-10 | Physiological aspects | Regulation | Genetic aspects | T cells | Transforming growth factors | Health aspects | Allergic reaction
Journal Article
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 2, pp. 1525 - 1534
FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine... 
SUPERRESOLUTION | ORGANIZATION | BACTERIAL CYTOKINESIS | GTP | ALPHA-BETA-TUBULIN | FILAMENTS | Z-RING | STAPHYLOCOCCUS-AUREUS | POLYMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | MODULATION | Filaments | Switches | Cell division | Fluorescence | Bacteria | Benzamide | Monomers | Assembly
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 03/2015, Volume 10, Issue 3, pp. 834 - 843
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 07/2012, Volume 51, Issue 28, pp. 6896 - 6899
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 2009, Volume 2009, Issue 10, pp. 1606 - 1611
Allyl ethers of the tricarbonylchromium(0) complexes of benzylic alcohols undergo highly enantioselective benzylic functionalisation using a chiral... 
Chromium | Chiral base | Allylic compounds | Enantioselectivity | Alkylation | Alcohols | CORE | LIGANDS | CHEMISTRY, ORGANIC | POLYETHERS | CHIRALITY | ZINC
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 03/2013, Volume 110, Issue 12, p. 4786
Complex interactions between periphery and the brain regulate food intake in mammals. Cannabinoid type-1 ([CB.sub.1]) receptor antagonists are potent... 
Nervous system, Sympathetic | Fear | Anxiety | Research
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2009, Volume 50, Issue 26, pp. 3690 - 3692
Deprotonation of a chromium tricarbonyl complex of a benzyl ether followed by reaction with -fluorobenzenesulfonimide (NFSI) generated a species that reacts... 
Chromium | Thioacetal | Acetal | Ether | N-Fluorobenzenesulfonimide | CHEMISTRY | CHEMISTRY, ORGANIC | FLUORINATION | FLUORIDE | Sulfur compounds
Journal Article
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