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Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9971, pp. 857 - 866
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9691, pp. 685 - 694
Summary Background The phosphodiesterase-4 inhibitor roflumilast can improve lung function and prevent exacerbations in certain patients with chronic... 
Internal Medicine | PDE4 INHIBITOR ROFLUMILAST | MEDICINE, GENERAL & INTERNAL | FLUTICASONE PROPIONATE | SPUTUM | INFLAMMATION | COPD EXACERBATIONS | PREVENTION | TIOTROPIUM | STATISTICAL-ANALYSIS | HEALTH-STATUS | SALMETEROL | Phosphodiesterase Inhibitors - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - etiology | Cyclopropanes - therapeutic use | Vital Capacity - drug effects | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Phosphodiesterase 4 Inhibitors | Female | Benzamides - pharmacology | Adrenergic beta-Agonists - therapeutic use | Drug Therapy, Combination | Cholinergic Antagonists - therapeutic use | Cyclopropanes - pharmacology | Severity of Illness Index | Pulmonary Disease, Chronic Obstructive - diagnosis | Double-Blind Method | Administration, Oral | Proportional Hazards Models | Phosphodiesterase Inhibitors - pharmacology | Treatment Outcome | Regression Analysis | Analysis of Variance | Smoking - epidemiology | Aminopyridines - pharmacology | Aged | Pulmonary Disease, Chronic Obstructive - drug therapy | Lung diseases, Obstructive | Dosage and administration | Enzyme inhibitors | Research | Drug therapy | Studies | Clinical trials | Chronic obstructive pulmonary disease | Health economics | Disease management | Corticoids | Respiratory function | Side effects | Historical account | Motivation | Smoking | air flow
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9691, pp. 695 - 703
Summary Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of the... 
Internal Medicine | PDE4 INHIBITOR ROFLUMILAST | MEDICINE, GENERAL & INTERNAL | IN-VITRO | PHOSPHODIESTERASE-4 INHIBITORS | MANAGEMENT | THERAPY | INFLAMMATION | THEOPHYLLINE | FLUTICASONE | COPD | SALMETEROL | Bronchodilator Agents - therapeutic use | Phosphodiesterase Inhibitors - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - etiology | Cyclopropanes - therapeutic use | Vital Capacity - drug effects | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Phosphodiesterase 4 Inhibitors | Female | Drug Therapy, Combination | Scopolamine Derivatives - therapeutic use | Tiotropium Bromide | Severity of Illness Index | Pulmonary Disease, Chronic Obstructive - diagnosis | Salmeterol Xinafoate | Double-Blind Method | Administration, Oral | Administration, Inhalation | Albuterol - analogs & derivatives | Treatment Outcome | Regression Analysis | Analysis of Variance | Smoking - epidemiology | Albuterol - therapeutic use | Aged | Pulmonary Disease, Chronic Obstructive - drug therapy | Lung diseases, Obstructive | Dosage and administration | Enzyme inhibitors | Research | Drug therapy | Bronchodilator agents | Studies | Smoking cessation | Molecular structure | Clinical trials | Chronic obstructive pulmonary disease | Clinical medicine | Headache | Respiratory function | Side effects | Motivation | salmeterol | Lung | Bronchodilators | Diarrhea | Nausea
Journal Article